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Journal Articles

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation

Blood blood.2022019306.

https://doi.org/10.1182/blood.2022019306

Published: 2024

Includes: Supplemental data

Journal Articles

Synergistic Efficacy of Dual Menin and PRMT5 Targeting Against NPM1 mutated and KMT2A- rearranged Leukemia

Nadezda Dolgikh, Johanna Rausch, Marlene Steiner, Jonas Schönfeld, Catharina Lahrmann, Nina Hilke, Maria Alejandra Vila Molerio, Simon Weisemann, Maria Saura-Pañella, Aarón Gallego-Crespo, Matthias Theobald, Daniel Sasca, Chun-Wei David Chen, Michael W.M. Kühn

Blood (2024) 144 (Supplement 1): 206.

https://doi.org/10.1182/blood-2024-202460

Published: 2024

Journal Articles

Deep Cellular and Molecular Characterization Reveal a Distinct Phenotype and Metabolic Signature of Human Senescent CD8 + T Cells: Implication for Cancer Cellular Therapy

Kevin Jan Jan Legscha, Lea Philine Märker, Najla Abassi, Abdul Yilmaz, Catherine Woelfel, Edite Antunes Ferreira, Annekathrin Nedwed, Sara Salome Helbich, Michael Delacher, Federico Marini, Stefan Porubsky, Matthias Theobald, Hakim Echchannaoui

Blood (2024) 144 (Supplement 1): 2536.

https://doi.org/10.1182/blood-2024-194719

Published: 2024

Journal Articles

Dual Inhibition of Histone and DNA Methylation in AML Enhances the Effectiveness of TCR-Based Cellular Therapy through Upregulation of Surface MHC Class I/p53 Antigen Complex

Ulrike Regina Schmits, Edite Antunes Ferreira, Borhane Guezguez, David Gomez-Zepeda, Stefan Tenzer, Kevin Jan Legscha, Matthias Theobald, Hakim Echchannaoui

Blood (2024) 144 (Supplement 1): 3444.

https://doi.org/10.1182/blood-2024-201347

Published: 2024

Journal Articles

The Transcriptional Activators p300/Crebbp Are Context-Dependent Functional Repressors of Interferon Genes, Offering Therapeutic Promise in AML

Markus Meyerhöfer, Viral Shah, Aarón Gallego-Crespo, Malte Andreas Behrendt, Yawen Zhou, Maria Saura-Pañella, Björn Häupl, Thomas Kindler, Matthias Theobald, Falk Butter, George S Vassiliou, Michael Kühn, Brian J P Huntly, Thomas Oellerich, Daniel Sasca

Blood (2024) 144 (Supplement 1): 152.

https://doi.org/10.1182/blood-2024-194781

Published: 2024

Journal Articles

Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation

Blood (2024) 144 (Supplement 1): 722.

https://doi.org/10.1182/blood-2024-202515

Published: 2024

Journal Articles

Implementation of CMV-T-Track® in Clinical Routine to Guide Management of CMV Reactivation

Jonas Wißkirchen, Diana Wolff, Isabelle Ries, Oliver Kriege, Pascal Wölfinger, Beate Hauptrock, Matthias Theobald, Eva-Maria Wagner Drouet

Blood (2023) 142 (Supplement 1): 2180.

https://doi.org/10.1182/blood-2023-187382

Published: 2023

Journal Articles

Real World Results of Brexucabtagene Autoleucel for Patients with Relapsed/Refractory Mantle Cell Lymphoma - First German/Swiss Analysis

Blood (2023) 142 (Supplement 1): 4394.

https://doi.org/10.1182/blood-2023-182415

Published: 2023

Journal Articles

Immune-Effector-Cell-Associated-Neurotoxicity-Syndrome (ICANS) Pathophysiology Is Mediated By Microglia TGF-β-Activated Kinase-1 Signaling

Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland, Chintan Chhatbar, Rachael C Adams, Daniel Erny, Sandra Duquesne, Nadia El Khawanky, Henrike Salié, Dimitrios Athanassopoulos, Lukas Braun, Dominik Schmidt, Viktor Fetsch, Rebeka N. Javorniczky, Jenny N.H.G Ho, Reinhard Marks, Ralph Wäsch, Federico Simonetta, Geoffroy Andrieux, Dietmar Pfeifer, Gianni Monaco, Christian Capitini, Terry J. Fry, Thomas Blank, Bruce R Blazar, Eva-Maria Wagner Drouet, Matthias Theobald, Clemens Sommer, Matthias Stelljes, Christian Reicherts, Astrid Jeibmann, Jens Schittenhelm, Camelia-Maria Monoranu, Andreas Rosenwald, K. Martin Kortüm, Leo Rasche, Hermann Einsele, Philipp Tobias Meyer, Joachim Brumberg, Andreas Mackensen, Michael von Bergwelt-Baildon, Roland Coras, Nathalie L. Albert, Laura M. Bartos, Matthias Brendel, Adrien Holzgreve, Melanie Boerries, Crystal L. Mackall, Justus Duyster, Natalie Koehler, Felix Strübing, Bertram Bengsch, Marco Ruella, Marion Subklewe, Louisa von Baumgarten, Saar Gill, Marco Prinz, Robert Zeiser

Blood (2023) 142 (Supplement 1): 100.

https://doi.org/10.1182/blood-2023-184867

Published: 2023

Journal Articles

The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax

Johanna Rausch, Margarita M. Dzama, Nadezda Dolgikh, Hanna Stiller, Stephan Bohl, Catharina Lahrmann, Kerstin Kunz, Linda Kessler, Hakim Echchannaoui, Chun-Wei David Chen, Thomas Kindler, Francis Burrows, Matthias Theobald, Daniel Sasca, Scott A. Armstrong, Michael Kuehn

Blood (2022) 140 (Supplement 1): 6226–6227.

https://doi.org/10.1182/blood-2022-167566

Published: 2022

Journal Articles

Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition

Margarita M. Dzama, Marlene Steiner, Johanna Rausch, Daniel Sasca, Jonas Schönfeld, Kerstin Kunz, Martha C. Taubert, Gerard M. McGeehan, Chun-Wei Chen, Annalisa Mupo, Patricia Hähnel, Matthias Theobald, Thomas Kindler, Richard P. Koche, George S. Vassiliou, Scott A. Armstrong, Michael W. M. Kühn

Blood (2020) 136 (21): 2442–2456.

https://doi.org/10.1182/blood.2020005037

Published: 2020

Includes: Supplemental data

Journal Articles

Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL -Rearranged AML with Mutated FLT3

Margarita M. Dzama, MSc, Martha C. Taubert, MSc, Kerstin Kunz, Johanna Rausch, MD, Chun-Wei David Chen, PhD, Annalisa Mupo, PhD, Patricia Hähnel, PhD, Matthias Theobald, MD PhD, Thomas Kindler, MD, Richard P. Koche, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Scott A. Armstrong, MD PhD, Michael W.M. Kühn, MD

Blood (2019) 134 (Supplement_1): 1441.

https://doi.org/10.1182/blood-2019-122847

Published: 2019

Journal Articles

NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in AML

Daniel Sasca, Jakub Szybinski, Andrea Schüler, Viral Shah, Jan Heidelberger, Patricia S. Haehnel, Anna Dolnik, Oliver Kriege, Eva-Marie Fehr, Wolf H. Gebhardt, George Reid, Claudia Scholl, Matthias Theobald, Lars Bullinger, Petra Beli, Thomas Kindler

Blood (2019) 133 (21): 2305–2319.

https://doi.org/10.1182/blood-2018-12-889725

Published: 2019

Includes: Supplemental data

Journal Articles

p53 Isoform D133p53a: A Novel Transcriptional Enhancer of T-Cell Effector Function to Improve T-Cell Based Cancer Immunotherapy

Kevin Jan Legscha, MDcal Student, Edite Antunes, Research Assistant, Borhane Guezguez, BSc, MSc, PhD, Matthias Theobald, Hakim Echchannaoui, BSc, MSc, PhD

Blood (2018) 132 (Supplement 1): 3489.

https://doi.org/10.1182/blood-2018-99-116208

Published: 2018

Journal Articles

Arginine Depletion in Combination with Canavanine Supplementation Induces Massive Cell Death in Myeloma Cells By Interfering with Their Protein Metabolism and Bypassing Potential Rescue Mechanisms

Johannes Windschmitt, Björn Jacobi, MD, Yagmur Bülbül, Lilli Sester, Janine Tappe, Christof Hiebel, PhD, Christian Behl, PhD, Matthias Theobald, Markus Munder, MD

Blood (2018) 132 (Supplement 1): 3205.

https://doi.org/10.1182/blood-2018-99-113396

Published: 2018

Journal Articles

CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis

Daniel Teschner, MD, Anna Cholaszczyńska, Frederic Ries, Hendrik Beckert, Matthias Theobald, Stephan Grabbe, MD, Markus P. Radsak, MD, Matthias Bros, PhD

Blood (2018) 132 (Supplement 1): 3690.

https://doi.org/10.1182/blood-2018-99-111843

Published: 2018

Journal Articles

Obinutuzumab (GA101) in Combination with Pixantrone for the Treatment of Patients with Relapsed Aggressive B-Cell Lymphoma:Â a Phase II Trial (GOAL)

Georg Hess, Andreas Hüttmann, MD, Julia Meissner, MD, Reinhard Marks, Martin Dreyling, MD PhD, Ulrich Keller, Thomas Ernst, Christiane Pott, Andreas Viardot, MD, Oliver Deuster, Christina van Oordt, Matthias Theobald, Georg Lenz

Blood (2018) 132 (Supplement 1): 1678.

https://doi.org/10.1182/blood-2018-99-116670

Published: 2018

Journal Articles

Ruxolitinib Inhibits Toll-like Receptor or GM-CSF, but Not TREM-1 Mediated Neutrophil Activation

Pamela Aranda Lopez, PhD, Astrid Alflen, MD, Nicole Stadler, Cornelia Schmidt, Thomas Kindler, MD, Matthias Theobald, MD PhD, Markus P. Radsak, MD

Blood (2017) 130 (Supplement 1): 4805.

https://doi.org/10.1182/blood.V130.Suppl_1.4805.4805

Published: 2017

Journal Articles

How to Identify Patients for Treg DLI - Treg Subsets in Gvhd As Biomarker for Successful Treg DLI

Pascal Wölfinger, Lukas Schäfer, Katharina Epp, Matthias Theobald, MD PhD, Tobias Bopp, Eva-Maria Wagner, MD

Blood (2017) 130 (Supplement 1): 1989.

https://doi.org/10.1182/blood.V130.Suppl_1.1989.1989

Published: 2017

Journal Articles

Idelalisib Impairs TREM-1 Mediated Neutrophil Inflammatory Responses

Astrid Alflen, Nicole Stadler, Pamela Aranda Lopez, PhD, Daniel Teschner, MD, Georg Hess, Matthias Theobald, MD PhD, Markus P. Radsak, MD

Blood (2017) 130 (Supplement 1): 3569.

https://doi.org/10.1182/blood.V130.Suppl_1.3569.3569

Published: 2017

NARROW

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation

Synergistic Efficacy of Dual Menin and PRMT5 Targeting Against NPM1 mutated and KMT2A- rearranged Leukemia

Deep Cellular and Molecular Characterization Reveal a Distinct Phenotype and Metabolic Signature of Human Senescent CD8 + T Cells: Implication for Cancer Cellular Therapy

Dual Inhibition of Histone and DNA Methylation in AML Enhances the Effectiveness of TCR-Based Cellular Therapy through Upregulation of Surface MHC Class I/p53 Antigen Complex

The Transcriptional Activators p300/Crebbp Are Context-Dependent Functional Repressors of Interferon Genes, Offering Therapeutic Promise in AML

Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation

Implementation of CMV-T-Track® in Clinical Routine to Guide Management of CMV Reactivation

Real World Results of Brexucabtagene Autoleucel for Patients with Relapsed/Refractory Mantle Cell Lymphoma - First German/Swiss Analysis

Immune-Effector-Cell-Associated-Neurotoxicity-Syndrome (ICANS) Pathophysiology Is Mediated By Microglia TGF-β-Activated Kinase-1 Signaling

The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax

Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition

Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL -Rearranged AML with Mutated FLT3

NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in AML

p53 Isoform D133p53a: A Novel Transcriptional Enhancer of T-Cell Effector Function to Improve T-Cell Based Cancer Immunotherapy

Arginine Depletion in Combination with Canavanine Supplementation Induces Massive Cell Death in Myeloma Cells By Interfering with Their Protein Metabolism and Bypassing Potential Rescue Mechanisms

CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis

Obinutuzumab (GA101) in Combination with Pixantrone for the Treatment of Patients with Relapsed Aggressive B-Cell Lymphoma:Â a Phase II Trial (GOAL)

Ruxolitinib Inhibits Toll-like Receptor or GM-CSF, but Not TREM-1 Mediated Neutrophil Activation

How to Identify Patients for Treg DLI - Treg Subsets in Gvhd As Biomarker for Successful Treg DLI

Idelalisib Impairs TREM-1 Mediated Neutrophil Inflammatory Responses

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American Society of Hematology

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