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Yasutaka Hayashi
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Journal Articles

Aberrant EVI1 splicing contributes to EVI1 -rearranged leukemia

Atsushi Tanaka, Taizo A. Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P. Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C. Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue
Journal: Blood
Blood (2022) 140 (8): 875–888.
https://doi.org/10.1182/blood.2021015325
Published: 2022
Includes: Supplemental data
Journal Articles

ZRSR2 Mutation Induced Minor Intron Retention Drives MDS and Diverse Cancer Predisposition Via Aberrant Splicing of LZTR1

Daichi Inoue, MDPhD, Jacob T. Polaski, Justin Taylor, MD, Pau Castel, Sisi Chen, Susumu Kobayashi, Simon J. Hogg, PhD BSc, Yasutaka Hayashi, MDPhD, Jose Mario Bello Pineda, Alexander V Penson, PhD, Ettaib El Marabti, Caroline Erickson, Miki Fukumoto, Hiromi Yamazaki, PhD, Chie Fukui, Sydney X. Lu, MD PhD, Benjamin H. Durham, Bo Liu, PhD, Sanjoy Mehta, Daniel Zakheim, Ralph Garippa, PhD, Guo-Liang Chew, Frank McCormick, PhD, Robert K. Bradley, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-136445
Published: 2020
Journal Articles

Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS

Yasutaka Hayashi, MDPhD, Kimihito Cojin Kawabata, MD PhD, Yosuke Tanaka, PhD, Yasufumi Uehara, MDPhD, Shigeru Kiryu, MD PhD, Yasunori Ota, MD PhD, Yusuke Yoshioka, PhD, Yo Mabuchi, PhD, Tatsuki Sugiyama, MDPhD, Keiko Mikami, MSc, Moe Tamura, MSc, Tsuyoshi Fukushima, MD PhD, Shuhei Asada, MDPhD, Reina Takeda, MDPhD, Yuya Kunisaki, MD PhD, Tomofusa Fukuyama, MD PhD, Susumu Goyama, MD PhD, Kazuaki Yokoyama, MD PhD, Arinobu Tojo, MD PhD, Yoshio Katayama, MD PhD, Fumio Arai, PhD, Takashi Nagasawa, MDPhD, Takahiro Ochiya, PhD, Daichi Inoue, MDPhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142284
Published: 2020
Journal Articles

HHEX promotes myeloid transformation in cooperation with mutant ASXL1

Reina Takeda, Shuhei Asada, Sung-Joon Park, Akihiko Yokoyama, Hans Jiro Becker, Akinori Kanai, Valeria Visconte, Courtney Hershberger, Yasutaka Hayashi, Taishi Yonezawa, Moe Tamura, Tsuyoshi Fukushima, Yosuke Tanaka, Tomofusa Fukuyama, Akiko Matsumoto, Satoshi Yamasaki, Kenta Nakai, Satoshi Yamazaki, Toshiya Inaba, Tatsuhiro Shibata, Daichi Inoue, Hiroaki Honda, Susumu Goyama, Jaroslaw P. Maciejewski, Toshio Kitamura
Journal: Blood
Blood (2020) 136 (14): 1670–1684.
https://doi.org/10.1182/blood.2019004613
Published: 2020
Includes: Supplemental data
Journal Articles

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Reina Takeda, MD, Shuhei Asada, MD PhD, Sung-Joon Park, PhD, Akihiko Yokoyama, PhD, Akinori Kanai, PhD, Valeria Visconte, PhD, Courtney Hershberger, BS, Yasutaka Hayashi, MD PhD, Taishi Yonezawa, MSc, Moe Tamura, Tomofusa Fukuyama, MD PhD, Akiko Matsumoto, Satoshi Yamasaki, PhD, Kenta Nakai, PhD, Toshiya Inaba, MD PhD, Tatsuhiro Shibata, MD PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Susumu Goyama, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2525.
https://doi.org/10.1182/blood-2019-126663
Published: 2019
Journal Articles

Aberrant RNA Splicing Contributes to the Pathogenesis of EVI-Rearranged Myeloid Leukemias

Daichi Inoue, MD PhD, Stanley C Lee, PhD, Akihide Yoshimi, MD PhD, Justin Taylor, MD, Lillian E Bitner, BSc, Atsushi Tanaka, MD, Yasutaka Hayashi, MD PhD, Hana Cho, MSc, Chie Fukui, Ruth Saganty, Alexander V Penson, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 917.
https://doi.org/10.1182/blood-2019-124722
Published: 2019
Journal Articles

A p53-MDM2 Interaction Inhibitor, DS-5272, Inhibits the Development of MLL-Fusion Leukemia with the Assistance of Tumor Immunity

Susumu Goyama, MD PhD, Yasutaka Hayashi, XiaoXiao Liu, Shiori Shikata, Yosuke Tanaka, Tomofusa Fukuyama, MD PhD, Akiko Matsumoto, Satoshi Yamasaki, Tatsuhiro Shibata, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 796.
https://doi.org/10.1182/blood.V130.Suppl_1.796.796
Published: 2017
Journal Articles

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Susumu Goyama, MD PhD, Shiori Shikata, Yasutaka Hayashi, Yuto Izawa, Janet Schibler, Hiroyuki Iwamura, Dphil, Motoki Saito, PhD, Satoshi Kofuji, Kazutaka Sumita, Atsuo T Sasaki, James C. Mulloy, PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2016) 128 (22): 750.
https://doi.org/10.1182/blood.V128.22.750.750
Published: 2016
Journal Articles

SETBP1 Mutations Drive Leukemic Transformation in ASXL1 -Mutated MDS

Daichi Inoue, MD PhD, Hirotaka Matsui, MD PhD, Hsin-An Hou, MD PhD, Wen-Chien Chou, MD PhD, Akiko Nagamachi, PhD, Jiro Kitaura, MD PhD, Kimihito Cojin Kawabata, MD PhD, Katsuhiro Togami, MD PhD, Reina Nagase, Sayuri Horikawa, Makoto Saika, MD, Jean-Baptiste Micol, MD, Yasutaka Hayashi, MD, Yuka Harada, MD PhD, Hironori Harada, MD PhD, Hwei-Fang Tien, MD PhD, Omar Abdel-Wahab, MD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2014) 124 (21): 525.
https://doi.org/10.1182/blood.V124.21.525.525
Published: 2014