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Journal Articles

Long Term Follow up after Adoptive Transfer of CD19-Specific CAR + T Cells Genetically Modified Via Non-Viral Sleeping Beauty S ystem Following Hematopoietic Stem Cell Transplantation (HSCT)

Blood (2017) 130 (Supplement 1): 2059.

https://doi.org/10.1182/blood.V130.Suppl_1.2059.2059

Published: 2017

Journal Articles

Shortening the Time to Manufacture CAR + T Cells with Sleeping Beauty System Supports T-Cell Engraftment and Anti-Tumor Effects in Patients with Refractory CD19 + Tumors

Partow Kebriaei, MD, Helen Huls, Susan Lynn Neel, RN, OCN, Simon Olivares, Aaron F Orozco, Shihuang Su, Sourindra N Maiti, Amy Smith, Elenanor De Groot, Hagop M. Kantarjian, MD, Maro Ohanian, DO, Katy Rezvani, MD PhD, Elizabeth J Shpall, MD, Richard E Champlin, MD, Laurence J N Cooper, MDPhD, Harjeet Singh, MSc, PhD

Blood (2017) 130 (Supplement 1): 2060.

https://doi.org/10.1182/blood.V130.Suppl_1.2060.2060

Published: 2017

Journal Articles

Very Rapid Production of CAR + T-Cells upon Non-Viral Gene Transfer Using the Sleeping Beauty System

Lenka V. Hurton, PhD, Harjeet Singh, PhD, Kirsten C. Switzer, PhD, Tiejuan Mi, MS, Leo G. Flores, Aaron Orozco, Sourindra N. Maiti, PhD, Shihuang Su, MS, Amer Najjar, PhD, Mary Helen Huls, BS, Partow Kebriaei, MD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD PhD

Blood (2016) 128 (22): 2807.

https://doi.org/10.1182/blood.V128.22.2807.2807

Published: 2016

Journal Articles

Combination Immunotherapy with NY-ESO-1-Specific CAR + T Cells with T-Cell Vaccine Improves Anti-Myeloma Effect

Krina Patel, MD, Simon Olivares, BS, Harjeet Singh, PhD, Lenka V. Hurton, PhD, Mary Helen Huls, BS, Muzaffar H. Qazilbash, MD, Partow Kebriaei, MD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD PhD

Blood (2016) 128 (22): 3366.

https://doi.org/10.1182/blood.V128.22.3366.3366

Published: 2016

Journal Articles

Pre-Emptive Donor Lymphocyte Infusion with CD19-Directed, CAR-Modified T Cells Infused after Allogeneic Hematopoietic Cell Transplantation for Patients with Advanced CD19 + Malignancies

Blood (2015) 126 (23): 862.

https://doi.org/10.1182/blood.V126.23.862.862

Published: 2015

Journal Articles

Adoptive Therapy Using Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells to Manufacture T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Blood (2014) 124 (21): 311.

https://doi.org/10.1182/blood.V124.21.311.311

Published: 2014

Journal Articles

Specifically Targeting the Interface Between HER1-HER3 Heterodimer on Breast Cancer to Limit Off-Target Effects Using Chimeric Antigen Receptor Designs with Improved T-Cell Energy Balance

Bipulendu Jena, PhD, Natalya Belousova, PhD, George T McNamara, PhD, David Rushworth, BS, Tiejuan Mi, MS, Helen Huls, BS, Richard E. Champlin, Laurence JN Cooper, MD PhD

Blood (2014) 124 (21): 2151.

https://doi.org/10.1182/blood.V124.21.2151.2151

Published: 2014

Journal Articles

T-Cell Therapy for Multiple Myeloma Using NY-ESO-1 + T-Cell Antigen Presenting Cells (T-APC) Combined with Adoptive Cellular Transfer (ACT) to Augment Immunotherapy

Krina K. Patel, MD, Simon Olivares, Lenka V. Hurton, PhD, Helen Huls, BS, Muzaffar H. Qazilbash, Richard E. Champlin, Laurence JN Cooper, MD PhD

Blood (2014) 124 (21): 3843.

https://doi.org/10.1182/blood.V124.21.3843.3843

Published: 2014

Journal Articles

Targeting An Ancient Retrovirus In Tumor Using Engineered T Cells

Janani Krishnamurthy, Brian Rabinovich, Simon Olivares, BS, Mi Teijuan, Kirsten Switzer, Joshua Plummer, Sourindra Maiti, PHD, Harjeet Singh, PhD, Helen Huls, BS, Feng-wang Johanning, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 4206.

https://doi.org/10.1182/blood.V122.21.4206.4206

Published: 2013

Journal Articles

Adoptive Immunotherapy Following Umbilical Cord Blood Transplantation Using The Sleeping Beauty System and Artificial Antigen Presenting Cells To Generate Donor-Derived T Cells Expressing a CD19-Specific Chimeric Antigen Receptor

Partow Kebriaei, MD, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Pappanaicken R Kumar, BS, Bipulendu Jena, PhD, Rineka N Jackson, BBA, Tingting Liu, BS, Ian K. McNiece, PhD, Gabriela Rondon, MD, Perry Hackett, PhD, Richard E Champlin, MD, Elizabeth J Shpall, MD, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 4208.

https://doi.org/10.1182/blood.V122.21.4208.4208

Published: 2013

Journal Articles

Immune Reconstitution With Activated T Cells In Companion Canines With Lymphoma

Colleen M. O'Connor, PhD, Sonny Ang, PhD, Sourindra Maiti, PHD, George McNamara, PHD, Sabina Sheppard, MS, Tasha Miller, BS, Helen Huls, BS, Richard E Champlin, MD, Heather Wilson, DVM, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 5153.

https://doi.org/10.1182/blood.V122.21.5153.5153

Published: 2013

Journal Articles

ZFN-Driven Gene Editing Prevents HLA-A Expression On Hematopoietic Stem Cells -Improving The Chance Of Finding An HLA-Matched Donor

Hiroki Torikai, Tiejuan Mi, Sonny O Ang, PhD, Loren Gragert, Martin Maiers, Sourindra Maiti, PHD, Kirsten Switzer, Helen Huls, BS, Andreas Reik, Michael C. Holmes, PhD, Philip D Gregory, PhD, Richard E Champlin, MD, Elizabeth J Shpall, MD, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 1655.

https://doi.org/10.1182/blood.V122.21.1655.1655

Published: 2013

Journal Articles

First Clinical Trials Employing Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells To Generate and Infuse T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Partow Kebriaei, MD, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Pappanaicken R. Kumar, BS, Bipulendu Jena, PhD, Marie Andree Forget, Sonny Ang, PhD, Rineka N. Jackson, BBA, Tingting Liu, BS, Doyle Bosque, ADN, Ian K. McNiece, PhD, Gabriela Rondon, MD, Perry Hackett, PhD, Chitra M. Hosing, MD, Elizabeth J. Shpall, MD, Richard E. Champlin, MD, Laurence J N. Cooper, MD, PhD

Blood (2013) 122 (21): 166.

https://doi.org/10.1182/blood.V122.21.166.166

Published: 2013

Journal Articles

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

Blood (2013) 122 (8): 1341–1349.

https://doi.org/10.1182/blood-2013-03-478255

Published: 2013

Includes: Supplemental data

Journal Articles

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR

Hiroki Torikai, Andreas Reik, Pei-Qi Liu, Yuanyue Zhou, Ling Zhang, Sourindra Maiti, Helen Huls, Jeffrey C. Miller, Partow Kebriaei, Brian Rabinovitch, Dean A. Lee, Richard E. Champlin, Chiara Bonini, Luigi Naldini, Edward J. Rebar, Philip D. Gregory, Michael C. Holmes, Laurence J. N. Cooper

Blood (2012) 119 (24): 5697–5705.

https://doi.org/10.1182/blood-2012-01-405365

Published: 2012

Includes: Supplemental data

Journal Articles

Assessing Potential Genotoxicity of Sleeping Beauty Transposition Events in T-Cell Immunotherapy by Supercomputer-Based High Throughput Profiling,

Sonny O. Ang, PhD, Sourindra Maiti, PHD, Branden Moriarity, Martin Ossowski, PHD, Kim Andrews, PHD, Kathy Tzeng, PHD, Richard Talbot, PHD, Denise Kellar, Helen Huls, BS, Partow Kebriaei, MD, David A. Largaespada, PhD, Richard Champlin, MD, Perry Hackett, PHD, Laurence J N Cooper, MD, PhD

Blood (2011) 118 (21): 4174.

https://doi.org/10.1182/blood.V118.21.4174.4174

Published: 2011

Journal Articles

HLA and TCR Knockout by Zinc Finger Nucleases: Toward “off-the-Shelf” Allogeneic T-Cell Therapy for CD19 + Malignancies.

Hiroki Torikai, Andreas Reik, Carrie Yuen, Yuanyue Zhou, Denise Kellar, Helen Huls, Edus H. Warren, III, Scott S. Tykodi, Philip D. Gregory, Michael C. Holmes, Edward J. Rebar, Dean A. Lee, Richard E. Champlin, Chiara Bonini, Laurence Cooper

Blood (2010) 116 (21): 3766.

https://doi.org/10.1182/blood.V116.21.3766.3766

Published: 2010

Journal Articles

NK Cell Proliferation and Cytolytic Function Are Compromised In the Hypoxic Tumor Microenvironment

Sonny Ang, PhD, Maria Lima Da Silva, PhD, Margaret Dawson, PhD, Matthew Figliola, PhD, Sourindra Maiti, PhD, Helen Huls, PhD, Elizabeth J. Shpall, PhD, Richard Champlin, Dean A. Lee, MD, PhD, Lucia Silla, MD, PhD, Laurence J.N. Cooper, MD, PhD

Blood (2010) 116 (21): 4291.

https://doi.org/10.1182/blood.V116.21.4291.4291

Published: 2010

Journal Articles

Third Generation Chimeric Antigen Receptors Containing CD137 or CD134 Signaling Endodomains Augment CD19-Specific T-Cell Effector Function.

Harjeet Singh, PhD, Hillary N Gibbons, BS, Simon Olivares, BS, Matthew J. Figliola, BS, Margaret J. Dawson, BS, Mary Helen Huls, BS, Dean A Lee, MD, Ph.D, Partow Kebriaei, MD, Richard E Champlin, MD, Laurence J.N. Cooper, MD, PhD

Blood (2009) 114 (22): 4097.

https://doi.org/10.1182/blood.V114.22.4097.4097

Published: 2009

Journal Articles

Sustained Ex Vivo Expansion of Human Peripheral Blood NK Cells Using Artificial APCs Bearing Membrane-Bound IL-21.

Cecele J Denman, MS, Lisa M. Kopp, DO, Vladimir Senyukov, PhD, Sarah Hagemeister, Jennifer Johnson, Maria A Lima Da Silva, Harjeet Singh, PhD, Lenka Hurton, Simon Olivares, BS, Mary Helen Huls, BS, Richard E Champlin, MD, Laurence J.N. Cooper, MD, PhD, Dean A. Lee, MD, PhD

Blood (2009) 114 (22): 3030.

https://doi.org/10.1182/blood.V114.22.3030.3030

Published: 2009

NARROW

Long Term Follow up after Adoptive Transfer of CD19-Specific CAR + T Cells Genetically Modified Via Non-Viral Sleeping Beauty S ystem Following Hematopoietic Stem Cell Transplantation (HSCT)

Shortening the Time to Manufacture CAR + T Cells with Sleeping Beauty System Supports T-Cell Engraftment and Anti-Tumor Effects in Patients with Refractory CD19 + Tumors

Very Rapid Production of CAR + T-Cells upon Non-Viral Gene Transfer Using the Sleeping Beauty System

Combination Immunotherapy with NY-ESO-1-Specific CAR + T Cells with T-Cell Vaccine Improves Anti-Myeloma Effect

Pre-Emptive Donor Lymphocyte Infusion with CD19-Directed, CAR-Modified T Cells Infused after Allogeneic Hematopoietic Cell Transplantation for Patients with Advanced CD19 + Malignancies

Adoptive Therapy Using Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells to Manufacture T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Specifically Targeting the Interface Between HER1-HER3 Heterodimer on Breast Cancer to Limit Off-Target Effects Using Chimeric Antigen Receptor Designs with Improved T-Cell Energy Balance

T-Cell Therapy for Multiple Myeloma Using NY-ESO-1 + T-Cell Antigen Presenting Cells (T-APC) Combined with Adoptive Cellular Transfer (ACT) to Augment Immunotherapy

Targeting An Ancient Retrovirus In Tumor Using Engineered T Cells

Adoptive Immunotherapy Following Umbilical Cord Blood Transplantation Using The Sleeping Beauty System and Artificial Antigen Presenting Cells To Generate Donor-Derived T Cells Expressing a CD19-Specific Chimeric Antigen Receptor

Immune Reconstitution With Activated T Cells In Companion Canines With Lymphoma

ZFN-Driven Gene Editing Prevents HLA-A Expression On Hematopoietic Stem Cells -Improving The Chance Of Finding An HLA-Matched Donor

First Clinical Trials Employing Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells To Generate and Infuse T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR

Assessing Potential Genotoxicity of Sleeping Beauty Transposition Events in T-Cell Immunotherapy by Supercomputer-Based High Throughput Profiling,

HLA and TCR Knockout by Zinc Finger Nucleases: Toward “off-the-Shelf” Allogeneic T-Cell Therapy for CD19 + Malignancies.

NK Cell Proliferation and Cytolytic Function Are Compromised In the Hypoxic Tumor Microenvironment

Third Generation Chimeric Antigen Receptors Containing CD137 or CD134 Signaling Endodomains Augment CD19-Specific T-Cell Effector Function.

Sustained Ex Vivo Expansion of Human Peripheral Blood NK Cells Using Artificial APCs Bearing Membrane-Bound IL-21.

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American Society of Hematology

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American Society of Hematology

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