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Journal Articles

Initial Experience with CD19/CD22 BiCistronic CAR T-Cells in Children and Young Adults with Recurrent or Refractory B-Cell Malignancies

Brynn B. Duncan, Sara K. Silbert, Alexander W. Rankin, Bonnie Yates, Lauren Little, Toni Foley, Hao-Wei Wang, Constance M. Yuan, Dana I. Delgado Colon, Yanyu Wang, Jon Inglefield, John A Ligon, Hannah W. Song, Steven L. Highfill, Haneen Shalabi, David F. Stroncek, Naomi Taylor, Nirali N. Shah

Blood (2024) 144 (Supplement 1): 680.

https://doi.org/10.1182/blood-2024-198259

Published: 2024

Journal Articles

CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR

Blood (2022) 140 (5): 451–463.

https://doi.org/10.1182/blood.2022015795

Published: 2022

Includes: Supplemental data

Journal Articles

Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells

Blood (2021) 138 (24): 2469–2484.

https://doi.org/10.1182/blood.2021011898

Published: 2021

Includes: Supplemental data

Journal Articles

Deep and Durable Remissions of Relapsed Multiple Myeloma on a First-in-Humans Clinical Trial of T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor (CAR) with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain

Blood (2020) 136 (Supplement 1): 50–51.

https://doi.org/10.1182/blood-2020-138839

Published: 2020

Journal Articles

Cell Density of NK Cells during Ex Vivo Expansion Impacts NK Cell Surface TRAIL Expression

Joseph A. Clara, MD, Robert Reger, MS, Mala Chakraborty, PhD, Steven L Highfill, PhD, Jianjian Jin, PhD, David F. Stroncek, MD, Richard W. Childs, MD

Blood (2020) 136 (Supplement 1): 5–6.

https://doi.org/10.1182/blood-2020-141487

Published: 2020

Journal Articles

Abbreviated T-Cell Activation on the Automated Clinimacs Prodigy Device Enhances Bispecific CD19/22 Chimeric Antigen Receptor T-Cell Viability and Fold Expansion, Reducing Total Culture Duration

Sandeep K Srivastava, PhD, Sandhya R. Panch, MD MPH, Jianjian Jin, PhD, Haneen Shalabi, DO, Nirali N. Shah, MD, Steven L Highfill, PhD, David F. Stroncek

Blood (2018) 132 (Supplement 1): 4551.

https://doi.org/10.1182/blood-2018-99-116846

Published: 2018

Journal Articles

Very Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells Is a Safe Strategy for Prevention of Viral Infection after Allogeneic T Cell Depleted Stem Cell Transplantation

Pawel Muranski, MD, Sarah I Davies, Sawa Ito, MD, Eleftheria Koklanaris, RN, Jeanine Superata, RN, Quan Yu, Steven L Highfill, PhD, Marianna Sabatino, MD, David F. Stroncek, Minoo Battiwalla, MD, Austin John Barrett

Blood (2018) 132 (Supplement 1): 812.

https://doi.org/10.1182/blood-2018-99-119314

Published: 2018

Journal Articles

Modulation of CD22 Antigen Density Improves Efficacy of CD22 Chimeric Antigen Receptor (CAR) T Cells Against CD22 lo B-Lineage Leukemia and Lymphoma

Sneha Ramakrishna, MD, Sang M Nguyen, BS, Haiying Qin, MS, Steven L Highfill, PhD, Ira Kraft, John Shern, MD, Zachary Walsh, Dimiter Dimitrov, PhD, Terry J Fry, MD

Blood (2017) 130 (Supplement 1): 3894.

https://doi.org/10.1182/blood.V130.Suppl_1.3894.3894

Published: 2017

Journal Articles

The Post-Thaw Recovery of Cryopreserved Chimeric Antigen Receptor (CAR) T-Cells during Manufacture Is Better Than That of Cryopreserved Peripheral Blood CD3+ Cells

Nasha Elavia, MD MBBS, Andrew McManus, Steven L Highfill, PhD, Jiaqiang Ren, MD PhD, Nirali N Shah, MD, Terry J. Fry, MD, Jennifer Brudno, MD, James N. Kochenderfer, MD, David Stroncek, MD, Sandhya R. Panch, MDMPH

Blood (2017) 130 (Supplement 1): 4475.

https://doi.org/10.1182/blood.V130.Suppl_1.4475.4475

Published: 2017

Journal Articles

CD4/CD8 T-Cell Selection Enhances CD22 CAR-T Cell Transduction and in-Vivo CAR-T Expansion: Updated Results on Phase I Anti-CD22 CAR Dose Expansion Cohort

Nirali N Shah, MD, Steven L Highfill, PhD, Haneen Shalabi, DO, Bonnie Yates, RN, Eli Kane, Vicki Fellowes, Cynthia Delbrook, RN, Jiaqiang Ren, MD PhD, Jianjian Jin, David Stroncek, MD, Terry J. Fry, MD

Blood (2017) 130 (Supplement 1): 809.

https://doi.org/10.1182/blood.V130.Suppl_1.809.809

Published: 2017

Journal Articles

Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells Is a Safe Strategy to Prevent Viral Reactivation in Recipients of Allogeneic T Cell Depleted Stem Cell Transplant

Pawel Muranski, MD, Greg Whitehill, BS, Debbie Draper, RN, Eleftheria Koklanaris, RN, Jeanine Superata, RN, Quan Yu, MS, Marianna Sabatino, MD, Steven L. Highfill, PhD, Hanh Khuu, MD, Sarah I Davies, Mark Chang, Upneet Chawla, BS, MD, Alexandros Spyridonidis, MD PhD, Gary Fahle, MT,SM, Sawa Ito, MD PhD, David Stroncek, MD, Minoo Battiwalla, MDMS, John Barrett, MD

Blood (2016) 128 (22): 979.

https://doi.org/10.1182/blood.V128.22.979.979

Published: 2016

Journal Articles

Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1–dependent mechanism that is up-regulated by interleukin-13

Steven L. Highfill, Paulo C. Rodriguez, Qing Zhou, Christine A. Goetz, Brent H. Koehn, Rachelle Veenstra, Patricia A. Taylor, Angela Panoskaltsis-Mortari, Jonathan S. Serody, David H. Munn, Jakub Tolar, Augusto C. Ochoa, Bruce R. Blazar

Blood (2010) 116 (25): 5738–5747.

https://doi.org/10.1182/blood-2010-06-287839

Published: 2010

Includes: Supplemental data

Journal Articles

Bone Marrow Myeloid-Derived Suppressor Cells (MDSC) Inhibit Graft Versus Host Disease (GVHD) Via An Arginase-1 Dependant Mechanism That Is Upregulated by IL-13

Steven L Highfill, PhD, Paulo Rodriguez, PhD, Qing Zhou, PhD, Christine A Goetz, PhD, Rachelle Veenstra, Patricia A Taylor, DVM, Angela Panoskaltsis-Mortari, PhD, Jonathan Serody, MD, David Munn, Jakub Tolar, MD, PhD, Augusto C Ochoa, MD, Bruce R. Blazar, MD

Blood (2010) 116 (21): 241.

https://doi.org/10.1182/blood.V116.21.241.241

Published: 2010

Journal Articles

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

Qing Zhou, Meghan E. Munger, Steven L. Highfill, Jakub Tolar, Brenda J. Weigel, Megan Riddle, Arlene H. Sharpe, Daniel A. Vallera, Miyuki Azuma, Bruce L. Levine, Carl H. June, William J. Murphy, David H. Munn, Bruce R. Blazar

Blood (2010) 116 (14): 2484–2493.

https://doi.org/10.1182/blood-2010-03-275446

Published: 2010

Includes: Supplemental data

Journal Articles

Constitutively active Stat5b in CD4 + T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses

Christine Vogtenhuber, Christoph Bucher, Steven L. Highfill, Lisa K. Koch, Emily Goren, Angela Panoskaltsis-Mortari, Patricia A. Taylor, Michael A. Farrar, Bruce R. Blazar

Blood (2010) 116 (3): 466–474.

https://doi.org/10.1182/blood-2009-11-252825

Published: 2010

Includes: Supplemental data

Journal Articles

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

Qing Zhou, Christoph Bucher, Meghan E. Munger, Steven L. Highfill, Jakub Tolar, David H. Munn, Bruce L. Levine, Megan Riddle, Carl H. June, Daniel A. Vallera, Brenda J. Weigel, Bruce R. Blazar

Blood (2009) 114 (18): 3793–3802.

https://doi.org/10.1182/blood-2009-03-208181

Published: 2009

Includes: Supplemental data

Journal Articles

Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E 2 synthesis and only if localized to sites of allopriming

Steven L. Highfill, Ryan M. Kelly, Matthew J. O'Shaughnessy, Qing Zhou, Lily Xia, Angela Panoskaltsis-Mortari, Patricia A. Taylor, Jakub Tolar, Bruce R. Blazar

Blood (2009) 114 (3): 693–701.

https://doi.org/10.1182/blood-2009-03-213850

Published: 2009

Includes: Supplemental data

Journal Articles

Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation

Ryan M. Kelly, Steven L. Highfill, Angela Panoskaltsis-Mortari, Patricia A. Taylor, Richard L. Boyd, Georg A. Holländer, Bruce R. Blazar

Blood (2008) 111 (12): 5734–5744.

https://doi.org/10.1182/blood-2008-01-136531

Published: 2008

Includes: Supplemental data

NARROW

Initial Experience with CD19/CD22 BiCistronic CAR T-Cells in Children and Young Adults with Recurrent or Refractory B-Cell Malignancies

CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR

Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells

Deep and Durable Remissions of Relapsed Multiple Myeloma on a First-in-Humans Clinical Trial of T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor (CAR) with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain

Cell Density of NK Cells during Ex Vivo Expansion Impacts NK Cell Surface TRAIL Expression

Abbreviated T-Cell Activation on the Automated Clinimacs Prodigy Device Enhances Bispecific CD19/22 Chimeric Antigen Receptor T-Cell Viability and Fold Expansion, Reducing Total Culture Duration

Very Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells Is a Safe Strategy for Prevention of Viral Infection after Allogeneic T Cell Depleted Stem Cell Transplantation

Modulation of CD22 Antigen Density Improves Efficacy of CD22 Chimeric Antigen Receptor (CAR) T Cells Against CD22 lo B-Lineage Leukemia and Lymphoma

The Post-Thaw Recovery of Cryopreserved Chimeric Antigen Receptor (CAR) T-Cells during Manufacture Is Better Than That of Cryopreserved Peripheral Blood CD3+ Cells

CD4/CD8 T-Cell Selection Enhances CD22 CAR-T Cell Transduction and in-Vivo CAR-T Expansion: Updated Results on Phase I Anti-CD22 CAR Dose Expansion Cohort

Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells Is a Safe Strategy to Prevent Viral Reactivation in Recipients of Allogeneic T Cell Depleted Stem Cell Transplant

Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1–dependent mechanism that is up-regulated by interleukin-13

Bone Marrow Myeloid-Derived Suppressor Cells (MDSC) Inhibit Graft Versus Host Disease (GVHD) Via An Arginase-1 Dependant Mechanism That Is Upregulated by IL-13

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

Constitutively active Stat5b in CD4 + T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E 2 synthesis and only if localized to sites of allopriming

Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation

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American Society of Hematology

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American Society of Hematology

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