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Journal Articles

SHP2 Inhibition Enhances JAK2 Inhibitor Therapy in Preclinical Models of Myeloproliferative Neoplasms

Garima Pandey, Lucia Mazzacurati, Nathan P. Horvat, Tegan Rowsell, Narmin E. Amin, Guolin Zhang, Afua Adutwumwa Akuffo, Christelle M. Colin-Leitzinger, Eric B. Haura, Andrew T. Kuykendall, PK Epling-Burnette, Gary W. Reuther
Journal: Blood
Blood (2023) 142 (Supplement 1): 4530.
https://doi.org/10.1182/blood-2023-189657
Published: 2023
Journal Articles

SHP2 Inhibition Suppresses RAS-ERK Signaling, the Development of JAK2 Inhibitor Persistence, and MPN Development in Pre-Clinical Models of Myeloproliferative Neoplasms

Garima Pandey, Nathan Horvat, Narmin E. Amin, Guolin Zhang, Lucia Mazzacurati, Afua A. Akuffo, Christelle Colin-Leitzinger, Eric B. Haura, Pearlie K. Epling-Burnette, Gary W. Reuther
Journal: Blood
Blood (2022) 140 (Supplement 1): 9573–9574.
https://doi.org/10.1182/blood-2022-160349
Published: 2022
Journal Articles

Bromodomain and Extra Terminal Domain (BET) Inhibitors Sensitize Chronic Myelomonocytic Leukemia (CMML) to PIM Inhibition Via Downregulation of Mir-33a

Christopher Letson, BS, Alexis Vedder, BS, Ariel Quintana, PhD, Phillip Liu, PhD, Brett Reid, Maria E Balasis, Hannah Newman, BS, Traci Kruer, PhD, Luciana L Almada, PhD, Guolin Zhang, PhD, Martin Fernandez-Zapico, MD, Mrinal M Patnaik, MDMBBS, Jeffrey E. Lancet, MD, Rami S. Komrokji, MD, P.K. Epling-Burnette, PharmD, PhD, Alan F. List, MD, Eric B. Haura, MD, Gary W. Reuther, Thomas A. Sellers, PhD, Holly K. Koblish, PhD, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4220.
https://doi.org/10.1182/blood-2019-128165
Published: 2019
Journal Articles

The Persistent Survival of MPN Cells to JAK2 Inhibition Is Dependent on SHP2 Activity, Which May Provide a Therapeutic Target to Enhance Current Anti-MPN Therapies

Garima Pandey, Guolin Zhang, Narmin Amin, Lucia Mazzacurati, Eric B. Haura, Gary W. Reuther, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3064.
https://doi.org/10.1182/blood-2018-99-118641
Published: 2018