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William E Dowdle
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Journal Articles

Engineered Hypoimmune CAR T Cells Provide Lasting Tumor Control in Fully Immunocompetent Allogeneic Humanized Mice

Xiaomeng Hu, Pascal Beauchesne, Karl Manner, Corie Gattis, Priscilla Ngo, Rowena De Jesus, Chi Young, Frank Wells, Lindong Weng, Kathy White, William E Dowdle, Aaron Foster, Terry Fry, Sonja Schrepfer
Journal: Blood
Blood (2022) 140 (Supplement 1): 1173–1175.
https://doi.org/10.1182/blood-2022-167943
Published: 2022
Journal Articles

Efficient and Specific Multi-Locus Editing of Allogeneic CAR T Cells for Hypoimmunity during Large Scale Manufacture Using Cas12b

Christina Chaivorapol, Pascal Beauchesne, Rowena De Jesus, William E Dowdle, Xiaoyu Chen, Alison Bayley, Yunjiang Qiu, Andrew Birnberg, Yu Zheng, Antonino Montalbano, Angela Liu, Misbah Zafar, Karl Manner, Ramya Ankala, Eleonore Tham, Heer Shah, Ben Lam, Jaclyn Lock, Lindong Weng, Kate Watts, Amanda Valdiosera, Kimberly Davis, Lei Wang, Divy Kangeyan, PhD, Nicolas Devos, Athena Wong, Jason Lih, Edward J Rebar
Journal: Blood
Blood (2022) 140 (Supplement 1): 1606–1607.
https://doi.org/10.1182/blood-2022-167627
Published: 2022
Journal Articles

Engineered Hypoimmune Allogeneic CAR T Cells Exhibit Innate and Adaptive Immune Evasion Even after Sensitization in Humanized Mice and Retain Potent Anti-Tumor Activity

Xiaomeng Hu, Mo Dao, Kathy White, Corie Gattis, Ryan Clarke, Sam Landry, Ron Basco, Eleonore Tham, Andrew Tucker, Emily Luo, Christopher Bandoro, Elaine Chu, Chi Young, Aaron E. Foster, William E Dowdle, Edward J Rebar, Terry J. Fry, Sonja Schrepfer
Journal: Blood
Blood (2021) 138 (Supplement 1): 1690.
https://doi.org/10.1182/blood-2021-150021
Published: 2021