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Journal Articles

KPT-8602 Induced Hematopoietic Differentiation in U2AF1 S34F Mutant Cells and Myelodysplastic Syndromes Bone Marrow Stem and Progenitor Cells

Valeria Velez Galiano, Gloria Garcia, David M Swoboda, Katherine McKinnon, Dan Larson, Kathy L McGraw

Blood (2023) 142 (Supplement 1): 1849.

https://doi.org/10.1182/blood-2023-189630

Published: 2023

Journal Articles

Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A

Blood (2023) 141 (20): 2520–2536.

https://doi.org/10.1182/blood.2022017584

Published: 2023

Includes: Supplemental data

Journal Articles

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions

Blood (2022) 140 (16): 1774–1789.

https://doi.org/10.1182/blood.2021014875

Published: 2022

Includes: Supplemental data

Journal Articles

TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype

Blood (2020) 136 (24): 2812–2823.

https://doi.org/10.1182/blood.2020006158

Published: 2020

Includes: Supplemental data

Journal Articles

SNP-Array Genome Wide Association Study Meta-Analysis Identifies Innate Immune Susceptibility Loci Associated with Non-Del(5q) Myelodysplastic Syndromes Predisposition

Blood (2018) 132 (Supplement 1): 107.

https://doi.org/10.1182/blood-2018-99-118747

Published: 2018

Journal Articles

Genomic-DNA Exposed By Somatic Gene Mutations Engages the cGAS/STING Axis to License the NLRP3 Inflammasome in Myelodysplastic Syndromes

Amy F McLemore, M.S., Kathy L McGraw, PhD, Hsin-An Hou, MD PhD, Grace A Ward, BS, Alexis H Onimus, BS, Nicole D. Vincelette, PhD, Matthew A. Rodrigues, PhD, Neelkamal Chaudhary, PhD, Ling Zhang, MD, Benjamin S. Meyer, Erika A Eksioglu, PhD MS, Sheng Wei, MD, Alan F. List, MD

Blood (2018) 132 (Supplement 1): 3075.

https://doi.org/10.1182/blood-2018-99-116929

Published: 2018

Journal Articles

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy L McGraw, PhD, Amy F McLemore, M.S., Farnoosh Abbas-Aghababazadeh, PhD, Hsin-An Hou, MD PhD, Thu Le Trinh, PhD, Nicole D. Vincelette, PhD, Benjamin S. Meyer, Alexis H Onimus, BS, Alexandra Calescibetta, Erika A Eksioglu, PhD MS, Sheng Wei, MD, Alan F. List, MD

Blood (2018) 132 (Supplement 1): 3076.

https://doi.org/10.1182/blood-2018-99-118493

Published: 2018

Journal Articles

Phase 1b/2 Combination Study of APR-246 and Azacitidine (AZA) in Patients with TP53 mutant Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Blood (2018) 132 (Supplement 1): 3091.

https://doi.org/10.1182/blood-2018-99-119990

Published: 2018

Journal Articles

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Blood (2016) 128 (25): 2960–2975.

https://doi.org/10.1182/blood-2016-07-730556

Published: 2016

Includes: Supplemental data

Journal Articles

Phase 2 Trial of Smoothened (SMO) Inhibitor PF-04449913 (PF-04) in Refractory Myelodysplastic Syndromes (MDS)

Jeffrey E. Lancet, MD, Rami S Komrokji, MD, Kendra L. Sweet, MD, Vu H. Duong, MD, Kathy L McGraw, PhD, Ling Zhang, MD, Lisa Ann Nardelli, BS, Zhenjun Ma, PhD, Richard R Reich, PhD, Eric Padron, MD, Alan F List, MD

Blood (2016) 128 (22): 3174.

https://doi.org/10.1182/blood.V128.22.3174.3174

Published: 2016

Journal Articles

NLRP3 Inflammasome-Derived ASC Specks Are a Diagnostic Biomarker for Myelodysplastic Syndromes (MDS)

Ashley A Basiorka, Zhenjun Ma, PhD, Kathy L Mcgraw, PhD, David Sallman, MD, Brittany A Irvine, Najla H Al Ali, Eric Padron, MD, Javier Pinilla-Ibarz, MD PhD, Rami S. Komrokji, MD, Lubomir Sokol, Sheng Wei, Alan F List, MD

Blood (2016) 128 (22): 2005.

https://doi.org/10.1182/blood.V128.22.2005.2005

Published: 2016

Journal Articles

Combined Treatment with Lenalidomide (LEN) and Epoetin Alfa (EA) Is Superior to Lenalidomide Alone in Patients with Erythropoietin (Epo)-Refractory, Lower Risk (LR) Non-Deletion 5q [Del(5q)] Myelodysplastic Syndrome (MDS): Results of the E2905 Intergroup Study-an ECOG-ACRIN Cancer Research Group Study, Grant CA180820, and the National Cancer Institute of the National Institutes of Health

Alan F List, MD, Zhuoxin Sun, PhD, Amit Verma, MD, John M. Bennett, MD, Kathy L McGraw, PhD, Lisa Ann Nardelli, BS, Jaroslaw P Maciejewski, MD PhD FACP, Jessica K Altman, MD, Puneet Cheema, MD, David F. Claxton, MD, Rami S. Komrokji, MD, Selina Luger, MD, Ryan Mattison, MD, Tim Wassenaar, MD, Andrew Artz, MD, Charles A Schiffer, MD, Martin S. Tallman, MD

Blood (2016) 128 (22): 223.

https://doi.org/10.1182/blood.V128.22.223.223

Published: 2016

Journal Articles

EZH2 Protein Expression Is Decreased in MDS and MDS/MPN and Correlated with EZH2 Mutation Status, Chromosomal 7 Abnormalities and Clinical Outcome

Kathy L Mcgraw, PhD, Johnny Nguyen, Najla Alali, MS, Jinming Song, MD PhD, David Sallman, MD, Eric Padron, MD, Jeffrey E. Lancet, MD, Daihui Qin, P.K. Epling-Burnette, PhD, Lynn C. Moscinski, MD, Rami S. Komrokji, MD, Alan F List, MD, Ling Zhang, MD

Blood (2016) 128 (22): 4305.

https://doi.org/10.1182/blood.V128.22.4305.4305

Published: 2016

Journal Articles

P53 Protein Overexpression By Immunohistochemical Staining Is Correlated with TP53 Mutation Burden and Adverse Clinical Outcome in Myelodysplastic Syndromes

Nguyen Johnny, MD, Kathy L McGraw, PhD, Rami S. Komrokji, MD, David Sallman, MD, Najla H. Al Ali, BDS, MSc, Eric Padron, MD, Jeffrey E Lancet, MD, Lynn C. Moscinski, MD, Alan F. List, MD, Ling Zhang, MD

Blood (2015) 126 (23): 4121.

https://doi.org/10.1182/blood.V126.23.4121.4121

Published: 2015

Journal Articles

NLRP3 Inflammosome Polymorphisms Are Enriched in Myelodysplastic Syndrome Patients with Autoimmune Disorders

Syed A Mian, BSc, M.Phil, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Aytug Kizilors, PhD, Kathy L McGraw, PhD, Shahram Kordasti, MD PhD, Stephan Menzel, PhD, Alexander e Smith, PhD, Pilar Perezabellan, BSc, David Sallman, MD, Alan F. List, MD, Ghulam J Mufti, FRCP, FRCPath

Blood (2015) 126 (23): 1659.

https://doi.org/10.1182/blood.V126.23.1659.1659

Published: 2015

Journal Articles

Inflammaging-Associated Metabolic Alterations Foster Development of the MDS Genotype

Sheng Wei, MD, Erika Adriana Eksioglu, PhD MS, Xianghong Chen, PhD, Thomas Cluzeau, MDPhD, Ashley Basiorka, Alexis Burnette, Max Wei, Kathy L McGraw, PhD, Eric Padron, MD, Alan F. List, MD

Blood (2015) 126 (23): 144.

https://doi.org/10.1182/blood.V126.23.144.144

Published: 2015

Journal Articles

The Proinflammatory Protein S100A9 Suppresses Erythropoietin Elaboration in Patients with Myelodysplastic Syndromes

Thomas Cluzeau, MDPhD, Kathy L McGraw, PhD, Brittany Irvine, Erico Masala, Lionel Ades, MD PhD, Ashley A Basiorka, Ghulam J Mufti, FRCP, FRCPath, Jaroslaw P. Maciejewski, MD PhD, Sheng Wei, MD, Pierre Fenaux, MD PhD, Valeria Santini, MD, Alan F. List, MD

Blood (2015) 126 (23): 355.

https://doi.org/10.1182/blood.V126.23.355.355

Published: 2015

Journal Articles

Targeted Re-Sequencing Analysis of 31 Genes Commonly Mutated in Myeloid Disorders in Serial Samples from Myelodysplastic Syndrome Patients with Disease Progression

Andrea Pellagatti, Cristina Di Genua, Swagata Roy, Adam Burns, BSc, Kathy L McGraw, PhD, Maria José Larrayoz, Marta Fernandez-Mercado, Simona Valletta, Joanne Mason, PhD, Sally Killick, Cristina Mecucci, MD PhD, Maria José Calasanz, Alan F. List, MD, Anna Schuh, MDPhD, Jacqueline Boultwood, PhD

Blood (2014) 124 (21): 1901.

https://doi.org/10.1182/blood.V124.21.1901.1901

Published: 2014

Journal Articles

Lenalidomide Induces Lipid Raft Assembly to Enhance Erythropoietin Receptor Signaling in Myelodysplastic Syndrome Progenitors

Kathy L McGraw, PhD, Ashley A Basiorka, Joseph Johnson, Justine Clark, Gisela Caceres, Eric Padron, MD, Ruth Heaton, Yukiyasu Ozawa, MD PhD, Sheng Wei, MD, Lubomir Sokol, MD PhD, Alan F List, MD

Blood (2014) 124 (21): 4623.

https://doi.org/10.1182/blood.V124.21.4623.4623

Published: 2014

Journal Articles

Lenalidomide Upregulates Erythropoietin Receptor Expression Through Inhibition of the E3-Ubiquitin Ligase Ring Finger Protein 41 (RNF41)

Ashley A. Basiorka, Kathy L. McGraw, Lori N. Griner, Ling Zhang, MD, Leentje De Ceuninck, Gisela Caceres, Lubomir Sokol, MD, Ph.D, Rami S. Komrokji, MD, Sheng Wei, MD, Jan Tavernier, Ph.D., Alan F. List, MD

Blood (2012) 120 (21): 3455.

https://doi.org/10.1182/blood.V120.21.3455.3455

Published: 2012

NARROW

KPT-8602 Induced Hematopoietic Differentiation in U2AF1 S34F Mutant Cells and Myelodysplastic Syndromes Bone Marrow Stem and Progenitor Cells

Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions

TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype

SNP-Array Genome Wide Association Study Meta-Analysis Identifies Innate Immune Susceptibility Loci Associated with Non-Del(5q) Myelodysplastic Syndromes Predisposition

Genomic-DNA Exposed By Somatic Gene Mutations Engages the cGAS/STING Axis to License the NLRP3 Inflammasome in Myelodysplastic Syndromes

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Phase 1b/2 Combination Study of APR-246 and Azacitidine (AZA) in Patients with TP53 mutant Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Phase 2 Trial of Smoothened (SMO) Inhibitor PF-04449913 (PF-04) in Refractory Myelodysplastic Syndromes (MDS)

NLRP3 Inflammasome-Derived ASC Specks Are a Diagnostic Biomarker for Myelodysplastic Syndromes (MDS)

EZH2 Protein Expression Is Decreased in MDS and MDS/MPN and Correlated with EZH2 Mutation Status, Chromosomal 7 Abnormalities and Clinical Outcome

P53 Protein Overexpression By Immunohistochemical Staining Is Correlated with TP53 Mutation Burden and Adverse Clinical Outcome in Myelodysplastic Syndromes

NLRP3 Inflammosome Polymorphisms Are Enriched in Myelodysplastic Syndrome Patients with Autoimmune Disorders

Inflammaging-Associated Metabolic Alterations Foster Development of the MDS Genotype

The Proinflammatory Protein S100A9 Suppresses Erythropoietin Elaboration in Patients with Myelodysplastic Syndromes

Targeted Re-Sequencing Analysis of 31 Genes Commonly Mutated in Myeloid Disorders in Serial Samples from Myelodysplastic Syndrome Patients with Disease Progression

Lenalidomide Induces Lipid Raft Assembly to Enhance Erythropoietin Receptor Signaling in Myelodysplastic Syndrome Progenitors

Lenalidomide Upregulates Erythropoietin Receptor Expression Through Inhibition of the E3-Ubiquitin Ligase Ring Finger Protein 41 (RNF41)

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American Society of Hematology

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American Society of Hematology

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