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Journal Articles

MYC-Alarmin Axis As a Novel Oncogenic Driver in a Subgroup of Triple Negative Myeloproliferative Neoplasms

Blood (2023) 142 (Supplement 1): 994.

https://doi.org/10.1182/blood-2023-174383

Published: 2023

Journal Articles

CAR-T Phenotype and Efficacy Is Impaired By Lymphoma-Associated CD39 + T Cells

Blood (2023) 142 (Supplement 1): 3500.

https://doi.org/10.1182/blood-2023-178113

Published: 2023

Journal Articles

C-MYC Augments the Proliferation and Survival of Hematopoietic Stem Cells and Multipotent Progenitors to Drive Myeloproliferative Neoplasms

Nicole D. Vincelette, Jungwon Moon, Andrew T. Kuykendall, Ling Zhang, Rami S. Komrokji, Daniel Murphy, John L. Cleveland, Seongseok Yun

Blood (2021) 138 (Supplement 1): 28.

https://doi.org/10.1182/blood-2021-146399

Published: 2021

Journal Articles

TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype

Blood (2020) 136 (24): 2812–2823.

https://doi.org/10.1182/blood.2020006158

Published: 2020

Includes: Supplemental data

Journal Articles

Tfeb Links MYC Signaling to Epigenetic Control of Acute Myeloid Leukemia Cell Death and Differentiation

Blood (2020) 136 (Supplement 1): 12–13.

https://doi.org/10.1182/blood-2020-137209

Published: 2020

Journal Articles

Cereblon harnesses Myc-dependent bioenergetics and activity of CD8 + T lymphocytes

Blood (2020) 136 (7): 857–870.

https://doi.org/10.1182/blood.2019003257

Published: 2020

Includes: Supplemental data

Journal Articles

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Blood (2016) 128 (25): 2960–2975.

https://doi.org/10.1182/blood-2016-07-730556

Published: 2016

Includes: Supplemental data

Journal Articles

Identification of Target Pathways Induced By the Multiple Myeloma Tumor Microenvironment Using Activity-Based Protein Profiling and Ex Vivo Protein Kinase Inhibitor Screening

Mark B Meads, PhD, Paula Oliveira, BS, Allison Distler, B.S., Maria Silva, M.Sc, Karen Burger, PhD, Bin Fang, PhD, Aunshka Collins, BS, John L. Cleveland, PhD, John M. Koomen, PhD, Ariosto Silva, PhD, Dmitri Rebatchouk, PhD, Kenneth H. Shain, MD PhD, William R. Roush, PhD

Blood (2016) 128 (22): 3288.

https://doi.org/10.1182/blood.V128.22.3288.3288

Published: 2016

Journal Articles

A CK1δ/CK1ε-to-Wnt/β-Catenin Circuit Is a Therapeutic Vulnerability in Primary and Drug Resistant Multiple Myeloma

Karen L. Burger, PhD, Mark B Meads, PhD, Ariosto Silva, PhD, Allison Distler, B.S., Maria Coelho Siqueira Silva, Timothy Jacobson, B.S., Jamie K Teer, PhD, William R. Roush, PhD, Kenneth H. Shain, MD PhD, John L. Cleveland, PhD

Blood (2016) 128 (22): 2094.

https://doi.org/10.1182/blood.V128.22.2094.2094

Published: 2016

Journal Articles

Myc-Directed Suppression of Autophagy Provides Therapeutic Vulnerabilities Targeting Amino Acid Homeostasis

Franz X Schaub, Weimin Li, Mohammad Fallahi, Chunying Yang, Stephanie K Schaub, Soyoung Lee, Alexandar Tzankov, Clemens Schmitt, Antonio L Amelio, John L. Cleveland

Blood (2015) 126 (23): 2450.

https://doi.org/10.1182/blood.V126.23.2450.2450

Published: 2015

Journal Articles

Myc Commands an Aurora Kinase – Sumoylation Circuit Required for B Cell Lymphoma Growth and Survival

Alexander Hoellein, MD, Stephanie Schoeffmann, Fallahi Mohammad, PhD, John L Cleveland, PhD, Johannes Gloeckner, PhD, Marius Ueffing, PhD, Martina Rudelius, MD, Christian Peschel, MD, Ulrich Keller, MD

Blood (2014) 124 (21): 3107.

https://doi.org/10.1182/blood.V124.21.3107.3107

Published: 2014

Journal Articles

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

Alexander Hoellein, Mohammad Fallahi, Stephanie Schoeffmann, Sabine Steidle, Franz X. Schaub, Martina Rudelius, Iina Laitinen, Lisa Nilsson, Andrei Goga, Christian Peschel, Jonas A. Nilsson, John L. Cleveland, Ulrich Keller

Blood (2014) 124 (13): 2081–2090.

https://doi.org/10.1182/blood-2014-06-584524

Published: 2014

Includes: Supplemental data

Journal Articles

Activated Sumoylation Is a Hallmark Of Burkitt's Lymphoma and MYC Driven Cancer Leading To Synthetic Lethal Interactions With Sumoylation Inhibitors

Alexander Hoellein, MD, Sabine Steidle, MD, Mohammad Fellahi, PhD, Stephanie Schoeffmann, Martina Rudelius, MD, Christian Peschel, John L Cleveland, Ulrich Keller

Blood (2013) 122 (21): 3783.

https://doi.org/10.1182/blood.V122.21.3783.3783

Published: 2013

Journal Articles

Tfeb Functions As a Tumor Suppressor That Harnesses Myc-Induced Lymphomagenesis By Provoking Senescence and Metabolic Catastrophe

Franz X Schaub, Mohammad Fallahi, Weimin Li, Stephanie K Demetriou, Chunying Yang, Antonio L Amelio, John L Cleveland

Blood (2013) 122 (21): 3784.

https://doi.org/10.1182/blood.V122.21.3784.3784

Published: 2013

Journal Articles

Mitochondrial dysfunction in ataxia-telangiectasia

Yasmine A. Valentin-Vega, Kirsteen H. MacLean, Jacqueline Tait-Mulder, Sandra Milasta, Meredith Steeves, Frank C. Dorsey, John L. Cleveland, Douglas R. Green, Michael B. Kastan

Blood (2012) 119 (6): 1490–1500.

https://doi.org/10.1182/blood-2011-08-373639

Published: 2012

Includes: Supplemental data

Journal Articles

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

Jürgen den Hollander, Sara Rimpi, Joanne R. Doherty, Martina Rudelius, Andreas Buck, Alexander Hoellein, Marcus Kremer, Nikolas Graf, Markus Scheerer, Mark A. Hall, Andrei Goga, Nikolas von Bubnoff, Justus Duyster, Christian Peschel, John L. Cleveland, Jonas A. Nilsson, Ulrich Keller

Blood (2010) 116 (9): 1498–1505.

https://doi.org/10.1182/blood-2009-11-251074

Published: 2010

Includes: Supplemental data

Journal Articles

Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation

Ji Zhang, Mindy S. Randall, Melanie R. Loyd, Frank C. Dorsey, Mondira Kundu, John L. Cleveland, Paul A. Ney

Blood (2009) 114 (1): 157–164.

https://doi.org/10.1182/blood-2008-04-151639

Published: 2009

Includes: Supplemental data

Journal Articles

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA

Steffan T. Nawrocki, Jennifer S. Carew, Kirsteen H. Maclean, James F. Courage, Peng Huang, Janet A. Houghton, John L. Cleveland, Francis J. Giles, David J. McConkey

Blood (2008) 112 (7): 2917–2926.

https://doi.org/10.1182/blood-2007-12-130823

Published: 2008

Includes: Supplemental data

Journal Articles

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl–mediated drug resistance

Jennifer S. Carew, Steffan T. Nawrocki, Charissa N. Kahue, Hui Zhang, Chunying Yang, Linda Chung, Janet A. Houghton, Peng Huang, Francis J. Giles, John L. Cleveland

Blood (2007) 110 (1): 313–322.

https://doi.org/10.1182/blood-2006-10-050260

Published: 2007

Includes: Supplemental data

Journal Articles

Myc Promotes Tumorigenesis by Supressing Nfkb2.

Ulrich Keller, MD, Juergen Huber, Jonas Nilsson, PhD, Mark Hall, PhD, Christian Peschel, MD, John L. Cleveland, PhD

Blood (2006) 108 (11): 1422.

https://doi.org/10.1182/blood.V108.11.1422.1422

Published: 2006

NARROW

MYC-Alarmin Axis As a Novel Oncogenic Driver in a Subgroup of Triple Negative Myeloproliferative Neoplasms

CAR-T Phenotype and Efficacy Is Impaired By Lymphoma-Associated CD39 + T Cells

C-MYC Augments the Proliferation and Survival of Hematopoietic Stem Cells and Multipotent Progenitors to Drive Myeloproliferative Neoplasms

TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype

Tfeb Links MYC Signaling to Epigenetic Control of Acute Myeloid Leukemia Cell Death and Differentiation

Cereblon harnesses Myc-dependent bioenergetics and activity of CD8 + T lymphocytes

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Identification of Target Pathways Induced By the Multiple Myeloma Tumor Microenvironment Using Activity-Based Protein Profiling and Ex Vivo Protein Kinase Inhibitor Screening

A CK1δ/CK1ε-to-Wnt/β-Catenin Circuit Is a Therapeutic Vulnerability in Primary and Drug Resistant Multiple Myeloma

Myc-Directed Suppression of Autophagy Provides Therapeutic Vulnerabilities Targeting Amino Acid Homeostasis

Myc Commands an Aurora Kinase – Sumoylation Circuit Required for B Cell Lymphoma Growth and Survival

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

Activated Sumoylation Is a Hallmark Of Burkitt's Lymphoma and MYC Driven Cancer Leading To Synthetic Lethal Interactions With Sumoylation Inhibitors

Tfeb Functions As a Tumor Suppressor That Harnesses Myc-Induced Lymphomagenesis By Provoking Senescence and Metabolic Catastrophe

Mitochondrial dysfunction in ataxia-telangiectasia

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl–mediated drug resistance

Myc Promotes Tumorigenesis by Supressing Nfkb2.

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American Society of Hematology

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American Society of Hematology

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