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Journal Articles

Use of CD19 CAR-T Cells in Adult B-Cell Acute Lymphoblastic Leukemia (B-ALL) with Minimal Residual Disease (MRD) Positivity at First Complete Remission: Preliminary Outcomes from a Phase I Clinical Trial

Marc Schwartz, Navin R. Pinto, Jonathan Gutman, Michael R Verneris, Andrew Roth, Jason S. Gilbert, Dina Schneider, Terry J Fry

Blood (2024) 144 (Supplement 1): 5876.

https://doi.org/10.1182/blood-2024-204262

Published: 2024

Journal Articles

Developing a Pediatric-Relevant Murine MLL-r B-ALL Model to Study Factors Involved in Lineage Switching

Wenjuan Liao, Tian Liu, Julian Grandvallet Contreras, Lynn Heltemes Harris, Tzu Phang, Michael A. Farrar, M. Eric Kohler, Terry J Fry, Patricia Ernst

Blood (2024) 144 (Supplement 1): 4129.

https://doi.org/10.1182/blood-2024-208932

Published: 2024

Journal Articles

Enabling Potent T Cell Delivery and Mitigating Key Off-Target Concerns of In Vivo CAR T Lentiviral Vectors with the Targeted Paramyxovirus Fusogen System

Shirisha Amatya, Jesse Green, Chi-Shuen Chu, Adam Hilterbrand, Reuben Burch, Chris Baldeviano, Edward Rebar, Terry J Fry, Albert Ruzo, Kutlu G Elpek, Kyle Trudeau

Blood (2024) 144 (Supplement 1): 2047.

https://doi.org/10.1182/blood-2024-211267

Published: 2024

Journal Articles

Gilteritinib Augments Preclinical FLT3 and CD19 CAR T Cell Immunotherapy in High-Risk Pediatric Leukemias

Lisa M Niswander, Samantha McClellan, Diego Alberto Barcenas-Lopez, Michael Yarnell, Shubhmita Bhatnagar, Terry J Fry, Sarah K. Tasian

Blood (2024) 144 (Supplement 1): 370.

https://doi.org/10.1182/blood-2024-206467

Published: 2024

Journal Articles

Autologous CD33CART for Children and Adolescents/Young Adults with Relapsed/Refractory AML: Phase 1/2 Clinical Trial Correlative Biology Analyses Demonstrate Potent in Vitro , In Vivo , and Ex Vivo Anti-Leukemia Activity

Tommaso Balestra, Camilo Arenas Merizalde, Robert K Chen, John Roach, Brian Bowser, Rachelle Salomon, Anthony Welch, Bonnie Yates, Kristin Schaller, Michael R Verneris, Susanne H.C. Baumeister, Emily M. Hsieh, M. Eric Kohler, Katherine Tarlock, Steven M. Devine, Richard Aplenc, Nirali N. Shah, Terry J Fry, Sarah K. Tasian

Blood (2024) 144 (Supplement 1): 369.

https://doi.org/10.1182/blood-2024-211517

Published: 2024

Journal Articles

Validation of a Digital Polymerase Chain Reaction Assay to Quantify Chimeric Antigen Receptor-Positive T-Cells Relative to Total T-Cells

Lindsey A. Murphy, Laura Sedivy, M. Eric Kohler, Kimberly Jordan, Jill Slansky, Michael Yarnell, Terry J Fry, Amanda Winters

Blood (2024) 144 (Supplement 1): 2219.

https://doi.org/10.1182/blood-2024-208786

Published: 2024

Journal Articles

Co-Targeting of the Thymic Stromal Lymphopoietin Receptor to Decrease Immunotherapeutic Resistance in CRLF2 -Rearranged Ph-like and Down Syndrome ALL

Tommaso Balestra, Lisa M Niswander, Asen Bagashev, Joseph P Loftus, Savannah L Ross, Robert K Chen, Samantha M McClellan, Jacob J Junco, Diego Alberto Barcenas-Lopez, Karen R Rabin, Terry J Fry, Sarah K. Tasian

Blood (2024) 144 (Supplement 1): 3424.

https://doi.org/10.1182/blood-2024-208383

Published: 2024

Journal Articles

Relieving Restriction in Resting CD8+ T Cells Increases Gene Transfer and Improves Tumor Killing after Transduction with CD8-Targeted CD19CAR Fusosome

Mariliis Ott, Hadega Aamer, Daryl Humes, Reuben Burch, Christina Proano, Brian Dolinski, Diana Vedenova, Ashley Benson, Ryan White, Semih Tareen, Jesse Green, Kutlu G Elpek, Neal van Hoeven, Terry J Fry

Blood (2024) 144 (Supplement 1): 2196.

https://doi.org/10.1182/blood-2024-208368

Published: 2024

Journal Articles

Preliminary Safety and Tolerability of CD19x22 CAR-T Cell Therapy in Adolescent and Adult Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Manali K. Kamdar, Bradley M. Haverkos, Alexander W. Rankin, Cheri Adams, Michael R Verneris, Andrew Roth, Kimberly Jordan, Navin R. Pinto, M. Eric Kohler, Angela Ohm, Terry J Fry

Blood (2024) 144 (Supplement 1): 4510.

https://doi.org/10.1182/blood-2024-210123

Published: 2024

Journal Articles

Runx2 Overexpression Enhances Potency and Counteracts Exhaustion in CD8+ CAR T Cells

Kole R. Degolier, Etienne Danis, Jennifer Cimons, Michael Yarnell, Ross Kedl, M. Eric Kohler, James Scott-Browne, Terry J. Fry

Blood (2023) 142 (Supplement 1): 2082.

https://doi.org/10.1182/blood-2023-186898

Published: 2023

Journal Articles

Development of a Novel, Allogeneic GPRC5D-Directed CAR for Treatment of Multiple Myeloma Patients

Jeremy Kinder, Chanel Athena Estrada, Brian Granger, Allison O'Rourke, Ouwen Liang, Aaron Lampano, Garrett Zipp, Vandana Chaturvedi, Xiaomeng Hu, Chi Young, Neal van Hoeven, Sonja Schrepfer, Terry J. Fry

Blood (2023) 142 (Supplement 1): 3290.

https://doi.org/10.1182/blood-2023-189665

Published: 2023

Journal Articles

Immune-Effector-Cell-Associated-Neurotoxicity-Syndrome (ICANS) Pathophysiology Is Mediated By Microglia TGF-β-Activated Kinase-1 Signaling

Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland, Chintan Chhatbar, Rachael C Adams, Daniel Erny, Sandra Duquesne, Nadia El Khawanky, Henrike Salié, Dimitrios Athanassopoulos, Lukas Braun, Dominik Schmidt, Viktor Fetsch, Rebeka N. Javorniczky, Jenny N.H.G Ho, Reinhard Marks, Ralph Wäsch, Federico Simonetta, Geoffroy Andrieux, Dietmar Pfeifer, Gianni Monaco, Christian Capitini, Terry J. Fry, Thomas Blank, Bruce R Blazar, Eva-Maria Wagner Drouet, Matthias Theobald, Clemens Sommer, Matthias Stelljes, Christian Reicherts, Astrid Jeibmann, Jens Schittenhelm, Camelia-Maria Monoranu, Andreas Rosenwald, K. Martin Kortüm, Leo Rasche, Hermann Einsele, Philipp Tobias Meyer, Joachim Brumberg, Andreas Mackensen, Michael von Bergwelt-Baildon, Roland Coras, Nathalie L. Albert, Laura M. Bartos, Matthias Brendel, Adrien Holzgreve, Melanie Boerries, Crystal L. Mackall, Justus Duyster, Natalie Koehler, Felix Strübing, Bertram Bengsch, Marco Ruella, Marion Subklewe, Louisa von Baumgarten, Saar Gill, Marco Prinz, Robert Zeiser

Blood (2023) 142 (Supplement 1): 100.

https://doi.org/10.1182/blood-2023-184867

Published: 2023

Journal Articles

In Vitro and In Vivo Specificity and Biodistribution of a Novel CD8-Targeted Fusosome

Hemantkumar Chavan, Shirisha Amatya, Valeria Berlfein, Patricia Cruite, Vandana Chaturvedi, Vasily Vagin, Neal van Hoeven, Jagesh Shah, Terry J. Fry, Boris Gorovits, Sundeep Chandra

Blood (2023) 142 (Supplement 1): 3630.

https://doi.org/10.1182/blood-2023-190158

Published: 2023

Journal Articles

Hypoimmune, Allogeneic CD22-Directed CAR T Cells That Evade Innate and Adaptive Immune Rejection for the Treatment of Large B Cell Lymphoma Patients That Are Relapsed/Refractory to CD19-Directed CAR T Cell Therapy

Blood (2023) 142 (Supplement 1): 3437.

https://doi.org/10.1182/blood-2023-187096

Published: 2023

Journal Articles

Phase 1 Study of SC291, a Hypoimmune, Allogeneic CD19-Directed CAR T Cell Therapy for Relapsed/Refractory B-Cell Malignancies (ARDENT) - Initial Clinical Data

Sattva S. Neelapu, L. Elizabeth Budde, Joseph P McGuirk, Saurabh Dahiya, Abhinav Deol, Philip A. Thompson, Nitin Jain, Matthew A Lunning, Xiaomeng Hu, Boris Gorovits, Danielle Quarles, Barbara Metallo, Meghan Flaherty, Weidong Zhang, Hosein Kouros-Mehr, Terry J. Fry, Sonja Schrepfer

Blood (2023) 142 (Supplement 1): 6852.

https://doi.org/10.1182/blood-2023-179441

Published: 2023

Journal Articles

CD33 CAR T-Cells (CD33CART) for Children and Young Adults with Relapsed/Refractory AML: Dose-Escalation Results from a Phase I/II Multicenter Trial

Blood (2023) 142 (Supplement 1): 771.

https://doi.org/10.1182/blood-2023-179667

Published: 2023

Journal Articles

T-Bet Overexpression Increases 4-1BB-Costimulated CAR T Cell Potency

Jennifer Cimons, Kole R. Degolier, Michael Yarnell, M. Eric Kohler, Terry J. Fry

Blood (2023) 142 (Supplement 1): 4816.

https://doi.org/10.1182/blood-2023-186902

Published: 2023

Journal Articles

Murine allogeneic CAR T cells integrated before or early after posttransplant cyclophosphamide exert antitumor effects

Michael T. Patterson, Shanzay M. Khan, Natalia S. Nunes, Rochelle E. Fletcher, Jing Bian, Ashley D. Hadjis, Michael A. Eckhaus, Suresh K. Mendu, Alessandra de Paula Pohl, David J. Venzon, Hyoyoung Choo-Wosoba, Kazusa Ishii, Haiying Qin, Terry J. Fry, Maggie Cam, Christopher G. Kanakry

Blood (2023) 141 (6): 659–672.

https://doi.org/10.1182/blood.2022016660

Published: 2023

Includes: Supplemental data

Journal Articles

Utilization of the Tapestri Platform for Quantification of Single Cell Vector Copy Number in CAR T Cell Products

Lindsey A. Murphy, Alex Li, Saurabh Parikh, Shu Wang, Daniel Mendoza, Khushali Patel, Yilong Yang, Yue Wang, Terry J. Fry, Amanda C. Winters

Blood (2022) 140 (Supplement 1): 4992.

https://doi.org/10.1182/blood-2022-170671

Published: 2022

Journal Articles

A Dual-Antigen Targeting, Hypoimmune Allogeneic CAR T to Evade Innate and Adaptive Immune Rejection and Overcome Antigen Escape

Adam Johnson, Hallee Wright, Xiaomeng Hu, Neal van Hoeven, PhD, Brian Granger, Ouwen Liang, Jesus Moreno, Meghan Lamba, Chi Young, Andrew McAlister, Terry J. Fry, Sonja Schrepfer, Aaron Foster

Blood (2022) 140 (Supplement 1): 4552–4553.

https://doi.org/10.1182/blood-2022-168251

Published: 2022

NARROW

Use of CD19 CAR-T Cells in Adult B-Cell Acute Lymphoblastic Leukemia (B-ALL) with Minimal Residual Disease (MRD) Positivity at First Complete Remission: Preliminary Outcomes from a Phase I Clinical Trial

Developing a Pediatric-Relevant Murine MLL-r B-ALL Model to Study Factors Involved in Lineage Switching

Enabling Potent T Cell Delivery and Mitigating Key Off-Target Concerns of In Vivo CAR T Lentiviral Vectors with the Targeted Paramyxovirus Fusogen System

Gilteritinib Augments Preclinical FLT3 and CD19 CAR T Cell Immunotherapy in High-Risk Pediatric Leukemias

Autologous CD33CART for Children and Adolescents/Young Adults with Relapsed/Refractory AML: Phase 1/2 Clinical Trial Correlative Biology Analyses Demonstrate Potent in Vitro , In Vivo , and Ex Vivo Anti-Leukemia Activity

Validation of a Digital Polymerase Chain Reaction Assay to Quantify Chimeric Antigen Receptor-Positive T-Cells Relative to Total T-Cells

Co-Targeting of the Thymic Stromal Lymphopoietin Receptor to Decrease Immunotherapeutic Resistance in CRLF2 -Rearranged Ph-like and Down Syndrome ALL

Relieving Restriction in Resting CD8+ T Cells Increases Gene Transfer and Improves Tumor Killing after Transduction with CD8-Targeted CD19CAR Fusosome

Preliminary Safety and Tolerability of CD19x22 CAR-T Cell Therapy in Adolescent and Adult Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Runx2 Overexpression Enhances Potency and Counteracts Exhaustion in CD8+ CAR T Cells

Development of a Novel, Allogeneic GPRC5D-Directed CAR for Treatment of Multiple Myeloma Patients

Immune-Effector-Cell-Associated-Neurotoxicity-Syndrome (ICANS) Pathophysiology Is Mediated By Microglia TGF-β-Activated Kinase-1 Signaling

In Vitro and In Vivo Specificity and Biodistribution of a Novel CD8-Targeted Fusosome

Hypoimmune, Allogeneic CD22-Directed CAR T Cells That Evade Innate and Adaptive Immune Rejection for the Treatment of Large B Cell Lymphoma Patients That Are Relapsed/Refractory to CD19-Directed CAR T Cell Therapy

Phase 1 Study of SC291, a Hypoimmune, Allogeneic CD19-Directed CAR T Cell Therapy for Relapsed/Refractory B-Cell Malignancies (ARDENT) - Initial Clinical Data

CD33 CAR T-Cells (CD33CART) for Children and Young Adults with Relapsed/Refractory AML: Dose-Escalation Results from a Phase I/II Multicenter Trial

T-Bet Overexpression Increases 4-1BB-Costimulated CAR T Cell Potency

Murine allogeneic CAR T cells integrated before or early after posttransplant cyclophosphamide exert antitumor effects

Utilization of the Tapestri Platform for Quantification of Single Cell Vector Copy Number in CAR T Cell Products

A Dual-Antigen Targeting, Hypoimmune Allogeneic CAR T to Evade Innate and Adaptive Immune Rejection and Overcome Antigen Escape

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American Society of Hematology

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American Society of Hematology

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