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Journal Articles

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation

Blood blood.2022019306.

https://doi.org/10.1182/blood.2022019306

Published: 2024

Includes: Supplemental data

Journal Articles

Delayed Trp53 Activation Protects Dnmt3a -Mutant Haematopoietic Stem Cells from Inflammatory Attrition

Ludovica Marando, George Giotopoulos, Pedro Madrigal, Dhoyazan M A Azazi, Ryan Asby, Maria Erendira Calleja-Cervantes, David Lara-Astiaso, Nicola K. Wilson, Rebecca Hannah, Jaana Bagri, Elsa Barnard, Sarah J Horton, Berthold Gottgens, Elli Papaemmanuil, Shuchi Agrawal Singh, Malgorzata Gozdecka, George S Vassiliou, Brian J P Huntly

Blood (2024) 144 (Supplement 1): 190.

https://doi.org/10.1182/blood-2024-201612

Published: 2024

Journal Articles

Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation

Blood (2024) 144 (Supplement 1): 722.

https://doi.org/10.1182/blood-2024-202515

Published: 2024

Journal Articles

HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia

Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan M. A. Azazi, Sarah J. Horton, Cecile K. Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J. P. Huntly

Blood (2023) 141 (14): 1737–1754.

https://doi.org/10.1182/blood.2022016528

Published: 2023

Includes: Supplemental data

Journal Articles

HOXA9 Nucleates a Repressive Chromatin Complex with Nuclear Matrix-Associated Protein- Safb to Maintain Acute Myeloid Leukemia

Shuchi Agrawal Singh, Jaana Bagri, George Giotopoulos, Eshwar Meduri, Shubha Anad, Sarah J. Horton, Daniel Sasca, Haiyang Yun, Anthony Whetton, Brian James Patrick Huntly

Blood (2022) 140 (Supplement 1): 720–721.

https://doi.org/10.1182/blood-2022-156341

Published: 2022

Journal Articles

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma

Blood (2022) 139 (16): 2471–2482.

https://doi.org/10.1182/blood.2021015161

Published: 2022

Includes: Supplemental data

Journal Articles

Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia

Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Konstantinos Tzelepis, Celine Philippe, Kevin Rattigan, Ryan Asby, Vilma Dembitz, Aoife S.M. Magee, Gudmundur Helgason, Kevin Rouault-Pierre, George S. Vassiliou, Brian J.P Huntly, Paolo Gallipoli

Blood (2021) 138 (Supplement 1): 508.

https://doi.org/10.1182/blood-2021-148489

Published: 2021

Journal Articles

Transcriptional Heterogeneity Governs Cell Fate Diversification during Pre-Leukemia to Leukemia Progression

Shikha Gupta, MS, Ana Filipa Domingues, Oliwia Cyran, George Giotopoulos, PhD, Sudhakaran Prabakaran, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, Oliver M. Dovey, PhD, George S. Vassiliou, MD PhD FRCPath, MRCP, Cristina Pina, MDDPhil

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-136504

Published: 2020

Journal Articles

CML: new tools to answer old questions

George Giotopoulos, Brian J. P. Huntly

Blood (2020) 135 (26): 2327–2328.

https://doi.org/10.1182/blood.2020005599

Published: 2020

Journal Articles

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Daniel Sasca, Haiyang Yun, George Giotopoulos, Jakub Szybinski, Theo Evan, Nicola K. Wilson, Moritz Gerstung, Paolo Gallipoli, Anthony R. Green, Robert Hills, Nigel Russell, Cameron S. Osborne, Elli Papaemmanuil, Berthold Göttgens, Peter Campbell, Brian J. P. Huntly

Blood (2019) 134 (24): 2195–2208.

https://doi.org/10.1182/blood.2019001553

Published: 2019

Includes: Supplemental data

Journal Articles

Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction

Haiyang Yun, PhD, Shabana Vohra, PhD, Annalisa Mupo, PhD, George Giotopoulos, PhD, Daniel Sasca, MD, Sarah J. Horton, PhD, Shuchi Agrawal-Singh, PhD, Eshwar Meduri, PhD, Faisal Basheer, MBBChir, MA, PhD, Ludovica Marando, Malgorzata Gozdecka, PhD, Oliver M. Dovey, PhD, Xiaonan Wang, PhD, Paolo Gallipoli, PhD, Cameron Osborne, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath

Blood (2019) 134 (Supplement_1): 278.

https://doi.org/10.1182/blood-2019-122413

Published: 2019

Journal Articles

Single Cell RNA-Seq Characterises Pre-Leukemic Transformation Driven By CEBPA N321D in the Hoxb8-FL Cell Line

Moosa Qureshi, MBBS, MRCP, Fernando Calero-Nieto, Iwo Kucinski, Sarah Kinston, George Giotopoulos, Dean Pask, Rebecca Hannah, Evangelia Diamanti, Xiaonan Wang, Reiner Schulte, Chiara Cossetti, Anthony R Green, Brian J.P Huntly, Berthold Gottgens

Blood (2018) 132 (Supplement 1): 3887.

https://doi.org/10.1182/blood-2018-99-110626

Published: 2018

Journal Articles

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S. H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M. L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza, Brian J. P. Huntly

Blood (2018) 131 (15): 1639–1653.

https://doi.org/10.1182/blood-2017-12-820035

Published: 2018

Includes: Supplemental data

Journal Articles

Histone Acetyl-Transferase Kat2a Regulates Transcriptional Heterogeneity and Impacts Self-Renewal of Acute Myeloid Leukemia Cells in a Disease-Specific Manner

Ana Filipa Domingues, MSc, Rashmi Kulkarni, PhD, George Giotopoulos, PhD, Brian J.P Huntly, Sudhakaran Prabakaran, PhD, Cristina Pina, MDDPhil

Blood (2017) 130 (Supplement 1): 2486.

https://doi.org/10.1182/blood.V130.Suppl_1.2486.2486

Published: 2017

Journal Articles

Contrasting Stage Dependent Requirements for the Histone Methyltransferase EZH2 during the Evolution of Acute Myeloid Leukemia

Faisal Basheer, MBBChir, MA, George Giotopoulos, PhD, Eshwar Meduri, PhD, Haiyang Yun, PhD, Milena Mazan, PhD, Olivia Sheppard, Daniel Sasca, MD, Malgorzata Gozdecka, PhD, George S. Vassiliou, MD PhD, Brian J.P Huntly

Blood (2017) 130 (Supplement 1): 1215.

https://doi.org/10.1182/blood.V130.Suppl_1.1215.1215

Published: 2017

Journal Articles

Early Loss of CREBBP Confers Malignant Stem Cell Properties on Lymphoid Progenitors

Brian J.P Huntly, MD PhD, Sarah Jayne Horton, BSc, PhD, George Giotopoulos, Haiyang Yun, MD PhD, Shabana Vohra, BSc, PhD, Olivia Sheppard, Bsc, PhD, Rachael Bashford-Rogers, PhD, Mamunur Rashid, PhD, Daniel Sasca, MD, Faisal Basheer, MBBChir, MA, Paolo Gallipoli, MD PhD, Jessica Okosun, Daniel James Hodson, MD PhD, Jude Fitzgibbon, Ming Du, David Adams

Blood (2016) 128 (22): 460.

https://doi.org/10.1182/blood.V128.22.460.460

Published: 2016

Journal Articles

Modelling Resistance to Emerging Epigenetic Therapies

Blood (2014) 124 (21): 3546.

https://doi.org/10.1182/blood.V124.21.3546.3546

Published: 2014

Journal Articles

Mll-AF4 Induction during Ontogeny Reveals Early Changes in Myeloid and Lymphoid potential and Results in Hematopoietic Malignancies in Adult Mice

Neil A Barrett, MB BCh, Chrysa Kapeni, MSc, Camille Malouf, PhD, George Giotopoulos, PhD, Simon Fitch, PhD, Wendi A. Bacon, BSc, Brian Huntly, MD PhD, Katrin Ottersbach, PhD

Blood (2014) 124 (21): 892.

https://doi.org/10.1182/blood.V124.21.892.892

Published: 2014

Journal Articles

The Epigenetic Regulators CBP and p300 Facilitate Leukemogenesis and Represent Therapeutic Targets In Acute Myeloid Leukemia (AML)

George Giotopoulos, Wai-In Chan, David Ruau, Paolo Gallipoli, Alexis Fowler, Berthold Göttgens, Jan Van Deursen, Philip Cole, Brian Huntly

Blood (2013) 122 (21): 3732.

https://doi.org/10.1182/blood.V122.21.3732.3732

Published: 2013

Journal Articles

Modelling Cellular and Molecular Progression Of CML In The Mouse

George Giotopoulos, Louise Van Der Weyden, Hikari Osaki, Wai-In Chan, Alistair Rust, Eshwar Meduri, Steffen Koschmieder, Daniel Tenen, George Vassiliou, David Adams, Brian Huntly

Blood (2013) 122 (21): 2706.

https://doi.org/10.1182/blood.V122.21.2706.2706

Published: 2013

NARROW

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation

Delayed Trp53 Activation Protects Dnmt3a -Mutant Haematopoietic Stem Cells from Inflammatory Attrition

Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation

HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia

HOXA9 Nucleates a Repressive Chromatin Complex with Nuclear Matrix-Associated Protein- Safb to Maintain Acute Myeloid Leukemia

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma

Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia

Transcriptional Heterogeneity Governs Cell Fate Diversification during Pre-Leukemia to Leukemia Progression

CML: new tools to answer old questions

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction

Single Cell RNA-Seq Characterises Pre-Leukemic Transformation Driven By CEBPA N321D in the Hoxb8-FL Cell Line

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Histone Acetyl-Transferase Kat2a Regulates Transcriptional Heterogeneity and Impacts Self-Renewal of Acute Myeloid Leukemia Cells in a Disease-Specific Manner

Contrasting Stage Dependent Requirements for the Histone Methyltransferase EZH2 during the Evolution of Acute Myeloid Leukemia

Early Loss of CREBBP Confers Malignant Stem Cell Properties on Lymphoid Progenitors

Modelling Resistance to Emerging Epigenetic Therapies

Mll-AF4 Induction during Ontogeny Reveals Early Changes in Myeloid and Lymphoid potential and Results in Hematopoietic Malignancies in Adult Mice

The Epigenetic Regulators CBP and p300 Facilitate Leukemogenesis and Represent Therapeutic Targets In Acute Myeloid Leukemia (AML)

Modelling Cellular and Molecular Progression Of CML In The Mouse

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American Society of Hematology

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American Society of Hematology

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