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Journal Articles

AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model

Mark Wunderlich, Benjamin Mizukawa, Fu-Sheng Chou, Christina Sexton, Mahesh Shrestha, Yogen Saunthararajah, James C. Mulloy

Blood (2013) 121 (12): e90–e97.

https://doi.org/10.1182/blood-2012-10-464677

Published: 2013

Journal Articles

The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO

Fu-Sheng Chou, Andrea Griesinger, Mark Wunderlich, Shan Lin, Kevin A. Link, Mahesh Shrestha, Susumu Goyama, Benjamin Mizukawa, Shuhong Shen, Guido Marcucci, James C. Mulloy

Blood (2012) 120 (4): 709–719.

https://doi.org/10.1182/blood-2012-01-403212

Published: 2012

Includes: Supplemental data

Journal Articles

Rac GTPase Survival Signaling Through Anti-Apoptotic Bcl-2 Proteins Reveals a Target for Combination Therapy in MLL-AF9 Acute Myeloid Leukemia

Benjamin Mizukawa, MD, Mahesh Shrestha, MS, Mark Wunderlich, MS, Fu-Sheng Chou, MD, PhD, Andrea Griesinger, BS, Ashish Kumar, MBBS, PhD, Yi Zheng, PhD, David A. Williams, MD, James C. Mulloy, PhD

Blood (2011) 118 (21): 1536.

https://doi.org/10.1182/blood.V118.21.1536.1536

Published: 2011

Journal Articles

Chromatin Modifications Induced by the AML1/ETO Fusion Protein Reversibly Silence Its Genomic Targets Through AML1 and Sp1 Binding Motifs

Alba Maiques-Díaz, Fu-Sheng Chou, MD, PhD, Mark Wunderlich, MS, Gonzalo Gómez López, phD, Filipe V. Jacinto, phD, Sandra Rodriguez-Perales, phD, María José Larrayoz, phD, María José Calasanz, phD, James C. Mulloy, PhD, Juan Cigudosa, phD, Sara Alvarez, MD, PhD

Blood (2011) 118 (21): 2422.

https://doi.org/10.1182/blood.V118.21.2422.2422

Published: 2011

Journal Articles

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

Benjamin Mizukawa, Junping Wei, Mahesh Shrestha, Mark Wunderlich, Fu-Sheng Chou, Andrea Griesinger, Chad E. Harris, Ashish R. Kumar, Yi Zheng, David A. Williams, James C. Mulloy

Blood (2011) 118 (19): 5235–5245.

https://doi.org/10.1182/blood-2011-04-351817

Published: 2011

Journal Articles

N-Ras G12D induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene

Fu-Sheng Chou, Mark Wunderlich, Andrea Griesinger, James C. Mulloy

Blood (2011) 117 (7): 2237–2240.

https://doi.org/10.1182/blood-2010-01-264119

Published: 2011

Includes: Supplemental data

Journal Articles

Adaptation of a Xenograft AML Model to Evaluate Chemotherapeutic Efficacy In Vivo

Mark Wunderlich, M.S., Fu-Sheng Chou, M.D., Mahesh Shrestha, Benjamin Mizukawa, M.D., James C. Mulloy, PhD

Blood (2010) 116 (21): 3304.

https://doi.org/10.1182/blood.V116.21.3304.3304

Published: 2010

Journal Articles

Enhanced Myeloid and T Cell Development and Improved Functionality of Cord Blood Xenografts In the NSGS Mouse.

Mark Wunderlich, M.S., Pietro Presicce, PhD, Fu-Sheng Chou, M.D., Claire Chougnet, PhD, Julio Aliberti, PhD, James C. Mulloy, PhD

Blood (2010) 116 (21): 3729.

https://doi.org/10.1182/blood.V116.21.3729.3729

Published: 2010

Journal Articles

A New Immunodeficient Mouse Strain, NOD/SCID IL2Rγ−/− SGM3, Promotes Enhanced Human Hematopoietic Cell Xenografts with a Robust T Cell Component.

Mark Wunderlich, MS, Fu-Sheng Chou, MD, Benjamin Mizukawa, MD, Kevin A Link, PhD, James C. Mulloy, PhD

Blood (2009) 114 (22): 3524.

https://doi.org/10.1182/blood.V114.22.3524.3524

Published: 2009

Journal Articles

Constitutive Activation of Rac GTPases Is Induced by Cooperating Mutations in a Human Model of MLL-AF9 Leukemia.

Mark Wunderlich, MS, Kevin A Link, PhD, Fu-Sheng Chou, MD, James C. Mulloy, PhD

Blood (2009) 114 (22): 2959.

https://doi.org/10.1182/blood.V114.22.2959.2959

Published: 2009

Journal Articles

Bcl-Xl Mitigates p53 Activity in AML1-ETO-Expressing Human Hematopoietic Cells.

Fu-Sheng Chou, MD, Mark Wunderlich, MS, James C. Mulloy, PhD

Blood (2009) 114 (22): 387.

https://doi.org/10.1182/blood.V114.22.387.387

Published: 2009

Journal Articles

Thrombopoietin/Bcl-Xl Signaling Is Essential for the Self-Renewal Phenotypes of AML1-ETO Expressing Human Hematopoietic Cells.

Fu-Sheng Chou, MD, Mark Wunderlich, MS, James C. Mulloy, PhD

Blood (2009) 114 (22): 1424.

https://doi.org/10.1182/blood.V114.22.1424.1424

Published: 2009

Journal Articles

Bcl-XL Is a Critical Mediator of Rac Signaling in MLL-AF9-Induced Acute Myeloid Leukemia.

Benjamin Mizukawa, MD, Junping Wei, MD, PhD, Mark Wunderlich, MS, Fu-Sheng Chou, MD, Yi Zheng, PhD, David A. Williams, MD, James C. Mulloy, PhD

Blood (2009) 114 (22): 1971.

https://doi.org/10.1182/blood.V114.22.1971.1971

Published: 2009

Journal Articles

Bcl-2 Family Dysregulation in AML1-ETO-Expressing Human Hematopoietic Cells

Fu-Sheng Chou, MD, Mark Wunderlich, MS, James C. Mulloy, PhD

Blood (2008) 112 (11): 5330.

https://doi.org/10.1182/blood.V112.11.5330.5330

Published: 2008

Journal Articles

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death

Ondrej Krejci, Mark Wunderlich, Hartmut Geiger, Fu-Sheng Chou, David Schleimer, Michael Jansen, Paul R. Andreassen, James C. Mulloy

Blood (2008) 111 (4): 2190–2199.

https://doi.org/10.1182/blood-2007-06-093682

Published: 2008

Journal Articles

p53 Signaling in Response to Increased DNA Damage Sensitizes AML1-ETO Cells to Stress-Induced Death.

Ondrej Krejci, MD, PhD, Mark Wunderlich, MS, Hartmut Geiger, PhD, Fu-Sheng Chou, David Schleimer, Michael Jansen, MD, Paul R. Andreassen, PhD, James C. Mulloy, PhD

Blood (2007) 110 (11): 3176.

https://doi.org/10.1182/blood.V110.11.3176.3176

Published: 2007

NARROW

AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model

The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO

Rac GTPase Survival Signaling Through Anti-Apoptotic Bcl-2 Proteins Reveals a Target for Combination Therapy in MLL-AF9 Acute Myeloid Leukemia

Chromatin Modifications Induced by the AML1/ETO Fusion Protein Reversibly Silence Its Genomic Targets Through AML1 and Sp1 Binding Motifs

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

N-Ras G12D induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene

Adaptation of a Xenograft AML Model to Evaluate Chemotherapeutic Efficacy In Vivo

Enhanced Myeloid and T Cell Development and Improved Functionality of Cord Blood Xenografts In the NSGS Mouse.

A New Immunodeficient Mouse Strain, NOD/SCID IL2Rγ−/− SGM3, Promotes Enhanced Human Hematopoietic Cell Xenografts with a Robust T Cell Component.

Constitutive Activation of Rac GTPases Is Induced by Cooperating Mutations in a Human Model of MLL-AF9 Leukemia.

Bcl-Xl Mitigates p53 Activity in AML1-ETO-Expressing Human Hematopoietic Cells.

Thrombopoietin/Bcl-Xl Signaling Is Essential for the Self-Renewal Phenotypes of AML1-ETO Expressing Human Hematopoietic Cells.

Bcl-XL Is a Critical Mediator of Rac Signaling in MLL-AF9-Induced Acute Myeloid Leukemia.

Bcl-2 Family Dysregulation in AML1-ETO-Expressing Human Hematopoietic Cells

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death

p53 Signaling in Response to Increased DNA Damage Sensitizes AML1-ETO Cells to Stress-Induced Death.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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