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Journal Articles

Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable EVI1-CtBP1/2 Interaction and By Repressing Myeloid Regulator CEBPA

Dorien Pastoors, Marije Havermans, Remco Hoogenboezem, Roger Mulet-Lazaro, Duncan Brian, Leonie Smeenk, Claudia Erpelinck-Verschueren, Stanley van Herk, Bas Wouters, Jeroen A.A. Demmers, Johannes Zuber, Tariq Enver, Richard WJ Groen, Eric Bindels, Ruud Delwel

Blood (2022) 140 (Supplement 1): 83–84.

https://doi.org/10.1182/blood-2022-156994

Published: 2022

Journal Articles

Functional Genomic and Immune Response Characterization of PTEN Loss: Therapeutic Implications for Myeloma

Olga Dashevsky, Ricardo De Matos Simoes, Benjamin G Barwick, Sara Gandolfi, Ryosuke Shirasaki, Michal Sheffer, Aedin Culhane, Richard WJ Groen, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades

Blood (2021) 138 (Supplement 1): 1612.

https://doi.org/10.1182/blood-2021-153870

Published: 2021

Journal Articles

Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Megan Bariteau, BSc, Jonathan D. Licht, MD, Brian Glassner, PhD, Richard WJ Groen, PhD, Joan Levy, PhD, Daniel Auclair, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Aedin Culhane, PhD, Constantine S. Mitsiades, MD PhD

Blood (2018) 132 (Supplement 1): 189.

https://doi.org/10.1182/blood-2018-189

Published: 2018

Journal Articles

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Blood (2018) 132 (Supplement 1): 1367.

https://doi.org/10.1182/blood-2018-99-116232

Published: 2018

Journal Articles

BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone

Toril Holien, PhD, Marita Westhrin, PhD, Siv Helen Moen, PhD, Muhammad Zahoor, PhD, Glenn Buene, Berit Størdal, Hanne Hella, Huipin Yuan, Joost D de Bruijn, PhD, Anton Martens, PhD, Richard WJ Groen, PhD, Fatima Bosch, PhD, Ulf Smith, MD PhD, Anders Sundan, PhD, Therese Standal, PhD

Blood (2018) 132 (Supplement 1): 1928.

https://doi.org/10.1182/blood-2018-99-112429

Published: 2018

Journal Articles

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

Blood (2017) 130 (Supplement 1): 1212.

https://doi.org/10.1182/blood.V130.Suppl_1.1212.1212

Published: 2017

Journal Articles

The Combination of 41BB and CD28 Costimulatory Signals Endows Lower Affinity CAR T Cells with the Most Optimal Properties for Selective Targeting of the Tumor Associated Antigen CD38

Esther Drent, MSc, Renée Poels, BSc, Niels WCJ Van De Donk, Sonja Zweegman, MD PhD, Henk M Lokhorst, Richard WJ Groen, PhD, Tuna Mutis, PhD, Maria Themeli, MD PhD

Blood (2017) 130 (Supplement 1): 3183.

https://doi.org/10.1182/blood.V130.Suppl_1.3183.3183

Published: 2017

Journal Articles

In Vivo Validation of Essential Genes for Myeloma Cells By CRISPR/Cas9 Studies in a Scaffold-Based System Engineered to Establish a "Humanized" Bone Marrow-like Microenvironment

Ryosuke Shirasaki, MD, Csikos Tamas, PhD, Geoffrey Matthews, PhD, Ricardo De Matos Simoes, PhD, Subhashis Sarkar, PhD, Olga Dashevsky, PhD, Hu Yiguo, PhD, Jeffrey Sorrell, BA, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Megan Bariteau, Brian Glassner, PhD, Aedin Culhane, PhD, Richard WJ Groen, PhD, Constantine S. Mitsiades, MD PhD

Blood (2017) 130 (Supplement 1): 4414.

https://doi.org/10.1182/blood.V130.Suppl_1.4414.4414

Published: 2017

Journal Articles

Functional Genomic Landscape of Epigenetic Dependencies in Myeloma

Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Daphne Dupere Richer, PhD, Ryosuke Shirasaki, MD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Brian Glassner, PhD, Richard WJ Groen, PhD, Franciska Vazquez, PhD, Joshua Dempster, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Aedin Culhane, PhD, Jonathan D. Licht, MD, Constantine S. Mitsiades, MD PhD

Blood (2017) 130 (Supplement 1): 1209.

https://doi.org/10.1182/blood.V130.Suppl_1.1209.1209

Published: 2017

Journal Articles

Addition of the Vascular Niche Component to the Human Bone Marrow-like Scaffold Model

Willy A Noort, PhD, Regina de Jong-Korlaar, Linda Lubbers-Aalders, Huipin Yuan, PhD, Joost D de Bruijn, PhD, Constantine S Mitsiades, MD PhD, Anton CM Martens, PhD, Richard WJ Groen, PhD

Blood (2015) 126 (23): 2402.

https://doi.org/10.1182/blood.V126.23.2402.2402

Published: 2015

Journal Articles

Induction of Potent Anti-Tumor Effects by Original and TCR-Redirected CD4 + Cytotoxic T Cells.

Robbert M Spaapen, Kelly van den Oudenalder, Maureen van Elk, Tineke Aarts, Teun Guichelaar, Richard WJ Groen, Andries C Bloem, Gert Storm, Anton C Martens, Henk M Lokhorst, MD, PhD, Tuna Mutis, MD, PhD

Blood (2009) 114 (22): 1333.

https://doi.org/10.1182/blood.V114.22.1333.1333

Published: 2009

NARROW

Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable EVI1-CtBP1/2 Interaction and By Repressing Myeloid Regulator CEBPA

Functional Genomic and Immune Response Characterization of PTEN Loss: Therapeutic Implications for Myeloma

Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

The Combination of 41BB and CD28 Costimulatory Signals Endows Lower Affinity CAR T Cells with the Most Optimal Properties for Selective Targeting of the Tumor Associated Antigen CD38

In Vivo Validation of Essential Genes for Myeloma Cells By CRISPR/Cas9 Studies in a Scaffold-Based System Engineered to Establish a "Humanized" Bone Marrow-like Microenvironment

Functional Genomic Landscape of Epigenetic Dependencies in Myeloma

Addition of the Vascular Niche Component to the Human Bone Marrow-like Scaffold Model

Induction of Potent Anti-Tumor Effects by Original and TCR-Redirected CD4 + Cytotoxic T Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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