Page 1 | Search Results | Blood | American Society of Hematology

1-18 of 18

Sort by

Sort Order Select

Journal Articles

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation

Blood blood.2022019306.

https://doi.org/10.1182/blood.2022019306

Published: 2024

Includes: Supplemental data

Journal Articles

Synergistic Efficacy of Dual Menin and PRMT5 Targeting Against NPM1 mutated and KMT2A- rearranged Leukemia

Nadezda Dolgikh, Johanna Rausch, Marlene Steiner, Jonas Schönfeld, Catharina Lahrmann, Nina Hilke, Maria Alejandra Vila Molerio, Simon Weisemann, Maria Saura-Pañella, Aarón Gallego-Crespo, Matthias Theobald, Daniel Sasca, Chun-Wei David Chen, Michael W.M. Kühn

Blood (2024) 144 (Supplement 1): 206.

https://doi.org/10.1182/blood-2024-202460

Published: 2024

Journal Articles

The Transcriptional Activators p300/Crebbp Are Context-Dependent Functional Repressors of Interferon Genes, Offering Therapeutic Promise in AML

Markus Meyerhöfer, Viral Shah, Aarón Gallego-Crespo, Malte Andreas Behrendt, Yawen Zhou, Maria Saura-Pañella, Björn Häupl, Thomas Kindler, Matthias Theobald, Falk Butter, George S Vassiliou, Michael Kühn, Brian J P Huntly, Thomas Oellerich, Daniel Sasca

Blood (2024) 144 (Supplement 1): 152.

https://doi.org/10.1182/blood-2024-194781

Published: 2024

Journal Articles

Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation

Blood (2024) 144 (Supplement 1): 722.

https://doi.org/10.1182/blood-2024-202515

Published: 2024

Journal Articles

HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia

Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan M. A. Azazi, Sarah J. Horton, Cecile K. Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J. P. Huntly

Blood (2023) 141 (14): 1737–1754.

https://doi.org/10.1182/blood.2022016528

Published: 2023

Includes: Supplemental data

Journal Articles

HOXA9 Nucleates a Repressive Chromatin Complex with Nuclear Matrix-Associated Protein- Safb to Maintain Acute Myeloid Leukemia

Shuchi Agrawal Singh, Jaana Bagri, George Giotopoulos, Eshwar Meduri, Shubha Anad, Sarah J. Horton, Daniel Sasca, Haiyang Yun, Anthony Whetton, Brian James Patrick Huntly

Blood (2022) 140 (Supplement 1): 720–721.

https://doi.org/10.1182/blood-2022-156341

Published: 2022

Journal Articles

The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax

Johanna Rausch, Margarita M. Dzama, Nadezda Dolgikh, Hanna Stiller, Stephan Bohl, Catharina Lahrmann, Kerstin Kunz, Linda Kessler, Hakim Echchannaoui, Chun-Wei David Chen, Thomas Kindler, Francis Burrows, Matthias Theobald, Daniel Sasca, Scott A. Armstrong, Michael Kuehn

Blood (2022) 140 (Supplement 1): 6226–6227.

https://doi.org/10.1182/blood-2022-167566

Published: 2022

Journal Articles

Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition

Margarita M. Dzama, Marlene Steiner, Johanna Rausch, Daniel Sasca, Jonas Schönfeld, Kerstin Kunz, Martha C. Taubert, Gerard M. McGeehan, Chun-Wei Chen, Annalisa Mupo, Patricia Hähnel, Matthias Theobald, Thomas Kindler, Richard P. Koche, George S. Vassiliou, Scott A. Armstrong, Michael W. M. Kühn

Blood (2020) 136 (21): 2442–2456.

https://doi.org/10.1182/blood.2020005037

Published: 2020

Includes: Supplemental data

Journal Articles

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Daniel Sasca, Haiyang Yun, George Giotopoulos, Jakub Szybinski, Theo Evan, Nicola K. Wilson, Moritz Gerstung, Paolo Gallipoli, Anthony R. Green, Robert Hills, Nigel Russell, Cameron S. Osborne, Elli Papaemmanuil, Berthold Göttgens, Peter Campbell, Brian J. P. Huntly

Blood (2019) 134 (24): 2195–2208.

https://doi.org/10.1182/blood.2019001553

Published: 2019

Includes: Supplemental data

Journal Articles

Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction

Haiyang Yun, PhD, Shabana Vohra, PhD, Annalisa Mupo, PhD, George Giotopoulos, PhD, Daniel Sasca, MD, Sarah J. Horton, PhD, Shuchi Agrawal-Singh, PhD, Eshwar Meduri, PhD, Faisal Basheer, MBBChir, MA, PhD, Ludovica Marando, Malgorzata Gozdecka, PhD, Oliver M. Dovey, PhD, Xiaonan Wang, PhD, Paolo Gallipoli, PhD, Cameron Osborne, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath

Blood (2019) 134 (Supplement_1): 278.

https://doi.org/10.1182/blood-2019-122413

Published: 2019

Journal Articles

NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in AML

Daniel Sasca, Jakub Szybinski, Andrea Schüler, Viral Shah, Jan Heidelberger, Patricia S. Haehnel, Anna Dolnik, Oliver Kriege, Eva-Marie Fehr, Wolf H. Gebhardt, George Reid, Claudia Scholl, Matthias Theobald, Lars Bullinger, Petra Beli, Thomas Kindler

Blood (2019) 133 (21): 2305–2319.

https://doi.org/10.1182/blood-2018-12-889725

Published: 2019

Includes: Supplemental data

Journal Articles

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S. H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M. L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza, Brian J. P. Huntly

Blood (2018) 131 (15): 1639–1653.

https://doi.org/10.1182/blood-2017-12-820035

Published: 2018

Includes: Supplemental data

Journal Articles

Contrasting Stage Dependent Requirements for the Histone Methyltransferase EZH2 during the Evolution of Acute Myeloid Leukemia

Faisal Basheer, MBBChir, MA, George Giotopoulos, PhD, Eshwar Meduri, PhD, Haiyang Yun, PhD, Milena Mazan, PhD, Olivia Sheppard, Daniel Sasca, MD, Malgorzata Gozdecka, PhD, George S. Vassiliou, MD PhD, Brian J.P Huntly

Blood (2017) 130 (Supplement 1): 1215.

https://doi.org/10.1182/blood.V130.Suppl_1.1215.1215

Published: 2017

Journal Articles

Early Loss of CREBBP Confers Malignant Stem Cell Properties on Lymphoid Progenitors

Brian J.P Huntly, MD PhD, Sarah Jayne Horton, BSc, PhD, George Giotopoulos, Haiyang Yun, MD PhD, Shabana Vohra, BSc, PhD, Olivia Sheppard, Bsc, PhD, Rachael Bashford-Rogers, PhD, Mamunur Rashid, PhD, Daniel Sasca, MD, Faisal Basheer, MBBChir, MA, Paolo Gallipoli, MD PhD, Jessica Okosun, Daniel James Hodson, MD PhD, Jude Fitzgibbon, Ming Du, David Adams

Blood (2016) 128 (22): 460.

https://doi.org/10.1182/blood.V128.22.460.460

Published: 2016

Journal Articles

Targeting Aberrant Ncam (neural cell adhesion molecule; CD56) Expression in Acute Myeloid Leukemia

Daniel Sasca, MD, Andrea Schueler, PhD, Jakub Szybinski, Oliver Kriege, MD, Kerstin Kunz, Eva Marie Fehr, MD, Patricia Haehnel, PhD, Wolf Henning Gebhardt, PhD, Gerge Reid, PhD, Matthias Theobald, MD PhD, Lars Bullinger, MD, Thomas Kindler, MD

Blood (2015) 126 (23): 311.

https://doi.org/10.1182/blood.V126.23.311.311

Published: 2015

Journal Articles

SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia

Daniel Sasca, Patricia S. Hähnel, Jakub Szybinski, Kaml Khawaja, Oliver Kriege, Saskia V. Pante, Lars Bullinger, Susanne Strand, Dennis Strand, Matthias Theobald, Thomas Kindler

Blood (2014) 124 (1): 121–133.

https://doi.org/10.1182/blood-2013-11-538819

Published: 2014

Includes: Supplemental data

Journal Articles

Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy

Patricia S. Hähnel, Birgit Enders, Daniel Sasca, Wynand P. Roos, Bernd Kaina, Lars Bullinger, Matthias Theobald, Thomas Kindler

Blood (2014) 123 (15): 2355–2366.

https://doi.org/10.1182/blood-2013-01-477620

Published: 2014

Includes: Supplemental data

Journal Articles

Expression Of FLT3-ITD Dysregulates The DBC1-Sirt1-p53 Signaling and Promotes Therapy Resistance

Daniel Sasca, MD, Patricia Haehnel, PhD, Kaml I.K. Khawaja, Birgit Enders, Lars Bullinger, MD, PhD, Matthias Theobald, MD, PhD, Thomas Kindler, MD

Blood (2013) 122 (21): 3789.

https://doi.org/10.1182/blood.V122.21.3789.3789

Published: 2013

NARROW

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation

Synergistic Efficacy of Dual Menin and PRMT5 Targeting Against NPM1 mutated and KMT2A- rearranged Leukemia

The Transcriptional Activators p300/Crebbp Are Context-Dependent Functional Repressors of Interferon Genes, Offering Therapeutic Promise in AML

Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation

HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia

HOXA9 Nucleates a Repressive Chromatin Complex with Nuclear Matrix-Associated Protein- Safb to Maintain Acute Myeloid Leukemia

The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax

Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction

NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in AML

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Contrasting Stage Dependent Requirements for the Histone Methyltransferase EZH2 during the Evolution of Acute Myeloid Leukemia

Early Loss of CREBBP Confers Malignant Stem Cell Properties on Lymphoid Progenitors

Targeting Aberrant Ncam (neural cell adhesion molecule; CD56) Expression in Acute Myeloid Leukemia

SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia

Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy

Expression Of FLT3-ITD Dysregulates The DBC1-Sirt1-p53 Signaling and Promotes Therapy Resistance

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only