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Journal Articles

GTB-3550 TriKE™ for the Treatment of High-Risk Myelodysplastic Syndromes (MDS) and Refractory/Relapsed Acute Myeloid Leukemia (AML) Safely Drives Natural Killer (NK) Cell Proliferation At Initial Dose Cohorts

Erica D. Warlick, MD, Daniel J. Weisdorf, MD, Daniel A. Vallera, PhD, Rose Wangen, Dixie Lewis, RN,BA, JoAnn Knox, Martin Schroeder, Martin Felices, PhD, Jeffrey S. Miller, MD

Blood (2020) 136 (Supplement 1): 7–8.

https://doi.org/10.1182/blood-2020-136398

Published: 2020

Journal Articles

PD-1 Is Expressed at Low Levels on All Peripheral Blood Natural Killer Cells but Is a Significant Suppressor of NK Function Against PD-1 Ligand Expressing Tumor Targets

Zachary Davis, PhD BS, Martin Felices, PhD, Todd R Lenvik, Sujan Badal, Peter Hinderlie, Bruce R. Blazar, MD, Daniel A. Vallera, PhD, Jeffrey S. Miller, MD

Blood (2019) 134 (Supplement_1): 621.

https://doi.org/10.1182/blood-2019-127261

Published: 2019

Journal Articles

CD16-IL15-CLEC12A Trispecific Killer Engager (TriKE) Drives NK Cell Expansion, Activation, and Antigen Specific Killing of Cancer Stem Cells in Acute Myeloid Leukemia

Upasana Sunil Arvindam, MSc, BSc, Paulien van Hauten, MSc-MD, Caroline Hallstrom, BS, Daniel A. Vallera, PhD, Harry Dolstra, PhD, Jeffrey S. Miller, MD, Martin Felices, PhD

Blood (2018) 132 (Supplement 1): 1454.

https://doi.org/10.1182/blood-2018-99-117150

Published: 2018

Journal Articles

64 cu-DOTA-Anti-CD33 PET-CT Imaging for Acute Myeloid Leukemia and Image-Guided Treatment

Srideshikan Sargur Madabushi, PhD, Darren Zuro, Jamison Brooks, B.S, Bijender Kumar, PhD, Liliana E Parra, Marvin Orellana, B.S, Indu Nair, PhD, Junie Chea, Kofi Poku, PharmD, Ching-Cheng Chen, PhD, James Sanchez, PhD, John E. Shively, Daniel A. Vallera, PhD, Jeffrey Wong, MD, Anthony S. Stein, MD, David Colcher, PhD, Paul Yazaki, PhD, Susanta Hui, PhD, DABR.

Blood (2018) 132 (Supplement 1): 2747.

https://doi.org/10.1182/blood-2018-99-117878

Published: 2018

Journal Articles

Second-Generation Camelid Trike Induces Improved NK Cell Mediated Targeting of AML in Pre-Clinical Models

Martin Felices, PhD, Craig E. Eckfeldt, MD PhD, Todd R Lenvik, Behiye Kodal, Alexander J. Lenvik, Laura Bendzick, Caitlin Ryan, Melissa A. Geller, Sarah Cooley, MD, Daniel J. Weisdorf, MD, Daniel A. Vallera, PhD, Jeffrey S. Miller, MD

Blood (2017) 130 (Supplement 1): 4465.

https://doi.org/10.1182/blood.V130.Suppl_1.4465.4465

Published: 2017

Journal Articles

CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33 + targets

Michelle K. Gleason, Julie A. Ross, Erica D. Warlick, Troy C. Lund, Michael R. Verneris, Andres Wiernik, Stephen Spellman, Michael D. Haagenson, Alexander J. Lenvik, Mark R. Litzow, Pearlie K. Epling-Burnette, Bruce R. Blazar, Louis M. Weiner, Daniel J. Weisdorf, Daniel A. Vallera, Jeffrey S. Miller

Blood (2014) 123 (19): 3016–3026.

https://doi.org/10.1182/blood-2013-10-533398

Published: 2014

Includes: Supplemental data

Journal Articles

A Novel CD16xCD33 Bispecific Killer Cell Engager (BiKE) Mediates a Double Hit For Natural Killer (NK) Cells To Target CD33 + Myelodysplastic Syndrome (MDS) Cells and Myeloid Derived Suppressor Cells (MDSCs) At All Disease Stages

Michelle K. Gleason, PhD, Julie A. Ross, PhD, Troy C. Lund, MD/PhD, Michael R. Verneris, MD, Andres Wiernik, MD, Erica D. Warlick, MD, Stephen Spellman, MBS, Michael D. Haagenson, MS, Alexander J. Lenvik, Mark R. Litzow, MD, Daniel J. Weisdorf, MD, Daniel A. Vallera, PhD, Jeffrey S. Miller, MD

Blood (2013) 122 (21): 385.

https://doi.org/10.1182/blood.V122.21.385.385

Published: 2013

Journal Articles

Bi-Specific Killer Cell Engagers (BiKEs) Signaling Through CD16 and Targeting CD33 (CD16 × CD33), Triggers Natural Killer (NK) Cell Cytotoxic and Cytokine Production Against Refractory Acute Myeloid Leukemia (AML)

Andres Wiernik, MD, Bree Foley, PhD, Bin Zhang, Michael R. Verneris, MD, Erica Warlick, MD, Julie A. Ross, PhD, Louis M. Weiner, MD, Daniel J. Weisdorf, MD, Daniel A Vallera, PhD, Jeffrey S. Miller, MD

Blood (2012) 120 (21): 256.

https://doi.org/10.1182/blood.V120.21.256.256

Published: 2012

Journal Articles

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

Qing Zhou, Meghan E. Munger, Steven L. Highfill, Jakub Tolar, Brenda J. Weigel, Megan Riddle, Arlene H. Sharpe, Daniel A. Vallera, Miyuki Azuma, Bruce L. Levine, Carl H. June, William J. Murphy, David H. Munn, Bruce R. Blazar

Blood (2010) 116 (14): 2484–2493.

https://doi.org/10.1182/blood-2010-03-275446

Published: 2010

Includes: Supplemental data

Journal Articles

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

Qing Zhou, Christoph Bucher, Meghan E. Munger, Steven L. Highfill, Jakub Tolar, David H. Munn, Bruce L. Levine, Megan Riddle, Carl H. June, Daniel A. Vallera, Brenda J. Weigel, Bruce R. Blazar

Blood (2009) 114 (18): 3793–3802.

https://doi.org/10.1182/blood-2009-03-208181

Published: 2009

Includes: Supplemental data

Journal Articles

Treg Depletion with Interleukin-2-Diphteriatoxin (IL-2DT) Is Sufficient to Induce Tumor Clearance in Acute Myeloid Leukemia (AML)

Christoph Bucher, MD, Johanna Zhou, PhD, Heidi Mondale, PhD, Meghan Johnson, Luna Liu, Christine Vogtenhuber, PhD, Chris Lees, Yoichiro Iwakura, PhD, Daniel A Vallera, PhD, Brenda Weigel, MD, MSc, Bruce R. Blazar, MD

Blood (2008) 112 (11): 2954.

https://doi.org/10.1182/blood.V112.11.2954.2954

Published: 2008

Journal Articles

Molecular modification of a recombinant anti-CD3ε-directed immunotoxin by inducing terminal cysteine bridging enhances anti-GVHD efficacy and reduces organ toxicity in a lethal murine model

Daniel A. Vallera, David W. Kuroki, Angela Panoskaltsis-Mortari, Donald J. Buchsbaum, Buck E. Rogers, Bruce R. Blazar

Blood (2000) 96 (3): 1157–1165.

https://doi.org/10.1182/blood.V96.3.1157

Published: 2000

Journal Articles

A Critical Role for CD48 Antigen in Regulating Alloengraftment and Lymphohematopoietic Recovery After Bone Marrow Transplantation

Bruce R. Blazar, Patricia A. Taylor, Angela Panoskaltsis-Mortari, Hideo Yagita, Jonathan S. Bromberg, Daniel A. Vallera

Blood (1998) 92 (11): 4453–4463.

https://doi.org/10.1182/blood.V92.11.4453

Published: 1998

Journal Articles

Keratinocyte Growth Factor Administered Before Conditioning Ameliorates Graft-Versus-Host Disease After Allogeneic Bone Marrow Transplantation in Mice

Angela Panoskaltsis-Mortari, David L. Lacey, Daniel A. Vallera, Bruce R. Blazar

Blood (1998) 92 (10): 3960–3967.

https://doi.org/10.1182/blood.V92.10.3960

Published: 1998

Journal Articles

Engraftment of Severe Combined Immune Deficient Mice Receiving Allogeneic Bone Marrow Via In Utero or Postnatal Transfer

Bruce R. Blazar, Patricia A. Taylor, Ron McElmurry, Lina Tian, Angela Panoskaltsis-Mortari, Sylvia Lam, Chris Lees, Thomas Waldschmidt, Daniel A. Vallera

Blood (1998) 92 (10): 3949–3959.

https://doi.org/10.1182/blood.V92.10.3949

Published: 1998

Journal Articles

The Role of B7 Costimulation by Murine Acute Myeloid Leukemia in the Generation and Function of a CD8 + T-Cell Line With Potent In Vivo Graft-Versus-Leukemia Properties

Michael W. Boyer, Daniel A. Vallera, Patricia A. Taylor, Gary S. Gray, Emmanuel Katsanis, Keith Gorden, Paul J. Orchard, Bruce R. Blazar

Blood (1997) 89 (9): 3477–3485.

https://doi.org/10.1182/blood.V89.9.3477

Published: 1997

NARROW

GTB-3550 TriKE™ for the Treatment of High-Risk Myelodysplastic Syndromes (MDS) and Refractory/Relapsed Acute Myeloid Leukemia (AML) Safely Drives Natural Killer (NK) Cell Proliferation At Initial Dose Cohorts

PD-1 Is Expressed at Low Levels on All Peripheral Blood Natural Killer Cells but Is a Significant Suppressor of NK Function Against PD-1 Ligand Expressing Tumor Targets

CD16-IL15-CLEC12A Trispecific Killer Engager (TriKE) Drives NK Cell Expansion, Activation, and Antigen Specific Killing of Cancer Stem Cells in Acute Myeloid Leukemia

64 cu-DOTA-Anti-CD33 PET-CT Imaging for Acute Myeloid Leukemia and Image-Guided Treatment

Second-Generation Camelid Trike Induces Improved NK Cell Mediated Targeting of AML in Pre-Clinical Models

CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33 + targets

A Novel CD16xCD33 Bispecific Killer Cell Engager (BiKE) Mediates a Double Hit For Natural Killer (NK) Cells To Target CD33 + Myelodysplastic Syndrome (MDS) Cells and Myeloid Derived Suppressor Cells (MDSCs) At All Disease Stages

Bi-Specific Killer Cell Engagers (BiKEs) Signaling Through CD16 and Targeting CD33 (CD16 × CD33), Triggers Natural Killer (NK) Cell Cytotoxic and Cytokine Production Against Refractory Acute Myeloid Leukemia (AML)

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

Treg Depletion with Interleukin-2-Diphteriatoxin (IL-2DT) Is Sufficient to Induce Tumor Clearance in Acute Myeloid Leukemia (AML)

Molecular modification of a recombinant anti-CD3ε-directed immunotoxin by inducing terminal cysteine bridging enhances anti-GVHD efficacy and reduces organ toxicity in a lethal murine model

A Critical Role for CD48 Antigen in Regulating Alloengraftment and Lymphohematopoietic Recovery After Bone Marrow Transplantation

Keratinocyte Growth Factor Administered Before Conditioning Ameliorates Graft-Versus-Host Disease After Allogeneic Bone Marrow Transplantation in Mice

Engraftment of Severe Combined Immune Deficient Mice Receiving Allogeneic Bone Marrow Via In Utero or Postnatal Transfer

The Role of B7 Costimulation by Murine Acute Myeloid Leukemia in the Generation and Function of a CD8 + T-Cell Line With Potent In Vivo Graft-Versus-Leukemia Properties

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American Society of Hematology

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American Society of Hematology

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