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Journal Articles

Acalabrutinib with Rituximab Is Highly Effective First Line Treatment for Older Patients with Mantle Cell Lymphoma

Preetesh Jain, Chi Young Ok, Jason R. Westin, Holly A Hill, Ranjit Nair, Swami P. Iyer, Ahmed Fetooh, Hun Ju Lee, Sairah Ahmed, Rashmi Kanagal-Shamanna, Fatima Z Jelloul, Luis Malpica, Yang Liu, Yijing Li, Lei Feng, Maria Badillo, Selvi Thirumurthi, Anita Deswal, Cezar Iliescu, Vinh Quang Nguyen, Anastasiia A. Bolshakova, Dmitry Tabakov, Michael G Goldberg, Andrey Tyshevich, Tatiana Vasileva, Daria Shavronskaya, Krystle Nomie, Guilin Tang, Keyur P. Patel, Francisco Vega, L. Jeffrey Medeiros, Christopher R. Flowers, Michael Wang
Journal: Blood
Blood (2024) 144 (Supplement 1): 3038.
https://doi.org/10.1182/blood-2024-206042
Published: 2024
Journal Articles

Myeloid Progenitor Cells with Preleukemic Immunophenotypes Are Common in Myelodysplasia-Related and NPM1- mutated Acute Myeloid Leukemia and Should Not be Interpreted As Measurable Residual Disease

Sanam Loghavi, Sa A. Wang, Wei-Ying Jen, Wei Wang, Hong Fang, Shaoying Li, Sofia A. Garces, Andres E Quesada, Jie Xu, Chi Young Ok, Shimin Hu, Jeffrey L. Jorgensen, Guilin Tang, Cedric Nasnas, Omer Karrar, Ghayas C. Issa, Naval Daver, Courtney D. DiNardo, Tapan M. Kadia, Hagop M. Kantarjian, L. Jeffrey Medeiros, Farhad Ravandi, Nicholas J. Short
Journal: Blood
Blood (2024) 144 (Supplement 1): 4336.
https://doi.org/10.1182/blood-2024-209462
Published: 2024
Journal Articles

Immature erythroblasts in pleural effusion: an initial presentation of acute erythroid leukemia in a patient with a history of MDS

Zhihong Hu, Chi Young Ok
Journal: Blood
Blood (2024) 144 (7): 794.
https://doi.org/10.1182/blood.2024024570
Published: 2024
Journal Articles

Acalabrutinib with Rituximab As First-Line Therapy for Older Patients with Mantle Cell Lymphoma - a Phase II Clinical Trial

Preetesh Jain, Chi Young OK, Loretta J. Nastoupil, Jason Westin, Holly A Hill, Ranjit Nair, Swami P. Iyer, Ahmed Fetooh, Hun Ju Lee, Sairah Ahmed, Rashmi Kanagal-Shamanna, Fatima Z Jelloul, Luis Enrique Malpica Castillo, Yang Liu, Yijing Li, Jovanny Vargas, Lei Feng, Maria Badillo, Selvi Thirumurthi, Guofan Xu, Anita Deswal, Cezar Iliescu, Vinh Quang Nguyen, Guilin Tang, Keyur P. Patel, Francisco Vega, L. Jeffrey Medeiros, Michael L. Wang, Christopher R. Flowers
Journal: Blood
Blood (2023) 142 (Supplement 1): 3036.
https://doi.org/10.1182/blood-2023-181216
Published: 2023
Journal Articles

Phase II Trial of Ibrutinib in Previously Untreated High-Risk Smoldering Mantle Cell Lymphoma

Charles Gaulin, Preetesh Jain, Ranjit Nair, Swami P. Iyer, Hun Ju Lee, Luis Fayad, Lei Feng, Yang Liu, Holly A Hill, Yijing Li, Chi Young Ok, Rashmi Kanagal-Shamanna, Onyeka Oriabure, Wendy Chen, Asiya Siddiqui, Guofan Xu, Anita Deswal, Cezar Iliescu, Maria Badillo, Shaoying Li, Michelle Ky, Michelle Avellaneda, Guilin Tang, Francisco Vega, Christopher R. Flowers, Michael L. Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 3034.
https://doi.org/10.1182/blood-2023-187903
Published: 2023
Journal Articles

Clinical and Prognostic Implications of WT1 Mutations in De Novo and Relapsed Acute Myeloid Leukemia

Himachandana Atluri, Jeremy DiGennaro, Keyur P. Patel, Mark Routbort, Betul Oran, Ghayas C. Issa, Nicholas J. Short, Naval Daver, Tapan M. Kadia, Farhad Ravandi, Uday R. Popat, Richard E. Champlin, Elizabeth J. Shpall, Sherry Pierce, Rashmi Kanagal-Shamanna, Chi Young Ok, Guilin Tang, Sa A. Wang, Raja Luthra, Audrey Lasry, Bettina Nadorp, Antonia Chroni, Ann-Kathrin Eisfeld, Iannis Aifantis, Najla H Al Ali, David A Sallman, Jeffrey Lancet, Onyee Chan, Eric Padron, Zhuoer Xie, L. Jeffrey Medeiros, Courtney D. DiNardo, Rami S. Komrokji, Sanam Loghavi
Journal: Blood
Blood (2023) 142 (Supplement 1): 959.
https://doi.org/10.1182/blood-2023-188319
Published: 2023
Journal Articles

Six Years Follow up of Ibrutinib Plus Rituximab (IR) Followed By Short Course R-Hyper CVAD/MTX in Patients (age ≤ 65 years) with Previously Untreated Mantle Cell Lymphoma - Phase-II Window-1 Clinical Trial

Preetesh Jain, Hun Ju Lee, Jason Westin, Loretta J. Nastoupil, Luis Fayad, Ranjit Nair, Swami P. Iyer, Rashmi Kanagal-Shamanna, Ahmed Fetooh, Holly A Hill, Chi Young Ok, Wendy Chen, Onyeka Oriabure, Lei Feng, Guilin Tang, Francisco Vega, Maria Badillo, Christopher R. Flowers, Michael L. Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1688.
https://doi.org/10.1182/blood-2023-181312
Published: 2023
Journal Articles

Development of a Novel, Allogeneic GPRC5D-Directed CAR for Treatment of Multiple Myeloma Patients

Jeremy Kinder, Chanel Athena Estrada, Brian Granger, Allison O'Rourke, Ouwen Liang, Aaron Lampano, Garrett Zipp, Vandana Chaturvedi, Xiaomeng Hu, Chi Young, Neal van Hoeven, Sonja Schrepfer, Terry J. Fry
Journal: Blood
Blood (2023) 142 (Supplement 1): 3290.
https://doi.org/10.1182/blood-2023-189665
Published: 2023
Journal Articles

Hypoimmune, Allogeneic CD22-Directed CAR T Cells That Evade Innate and Adaptive Immune Rejection for the Treatment of Large B Cell Lymphoma Patients That Are Relapsed/Refractory to CD19-Directed CAR T Cell Therapy

Adam Johnson, Hallee Wright, Xiaomeng Hu, Jeremy Kinder, Neal van Hoeven, Ouwen Liang, Brian Granger, Tori Duback, Chris Baldeviano, Sundeep Chandra, Trevor McGill, Boris Gorovits, Shannon Joyce, Sam Crocker, Anna Liang, Carrie Rocca, Jenny Migliaccio, Prasanna Kumar, Vasily Vagin, Kerrie Enger, Chi Young, Andrew McAlister, Sonja Schrepfer, Terry J. Fry
Journal: Blood
Blood (2023) 142 (Supplement 1): 3437.
https://doi.org/10.1182/blood-2023-187096
Published: 2023
Journal Articles

Genomic and Transcriptomic Profiles of Blastoid and Pleomorphic Mantle Cell Lymphoma Are Distinct from Classic Histology Mantle Cell Lymphoma

Preetesh Jain, Holly A Hill, Chi Young Ok, Alexander Nesmalov, Vitaly Segodin, Dmitry Tabakov, Nikita Kotlov, Pavel Zemskiy, Eleonora Belykh, Krystle Nomie, Ahmed Fetooh, Rashmi Kanagal-Shamanna, Fatima Z Jelloul, Guilin Tang, Francisco Vega, Nathan Fowler, Christopher R. Flowers, Michael L. Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 3001.
https://doi.org/10.1182/blood-2023-181319
Published: 2023
Journal Articles

The Adverse Effect of Myelodysplasia-Related Mutations in De Novo Acute Myeloid Leukemia Is Associated with Higher Variant Allelic Frequency (VAF): A Proposal for a Numeric Cutoff for Variant Allelic Frequency

Sanam Loghavi, Patrick K Reville, Curtis A Lachowiez, Mark Routbort, Keyur Patel, Rashmi Kanagal-Shamanna, Chi Young Ok, Joseph D. Khoury, Guilin Tang, Sa A Wang, Tapan M. Kadia, Naval Daver, Koichi Takahashi, Guillermo Garcia-Manero, Sherry A. Pierce, Marina Konopleva, L. Jeffrey Medeiros, Hagop Kantarjian, Farhad Ravandi, Nicholas Short, Courtney D. DiNardo
Journal: Blood
Blood (2022) 140 (Supplement 1): 6306–6308.
https://doi.org/10.1182/blood-2022-164494
Published: 2022
Journal Articles

Engineered Hypoimmune CAR T Cells Provide Lasting Tumor Control in Fully Immunocompetent Allogeneic Humanized Mice

Xiaomeng Hu, Pascal Beauchesne, Karl Manner, Corie Gattis, Priscilla Ngo, Rowena De Jesus, Chi Young, Frank Wells, Lindong Weng, Kathy White, William E Dowdle, Aaron Foster, Terry Fry, Sonja Schrepfer
Journal: Blood
Blood (2022) 140 (Supplement 1): 1173–1175.
https://doi.org/10.1182/blood-2022-167943
Published: 2022
Journal Articles

A Dual-Antigen Targeting, Hypoimmune Allogeneic CAR T to Evade Innate and Adaptive Immune Rejection and Overcome Antigen Escape

Adam Johnson, Hallee Wright, Xiaomeng Hu, Neal van Hoeven, PhD, Brian Granger, Ouwen Liang, Jesus Moreno, Meghan Lamba, Chi Young, Andrew McAlister, Terry J. Fry, Sonja Schrepfer, Aaron Foster
Journal: Blood
Blood (2022) 140 (Supplement 1): 4552–4553.
https://doi.org/10.1182/blood-2022-168251
Published: 2022
Journal Articles

Mutation Spectrum, Characteristics and Impact of Mutation Profiling on Prognosis, Outcome and Treatment Responses in Patients (pts) with Mantle Cell Lymphoma

Preetesh Jain, Chi Young Ok, Ahmed Fetooh, Rashmi Kanagal-Shamanna, Fatima Zahra Jelloul, Holly Hill, Kristen Floyd, Sanam Loghavi, Zhuang Zuo, C. Cameron Yin, Mark Routbort, Guilin Tang, Sairah Ahmed, Luis Enrique Malpica Castillo, Asiya Siddiqui, Wendy Chen, Onyeka Oriabure, Maria Badillo, Raphael E Steiner, Swaminathan P. Iyer, Hun Ju Lee, Rajyalakshmi Luthra, Francisco Vega, Christopher R. Flowers, Jeffrey Medeiros, Michael L. Wang, Keyur P. Patel, Nathan H. Fowler, Ranjit Nair
Journal: Blood
Blood (2022) 140 (Supplement 1): 3598–3600.
https://doi.org/10.1182/blood-2022-162806
Published: 2022
Journal Articles

BCMA-Targeted, Hypoimmune Allogeneic CAR T Cells Exhibit Potent Anti-Tumor Activity Together with the Ability to Evade Innate and Adaptive Immune Rejection in Pre-Clinical Tumor Models

Jeremy M. Kinder, Chanel Athena-Estrada, Danyal Malik, Xiaomeng Hu, Meghan Lamba, Chi Young, Neal Van Hoeven, Brian Granger, Vandana Chaturvedi, Ouwen Liang, Jesus Moreno, Aaron Lampano, Garrett Zipp, Adam Johnson, Terry Fry, Sonja Schrepfer, Aaron Foster
Journal: Blood
Blood (2022) 140 (Supplement 1): 7120–7121.
https://doi.org/10.1182/blood-2022-166845
Published: 2022
Journal Articles

Immune-Depleted Tumor Microenvironment Signature Is Associated with BTK Inhibitor Resistance in Mantle Cell Lymphoma

Preetesh Jain, Krystle Nomie, Vitaly Segodin, Evgeniy Egorov, Yixin Yao, Lucy Navsaria, Holly Hill, Nikita Kotlov, Rashmi Kanagal-Shamanna, Chi Young Ok, Francisco Vega, Shaoying Li, Yuxuan Che, Yijing Li, Viktor Svekolkin, Alexander Bagaev, Felix Frenkel, Ravshan Attaulakhanov, Nathan H. Fowler, Christopher R. Flowers, Michael Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 1321.
https://doi.org/10.1182/blood-2021-151416
Published: 2021
Journal Articles

Ibrutinib Plus Rituximab and Venetoclax (IRV) Followed By Risk-Stratified Observation or Short Course R-Hypercvad/MTX in Young Patients with Previously Untreated Mantle Cell Lymphoma - Phase-II Window-2 Clinical Trial

Michael Wang, Preetesh Jain, Hun Ju Lee, Chi Young Ok, Holly Hill, Lucy Navsaria, Rashmi Kanagal-Shamanna, Luis Malpica-Castillo, Ranjit Nair, Swaminathan Padmanabhan Iyer, Felipe Samaniego, Wendy Chen, Onyeka Oriabure, Lei Feng, Selvi Thirumurthi, David Santos, Guilin Tang, Francisco Vega, Shaoying Li, Michelle Avellaneda, Maria Badillo, Christopher R. Flowers
Journal: Blood
Blood (2021) 138 (Supplement 1): 3525.
https://doi.org/10.1182/blood-2021-153390
Published: 2021
Journal Articles

Engineered Hypoimmune Allogeneic CAR T Cells Exhibit Innate and Adaptive Immune Evasion Even after Sensitization in Humanized Mice and Retain Potent Anti-Tumor Activity

Xiaomeng Hu, Mo Dao, Kathy White, Corie Gattis, Ryan Clarke, Sam Landry, Ron Basco, Eleonore Tham, Andrew Tucker, Emily Luo, Christopher Bandoro, Elaine Chu, Chi Young, Aaron E. Foster, William E Dowdle, Edward J Rebar, Terry J. Fry, Sonja Schrepfer
Journal: Blood
Blood (2021) 138 (Supplement 1): 1690.
https://doi.org/10.1182/blood-2021-150021
Published: 2021
Journal Articles

Ibrutinib Plus Rituximab (IR) Followed By Short Course R-Hypercvad/MTX in Patients (age ≤ 65 years) with Previously Untreated Mantle Cell Lymphoma - Phase-II Window-1 Clinical Trial

Michael Wang, MD, Preetesh Jain, MBBS,MDDM,PhD, Yixin Yao, PhD, Yang Liu, PhD, Shuangtao Zhao, PhD, Holly Hill, Omar Moghrabi, Hun Ju Lee, MD, Felipe Samaniego, MD, Jason Westin, MD, Loretta J. Nastoupil, MD, Rashmi Kanagal-Shamanna, MD, Chi Young Ok, MD, Wendy Chen, Onyeka Oriabure, Yuxuan Che, Yijing Li, MS, Lei Feng, MS, Graciela M. Nogueras González, MPH, Guofang Xu, MD, Nicolaus Wagner-Bartak, MD, Selvi Thirumurthi, David Santos, Guilin Tang, MD, Francisco Vega, MDPhD, C. Cameron Yin, MD PhD, Michelle Avellaneda, Maria Badillo, MSN, RN, OCN, CCRP, Christopher Flowers, MDMS, Linghua Wang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-137259
Published: 2020
Journal Articles

Outcomes of Acalabrutinib Failures in Relapsed Mantle Cell Lymphoma

Preetesh Jain, MBBS,MDDM,PhD, Shaojun Zhang, PhD, Rashmi Kanagal-Shamanna, MD, Lucy Navsaria, MB BCh BAO, Chi Young Ok, MD, Guilin Tang, MD, C. Cameron Yin, MD PhD, Maria Badillo, MSN, RN, OCN, CCRP, Wendy Chen, Onyeka Oriabure, Hun Ju Lee, MD, Jason Westin, MD, Loretta J. Nastoupil, MD, Omar Moghrabi, Yuxuan Che, Felipe Samaniego, MD, Sairah Ahmed, MD, Ranjit Nair, Shaoying Li, MD, Francisco Vega, MDPhD, Christopher Flowers, MDMS, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-137440
Published: 2020