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Gary W. Reuther
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Journal Articles

SHP2 Inhibition Enhances JAK2 Inhibitor Therapy in Preclinical Models of Myeloproliferative Neoplasms

Garima Pandey, Lucia Mazzacurati, Nathan P. Horvat, Tegan Rowsell, Narmin E. Amin, Guolin Zhang, Afua Adutwumwa Akuffo, Christelle M. Colin-Leitzinger, Eric B. Haura, Andrew T. Kuykendall, PK Epling-Burnette, Gary W. Reuther
Journal: Blood
Blood (2023) 142 (Supplement 1): 4530.
https://doi.org/10.1182/blood-2023-189657
Published: 2023
Journal Articles

SHP2 Inhibition Suppresses RAS-ERK Signaling, the Development of JAK2 Inhibitor Persistence, and MPN Development in Pre-Clinical Models of Myeloproliferative Neoplasms

Garima Pandey, Nathan Horvat, Narmin E. Amin, Guolin Zhang, Lucia Mazzacurati, Afua A. Akuffo, Christelle Colin-Leitzinger, Eric B. Haura, Pearlie K. Epling-Burnette, Gary W. Reuther
Journal: Blood
Blood (2022) 140 (Supplement 1): 9573–9574.
https://doi.org/10.1182/blood-2022-160349
Published: 2022
Journal Articles

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Lanzhu Yue, Vasundhara Sharma, Nathan P. Horvat, Afua A. Akuffo, Matthew S. Beatty, Cem Murdun, Christelle Colin, Julia M. R. Billington, William E. Goodheart, Eva Sahakian, Ling Zhang, John J. Powers, Narmin E. Amin, Que T. Lambert-Showers, Lancia N. Darville, Javier Pinilla-Ibarz, Gary W. Reuther, Kenneth L. Wright, Chiara Conti, Jennifer Y. Lee, Xiaozhang Zheng, Pui Yee Ng, Matthew W. Martin, C. Gary Marshall, John M. Koomen, Ross L. Levine, Amit Verma, H. Leighton Grimes, Eduardo M. Sotomayor, Zonghong Shao, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2020) 135 (3): 191–207.
https://doi.org/10.1182/blood.2019895326
Published: 2020
Includes: Supplemental data
Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Vasundhara Sharma, PhD, Lanzhu Yue, MD, Nathan P. Horvat, MDCandidate, Agni Christodoulidou, PhD, Afua Adutwumwa Akuffo, PhDCandidate, Mathew Beatty, PhD, Cem Murdun, MS, Julia Billington, PhDCandidate, William E Goodheart, MS, PhDCandidate, Eva Sahakian, PhD, Ling Zhang, MD, John J. Powers, BS, Narmin E. Amin, Que T. Lambert-Showers, Lancia Darville, PhD, Javier Pinilla Ibarz, MD PhD, Gary W. Reuther, Jennifer Lee, PhD, Xiaozhang Zheng, PhD, Pui Yee Ng, PhD, Mathew W. Martin, PhD, Gary C. Marshall, PhD, John M. Koomen, PhD, Ross L. Levine, MD, Amit Verma, MBBS, H. Leighton Grimes, PhD, Eduardo Sotomayor, MD, Zonghong Shao, MD, Kenneth Wright, PhD, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2019) 134 (Supplement_1): 474.
https://doi.org/10.1182/blood-2019-127235
Published: 2019
Journal Articles

Bromodomain and Extra Terminal Domain (BET) Inhibitors Sensitize Chronic Myelomonocytic Leukemia (CMML) to PIM Inhibition Via Downregulation of Mir-33a

Christopher Letson, BS, Alexis Vedder, BS, Ariel Quintana, PhD, Phillip Liu, PhD, Brett Reid, Maria E Balasis, Hannah Newman, BS, Traci Kruer, PhD, Luciana L Almada, PhD, Guolin Zhang, PhD, Martin Fernandez-Zapico, MD, Mrinal M Patnaik, MDMBBS, Jeffrey E. Lancet, MD, Rami S. Komrokji, MD, P.K. Epling-Burnette, PharmD, PhD, Alan F. List, MD, Eric B. Haura, MD, Gary W. Reuther, Thomas A. Sellers, PhD, Holly K. Koblish, PhD, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4220.
https://doi.org/10.1182/blood-2019-128165
Published: 2019
Journal Articles

RMC-4550, an Allosteric Inhibitor of SHP2, Displays Therapeutic Efficacy in Pre-Clinical Models of Myeloproliferative Neoplasms

Garima Pandey, Nathan Horvat, Narmin E. Amin, Afua A. Akuffo, Christelle Colin, Pearlie K. Epling-Burnette, Gary W. Reuther
Journal: Blood
Blood (2019) 134 (Supplement_1): 4198.
https://doi.org/10.1182/blood-2019-128937
Published: 2019
Journal Articles

The Persistent Survival of MPN Cells to JAK2 Inhibition Is Dependent on SHP2 Activity, Which May Provide a Therapeutic Target to Enhance Current Anti-MPN Therapies

Garima Pandey, Guolin Zhang, Narmin Amin, Lucia Mazzacurati, Eric B. Haura, Gary W. Reuther, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3064.
https://doi.org/10.1182/blood-2018-99-118641
Published: 2018
Journal Articles

Targeting Insulin-like Growth Factor/Insulin Receptor Signaling to Overcome JAK2 Inhibitor Persistence in Myeloproliferative Neoplasms

Lucia Mazzacurati, Que T. Lambert, Gary W. Reuther, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2935.
https://doi.org/10.1182/blood.V130.Suppl_1.2935.2935
Published: 2017
Journal Articles

The Pan-PIM Inhibitor INCB053914 Displays Potent Synergy at Low Doses in Combination with Ruxolitinib in Pre-Clinical Models of MPNs

Lucia Mazzacurati, Que T. Lambert, Robert J. Collins, Holly K. Koblish, PhD, Bruce Ruggeri, Matthew C. Stubbs, Gary W. Reuther, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1661.
https://doi.org/10.1182/blood.V130.Suppl_1.1661.1661
Published: 2017
Journal Articles

Single Molecule Dual JAK2-BET Inhibition As an MPN Therapeutic

Que T. Lambert, Stuart W. Ember, Muhammad Ayaz, Harshani R. Lawrence, Norbert Berndt, Steven Gunawan, Nicholas J. Lawrence, Ernst Schönbrunn, Gary W. Reuther
Journal: Blood
Blood (2015) 126 (23): 2826.
https://doi.org/10.1182/blood.V126.23.2826.2826
Published: 2015
Journal Articles

Pims: Potential Therapeutic Targets for Myeloproliferative Neoplasms

Que T. Lambert, Anuradha Pradhan, Gary W. Reuther
Journal: Blood
Blood (2014) 124 (21): 4575.
https://doi.org/10.1182/blood.V124.21.4575.4575
Published: 2014
Journal Articles

A Mechanistic Rationale for the Use of Statins to Enhance JAK Inhibitor Therapy in MPNs

Lori N. Griner, Kathy L. McGraw, Joseph O. Johnson, Alan F. List, MD, Gary W. Reuther
Journal: Blood
Blood (2011) 118 (21): 2816.
https://doi.org/10.1182/blood.V118.21.2816.2816
Published: 2011
Journal Articles

Requirement of Lipid Raft Integrity for Signaling by JAK2-V617F

Lori N. Griner, PhD, Kathy L. McGraw, PhD, Joseph O. Johnson, PhD, Alan F. List, Gary W. Reuther
Journal: Blood
Blood (2010) 116 (21): 4191.
https://doi.org/10.1182/blood.V116.21.4191.4191
Published: 2010
Journal Articles

Activation of JAK2-V617F by Heterodimeric Receptor Components.

Anuradha R. Pradhan, PhD, Que T. Lambert, Lori N. Griner, Gary W. Reuther
Journal: Blood
Blood (2009) 114 (22): 2955.
https://doi.org/10.1182/blood.V114.22.2955.2955
Published: 2009
Journal Articles

A Component of a Heterodimeric Receptor Can Functionally Replace a Homodimeric Receptor in Supporting the Activation and Transforming Activity of JAK2-V617F

Anuradha R. Pradhan, Que Lambert, Gary W. Reuther
Journal: Blood
Blood (2008) 112 (11): 3732.
https://doi.org/10.1182/blood.V112.11.3732.3732
Published: 2008
Journal Articles

Leukemogenic Cascade Induced by a Constitutively Active Neurotrophin Receptor, ΔTrkA.

Zhixiong Li, MD, Johann Meyer, PhD, Mathias Rhein, Olga Kustikova, PhD, Cornelia Rudolph, PhD, Kenji Kamino, MD, Thomas Neumann, Min Yang, BSc, Anke Wahlers, PhD, Boris Fehse, PhD, Gary W. Reuther, PhD, Brigitte Schlegelberger, MD, Arnold Ganser, MD, Christopher Baum, MD
Journal: Blood
Blood (2006) 108 (11): 1442.
https://doi.org/10.1182/blood.V108.11.1442.1442
Published: 2006
Journal Articles

Treatment with the Heat Shock Protein (hsp) 90 Inhibitor17-Dimethylaminoethylamino-17-Demethoxygeldanamycin (DMAG) Abrogates the Levels and Activity of the Receptor Tyrosine Kinase TrkA in Acute Leukemia Cells.

Sandhya Kumaraswamy, PhD, Que T. Lambert, MS, Kathy Rocha, BS, Purva Bali, MS, Warren Fiskus, PhD, Maria Balasis, BS, Michael Pranpat, MS, Sandhya Boyapalle, PhD, Alison Hannah, MD, Gary W. Reuther, PhD, Kapil Bhalla, MD
Journal: Blood
Blood (2005) 106 (11): 4401.
https://doi.org/10.1182/blood.V106.11.4401.4401
Published: 2005
Journal Articles

Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases

Robert C. Quackenbush, Gary W. Reuther, Juli P. Miller, Kevin D. Courtney, Warren S. Pear, Ann Marie Pendergast
Journal: Blood
Blood (2000) 95 (9): 2913–2921.
https://doi.org/10.1182/blood.V95.9.2913.009k32_2913_2921
Published: 2000