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Ashish R. Kumar
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Journal Articles

Diagnostic guidelines for familial hemophagocytic lymphohistiocytosis revisited

Clinical Trials & Observations
Jan-Inge Henter, Elena Sieni, Julia Eriksson, Elisabet Bergsten, Ida Hed Myrberg, Scott W. Canna, Maria Luisa Coniglio, Randy Q. Cron, Kate F. Kernan, Ashish R. Kumar, Kai Lehmberg, Francesca Minoia, Ahmed Naqvi, Angelo Ravelli, Yong-Min Tang, Matteo Bottai, Yenan T. Bryceson, AnnaCarin Horne, Michael B. Jordan
Journal: Blood
Blood (2024) 144 (22): 2308–2318.
https://doi.org/10.1182/blood.2024025077
Published: 2024
Includes: Supplemental data
Journal Articles

ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition

Clinical Trials & Observations
Paul G. Kemps, Jennifer Picarsic, Benjamin H. Durham, Zofia Hélias-Rodzewicz, Laura Hiemcke-Jiwa, Cor van den Bos, Marianne D. van de Wetering, Carel J. M. van Noesel, Jan A. M. van Laar, Robert M. Verdijk, Uta E. Flucke, Pancras C. W. Hogendoorn, F. J. Sherida H. Woei-A-Jin, Raf Sciot, Andreas Beilken, Friedrich Feuerhake, Martin Ebinger, Robert Möhle, Falko Fend, Antje Bornemann, Verena Wiegering, Karen Ernestus, Tina Méry, Olga Gryniewicz-Kwiatkowska, Bozenna Dembowska-Baginska, Dmitry A. Evseev, Vsevolod Potapenko, Vadim V. Baykov, Stefania Gaspari, Sabrina Rossi, Marco Gessi, Gianpiero Tamburrini, Sébastien Héritier, Jean Donadieu, Jacinthe Bonneau-Lagacherie, Claire Lamaison, Laure Farnault, Sylvie Fraitag, Marie-Laure Jullié, Julien Haroche, Matthew Collin, Jackie Allotey, Majid Madni, Kerry Turner, Susan Picton, Pasquale M. Barbaro, Alysa Poulin, Ingrid S. Tam, Dina El Demellawy, Brianna Empringham, James A. Whitlock, Aditya Raghunathan, Amy A. Swanson, Mariko Suchi, Jon M. Brandt, Nabeel R. Yaseen, Joanna L. Weinstein, Irem Eldem, Bryan A. Sisk, Vaishnavi Sridhar, Mandy Atkinson, Lucas R. Massoth, Jason L. Hornick, Sanda Alexandrescu, Kee Kiat Yeo, Kseniya Petrova-Drus, Stephen Z. Peeke, Laura S. Muñoz-Arcos, Daniel G. Leino, David D. Grier, Robert Lorsbach, Somak Roy, Ashish R. Kumar, Shipra Garg, Nishant Tiwari, Kristian T. Schafernak, Michael M. Henry, Astrid G. S. van Halteren, Oussama Abla, Eli L. Diamond, Jean-François Emile
Journal: Blood
Blood (2022) 139 (2): 256–280.
https://doi.org/10.1182/blood.2021013338
Published: 2022
Includes: Supplemental data
Journal Articles

MLL-Fusion Leukemia Dependence on MBNL1 Is Associated with Alternative Splicing of Oncogenic Proteins

Arun Gurunathan, MD, Lana S Itskovich, PhD, Jason Clark, MS, Matthew Burwinkel, Nathan Salomonis, PhD, Meenakshi Venkatasubramanian, BS, Kashish Chetal, MS, Lynn Lee, MD, Ashish R Kumar, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3883.
https://doi.org/10.1182/blood-2018-99-112349
Published: 2018
Journal Articles

The Role of LAMP5 in Innate Immune Signaling Is Critical for the Survival of MLL Leukemias

Gabriel Gracia-Maldonado, BS, Jason Clark, MS, Philippe Pierre, PhD, James C. Mulloy, PhD, Ashish R Kumar, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3900.
https://doi.org/10.1182/blood-2018-99-120190
Published: 2018
Journal Articles

High-Risk Langerhans Cell Histiocytosis in Infants Exhibits Malignant Features in a Xenograft Model but Responds Durably to Targeted Therapy

Lynn Lee, MD, Mary Christa Krupski, DO, MPH, Jason Clark, MS, Robert B. Lorsbach, MD PhD, Michael Grimley, MD, Matthew Burwinkel, Adam S. Nelson, MBBS, Ashish R Kumar, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4323.
https://doi.org/10.1182/blood-2018-99-119383
Published: 2018
Journal Articles

Clinical Outcomes and Molecular Responses in Children with Langerhans Cell Histiocytosis Treated with MAPK Pathway Inhibitors

Olive S. Eckstein, MD, Daniel Zinn, MD, Carolyn Fein Levy, MD, Michael M. Henry, MD, Patrick Campbell, MD, Michael B. Jordan, MD, Ashish R Kumar, MD PhD, Carlos Rodriguez-Galindo, MD PhD, Nobuko Hijiya, MD, Oussama Abla, MD, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3684.
https://doi.org/10.1182/blood-2018-99-120393
Published: 2018
Journal Articles

Hematopoietic stem cell transplantation rescues the hematological, immunological, and vascular phenotype in DADA2

Clinical Trials & Observations
Hasan Hashem, Ashish R. Kumar, Ingo Müller, Florian Babor, Robbert Bredius, Jignesh Dalal, Amy P. Hsu, Steven M. Holland, Dennis D. Hickstein, Stephen Jolles, Robert Krance, Ghadir Sasa, Mervi Taskinen, Minna Koskenvuo, Janna Saarela, Joris van Montfrans, Keith Wilson, Barbara Bosch, Leen Moens, Michael Hershfield, Isabelle Meyts
Journal: Blood
Blood (2017) 130 (24): 2682–2688.
https://doi.org/10.1182/blood-2017-07-798660
Published: 2017
Journal Articles

Real-Time Genomic Profiling Identifies Novel Mutations and Improved Therapy for Histiocytoses

Lynn Lee, MD, Anjelika Gasilina, Jayeeta Roychoudhury, PhD, Jason Clark, Francis X McCormack, MD, Joseph Gerald Pressey, MD, Robert B. Lorsbach, MD PhD, Siraj M Ali, MD PhD, Mark Bailey, MSc, Philip Stevens, PhD, Jeffrey S Ross, MD, Vincent A. Miller, MD, Nicolas Nassar, PhD, Ashish R Kumar, MBBS, PhD
Journal: Blood
Blood (2016) 128 (22): 2723.
https://doi.org/10.1182/blood.V128.22.2723.2723
Published: 2016
Journal Articles

LAMP5 - a Novel Target of MLL-Fusion Proteins Is Required for the Propagation of Leukemia

Gabriel Gracia-Maldonado, Jason Clark, James C. Mulloy, PhD, Ashish R Kumar, MBBS, PhD
Journal: Blood
Blood (2016) 128 (22): 1512.
https://doi.org/10.1182/blood.V128.22.1512.1512
Published: 2016
Journal Articles

A Xenograft Model of Lymphocyte-Independent, Effector-Driven Macrophage Activation SyndRome Amenable to Anti-CD33 and Anti-IL-6R Treatment

Mark Wunderlich, MS, Courtney Stockman, Mahima Devarajan, Navin Ravishankar, Christina Sexton, Ashish R Kumar, MBBS, PhD, Benjamin Mizukawa, MD, James C. Mulloy, PhD
Journal: Blood
Blood (2016) 128 (22): 3684.
https://doi.org/10.1182/blood.V128.22.3684.3684
Published: 2016
Journal Articles

JAK1/2 Inhibition As a Salvage Therapy for Steroid Refractory Acute and Chronic Graft Versus Host Disease in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients

Pooja Khandelwal, MD, Ashley Teusink-Cross, PharmD, Adam S. Nelson, MBBS, Christopher E. Dandoy, MD, Javier A. El-Bietar, MD, Rebecca A Marsh, MD, Ashish R Kumar, MBBS, PhD, Michael S Grimley, MD, Sonata Jodele, MD, Stella M Davies, MBBS, PhD, Kasiani C. Myers, MD
Journal: Blood
Blood (2016) 128 (22): 4568.
https://doi.org/10.1182/blood.V128.22.4568.4568
Published: 2016
Journal Articles

Susceptibility of AML to Chloroquine Therapy Is Independent of Autophagy

Xiaoyi Chen, PhDcandidate, Jason Clark, Jun-lin Guan, PhD, Ashish R Kumar, MBBS, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2015) 126 (23): 1262.
https://doi.org/10.1182/blood.V126.23.1262.1262
Published: 2015
Journal Articles

MBNL1 As a New Therapeutic Target in MLL-Fusion Gene Leukemia

Svetlana S Itskovich, PhD, Jason Clark, James C. Mulloy, PhD, Matthew D Disney, Ashish R Kumar, MBBS, PhD
Journal: Blood
Blood (2015) 126 (23): 462.
https://doi.org/10.1182/blood.V126.23.462.462
Published: 2015
Journal Articles

MEIS1 regulates an HLF–oxidative stress axis in MLL-fusion gene leukemia

Jayeeta Roychoudhury, Jason P. Clark, Gabriel Gracia-Maldonado, Zeenath Unnisa, Mark Wunderlich, Kevin A. Link, Nupur Dasgupta, Bruce Aronow, Gang Huang, James C. Mulloy, Ashish R. Kumar
Journal: Blood
Blood (2015) 125 (16): 2544–2552.
https://doi.org/10.1182/blood-2014-09-599258
Published: 2015
Includes: Supplemental data
Journal Articles

Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes

Clinical Trials & Observations
Rebecca A. Marsh, Kanchan Rao, Prakash Satwani, Kai Lehmberg, Ingo Müller, Dandan Li, Mi-Ok Kim, Alain Fischer, Sylvain Latour, Petr Sedlacek, Vincent Barlogis, Kazuko Hamamoto, Hirokazu Kanegane, Sam Milanovich, David A. Margolis, David Dimmock, James Casper, Dorothea N. Douglas, Persis J. Amrolia, Paul Veys, Ashish R. Kumar, Michael B. Jordan, Jack J. Bleesing, Alexandra H. Filipovich
Journal: Blood
Blood (2013) 121 (6): 877–883.
https://doi.org/10.1182/blood-2012-06-432500
Published: 2013
Journal Articles

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress

Zeenath Unnisa, Jason P. Clark, Jayeeta Roychoudhury, Elizabeth Thomas, Lino Tessarollo, Neal G. Copeland, Nancy A. Jenkins, H. Leighton Grimes, Ashish R. Kumar
Journal: Blood
Blood (2012) 120 (25): 4973–4981.
https://doi.org/10.1182/blood-2012-06-435800
Published: 2012
Includes: Supplemental data
Journal Articles

EVI1 is critical for the pathogenesis of a subset of MLL-AF9 –rearranged AMLs

Clinical Trials & Observations
Eric M. J. Bindels, Marije Havermans, Sanne Lugthart, Claudia Erpelinck, Elizabeth Wocjtowicz, Andrei V. Krivtsov, Elwin Rombouts, Scott A. Armstrong, Erdogan Taskesen, Jurgen R. Haanstra, H. Berna Beverloo, Hartmut Döhner, Wendy A. Hudson, John H. Kersey, Ruud Delwel, Ashish R. Kumar
Journal: Blood
Blood (2012) 119 (24): 5838–5849.
https://doi.org/10.1182/blood-2011-11-393827
Published: 2012
Includes: Supplemental data
Journal Articles

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

Benjamin Mizukawa, Junping Wei, Mahesh Shrestha, Mark Wunderlich, Fu-Sheng Chou, Andrea Griesinger, Chad E. Harris, Ashish R. Kumar, Yi Zheng, David A. Williams, James C. Mulloy
Journal: Blood
Blood (2011) 118 (19): 5235–5245.
https://doi.org/10.1182/blood-2011-04-351817
Published: 2011
Journal Articles

Meis1 maintains stemness signature in MLL-AF9 leukemia

Ashish R. Kumar, Aaron L. Sarver, Baolin Wu, John H. Kersey
Journal: Blood
Blood (2010) 115 (17): 3642–3643.
https://doi.org/10.1182/blood-2010-01-264564
Published: 2010
Journal Articles

Infant ALL: diverse origins and outcomes

Ashish R. Kumar, John H. Kersey
Journal: Blood
Blood (2010) 115 (14): 2725.
https://doi.org/10.1182/blood-2010-01-262741
Published: 2010