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Daniel G. Tenen
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Journal Articles

Genome-Wide Methylation Sensitive Elements Demarcate Targetable Regulatory Elements for Controllable Gene Activation

Yanjing Vera Liu, Jeremiah Suryatenggara, Hannan Wong, Jing Ping Tang, Hong Kee Tan, Junsu Kwon, Qiling Zhou, Simone Ummarino, Alexander Ebralidze, John G. Doench, Li Chai, Touati Benoukraf, Devendra Hiwase, Daniel Thomas, Annalisa Di Ruscio, Daniel G. Tenen, Mahmoud Adel Bassal
Journal: Blood
Blood (2023) 142 (Supplement 1): 3647.
https://doi.org/10.1182/blood-2023-182715
Published: 2023
Journal Articles

C/EBPα Acts As an RNA Binding Protein Essential for, and Promotes End-Stage Macrophage Differentiation

Mahmoud Adel Bassal, Yanzhou Zhang, Yanjing Vera Liu, Virginia Camacho, Simone Ummarino, Robert Welner, Daniel G. Tenen
Journal: Blood
Blood (2023) 142 (Supplement 1): 5579.
https://doi.org/10.1182/blood-2023-181315
Published: 2023
Journal Articles

Targeting the Oncofetal Transcription Factor Protein SALL4 in Cancer By a Non-IMiD Degrader

Kim Anh L. Vu, Kalpana Kumari, Bee Hui Liu, Chong Gao, Feng Li, Jing Ping Tang, Danilo Maddalo, Xi Tian, Miao Liu, Mahmoud Adel Bassal, Shiva Moein, Viktoriia Iakovleva, Justin L. Tan, Alicia J. Stein, Qiling Zhou, Patrick D. Fischer, Logan H. Sigua, Jun Qi, Haribabu Arthanari, Daniel G. Tenen, Li Chai
Journal: Blood
Blood (2023) 142 (Supplement 1): 7144.
https://doi.org/10.1182/blood-2023-184502
Published: 2023
Journal Articles

Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis

Mingrui Guo, Tim Hon Man Chan, Qiling Zhou, Omer An, Ying Li, Yangyang Song, Zi Hui Tan, Vanessa Hui En Ng, Philomina Sona Peramangalam, Zhi Qing Tan, Xinang Cao, Eisaku Iwanaga, Masao Matsuoka, Melissa G. M. Ooi, Wei Ying Jen, Liang Piu Koh, Esther Chan, Lip Kun Tan, Yufen Goh, Wilson Wang, Bryan T. H. Koh, Chan Ming Chun, Melissa J. Fullwood, Wee Joo Chng, Motomi Osato, John Anto Pulikkan, Henry Yang, Leilei Chen, Daniel G. Tenen
Journal: Blood
Blood (2023) 141 (25): 3078–3090.
https://doi.org/10.1182/blood.2022015830
Published: 2023
Includes: Supplemental data
Journal Articles

Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Bon Q. Trinh, Simone Ummarino, Yanzhou Zhang, Alexander K. Ebralidze, Mahmoud A. Bassal, Tuan M. Nguyen, Gerwin Heller, Rory Coffey, Danielle E. Tenen, Emiel van der Kouwe, Emiliano Fabiani, Carmelo Gurnari, Chan-Shuo Wu, Vladimir Espinosa Angarica, Henry Yang, Sisi Chen, Hong Zhang, Abby R. Thurm, Francisco Marchi, Elena Levantini, Philipp B. Staber, Pu Zhang, Maria Teresa Voso, Pier Paolo Pandolfi, Susumu S. Kobayashi, Li Chai, Annalisa Di Ruscio, Daniel G. Tenen
Journal: Blood
Blood (2021) 138 (15): 1331–1344.
https://doi.org/10.1182/blood.2020007920
Published: 2021
Includes: Supplemental data
Journal Articles

Emerging therapies for inv(16) AML

Sridevi Surapally, Daniel G. Tenen, John A. Pulikkan
Journal: Blood
Blood (2021) 137 (19): 2579–2584.
https://doi.org/10.1182/blood.2020009933
Published: 2021
Journal Articles

β-Catenin–TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation

Petr Danek, Miroslava Kardosova, Lucie Janeckova, Elena Karkoulia, Karolina Vanickova, Matej Fabisik, Carlos Lozano-Asencio, Touati Benoukraf, Roberto Tirado-Magallanes, Qiling Zhou, Monika Burocziova, Sarka Rahmatova, Robert Pytlik, Tomas Brdicka, Daniel G. Tenen, Vladimir Korinek, Meritxell Alberich-Jorda
Journal: Blood
Blood (2020) 136 (22): 2574–2587.
https://doi.org/10.1182/blood.2019004664
Published: 2020
Includes: Supplemental data
Journal Articles

Oncofetal Protein SALL4 Is Highly Expressed in Myelodysplastic Syndrome Alongside with NAT10 and P53

Hiro Tatetsu, MD, Miho Watanabe, MD, Emily F Mason, MD PhD, Scott B Lovitch, MDPhD, Kenji Tokunaga, MD, Eisaku Iwanaga, MD, Masao Matsuoka, MDPhD, Daniel G. Tenen, MD, Li Chai, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-134533
Published: 2020
Journal Articles

Core Binding Factor Leukemias Utilize a Physiologic Sense/Antisense Promoter Switch Employed By T-Cells

Emiel van der Kouwe, PharmD, Gerwin Heller, PhD, Akos Czibere, MD, Lucio H. Castilla, PhD, Ruud Delwel, PhD, Annalisa Di Ruscio, MD PhD, Alexander Ebralidze, PhD, Maurizio Forte, MSc, Lukas Kazianka, MD, Christoph Kornauth, Trang Le, BSc, Karin Lind, MSc, Ines Barbosa, PhD, Alexander Pichler, MD, John Pulikkan, PhD, Ann-Sofie Schmolke, MD, Heinz Sill, MD, Wolfgang R. Sperr, MD, Andreas Spittler, MD, Bon Q. Trinh, PhD, Peter Valent, MD, Katrina Vanura, PhD, Robert Welner, PhD, Johannes Zuber, PhD, Daniel G. Tenen, MD, Philipp B. Staber, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-140776
Published: 2020
Journal Articles

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance

Akihiko Numata, Hui Si Kwok, Qi-Ling Zhou, Jia Li, Roberto Tirado-Magallanes, Vladimir Espinosa Angarica, Rebecca Hannah, Jihye Park, Chelsia Qiuxia Wang, Vaidehi Krishnan, Deepa Rajagopalan, Yanzhou Zhang, Siqin Zhou, Robert S. Welner, Motomi Osato, Sudhakar Jha, Stefan K. Bohlander, Berthold Göttgens, Henry Yang, Touati Benoukraf, John W. Lough, Deepak Bararia, Daniel G. Tenen
Journal: Blood
Blood (2020) 136 (15): 1735–1747.
https://doi.org/10.1182/blood.2019001279
Published: 2020
Includes: Supplemental data
Journal Articles

Β-Catenin-Tcf/Lef Signaling Promotes Steady State and Emergency Granulopoiesis through G-CSF Receptor Upregulation

Petr Danek, MSc, Miroslava Kardosova, PhD, Lucie Janeckova, PhD, Vladimir Korinek, PhD, Touati Benoukraf, PhD, Daniel G. Tenen, MD, Meritxell Alberich-Jorda
Journal: Blood
Blood (2019) 134 (Supplement_1): 1193.
https://doi.org/10.1182/blood-2019-122254
Published: 2019
Journal Articles

The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia

Shi Hao Tan, Wei Zhong Leong, Phuong Cao Thi Ngoc, Tze King Tan, Fatima Carla Bertulfo, Mei Chee Lim, Omer An, Zhenhua Li, Allen Eng Juh Yeoh, Melissa J. Fullwood, Daniel G. Tenen, Takaomi Sanda
Journal: Blood
Blood (2019) 134 (3): 239–251.
https://doi.org/10.1182/blood.2018874503
Published: 2019
Includes: Supplemental data
Journal Articles

C/Ebpg (CCAAT/Enhancer Binding Protein Gamma) Balances Cytotoxic and Secretory Potential of Natural Killer Cells

Izabela Aparecida Lopes, MSc, Miroslava Kardosova, MSc, Thiago Mantello Bianco, MSc, Adriana Queiroz Arantes, MD, Cleide Araújo Silva, MSc, Priscila Santos Scheucher, PhD, Daniel G. Tenen, MD, Sanghoon Lee, PhD, Eduardo Magalhães Rego, MD PhD, Robert S. Welner, PhD, Meritxell Alberich-Jorda, Lorena Lobo Figueiredo-Pontes, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3721.
https://doi.org/10.1182/blood-2018-99-119389
Published: 2018
Journal Articles

Cell Type-Specific Deregulation of Polypyrimidine Tract- Binding Proteins (PTBPs) Drive Aberrant Splicing in Multiple Myeloma (MM) and Acute Myeloid Leukemia (AML)

Sophia Adamia, PhD, Sigitas J Verselis, PhD, Teru Hideshima, MD PhD, Michael P. Chu, MD, Shruti Bhatt, PhD, David P. Steensma, MD, Daniel J Deangelo, Richard M. Stone, MD, Daniel G. Tenen, MD, Linda M. Pilarski, PhD, James D. Griffin, MD, Kenneth Anderson, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3895.
https://doi.org/10.1182/blood-2018-99-118501
Published: 2018
Journal Articles

The Lysine Acetyltransferase Tip60 Is Required for Hematopoietic Stem Cell Maintenance

Akihiko Numata, MD, Hui Si Kwok, PhD, Qi-Ling Zhou, Jia Li, PhD, Rebecca Hannah, Jihye Park, PhD, Vladimir Espinosa Angarcia, PhD, Berthold Gottgens, Henry Yang, PhD, John Lough, PhD, Deepak Bararia, PhD, Daniel G. Tenen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2554.
https://doi.org/10.1182/blood-2018-99-118316
Published: 2018
Journal Articles

Long Noncoding RNA Loup Interacts with Runx1 and Regulates Long-Range Transcription of PU.1 in Acute Myeloid Leukemia

Bon Q Trinh, PhD, Pu Zhang, MD, Alexander Ebralidze, PhD, Junyan Zhang, Chan-Shuo Guo, Abby Thurm, Henry Yang, PhD, Ying Li, Annalisa Di Ruscio, MD, Daniel G. Tenen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1281.
https://doi.org/10.1182/blood-2018-99-120252
Published: 2018
Journal Articles

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML

Monica Cusan, Sheng F. Cai, Helai P. Mohammad, Andrei Krivtsov, Alan Chramiec, Evangelia Loizou, Matthew D. Witkin, Kimberly N. Smitheman, Daniel G. Tenen, Min Ye, Britta Will, Ulrich Steidl, Ryan G. Kruger, Ross L. Levine, Hugh Y. Rienhoff, Jr, Richard P. Koche, Scott A. Armstrong
Journal: Blood
Blood (2018) 131 (15): 1730–1742.
https://doi.org/10.1182/blood-2017-09-807024
Published: 2018
Includes: Supplemental data
Journal Articles

Identification of Long Non-Coding RNAs Regulated By the TAL1 Complex in T-Cell Acute Lymphoblastic Leukemia

Shi Hao Tan, PhD, Phuong Cao Thi Ngoc, PhD, Wei Zhong Leong, BSc, Daniel G. Tenen, MD, Takaomi Sanda, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1201.
https://doi.org/10.1182/blood.V130.Suppl_1.1201.1201
Published: 2017
Journal Articles

CARM1/PRMT4 As a Novel Therapeutic Target for AML

Sarah Greenblatt, PhD, Na Man, Pierre-Jacques Hamard, PhD, Concepcion Martinez, B.S., Ye Xu, PhD, Fan Liu, PhD, Justin M Watts, MD, Daniel G. Tenen, MD, Stephen D. Nimer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 241.
https://doi.org/10.1182/blood.V130.Suppl_1.241.241
Published: 2017
Journal Articles

ARID5B Activates the TAL1-Induced Core Regulatory Circuit and the MYC Oncogene in T-Cell Acute Lymphoblastic Leukemia

Wei Zhong Leong, BSc, Shi Hao Tan, PhD, Phuong Cao Thi Ngoc, PhD, Stella Amanda, Alice Wei Yee Yam, Wei-Siang Liau, Zhiyuan Gong, Lee N. Lawton, PhD, Daniel G. Tenen, MD, Takaomi Sanda, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2502.
https://doi.org/10.1182/blood.V130.Suppl_1.2502.2502
Published: 2017