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Journal Articles

Single-cell epigenetic and clonal analysis decodes disease progression in pediatric acute myeloid leukemia

Boyu Cui, Lanlan Ai, Minghui Lei, Yongjuan Duan, Chao Tang, Jingliao Zhang, Yan Gao, Xuan Li, Caiying Zhu, Yingchi Zhang, Xiaofan Zhu, Tomoya Isobe, Wenyu Yang, Berthold Gottgens, Ping Zhu

Blood blood.2024025618.

https://doi.org/10.1182/blood.2024025618

Published: 2024

Includes: Supplemental data

Journal Articles

Delayed Trp53 Activation Protects Dnmt3a -Mutant Haematopoietic Stem Cells from Inflammatory Attrition

Ludovica Marando, George Giotopoulos, Pedro Madrigal, Dhoyazan M A Azazi, Ryan Asby, Maria Erendira Calleja-Cervantes, David Lara-Astiaso, Nicola K. Wilson, Rebecca Hannah, Jaana Bagri, Elsa Barnard, Sarah J Horton, Berthold Gottgens, Elli Papaemmanuil, Shuchi Agrawal Singh, Malgorzata Gozdecka, George S Vassiliou, Brian J P Huntly

Blood (2024) 144 (Supplement 1): 190.

https://doi.org/10.1182/blood-2024-201612

Published: 2024

Journal Articles

Multimodal Single Cell Analysis Reveals Hematopoietic Changes across the Human Lifespan

Tomoya Isobe, Mariana Quiroga Londoño, Nicole Mende, Emily Stephenson, Deena Iskander, Simone Webb, Issac Goh, Vijay Shanmugiah, Rebecca Hannah, Anindita Roy, Irene Roberts, Elisa Laurenti, Muzlifah Haniffa, Nicola K. Wilson, Berthold Gottgens

Blood (2024) 144 (Supplement 1): 2659.

https://doi.org/10.1182/blood-2024-204131

Published: 2024

Journal Articles

A Novel in Vitro Model of Pre-Leukemic Competition Reveals “Super-Competitive” TET2-Mutant Hematopoietic Stem Cell Clones

Lilia Cabrera-Cosme, Juan Rubio-Lara, Ellie Bennett, Joanna Milek, Maria Jassinskaja, Sandy MacDonald, Karen Hogg, Nicola K. Wilson, Berthold Gottgens, David Kent

Blood (2024) 144 (Supplement 1): 4115.

https://doi.org/10.1182/blood-2024-207127

Published: 2024

Journal Articles

Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle

Blood (2024) 144 (7): 729–741.

https://doi.org/10.1182/blood.2023021426

Published: 2024

Includes: Supplemental data

Journal Articles

NPM1c Mutations Are Associated with Reduced Levels of Multiple Ribosome Biogenesis Factors Leading to Therapeutic Vulnerabilities

Aristi Damaskou, Rachael Wilson, Vijay Shanmugiah, Justyna Rak, Konstantinos Tzelepis, Berthold Gottgens, Malgorzata Gozdecka, George Vassiliou

Blood (2023) 142 (Supplement 1): 2743.

https://doi.org/10.1182/blood-2023-186084

Published: 2023

Journal Articles

A Multimodal Single Cell Atlas of Adult Murine Haematopoiesis Reveals Nine Differentiation Trajectories and Epigenetic Regulatory Programs

Katherine Sturgess, Vijay Shanmugiah, Tomoya Isobe, Melania Barlie, Nicola K. Wilson, Berthold Gottgens

Blood (2023) 142 (Supplement 1): 2686.

https://doi.org/10.1182/blood-2023-189941

Published: 2023

Journal Articles

Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs

Blood (2023) 142 (17): 1448–1462.

https://doi.org/10.1182/blood.2023021120

Published: 2023

Includes: Supplemental data

Journal Articles

Introduction to a review series on single-cell genomics: getting ready for clinical impact in leukemia and myeloid neoplasms

Katherine H. M. Sturgess, Nicola K. Wilson, Berthold Göttgens

Blood (2023) 141 (4): 323–325.

https://doi.org/10.1182/blood.2022017361

Published: 2023

Journal Articles

STAT1 is essential for HSC function and maintains MHCII hi stem cells that resist myeloablation and neoplastic expansion

Blood (2022) 140 (14): 1592–1606.

https://doi.org/10.1182/blood.2021014009

Published: 2022

Includes: Supplemental data

Journal Articles

p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion

Chrysa Kapeni, Leslie Nitsche, Alastair M. Kilpatrick, Nicola K. Wilson, Kankan Xia, Bahar Mirshekar-Syahkal, Vashe Chandrakanthan, Camille Malouf, John E. Pimanda, Berthold Göttgens, Kristina Kirschner, Simon R. Tomlinson, Katrin Ottersbach

Blood (2022) 140 (5): 464–477.

https://doi.org/10.1182/blood.2021014853

Published: 2022

Includes: Supplemental data

Journal Articles

Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans

Blood (2022) 139 (23): 3387–3401.

https://doi.org/10.1182/blood.2021013450

Published: 2022

Includes: Supplemental data

Journal Articles

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

Julie A. I. Thoms, Peter Truong, Shruthi Subramanian, Kathy Knezevic, Gregory Harvey, Yizhou Huang, Janith A. Seneviratne, Daniel R. Carter, Swapna Joshi, Joanna Skhinas, Diego Chacon, Anushi Shah, Ineke de Jong, Dominik Beck, Berthold Göttgens, Jonas Larsson, Jason W. H. Wong, Fabio Zanini, John E. Pimanda

Blood (2021) 138 (16): 1441–1455.

https://doi.org/10.1182/blood.2020009707

Published: 2021

Includes: Supplemental data

Journal Articles

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance

Blood (2020) 136 (15): 1735–1747.

https://doi.org/10.1182/blood.2019001279

Published: 2020

Includes: Supplemental data

Journal Articles

Introduction to a review series on mechanisms and clinical implications of clonal hematopoiesis

Berthold Göttgens

Blood (2020) 136 (14): 1567.

https://doi.org/10.1182/blood.2020007974

Published: 2020

Journal Articles

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Daniel Sasca, Haiyang Yun, George Giotopoulos, Jakub Szybinski, Theo Evan, Nicola K. Wilson, Moritz Gerstung, Paolo Gallipoli, Anthony R. Green, Robert Hills, Nigel Russell, Cameron S. Osborne, Elli Papaemmanuil, Berthold Göttgens, Peter Campbell, Brian J. P. Huntly

Blood (2019) 134 (24): 2195–2208.

https://doi.org/10.1182/blood.2019001553

Published: 2019

Includes: Supplemental data

Journal Articles

New insights into hematopoietic differentiation landscapes from single-cell RNA sequencing

Sam Watcham, Iwo Kucinski, Berthold Gottgens

Blood (2019) 133 (13): 1415–1426.

https://doi.org/10.1182/blood-2018-08-835355

Published: 2019

Journal Articles

Single Cell RNA-Seq Characterises Pre-Leukemic Transformation Driven By CEBPA N321D in the Hoxb8-FL Cell Line

Moosa Qureshi, MBBS, MRCP, Fernando Calero-Nieto, Iwo Kucinski, Sarah Kinston, George Giotopoulos, Dean Pask, Rebecca Hannah, Evangelia Diamanti, Xiaonan Wang, Reiner Schulte, Chiara Cossetti, Anthony R Green, Brian J.P Huntly, Berthold Gottgens

Blood (2018) 132 (Supplement 1): 3887.

https://doi.org/10.1182/blood-2018-99-110626

Published: 2018

Journal Articles

The Lysine Acetyltransferase Tip60 Is Required for Hematopoietic Stem Cell Maintenance

Akihiko Numata, MD, Hui Si Kwok, PhD, Qi-Ling Zhou, Jia Li, PhD, Rebecca Hannah, Jihye Park, PhD, Vladimir Espinosa Angarcia, PhD, Berthold Gottgens, Henry Yang, PhD, John Lough, PhD, Deepak Bararia, PhD, Daniel G. Tenen, MD

Blood (2018) 132 (Supplement 1): 2554.

https://doi.org/10.1182/blood-2018-99-118316

Published: 2018

Journal Articles

Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal

Mairi S. Shepherd, Juan Li, Nicola K. Wilson, Caroline A. Oedekoven, Jiangbing Li, Miriam Belmonte, Juergen Fink, Janine C. M. Prick, Dean C. Pask, Tina L. Hamilton, Dirk Loeffler, Anjana Rao, Timm Schröder, Berthold Göttgens, Anthony R. Green, David G. Kent

Blood (2018) 132 (8): 791–803.

https://doi.org/10.1182/blood-2017-12-821066

Published: 2018

Includes: Supplemental data

NARROW

Single-cell epigenetic and clonal analysis decodes disease progression in pediatric acute myeloid leukemia

Delayed Trp53 Activation Protects Dnmt3a -Mutant Haematopoietic Stem Cells from Inflammatory Attrition

Multimodal Single Cell Analysis Reveals Hematopoietic Changes across the Human Lifespan

A Novel in Vitro Model of Pre-Leukemic Competition Reveals “Super-Competitive” TET2-Mutant Hematopoietic Stem Cell Clones

Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle

NPM1c Mutations Are Associated with Reduced Levels of Multiple Ribosome Biogenesis Factors Leading to Therapeutic Vulnerabilities

A Multimodal Single Cell Atlas of Adult Murine Haematopoiesis Reveals Nine Differentiation Trajectories and Epigenetic Regulatory Programs

Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs

Introduction to a review series on single-cell genomics: getting ready for clinical impact in leukemia and myeloid neoplasms

STAT1 is essential for HSC function and maintains MHCII hi stem cells that resist myeloablation and neoplastic expansion

p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion

Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance

Introduction to a review series on mechanisms and clinical implications of clonal hematopoiesis

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

New insights into hematopoietic differentiation landscapes from single-cell RNA sequencing

Single Cell RNA-Seq Characterises Pre-Leukemic Transformation Driven By CEBPA N321D in the Hoxb8-FL Cell Line

The Lysine Acetyltransferase Tip60 Is Required for Hematopoietic Stem Cell Maintenance

Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal

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American Society of Hematology

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American Society of Hematology

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