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Marije Havermans
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Journal Articles

Targeting Super-Enhancers Driving EVI1 Expression in Leukemia By Inhibition of p300/CBP

Dorien Pastoors, Claudia Erpelinck, Stanley Van Herk, Roger Mulet-Lazaro, Marije Havermans, Eric Bindels, Sophie Ottema, Ruud Delwel
Journal: Blood
Blood (2023) 142 (Supplement 1): 710.
https://doi.org/10.1182/blood-2023-181741
Published: 2023
Journal Articles

EVI1 drives leukemogenesis through aberrant ERG activation

Johannes Schmoellerl, Inês A.M. Barbosa, Martina Minnich, Florian Andersch, Leonie Smeenk, Marije Havermans, Thomas Eder, Tobias Neumann, Julian Jude, Michaela Fellner, Anja Ebert, Monika Steininger, Ruud Delwel, Florian Grebien, Johannes Zuber
Journal: Blood
Blood (2023) 141 (5): 453–466.
https://doi.org/10.1182/blood.2022016592
Published: 2023
Includes: Supplemental data
Journal Articles

Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable EVI1-CtBP1/2 Interaction and By Repressing Myeloid Regulator CEBPA

Dorien Pastoors, Marije Havermans, Remco Hoogenboezem, Roger Mulet-Lazaro, Duncan Brian, Leonie Smeenk, Claudia Erpelinck-Verschueren, Stanley van Herk, Bas Wouters, Jeroen A.A. Demmers, Johannes Zuber, Tariq Enver, Richard WJ Groen, Eric Bindels, Ruud Delwel
Journal: Blood
Blood (2022) 140 (Supplement 1): 83–84.
https://doi.org/10.1182/blood-2022-156994
Published: 2022
Journal Articles

Aberrant EVI1 splicing contributes to EVI1 -rearranged leukemia

Atsushi Tanaka, Taizo A. Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P. Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C. Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue
Journal: Blood
Blood (2022) 140 (8): 875–888.
https://doi.org/10.1182/blood.2021015325
Published: 2022
Includes: Supplemental data
Journal Articles

Atypical 3q26/ MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia

Sophie Ottema, Roger Mulet-Lazaro, H. Berna Beverloo, Claudia Erpelinck, Stanley van Herk, Robert van der Helm, Marije Havermans, Tim Grob, Peter J. M. Valk, Eric Bindels, Torsten Haferlach, Claudia Haferlach, Leonie Smeenk, Ruud Delwel
Journal: Blood
Blood (2020) 136 (2): 224–234.
https://doi.org/10.1182/blood.2019003701
Published: 2020
Includes: Supplemental data
Journal Articles

Complex 3q26/EVI1 Rearrangements Genocopy Inv(3)/t(3;3) Acute Myeloid Leukemias By Enhancer Hijacking, EVI1 Overexpression, Absent MDS1-EVI1 and Low GATA2 Expression

Sophie Ottema, MSc, Roger Mulet-Lazaro, B.Sc., Berna Beverloo, PhD, Marije Havermans, Ir, Claudia Erpelinck-Verschueren, B.Sc., Tim Grob, MD, Peter Valk, PhD, Eric Bindels, PhD, Torsten Haferlach, MD, Claudia Haferlach, MD, Leonie Smeenk, PhD, Ruud Delwel, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2766.
https://doi.org/10.1182/blood-2018-99-113339
Published: 2018
Journal Articles

An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

Roberto Avellino, Marije Havermans, Claudia Erpelinck, Mathijs A. Sanders, Remco Hoogenboezem, Harmen J. G. van de Werken, Elwin Rombouts, Kirsten van Lom, Paulina M. H. van Strien, Claudia Gebhard, Michael Rehli, John Pimanda, Dominik Beck, Stefan Erkeland, Thijs Kuiken, Hans de Looper, Stefan Gröschel, Ivo Touw, Eric Bindels, Ruud Delwel
Journal: Blood
Blood (2016) 127 (24): 2991–3003.
https://doi.org/10.1182/blood-2016-01-695759
Published: 2016
Includes: Supplemental data
Journal Articles

A Tissue-Specific Transcriptional Element for C/ebpa Is Required for HSC Maintenance and Neutrophil Development

Roberto Avellino, Marije Havermans, Claudia Erpelinck, Mathijs Sanders, Stefan Groeschel, Harmen Vandewerken, Remco M. Hoogenboezem, M.Sc., Elwin Rombouts, Kirsten Van Lom, Paulette Van Strien, Hans De Looper, Claudia Christine Gebhard, Michael Rehli, Dominik Beck, PhD, Julie A.I. Thoms, PhD, Stefan Erkeland, Ivo Touw, John E. Pimanda, MDPhD, Eric JM Bindels, Ruud Delwel
Journal: Blood
Blood (2015) 126 (23): 301.
https://doi.org/10.1182/blood.V126.23.301.301
Published: 2015
Journal Articles

Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways

Stefan Gröschel, Mathijs A. Sanders, Remco Hoogenboezem, Annelieke Zeilemaker, Marije Havermans, Claudia Erpelinck, Eric M. J. Bindels, H. Berna Beverloo, Hartmut Döhner, Bob Löwenberg, Konstanze Döhner, Ruud Delwel, Peter J. M. Valk
Journal: Blood
Blood (2015) 125 (1): 133–139.
https://doi.org/10.1182/blood-2014-07-591461
Published: 2015
Includes: Supplemental data
Journal Articles

Defects in the RAS/RTK Signaling Pathways Predominate the Mutational Spectrum of EVI1/GATA2 Rearranged Myeloid Malignancies with Inv(3)/t(3;3)

Mathijs A. Sanders, MSc, Stefan Gröschel, Remco M. Hoogenboezem, Annelieke Zeilemaker, Marije Havermans, Claudia Erpelinck, Eric M. J. Bindels, PhD, Berna Beverloo, PhD, Hartmut Döhner, MD, Bob Löwenberg, MD PhD, Konstanze Döhner, MD, Ruud Delwel, PhD, Peter J.M. Valk, PhD
Journal: Blood
Blood (2014) 124 (21): 701.
https://doi.org/10.1182/blood.V124.21.701.701
Published: 2014
Journal Articles

A Myeloid-Specific Gene-Dosage Regulator for CEBPA Expression in Myeloid Cells Is Commonly Targeted By Onco-Proteins in AML

Roberto Avellino, Stefan M Groschel, MD, Harmen Van de Werken, Mathijs A. Sanders, MSc, Remco M. Hoogenboezem, Claudia Erpelinck, Marije Havermans, Eric Bindels, Ruud Delwel, PhD
Journal: Blood
Blood (2014) 124 (21): 2205.
https://doi.org/10.1182/blood.V124.21.2205.2205
Published: 2014
Journal Articles

Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling

Erdogan Taskesen, Marije Havermans, Kirsten van Lom, Mathijs A. Sanders, Yvette van Norden, Eric Bindels, Remco Hoogenboezem, Marcel J. T. Reinders, Maria E. Figueroa, Peter J. M. Valk, Bob Löwenberg, Ari Melnick, Ruud Delwel
Journal: Blood
Blood (2014) 123 (21): 3327–3335.
https://doi.org/10.1182/blood-2013-07-512855
Published: 2014
Includes: Supplemental data
Journal Articles

EVI1 is critical for the pathogenesis of a subset of MLL-AF9 –rearranged AMLs

Clinical Trials & Observations
Eric M. J. Bindels, Marije Havermans, Sanne Lugthart, Claudia Erpelinck, Elizabeth Wocjtowicz, Andrei V. Krivtsov, Elwin Rombouts, Scott A. Armstrong, Erdogan Taskesen, Jurgen R. Haanstra, H. Berna Beverloo, Hartmut Döhner, Wendy A. Hudson, John H. Kersey, Ruud Delwel, Ashish R. Kumar
Journal: Blood
Blood (2012) 119 (24): 5838–5849.
https://doi.org/10.1182/blood-2011-11-393827
Published: 2012
Includes: Supplemental data