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Rajiv Sharma
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Journal Articles

Engineering Sequential Mutations into Human HSPCs Yields an Aggressive Myeloid Malignancy Allowing for Interrogation of Preleukemic Transformation

Cailin T Collins, Yusuke Nakauchi, Thomas Koehnke, James S Chavez, Suyoun Choi, Rajiv Sharma, Feifei Zhao, Ravindra Majeti
Journal: Blood
Blood (2023) 142 (Supplement 1): 953.
https://doi.org/10.1182/blood-2023-187422
Published: 2023
Journal Articles

Development of a β-Globin Gene Replacement Strategy As a β-Thalassemia Therapy

Kirby Wallace, Beeke Wienert, Christopher Bandoro, James Partridge, Craig L. Ennis, Casey D. Lalisan, Kristina Krassovsky, Gaia Andreoletti, Rajiv Sharma, Aishwarya Churi, William M. Matern, Sebastian Treusch, Jane Grogan, Daniel P. Dever
Journal: Blood
Blood (2022) 140 (Supplement 1): 12985–12986.
https://doi.org/10.1182/blood-2022-167676
Published: 2022
Journal Articles

Induction of Truncating ASXL1 Mutations in Human CD34+ HSPCs Mimics Human ASXL1-Mutated Clonal Hematopoiesis and Progression to Myeloid Malignancies

Thomas Koehnke, MD, Rajiv Sharma, PhD, Yusuke Nakauchi, MD PhD, Andreas Reinisch, MD PhD, Ravi Majeti, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 820.
https://doi.org/10.1182/blood-2019-130528
Published: 2019
Journal Articles

Azacitidine and Ascorbate Inhibit the Competitive Outgrowth of Human TET2 Mutant HSPCs in a Xenograft Model of Pre-Leukemia

Yusuke Nakauchi, MD PhD, Daniel Thomas, MD PhD, Rajiv Sharma, PhD, M. Ryan Corces, PhD, Andreas Reinisch, MD PhD, David Cruz, MS, Thomas Koehnke, MD PhD, Daiki Karigane, MDPhD, Amy Fan, BS, Ravindra Majeti, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 887.
https://doi.org/10.1182/blood-2018-99-113907
Published: 2018
Journal Articles

Characterization and Targeting TET2-Mutant HSPCs and AML

Yusuke Nakauchi, MD PhD, Daniel Thomas, MD PhD, Andreas Reinisch, MD PhD, Rajiv Sharma, PhD, David Cruz, BS, M. Ryan Corces, PhD, Ravi Majeti, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2509.
https://doi.org/10.1182/blood.V130.Suppl_1.2509.2509
Published: 2017
Journal Articles

In Vivo Genome Editing in Neonatal Mouse Liver Preferentially Utilizes Homology Directed Repair

Xavier M. Anguela, PhD, Rajiv Sharma, PhD, Yannick Doyon, PhD, Thomas Wechsler, PhD, David Paschon, PhD, Robert J. Davidson, Shangzhen Zhou, MD, Philip D Gregory, PhD, Michael C. Holmes, PhD, Katherine A. High, MD
Journal: Blood
Blood (2015) 126 (23): 4422.
https://doi.org/10.1182/blood.V126.23.4422.4422
Published: 2015
Journal Articles

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

Rajiv Sharma, Xavier M. Anguela, Yannick Doyon, Thomas Wechsler, Russell C. DeKelver, Scott Sproul, David E. Paschon, Jeffrey C. Miller, Robert J. Davidson, David Shivak, Shangzhen Zhou, Julianne Rieders, Philip D. Gregory, Michael C. Holmes, Edward J. Rebar, Katherine A. High
Journal: Blood
Blood (2015) 126 (15): 1777–1784.
https://doi.org/10.1182/blood-2014-12-615492
Published: 2015
Includes: Supplemental data
Journal Articles

ZFN Mediated Targeting Of Albumin “Safe Harbor” Results In Therapeutic Levels Of Human Factor VIII In a Mouse Model Of Hemophilia A

Xavier M Anguela, PhD, Rajiv Sharma, Yannick Doyon, PhD, Thomas Wechsler, PhD, David E Paschon, PhD, Robert J Davidson, Shangzhen Zhou, MD, Philip D Gregory, PhD, Michael C. Holmes, PhD, Edward J Rebar, PhD, Katherine A. High, MD
Journal: Blood
Blood (2013) 122 (21): 720.
https://doi.org/10.1182/blood.V122.21.720.720
Published: 2013
Journal Articles

Robust ZFN-mediated genome editing in adult hemophilic mice

Brief Report
Xavier M. Anguela, Rajiv Sharma, Yannick Doyon, Jeffrey C. Miller, Hojun Li, Virginia Haurigot, Michelle E. Rohde, Sunnie Y. Wong, Robert J. Davidson, Shangzhen Zhou, Philip D. Gregory, Michael C. Holmes, Katherine A. High
Journal: Blood
Blood (2013) 122 (19): 3283–3287.
https://doi.org/10.1182/blood-2013-04-497354
Published: 2013
Includes: Supplemental data
Journal Articles

In Vivo Genome Editing of Liver Albumin for Therapeutic Gene Expression: Rescue of Hemophilic Mice Via Integration of Factor 9

Xavier M Anguela, PhD, Rajiv Sharma, Yannick Doyon, PhD, Sunnie Y Wong, David E Paschon, Hojun Li, MD PhD, Virginia Haurigot, PhD, Robert J Davidson, Shangzhen Zhou, MD, Philip D. Gregory, PhD, Michael C. Holmes, PhD, Edward Rebar, PhD, Katherine A. High, MD
Journal: Blood
Blood (2012) 120 (21): 751.
https://doi.org/10.1182/blood.V120.21.751.751
Published: 2012
Journal Articles

Robust Factor IX Expression Following ZFN-Mediated Genome Editing in An Adult Mouse Model of Hemophilia B

Xavier M Anguela, Rajiv Sharma, Hojun Li, Virginia Haurigot, Anand Bhagwat, Robert J Davidson, Shangzhen Zhou, Yannick Doyon, Philip D. Gregory, PhD, Michael C. Holmes, PhD, Katherine A. High, MD
Journal: Blood
Blood (2011) 118 (21): 668.
https://doi.org/10.1182/blood.V118.21.668.668
Published: 2011
Journal Articles

Phenotypic Correction of a Mouse Model of Hemophilia B by In Vivo Genetic Correction of the F9 Gene

Hojun Li, Virginia Haurigot, Yannick Doyon, James Li, Anand Bhagwat, Sunnie Wong, Xavier Anguela, Rajiv Sharma, Lacramioara Ivanciu, Samuel Murphy, Shangzhen Zhou, David Paschon, Edward Rebar, Philip D. Gregory, PhD, Michael C. Holmes, Katherine A. High, MD
Journal: Blood
Blood (2010) 116 (21): LBA-5.
https://doi.org/10.1182/blood.V116.21.LBA-5.LBA-5
Published: 2010