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Journal Articles

SHP2 Inhibition Suppresses RAS-ERK Signaling, the Development of JAK2 Inhibitor Persistence, and MPN Development in Pre-Clinical Models of Myeloproliferative Neoplasms

Garima Pandey, Nathan Horvat, Narmin E. Amin, Guolin Zhang, Lucia Mazzacurati, Afua A. Akuffo, Christelle Colin-Leitzinger, Eric B. Haura, Pearlie K. Epling-Burnette, Gary W. Reuther

Blood (2022) 140 (Supplement 1): 9573–9574.

https://doi.org/10.1182/blood-2022-160349

Published: 2022

Journal Articles

Cereblon harnesses Myc-dependent bioenergetics and activity of CD8 + T lymphocytes

Blood (2020) 136 (7): 857–870.

https://doi.org/10.1182/blood.2019003257

Published: 2020

Includes: Supplemental data

Journal Articles

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Blood (2020) 135 (3): 191–207.

https://doi.org/10.1182/blood.2019895326

Published: 2020

Includes: Supplemental data

Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Blood (2019) 134 (Supplement_1): 474.

https://doi.org/10.1182/blood-2019-127235

Published: 2019

Journal Articles

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

Blood (2019) 134 (Supplement_1): 1692.

https://doi.org/10.1182/blood-2019-128573

Published: 2019

Journal Articles

RMC-4550, an Allosteric Inhibitor of SHP2, Displays Therapeutic Efficacy in Pre-Clinical Models of Myeloproliferative Neoplasms

Garima Pandey, Nathan Horvat, Narmin E. Amin, Afua A. Akuffo, Christelle Colin, Pearlie K. Epling-Burnette, Gary W. Reuther

Blood (2019) 134 (Supplement_1): 4198.

https://doi.org/10.1182/blood-2019-128937

Published: 2019

Journal Articles

Germ line tissues for optimal detection of somatic variants in myelodysplastic syndromes

Eric Padron, Markus C. Ball, Jamie K. Teer, Jeffrey S. Painter, Sean J. Yoder, Chaomei Zhang, Ling Zhang, Lynn C. Moscinski, Dana E. Rollison, Steven D. Gore, Rafael Bejar, Matthew J. Walter, Mikkael A. Sekeres, Rami S. Komrokji, Pearlie K. Epling-Burnette

Blood (2018) 131 (21): 2402–2405.

https://doi.org/10.1182/blood-2018-01-827881

Published: 2018

Includes: Supplemental data

Journal Articles

Cereblon Deficiency Leads to Alteration in c-Myc Regulated Genes, Increased Glucose Uptake and Resistance to JQ1 Bromodomain Inhibition

Matthew S Beatty, PhD, Rebecca S Hesterberg, BA, Ying Han, MD, Eric Padron, MD, Adam W Mailloux, PhD, Sean Yoder, M.S, Anjali M Rajadhyaksha, PhD, Alan F. List, MD, Pearlie K Epling-Burnette, PhD

Blood (2015) 126 (23): 286.

https://doi.org/10.1182/blood.V126.23.286.286

Published: 2015

Journal Articles

Somatic Gene Mutations Serve As Molecular Biomarkers Predictive for Response to Immunosuppressive Therapy (IST) in Myelodysplastic Syndromes (MDS)

Rami S. Komrokji, MD, Mintallah Haider, MD, Najla H. Al Ali, BDS, MSc, Jeffrey E Lancet, MD, Qing Zhang, MD, Pearlie K Epling-Burnette, PhD, Alan F. List, MD, Eric Padron, MD

Blood (2015) 126 (23): 1664.

https://doi.org/10.1182/blood.V126.23.1664.1664

Published: 2015

Journal Articles

Preclinical Efficacy of TGF-Beta Receptor I Kinase Inhibitor, Galunisertib, in Myelofibrosis

Lanzhu Yue, PhD, Matthias Bartenstein, Wanke Zhao, Wan-Ting Ho, Ling Zhang, MD, Franck Rapaport, PhD, Ross L. Levine, MD, Zonghong Shao, Zhizhuang Joe Zhao, PhD, Amit Verma, Pearlie K Epling-Burnette, PhD

Blood (2015) 126 (23): 603.

https://doi.org/10.1182/blood.V126.23.603.603

Published: 2015

Journal Articles

Mesenchymal Cell Associated Fibrosis in Experimental mpl W515L Mouse Model of Myelofibrosis

Lanzhu Yue, PhD, Ying Han, MD, Ling Zhang, MD, Sheng Wei, MD, Xiubao Ren, MD, Zonghong Shao, Pearlie K Epling-Burnette, PhD

Blood (2015) 126 (23): 604.

https://doi.org/10.1182/blood.V126.23.604.604

Published: 2015

Journal Articles

Genetic Ablation of Cereblon (CRBN) Increases Long-Lived Memory T Cells

Rebecca S Hesterberg, BA, Pearlie K Epling-Burnette, PharmD PhD

Blood (2015) 126 (23): 3440.

https://doi.org/10.1182/blood.V126.23.3440.3440

Published: 2015

Journal Articles

Prognostic Value of Circulating Myeloblasts in Patients with Myelodysplastic Syndromes (MDS): A Proposal for Incorporation in the Revised International Prognostic Scoring System (R-IPSS)

Rami S Komrokji, MD, Eric Padron, MD, Najla H Al Ali, Jeffrey E Lancet, MD, Jeff Hall, PhD, Brian Kwok, MD, Ling Zhang, MD, Pearlie K Epling-Burnette, PhD, Alan F List, MD

Blood (2014) 124 (21): 4650.

https://doi.org/10.1182/blood.V124.21.4650.4650

Published: 2014

Journal Articles

A Phase II Study to Determine the Safety and Efficacy of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase (IDO) Enzyme INCB024360 in Patients with Myelodysplastic Syndromes

Rami S Komrokji, MD, Sheng Wei, MD, Adam W Mailloux, PhD, Ling Zhang, MD, Eric Padron, MD, Jeffrey E. Lancet, MD, Sara Tinsley, ARNP, Lisa A Nardelli, BS, CCRP, Cynthia Benoit, RN, Javier Pinilla-Ibarz, MD PhD, Pearlie K Epling-Burnette, PhD, Alan F List, MD

Blood (2014) 124 (21): 4653.

https://doi.org/10.1182/blood.V124.21.4653.4653

Published: 2014

Journal Articles

ETV6 and signaling gene mutations are associated with secondary transformation of myelodysplastic syndromes to chronic myelomonocytic leukemia

Eric Padron, Sean Yoder, Sateesh Kunigal, Tania Mesa, Jamie K. Teer, Najla Al Ali, Mikkael A. Sekeres, Jeffrey S. Painter, Ling Zhang, Jeffrey Lancet, Jaroslaw P. Maciejewski, Pearlie K. Epling-Burnette, Eduardo Sotomayor, Rami S. Komrokji, Alan F. List

Blood (2014) 123 (23): 3675–3677.

https://doi.org/10.1182/blood-2014-03-562637

Published: 2014

Includes: Supplemental data

Journal Articles

CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33 + targets

Michelle K. Gleason, Julie A. Ross, Erica D. Warlick, Troy C. Lund, Michael R. Verneris, Andres Wiernik, Stephen Spellman, Michael D. Haagenson, Alexander J. Lenvik, Mark R. Litzow, Pearlie K. Epling-Burnette, Bruce R. Blazar, Louis M. Weiner, Daniel J. Weisdorf, Daniel A. Vallera, Jeffrey S. Miller

Blood (2014) 123 (19): 3016–3026.

https://doi.org/10.1182/blood-2013-10-533398

Published: 2014

Includes: Supplemental data

Journal Articles

Characterization Of RING Finger E3-Ubiquitin Ligase Cereblon In Hematopoietic Regulation

Ying Han, MD, Anjali M Rajadhyaksha, PhD, Adam W Mailloux, PhD, Jeff Painter, BS, Jessica M. McDaniel, PhD, Ling Zhang, MD, Pearlie K Epling-Burnette, PhD

Blood (2013) 122 (21): 1207.

https://doi.org/10.1182/blood.V122.21.1207.1207

Published: 2013

Journal Articles

The Utility Of Newer Risk Models In Predicting Outcomes Of Patients (pts) With Higher-Risk (HR) Myelodysplastic Syndromes (MDS) Treated With Azactidine (aza)

Amer M. Zeidan, MD, Najla H Al Ali, Mohamed A. Kharfan-Dabaja, MD, Eric Padron, MD, Ling Zhang, MD, Pearlie K Epling-Burnette, PhD, Jeffrey E Lancet, MD, Alan F List, MD, Rami S Komrokji, MD

Blood (2013) 122 (21): 2771.

https://doi.org/10.1182/blood.V122.21.2771.2771

Published: 2013

Journal Articles

JAK2 Dependent GM-CSF Signaling Triggers SRSF2 Phosphorylation: A Potential Cause Of Mutation-Independent RNA Splicing Aberrancy In CMML

Sateesh Kunigal, PhD, Jamie Teer, PhD, Jeff Painter, BS, Sean J Yoder, MS, Euhnee Kim, PhD, Ling Zhang, MD, Jeffrey E Lancet, MD, Rami S. Komrokji, MD, Omar Abdel-Wahab, MD, Alan List, MD, Pearlie K Epling-Burnette, PhD, Eric Padron, MD

Blood (2013) 122 (21): 2772.

https://doi.org/10.1182/blood.V122.21.2772.2772

Published: 2013

Journal Articles

Common γ Chain (γ c ) Cytokine Hypersensitivity Leads To T-Cell Homeostatic Deregulation Independent Of STAT3 Mutation In Large Granular Lymphocyte Leukemia

Adam W Mailloux, PhD, Jeff Painter, BS, Eric Padron, MD, Thomas P. Loughran, Jr., M.D., Pearlie K Epling-Burnette, PhD

Blood (2013) 122 (21): 1628.

https://doi.org/10.1182/blood.V122.21.1628.1628

Published: 2013

NARROW

SHP2 Inhibition Suppresses RAS-ERK Signaling, the Development of JAK2 Inhibitor Persistence, and MPN Development in Pre-Clinical Models of Myeloproliferative Neoplasms

Cereblon harnesses Myc-dependent bioenergetics and activity of CD8 + T lymphocytes

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

RMC-4550, an Allosteric Inhibitor of SHP2, Displays Therapeutic Efficacy in Pre-Clinical Models of Myeloproliferative Neoplasms

Germ line tissues for optimal detection of somatic variants in myelodysplastic syndromes

Cereblon Deficiency Leads to Alteration in c-Myc Regulated Genes, Increased Glucose Uptake and Resistance to JQ1 Bromodomain Inhibition

Somatic Gene Mutations Serve As Molecular Biomarkers Predictive for Response to Immunosuppressive Therapy (IST) in Myelodysplastic Syndromes (MDS)

Preclinical Efficacy of TGF-Beta Receptor I Kinase Inhibitor, Galunisertib, in Myelofibrosis

Mesenchymal Cell Associated Fibrosis in Experimental mpl W515L Mouse Model of Myelofibrosis

Genetic Ablation of Cereblon (CRBN) Increases Long-Lived Memory T Cells

Prognostic Value of Circulating Myeloblasts in Patients with Myelodysplastic Syndromes (MDS): A Proposal for Incorporation in the Revised International Prognostic Scoring System (R-IPSS)

A Phase II Study to Determine the Safety and Efficacy of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase (IDO) Enzyme INCB024360 in Patients with Myelodysplastic Syndromes

ETV6 and signaling gene mutations are associated with secondary transformation of myelodysplastic syndromes to chronic myelomonocytic leukemia

CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33 + targets

Characterization Of RING Finger E3-Ubiquitin Ligase Cereblon In Hematopoietic Regulation

The Utility Of Newer Risk Models In Predicting Outcomes Of Patients (pts) With Higher-Risk (HR) Myelodysplastic Syndromes (MDS) Treated With Azactidine (aza)

JAK2 Dependent GM-CSF Signaling Triggers SRSF2 Phosphorylation: A Potential Cause Of Mutation-Independent RNA Splicing Aberrancy In CMML

Common γ Chain (γ c ) Cytokine Hypersensitivity Leads To T-Cell Homeostatic Deregulation Independent Of STAT3 Mutation In Large Granular Lymphocyte Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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