1-16 of 16
Edward J Rebar
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Efficient and Specific Multi-Locus Editing of Allogeneic CAR T Cells for Hypoimmunity during Large Scale Manufacture Using Cas12b

Free
Christina Chaivorapol, Pascal Beauchesne, Rowena De Jesus, William E Dowdle, Xiaoyu Chen, Alison Bayley, Yunjiang Qiu, Andrew Birnberg, Yu Zheng, Antonino Montalbano, Angela Liu, Misbah Zafar, Karl Manner, Ramya Ankala, Eleonore Tham, Heer Shah, Ben Lam, Jaclyn Lock, Lindong Weng, Kate Watts, Amanda Valdiosera, Kimberly Davis, Lei Wang, Divy Kangeyan, PhD, Nicolas Devos, Athena Wong, Jason Lih, Edward J Rebar
Journal: Blood
Blood (2022) 140 (Supplement 1): 1606–1607.
https://doi.org/10.1182/blood-2022-167627
Published: 2022
Journal Articles

Engineered Hypoimmune Allogeneic CAR T Cells Exhibit Innate and Adaptive Immune Evasion Even after Sensitization in Humanized Mice and Retain Potent Anti-Tumor Activity

Free
Xiaomeng Hu, Mo Dao, Kathy White, Corie Gattis, Ryan Clarke, Sam Landry, Ron Basco, Eleonore Tham, Andrew Tucker, Emily Luo, Christopher Bandoro, Elaine Chu, Chi Young, Aaron E. Foster, William E Dowdle, Edward J Rebar, Terry J. Fry, Sonja Schrepfer
Journal: Blood
Blood (2021) 138 (Supplement 1): 1690.
https://doi.org/10.1182/blood-2021-150021
Published: 2021
Journal Articles

A Potential Therapy for Beta-Thalassemia (ST-400) and Sickle Cell Disease (BIVV003)

Free
Michael C. Holmes, PhD, Andreas Reik, PhD, Edward J. Rebar, PhD BS, Jeffrey C. Miller, PhD, Yuanyue Zhou, Lei Zhang, PhD, Patrick Li, Sagar Vaidya
Journal: Blood
Blood (2017) 130 (Supplement 1): 2066.
https://doi.org/10.1182/blood.V130.Suppl_1.2066.2066
Published: 2017
Journal Articles

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Free
Christopher W. Peterson, Jianbin Wang, Krystin K. Norman, Zachary K. Norgaard, Olivier Humbert, Collette K. Tse, Jenny J. Yan, Richard G. Trimble, David A. Shivak, Edward J. Rebar, Philip D. Gregory, Michael C. Holmes, Hans-Peter Kiem
Journal: Blood
Blood (2016) 127 (20): 2416–2426.
https://doi.org/10.1182/blood-2015-09-672337
Published: 2016
Includes: Supplemental data
Journal Articles

Genome Editing of the Bcl11A Erythroid Specific Enhancer in Bone Marrow Derived Hematopoietic Stem and Progenitor Cells for the Treatment of Sickle Cell Disease

Free
Siyuan Tan, PhD, Kai-Hsin Chang, PhD, Sarah Smith, BS, Kai Chen, MS, Timonthy Sullivan, BS, Qianhe Zhou, PhD, Andreas Reik, PhD, Fyodor D Urnov, PhD, Edward J. Rebar, PhD, Olivier Danos, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2015) 126 (23): 203.
https://doi.org/10.1182/blood.V126.23.203.203
Published: 2015
Journal Articles

Clinical-Scale Genome Editing of the Human BCL11A Erythroid Enhancer for Treatment of the Hemoglobinopathies

Free
Fyodor D Urnov, PhD, Andreas Reik, PhD, Jeff Vierstra, PhD, Kai-Hsin Chang, PhD, Yuanyue Zhou, Andrea Mich, Jennifer Adrian, Lisa Fox, Nikoletta Psatha, PhD, Siyuan Tan, PhD, Evangelia Yannaki, MD, Stewart Craig, PhD, Edward J. Rebar, PhD, John Stamatoyannopoulos, MD, Thalia Papayannopoulou, MD, George Stamatoyannopoulos, MD DSci, Haiyan Jiang, PhD
Journal: Blood
Blood (2015) 126 (23): 204.
https://doi.org/10.1182/blood.V126.23.204.204
Published: 2015
Journal Articles

ZFN-Mediated Gene Targeting at the Albumin Locus in Liver Results in Therapeutic Levels of Human FIX in Mice and Non-Human Primates

Free
Thomas Wechsler, PhD, Kathleen E. Meyer, S. Kaye Spratt, Judith Greengard, PhD, Yolanda Santiago, Scott Sproul, Richard Surosky, David E. Paschon, Nathalie Dubois-Stringfellow, Dale Genji Ando, MD, Geoff Nichol, Edward J. Rebar, PhD, Michael C. Holmes, PhD
Journal: Blood
Blood (2015) 126 (23): 200.
https://doi.org/10.1182/blood.V126.23.200.200
Published: 2015
Journal Articles

Clonal Analysis of Human Bone Marrow CD34+ Cells Edited By BCL11A-Targeting Zinc Finger Nucleases Reveals Clinically Relevant Levels of Fetal Globin Expression in Edited Erythroid Progeny

Free
Kai-Hsin Chang, PhD, Timothy Sullivan, MS, Mei Liu, BS, Xiao Yang, PhD, Chao Sun, PhD, Benjamin Vieira, BS, Ming Zhang, PhD, Vu P. Hong, PhD, Kai Chen, MS, Sarah Smith, BS, Siyuan Tan, PhD, Andreas Reik, PhD, Fyodor D Urnov, PhD, Edward J. Rebar, PhD, Olivier Danos, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2015) 126 (23): 3234.
https://doi.org/10.1182/blood.V126.23.3234.3234
Published: 2015
Journal Articles

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

Free
Rajiv Sharma, Xavier M. Anguela, Yannick Doyon, Thomas Wechsler, Russell C. DeKelver, Scott Sproul, David E. Paschon, Jeffrey C. Miller, Robert J. Davidson, David Shivak, Shangzhen Zhou, Julianne Rieders, Philip D. Gregory, Michael C. Holmes, Edward J. Rebar, Katherine A. High
Journal: Blood
Blood (2015) 126 (15): 1777–1784.
https://doi.org/10.1182/blood-2014-12-615492
Published: 2015
Includes: Supplemental data
Journal Articles

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

Free
Megan D. Hoban, Gregory J. Cost, Matthew C. Mendel, Zulema Romero, Michael L. Kaufman, Alok V. Joglekar, Michelle Ho, Dianne Lumaquin, David Gray, Georgia R. Lill, Aaron R. Cooper, Fabrizia Urbinati, Shantha Senadheera, Allen Zhu, Pei-Qi Liu, David E. Paschon, Lei Zhang, Edward J. Rebar, Andrew Wilber, Xiaoyan Wang, Philip D. Gregory, Michael C. Holmes, Andreas Reik, Roger P. Hollis, Donald B. Kohn
Journal: Blood
Blood (2015) 125 (17): 2597–2604.
https://doi.org/10.1182/blood-2014-12-615948
Published: 2015
Includes: Supplemental data
Journal Articles

Targeted Gene Modification In Hematopoietic Stem Cells: A Potential Treatment For Thalassemia and Sickle Cell Anemia

Free
Andreas Reik, PhD, Kai-Hsin Chang, PhD, Sandra Stehling-Sun, PhD, Yuanyue Zhou, Gary K Lee, PhD, Lynn Truong, Travis Wood, Ziying Zhang, Albert Luong, Andy Chan, Pei-Qi Liu, PhD, Jeffrey C Miller, PhD, David E Paschon, PhD, Dmitry Y Guschin, PhD, Lei Zhang, PhD, Evangelia Yannaki, MD, Martin A Giedlin, PhD, Edward J Rebar, PhD, Philip D Gregory, PhD, Fyodor D Urnov, PHD, Thalia Papayannopoulou, MD, George Stamatoyannopoulos, MD, DSci
Journal: Blood
Blood (2013) 122 (21): 434.
https://doi.org/10.1182/blood.V122.21.434.434
Published: 2013
Journal Articles

ZFN Mediated Targeting Of Albumin “Safe Harbor” Results In Therapeutic Levels Of Human Factor VIII In a Mouse Model Of Hemophilia A

Free
Xavier M Anguela, PhD, Rajiv Sharma, Yannick Doyon, PhD, Thomas Wechsler, PhD, David E Paschon, PhD, Robert J Davidson, Shangzhen Zhou, MD, Philip D Gregory, PhD, Michael C. Holmes, PhD, Edward J Rebar, PhD, Katherine A. High, MD
Journal: Blood
Blood (2013) 122 (21): 720.
https://doi.org/10.1182/blood.V122.21.720.720
Published: 2013
Journal Articles

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

Free
Hiroki Torikai, Andreas Reik, Frank Soldner, Edus H. Warren, Carrie Yuen, Yuanyue Zhou, Denise L. Crossland, Helen Huls, Nicholas Littman, Ziying Zhang, Scott S. Tykodi, Partow Kebriaei, Dean A. Lee, Jeffrey C. Miller, Edward J. Rebar, Michael C. Holmes, Rudolf Jaenisch, Richard E. Champlin, Philip D. Gregory, Laurence J. N. Cooper
Journal: Blood
Blood (2013) 122 (8): 1341–1349.
https://doi.org/10.1182/blood-2013-03-478255
Published: 2013
Includes: Supplemental data
Journal Articles

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR

Free
Hiroki Torikai, Andreas Reik, Pei-Qi Liu, Yuanyue Zhou, Ling Zhang, Sourindra Maiti, Helen Huls, Jeffrey C. Miller, Partow Kebriaei, Brian Rabinovitch, Dean A. Lee, Richard E. Champlin, Chiara Bonini, Luigi Naldini, Edward J. Rebar, Philip D. Gregory, Michael C. Holmes, Laurence J. N. Cooper
Journal: Blood
Blood (2012) 119 (24): 5697–5705.
https://doi.org/10.1182/blood-2012-01-405365
Published: 2012
Includes: Supplemental data
Journal Articles

HLA and TCR Knockout by Zinc Finger Nucleases: Toward “off-the-Shelf” Allogeneic T-Cell Therapy for CD19 + Malignancies.

Free
Hiroki Torikai, Andreas Reik, Carrie Yuen, Yuanyue Zhou, Denise Kellar, Helen Huls, Edus H. Warren, III, Scott S. Tykodi, Philip D. Gregory, Michael C. Holmes, Edward J. Rebar, Dean A. Lee, Richard E. Champlin, Chiara Bonini, Laurence Cooper
Journal: Blood
Blood (2010) 116 (21): 3766.
https://doi.org/10.1182/blood.V116.21.3766.3766
Published: 2010
Journal Articles

“Designer” Cells for Cellular Immunotherapy: Zinc Finger Nuclease (ZFN) Stimulated Targeted Recombination for the Simultaneous Disruption of the Endogenous Glucocorticoid Receptor and Site-Specific Addition of the IL13-Zetakine.

Free
Andreas Reik, PhD, Michael C. Holmes, Ph.D., Fyodor D. Urnov, Ph.D., Yuanyue Zhou, Matthew Mendel, Pei-Qi Liu, Ph.D., Erica Moehle, Edward J. Rebar, Ph.D., Jeffrey C. Miller, Ph.D., Dale Ando, M.D., Philip D. Gregory, Ph.D., Michael Jensen, M.D.
Journal: Blood
Blood (2006) 108 (11): 3705.
https://doi.org/10.1182/blood.V108.11.3705.3705
Published: 2006