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Journal Articles

Genome-Wide Mapping of R-Loops in Single Cells Reveals Cell-Type Specific Roles for R-Loops in Hematopoietic Cell Identity

Bin Lu, Pu Zhang, Sisi Chen, Salima Benbarche, Cynthia Castro, Nina Fox, Mohammad Abubakar, Jeetayu Biswas, Ruslan Soldatov, Richard Koche, Omar Abdel-Wahab
Journal: Blood
Blood (2023) 142 (Supplement 1): 242.
https://doi.org/10.1182/blood-2023-180913
Published: 2023
Journal Articles

Mutant p53 Drives the Development of Myelodysplastic Syndromes Via Dysregulating Pre-mRNA Splicing in Hematopoietic Stem and Progenitor Cells

Sergio Barajas, Sisi Chen, Sasidhar Vemula, Yuxia Yang, Edward Simpson, Wenjie Cai, Shiyu Xiao, Hongxia Chen, Stephanie Halene, Madina Sukhanova, Yunlong Liu, Omar Abdel-Wahab, Yan Liu
Journal: Blood
Blood (2023) 142 (Supplement 1): 4582.
https://doi.org/10.1182/blood-2023-180382
Published: 2023
Journal Articles

Polycom Group Protein Mel18 Inhibits Hematopoietic Stem Cell Self-Renewal through Repressing the Expression of Genes Important for Cellular Senescence and Proliferation

Wenjie Cai, Sisi Chen, Xicheng Liu, Xintong Chen, Sergio Barajas, Shiyu Xiao, Hongxia Chen, Rongwen Xi, Zhonghua Gao, Feng Yue, Yan Liu
Journal: Blood
Blood (2023) 142 (Supplement 1): 1310.
https://doi.org/10.1182/blood-2023-180201
Published: 2023
Journal Articles

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371

Hongxia Chen, Yunpeng Bai, Michihiro Kobayashi, Shiyu Xiao, Wenjie Cai, Sergio Barajas, Sisi Chen, Jinmin Miao, Frederick Nguele Meke, Sasidhar Vemula, James P. Ropa, James M. Croop, H. Scott Boswell, Jun Wan, Yuzhi Jia, Huiping Liu, Loretta S. Li, Jessica K. Altman, Elizabeth A. Eklund, Peng Ji, Wei Tong, Hamid Band, Danny T. Huang, Leonidas C. Platanias, Zhong-Yin Zhang, Yan Liu
Journal: Blood
Blood (2023) 141 (3): 244–259.
https://doi.org/10.1182/blood.2022016580
Published: 2023
Includes: Supplemental data
Journal Articles

Chronic Inflammation Drives p53 Mutant Clonal Hematopoiesis Via Activating the NLRP1 Inflammasome

Sergio of Barajas, Sasidhar Vemula, Sisi Chen, Hongxia Chen, Wenjie Cai, Shiyu Xiao, Stephanie Halene, Omar Abdel-Wahab, Linsey Mayo, Sharon A. Savage, Yan Liu
Journal: Blood
Blood (2022) 140 (Supplement 1): 5743–5744.
https://doi.org/10.1182/blood-2022-169754
Published: 2022
Journal Articles

Impaired RAS Proteolysis Drives Clonal Hematopoietic Transformation

Sisi Chen, Rahul S. Vedula, Pau Castel, Antonio Cuevas Navarro, Simon J. Hogg, Eric Wang, Xiaoli Mi, Salima Benbarche, Katherine Knorr, Won Jun Kim, Hana Cho, Caroline Erickson, Michael E Singer, Daniel Cui, Benjamin H. Durham, Daichi Inoue, Sebastien Monette, Neal Rosen, Frank McCormick, R. Coleman Lindsley, Jr., Omar Abdel-Wahab
Journal: Blood
Blood (2021) 138 (Supplement 1): 356.
https://doi.org/10.1182/blood-2021-147026
Published: 2021
Journal Articles

Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Bon Q. Trinh, Simone Ummarino, Yanzhou Zhang, Alexander K. Ebralidze, Mahmoud A. Bassal, Tuan M. Nguyen, Gerwin Heller, Rory Coffey, Danielle E. Tenen, Emiel van der Kouwe, Emiliano Fabiani, Carmelo Gurnari, Chan-Shuo Wu, Vladimir Espinosa Angarica, Henry Yang, Sisi Chen, Hong Zhang, Abby R. Thurm, Francisco Marchi, Elena Levantini, Philipp B. Staber, Pu Zhang, Maria Teresa Voso, Pier Paolo Pandolfi, Susumu S. Kobayashi, Li Chai, Annalisa Di Ruscio, Daniel G. Tenen
Journal: Blood
Blood (2021) 138 (15): 1331–1344.
https://doi.org/10.1182/blood.2020007920
Published: 2021
Includes: Supplemental data
Journal Articles

Splicing factor mutations in hematologic malignancies

Sisi Chen, Salima Benbarche, Omar Abdel-Wahab
Journal: Blood
Blood (2021) 138 (8): 599–612.
https://doi.org/10.1182/blood.2019004260
Published: 2021
Journal Articles

ZRSR2 Mutation Induced Minor Intron Retention Drives MDS and Diverse Cancer Predisposition Via Aberrant Splicing of LZTR1

Daichi Inoue, MDPhD, Jacob T. Polaski, Justin Taylor, MD, Pau Castel, Sisi Chen, Susumu Kobayashi, Simon J. Hogg, PhD BSc, Yasutaka Hayashi, MDPhD, Jose Mario Bello Pineda, Alexander V Penson, PhD, Ettaib El Marabti, Caroline Erickson, Miki Fukumoto, Hiromi Yamazaki, PhD, Chie Fukui, Sydney X. Lu, MD PhD, Benjamin H. Durham, Bo Liu, PhD, Sanjoy Mehta, Daniel Zakheim, Ralph Garippa, PhD, Guo-Liang Chew, Frank McCormick, PhD, Robert K. Bradley, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-136445
Published: 2020
Journal Articles

Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis

Zhigang Cai, PhD, Jonathan Kotzin, Baskar Ramdas, PhD, Sisi Chen, Sai Nelanuthala, Lakshmi Reddy Palam, PhD, Ruchi Pandey, Raghuveer Mali, PhD, Yan Liu, PhD, Mark R. Kelley, George Sandusky, DVM, PhD, Morvarid Mohseni, Adam Williams, Jorge Henao-Mejia, Reuben Kapur, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1288.
https://doi.org/10.1182/blood-2018-99-116703
Published: 2018
Journal Articles

Gain of Function Mutant p53 Drives Clonal Hematopoiesis and the Pathogenesis of Myelodysplastic Syndromes

Sisi Chen, Hao Yu, PhD, Rui Gao, PhD, Sarah C. Nabinger, PhD, Michihiro Kobayashi, MD PhD, Chonghua Yao, Linsey Mayo, PhD, Reuben Kapur, PhD, Mervin C. Yoder, MD, Hal E. Broxmeyer, PhD, Zhonghua Gao, Yan Liu, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2489.
https://doi.org/10.1182/blood.V130.Suppl_1.2489.2489
Published: 2017
Journal Articles

PRL2 Phosphatase Is a Key Mediator of Oncogenic Cytokine Signaling in Leukemia Stem Cells

Michihiro Kobayashi, MD PhD, Yunpeng Bai, PhD, Sisi Chen, BS, Sarah C Nabinger, PhD, Chonghua Yao, MD, Zhong-Yin Zhang, PhD, Yan Liu, PhD
Journal: Blood
Blood (2016) 128 (22): 724.
https://doi.org/10.1182/blood.V128.22.724.724
Published: 2016
Journal Articles

Polycomb Repressive Complex 1 Enhances HSC Self-Renewal through Repressing the Canonical Wnt Signaling Pathway

Sisi Chen, BS, Xicheng Liu, Rui Gao, PhD, Michihiro Kobayashi, MD PhD, Hao Yu, PhD, Chonghua Yao, MD, Zhijian Qian, PhD, Rongwen Xi, PhD, Yan Liu, PhD
Journal: Blood
Blood (2015) 126 (23): 2378.
https://doi.org/10.1182/blood.V126.23.2378.2378
Published: 2015
Journal Articles

Mutant p53 Drives the Development of Pre-Leukemic Hematopoietic Stem Cells through Modulating Epigenetic Regulators

Sarah C Nabinger, PhD, Michihiro Kobayashi, MD PhD, Rui Gao, PhD, Sisi Chen, BS, Chonghua Yao, MD, Feng-Chun Yang, MD PhD, Yan Liu, PhD
Journal: Blood
Blood (2015) 126 (23): 307.
https://doi.org/10.1182/blood.V126.23.307.307
Published: 2015
Journal Articles

Gain-of-Function Mutant p53 Enhances Hematopoietic Stem Cell Self-Renewal

Sisi Chen, Hao Yu, PhD, Michihiro Kobayashi, MDPhD, Rui Gao, PhD, H. Scott Boswell, MD, Yan Liu, PhD
Journal: Blood
Blood (2014) 124 (21): 260.
https://doi.org/10.1182/blood.V124.21.260.260
Published: 2014
Journal Articles

BMI1 Promotes Erythropoiesis Through Regulating Ribosome Biogenesis

Rui Gao, PhD, Sisi Chen, Michihiro Kobayashi, MD, PhD, Mervin C. Yoder, MD, Reuben Kapur, PhD, Xiaofan Zhu, MD/PhD, Yan Liu, PhD
Journal: Blood
Blood (2013) 122 (21): 3707.
https://doi.org/10.1182/blood.V122.21.3707.3707
Published: 2013
Journal Articles

PRL2 Maintains Hematopoietic Stem and Progenitor Cells Through Regulating SCF/KIT Signaling

Michihiro Kobayashi, MD, PhD, Yuanshu Dong, Ph.D., Hao Yu, Ph.D., Yunpeng Bai, Sisi Chen, Rui Gao, PhD, Mervin C. Yoder, MD, Reuben Kapur, PhD, Zhong-Yin Zhang, PhD, Yan Liu, PhD
Journal: Blood
Blood (2013) 122 (21): 3674.
https://doi.org/10.1182/blood.V122.21.3674.3674
Published: 2013