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Journal Articles

Use of CD19 CAR-T Cells in Adult B-Cell Acute Lymphoblastic Leukemia (B-ALL) with Minimal Residual Disease (MRD) Positivity at First Complete Remission: Preliminary Outcomes from a Phase I Clinical Trial

Marc Schwartz, Navin R. Pinto, Jonathan Gutman, Michael R Verneris, Andrew Roth, Jason S. Gilbert, Dina Schneider, Terry J Fry
Journal: Blood
Blood (2024) 144 (Supplement 1): 5876.
https://doi.org/10.1182/blood-2024-204262
Published: 2024
Journal Articles

Initial Results of a First-in-Human, Phase I Study Point-of-Care Manufacturing of Trispecific CAR-T Cells Targeting CD19/20/22 in B-Cell Malignancies

Sumithira Vasu, Evandro Bezerra, Nathan Denlinger, Nicole Szuminski, Dina Schneider, Pradyot Dash, Louisa Wirthlin, Narendranath Epperla, Yazeed Sawalha, Jennifer A. Woyach, Kerry A. Rogers, Seema A Bhat, Gregory K Behbehani, Karilyn T. Larkin, Adam S Kittai, Wing Chan, Ashley Angell Krull, Shamama Nishat, Lynn O'Donnell, Lapo Alinari, Marcos de Lima
Journal: Blood
Blood (2024) 144 (Supplement 1): 2078.
https://doi.org/10.1182/blood-2024-207532
Published: 2024
Journal Articles

Phase 1 Study of Trispecific Anti-CD20, Anti-CD19, Anti-CD22 (CAR20.19.22) T Cells for Relapsed, Refractory B-Cell Malignancies

Nirav N. Shah, Aniko Szabo, Tyce Kearl, Dina Schneider, Walter Longo, Bryon D. Johnson, Peiman Hematti, Mehdi Hamadani, Timothy S. Fenske
Journal: Blood
Blood (2024) 144 (Supplement 1): 3448.
https://doi.org/10.1182/blood-2024-200899
Published: 2024
Journal Articles

Spatial Tissue Analysis of Secondary Sarcoma Following CAR T Cell Therapy for B Cell Lymphoma

Dina Schneider, Jia-Jye Lee, Jinling Wang, Robert Pinard, Peirong Hu, Kun Luo, Ngoc Tran, Yazeed Sawalha, Nathan Denlinger, Evandro Bezerra, Pradyot Dash, Ashley Angell Krull, Lynn O'Donnell, Lapo Alinari, Dan Jones, Marcos de Lima, Sumithira Vasu
Journal: Blood
Blood (2024) 144 (Supplement 1): 7139.
https://doi.org/10.1182/blood-2024-203633
Published: 2024
Journal Articles

A Phase I Clinical Trial of Fully Human Anti-CD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Lymphoid Malignancies

Brenda W Cooper, Molly Megan Gallogly, Leland Metheny, Rebecca B. Klisovic, Kirsten Marie Boughan, Jane Reese Koc, Darong Wu, Changchun Deng, Koen Van Besien, Rose Tupta, Dina Schneider, Lisa Ciarrone, Marcos de Lima, Paolo F. Caimi, Benjamin K. Tomlinson
Journal: Blood
Blood (2023) 142 (Supplement 1): 6872.
https://doi.org/10.1182/blood-2023-191153
Published: 2023
Journal Articles

Adaptive Manufacturing of LV20.19 CAR T-Cells for Relapsed, Refractory Mantle Cell Lymphoma

Nirav N. Shah, Fateeha Furqan, Aniko Szabo, Tyce Kearl, Anthony Zamora, Jessica Neumann, Parameswaran N. Hari, Dina Schneider, Walter Longo, Peiman Hematti, Bryon D. Johnson, Mehdi Hamadani, Timothy S. Fenske
Journal: Blood
Blood (2023) 142 (Supplement 1): 1024.
https://doi.org/10.1182/blood-2023-173954
Published: 2023
Journal Articles

8-Day Versus 12-Day Manufactured LV20.19 CAR T-Cells for B-Cell Non-Hodgkin Lymphoma

Nirav N. Shah, Fateeha Furqan, Aniko Szabo, Jessica Neumann, Walter L. Longo, Parameswaran Hari, Dina Schneider, Bryon Johnson, Timothy S. Fenske, Mehdi Hamadani
Journal: Blood
Blood (2022) 140 (Supplement 1): 7480–7481.
https://doi.org/10.1182/blood-2022-169119
Published: 2022
Journal Articles

A Phase I Clinical Trial of Point-of-Care Manufactured Fresh Anti-CD19/20/22 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Lymphoid Malignancies (Non-Hodgkin Lymphoma, Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, B Prolymphocytic Leukemia)

Sumithira Vasu, Lapo Alinari, Nicole Szuminski, Dina Schneider, Nathan Denlinger, Wing Keung Chan, Khalid Parris, Nidhi Sharma, Hillary Bradbury, Beth Daneault, Lynn O'Donnell, Boro Dropulic, Marcos J.G. de Lima
Journal: Blood
Blood (2022) 140 (Supplement 1): 7474–7475.
https://doi.org/10.1182/blood-2022-167340
Published: 2022
Journal Articles

Results from a Phase 1/2 Study of Tandem, Bispecific Anti-CD20/Anti-CD19 (LV20.19) CAR T-Cells for Mantle Cell Lymphoma

Nirav N. Shah, Fateeha Furqan, Aniko Szabo, Jessica Neumann, Parameswaran Hari, Dina Schneider, Bryon Johnson, Mehdi Hamadani, Timothy S. Fenske
Journal: Blood
Blood (2022) 140 (Supplement 1): 9318–9319.
https://doi.org/10.1182/blood-2022-158695
Published: 2022
Journal Articles

Characterization and T-Cell Repertoire of MB-CART2019.1 (Zamtocabtagene autoleucel) - Data from the Phase I Trial in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Tatjana Holzer, Stefanie Biedermann, Inga Herfort, Birte Friedrichs, Silke Holtkamp, Linda Hanssens, Mario Assenmacher, Ulf Bethke, Dina Schneider, Stefan Miltenyi, Toon Overstijns, Christoph Schmid, Francis A. Ayuk, Christoph Scheid, Anja Jühling, Udo Holtick, Philipp Gödel, Peter Borchmann, Iris Bürger
Journal: Blood
Blood (2022) 140 (Supplement 1): 4581–4583.
https://doi.org/10.1182/blood-2022-164597
Published: 2022
Journal Articles

CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR

Clinical Trials & Observations
Haneen Shalabi, Haiying Qin, Angela Su, Bonnie Yates, Pamela L. Wolters, Seth M. Steinberg, John A. Ligon, Sara Silbert, Kniya DéDé, Mehdi Benzaoui, Sophia Goldberg, Sooraj Achar, Dina Schneider, Shilpa A. Shahani, Lauren Little, Toni Foley, John C. Molina, Sandhya Panch, Crystal L. Mackall, Daniel W. Lee, Christopher D. Chien, Marie Pouzolles, Mark Ahlman, Constance M. Yuan, Hao-Wei Wang, Yanyu Wang, Jon Inglefield, Mary Anne Toledo-Tamula, Staci Martin, Steven L. Highfill, Gregoire Altan-Bonnet, David Stroncek, Terry J. Fry, Naomi Taylor, Nirali N. Shah
Journal: Blood
Blood (2022) 140 (5): 451–463.
https://doi.org/10.1182/blood.2022015795
Published: 2022
Includes: Supplemental data
Journal Articles

A Phase I Open Label Dose Escalation Study of MB-CART19.1 in Relapsed and Refractory CD19+ B Cell Malignancies, Interim Preliminary Results in Pediatric ALL, Adult ALL Including CLL Cohorts

Andreas Mackensen, Linda Hanssens, Matthias Stelljes, Wolfgang A Bethge, Tobias Feuchtinger, Annette Künkele, Michael Aigner, Alisa Yakushina, Sandra Karitzky, Silke Holtkamp, Mario Assenmacher, Marion Jurk, Georg Rauser, Dina Schneider, Claudia Rossig
Journal: Blood
Blood (2021) 138 (Supplement 1): 3836.
https://doi.org/10.1182/blood-2021-152452
Published: 2021
Journal Articles

Bispecific LV20.19 CAR T-Cells Expanded in IL-7 and IL-15 Have Greater Polyfunctionality and Polyfunctional Strength Than CAR T-Cells Expanded in IL-2

Joanna C. Zurko, Huiqing Xu, Katherine Chaney, Timothy S. Fenske, Mehdi Hamadani, Dina Schneider, Parameswaran Hari, Bryon Johnson, Nirav N. Shah
Journal: Blood
Blood (2021) 138 (Supplement 1): 1728.
https://doi.org/10.1182/blood-2021-146882
Published: 2021
Journal Articles

Manufacturing Bispecific LV20.19 CAR T-Cells with IL-7 & IL-15 for a Shorter Duration Improves CAR T-Cell Immunophenotype While Maintaining Target Cell Dose

Joanna C. Zurko, Katherine Chaney, Huiqing Xu, Dina Schneider, Parameswaran Hari, Bryon Johnson, Nirav N. Shah
Journal: Blood
Blood (2021) 138 (Supplement 1): 3883.
https://doi.org/10.1182/blood-2021-147405
Published: 2021
Journal Articles

Final Results of a Phase 1 Study of AntiCD19 CAR-T Cells with TNFRSF19 Transmembrane Domain

Paolo F. Caimi, Armin Ghobadi, Jane Reese, Benjamin Tomlinson, Folashade Otegbeye, Julie K Ritchey, Tabatha Trummer, Jennifer Schiavone, Kayla Zamborsky, Linda G Eissenberg, Julia Hollaway, Dina Schneider, Kristen Bakalarz, Kirsten M Boughan, Leland Metheny, III, Seema Patel, Erin Galloway, Molly Gallogly, Winfried Krueger, Michael Kadan, Gabriela Pacheco Sanchez, Ashish Sharma, David Wald, Brenda W. Cooper, John F. DiPersio, Rafick Sekaly, Rimas J Orentas, Boro Dropulic, Marcos J.G. de Lima
Journal: Blood
Blood (2021) 138 (Supplement 1): 3833.
https://doi.org/10.1182/blood-2021-151155
Published: 2021
Journal Articles

Phase 1/2 Trial of IL7/IL15-Expanded Bispecific LV20.19 CAR T-Cells for Relapsed, Refractory B-Cell Non-Hodgkin Lymphoma

Nirav N. Shah, Joanna C. Zurko, Dina Schneider, Sharon Yim, Mehdi Hamadani, Timothy S. Fenske, Bryon Johnson, Parameswaran Hari
Journal: Blood
Blood (2021) 138 (Supplement 1): 95.
https://doi.org/10.1182/blood-2021-146638
Published: 2021
Journal Articles

A Fully-Human Armored BCMA CAR Boosts Function of CD4 + CAR-T Cells and Resists TGF-β Suppression in Pre-Clinical Models of Multiple Myeloma

Leah Alabanza, PhD, Bang Vu, PhD, Darong Wu, MS, Zhongyu Zhu, PhD, Boro Dropulic, PhDMBA, Dina Schneider, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-141062
Published: 2020
Journal Articles

Fully Human Tandem CD22-CD19 CAR-T Cells with Superior Sensitivity to Low Antigen Density Derived by Optimization of Co-Stimulation and CAR Architecture

Peirong Hu, PhD, Ying Xiong, PhD, Darong Wu, MS, Zhongyu Zhu, PhD, Boro Dropulic, PhDMBA, Dina Schneider, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-140836
Published: 2020
Journal Articles

Single-Cell RNA Sequencing Identifies Expression Patterns Associated with Clinical Responses to Dual-Targeted CAR-T Cell Therapy

Tyce Kearl, MD PhD, Ao Mei, Ryan Brown, Bryon Johnson, PhD, Dina Schneider, PhD, Boro Dropulic, PhDMBA, Parameswaran Hari, MD MRCP, Nirav N. Shah, MD, Subramaniam Malarkannan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-142937
Published: 2020
Journal Articles

Single-Cell Cytokine Analysis of LV20.19 Bispecific CAR T-Cell Products from a Phase I Clinical Trial

Huiqing Xu, MD, Katherine Chaney, MS, Bryon Johnson, PhD, Timothy S. Fenske, MD, Mehdi Hamadani, MD, Boro Dropulic, PhDMBA, Dina Schneider, PhD, Parameswaran Hari, MD MRCP, Nirav N. Shah, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22.
https://doi.org/10.1182/blood-2020-136805
Published: 2020