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Meghan Menges
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Journal Articles

Tumor burden quantified by Soluble B-Cell Maturation Antigen and Metabolic Tumor Volume determine myeloma CAR-T outcomes

Ciara L Freeman, Jerald Noble, Meghan Menges, Ricardo Villanueva, Justyn Y Nakashima, Nicholas B Figura, R. Petter Tonseth, Dietrich Werner Idiaquez, Lawrence Skelson, Eric C Smith, Julieta Abraham-Miranda, Salvatore Corallo, Gabriel De Avila, Omar Castaneda Puglianini, Hien D Liu, Melissa Alsina, Taiga Nishihori, Kenneth H Shain, Rachid C Baz, Brandon J Blue, Ariel Grajales-Cruz, John M. Koomen, Reginald M Atkins, Doris K Hansen, Ariosto Siqueira Silva, Jongphil Kim, Yoganand Balagurunathan, Frederick L Locke
Journal: Blood
Blood blood.2024024965.
https://doi.org/10.1182/blood.2024024965
Published: 2024
Includes: Supplemental data
Journal Articles

Comprehensive Analysis of Pre-Treatment Biomarkers Associated with Toxicity and Durable Responses in Idecabtagene Vicleucel Therapy for Relapsed/Refractory Multiple Myeloma

Doris K. Hansen, Ciara Louise Freeman, Meghan Menges, Brett Reid, Julieta Abraham-Miranda, Kayla Reid, Luis Cuadrado Delgado, Gabriel De Avila, Laura B. Oswald, Ariel F. Grajales-Cruz, Brandon Blue, Rebecca Gonzalez, Salvatore Corallo, David R. Noyes, Mark B. Meads, Hien Liu, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Melissa Alsina, Omar Castaneda, Frederick L. Locke, Lauren C. Peres
Journal: Blood
Blood (2024) 144 (Supplement 1): 896.
https://doi.org/10.1182/blood-2024-197929
Published: 2024
Journal Articles

Exercise Prehabilitation for Older Adults Undergoing CAR-T: Feasibility and Preliminary Outcomes from a Single-Arm Pilot Study

Nathan Parker, Morgan Bean, Mart Theodore De Vera, Rachel Carmella, Jessica McCoy, Salvatore Corallo, Luis Cuadrado Delgado, Meghan Menges, Omar Castaneda, Julio C. Chavez, Rawan Faramand, Michael D. Jain, Heather S.L. Jim, Aleksandr Lazaryan, Sayeef Mirza, Laura B. Oswald, Bijal D Shah, Frederick L. Locke, Ciara Louise Freeman
Journal: Blood
Blood (2024) 144 (Supplement 1): 7224.
https://doi.org/10.1182/blood-2024-208557
Published: 2024
Journal Articles

Genomic Determinants of Resistance to Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) Therapies in Patients with Relapsed/Refractory Multiple Myeloma

Francesco Maura, Ciara Louise Freeman, Holly Lee, Kylee H Maclachlan, Michael Durante, Bachisio Ziccheddu, Meghan Menges, Benjamin Diamond, Marios Papadimitriou, Ariosto Siqueira Silva, Praneeth Reddy Sudalagunta, Noemie Leblay, Sungwoo Ahn, Ethan Fuller, Edward Briercheck, Phaedra Agius, Doris K. Hansen, Xiaofei Song, Xiaohong Zhao, Mark B. Meads, Jamie Teer, Ross S Firestone, Juan-Jose Garces, Tomas Jelinek, Rachid Baz, Melissa Alsina, Anusuyam Ramasubramanian, Eric Smith, Sergio Giralt, Sham Mailankody, Paola Neri, Saad Z. Usmani, Frederick Locke, Nizar J. Bahlis, Ola Landgren, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 247.
https://doi.org/10.1182/blood-2024-201288
Published: 2024
Journal Articles

Single-Cell Analysis of CAR-T Cell Products Idecabtagene Vicleucel and Ciltacabtagene Autoleucel Reveals Factors That Influence Clinical Outcomes

Jerald Noble, Xiaofei Song, Meghan Menges, Julieta Abraham-Miranda, Salvatore Corallo, Gabriel De Avila, Omar Puglianini, Hien Liu, Melissa Alsina, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Brandon Blue, Ariel Grajales-Cruz, Doris K. Hansen, Reginald Atkins, Frederick L. Locke, Ciara Louise Freeman
Journal: Blood
Blood (2024) 144 (Supplement 1): 7173.
https://doi.org/10.1182/blood-2024-208709
Published: 2024
Journal Articles

Intrinsic Tumor Drivers and Immune Escape Mechanisms in CD19 CAR T-Cell Therapy Resistance for Aggressive Large B Cell Lymphoma

Bachisio Ziccheddu, Michael D. Jain, Monika Chojnacka, Michael Durante, Venu Venkatarame Gowda Saralamma, Austin Daniel Newsam, Jerald Noble, Nicholas B Figura, Meghan Menges, Ola Landgren, Marco Davila, Jonathan H. Schatz, Francesco Maura, Frederick L. Locke
Journal: Blood
Blood (2024) 144 (Supplement 1): 232.
https://doi.org/10.1182/blood-2024-208372
Published: 2024
Journal Articles

Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy

Rishika Prasad, Abdur Rehman, Lubna Rehman, Faezeh Darbaniyan, Viktoria Blumenberg, Maria-Luisa Schubert, Uria Mor, Eli Zamir, Sabine Schmidt, Tomo Hayase, Chang Chia-Chi, Lauren Kelley McDaniel, Ivonne Flores, Paolo Strati, Ranjit Nair, Dai Chihara, Luis E. Fayad, Sairah Ahmed, Swaminathan P. Iyer, Michael L Wang, Preetesh Jain, Loretta J. Nastoupil, Jason R Westin, Reetakshi Arora, Joel Gordon Turner, Fareed Khawaja, Ranran Wu, Jennifer B Dennison, Meghan Menges, Melanie Hidalgo-Vargas, Kayla M. Reid, Marco L. Davila, Peter Dreger, Felix Korell, Anita Schmitt, Mark R Tanner, Richard E. Champlin, Christopher R. Flowers, Elizabeth J Shpall, Samir Hanash, Sattva S. Neelapu, Michael Schmitt, Marion Subklewe, Johannes Fahrmann, Christoph Stein-Thoeringer, Eran Elinav, Michael D Jain, Eiko Hayase, Robert R Jenq, Neeraj Y Saini
Journal: Blood
Blood blood.2024025366.
https://doi.org/10.1182/blood.2024025366
Published: 2024
Includes: Supplemental data
Journal Articles

Cladribine and Cyclophosphamide Lymphodepletion Prior to Axicabtagene Ciloleucel in Relapsed or Refractory Large B-Cell Lymphoma

Filip Ionescu, Bijal D. Shah, Meghan Menges, Kayla Reid, Hanna Bailey, Elizabeth DiMaggio, Rebecca Gonzalez, Christina A Bachmeier, Salvatore Corallo, Luis Cuadrado Delgado, Turab Mohammed, Taiga Nishihori, Farhad Khimani, Aleksandr Lazaryan, Hien Liu, Marco Davila, Fabiana Perna, Julio C Chavez, Frederick L. Locke, Michael D. Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 4884.
https://doi.org/10.1182/blood-2023-187078
Published: 2023
Journal Articles

Poor Hematopoietic Reserve at the Time of CD19 CAR T-Cell Infusion Is Associated with Long Term B-Cell Aplasia

Grace Johnson, Kedar Patel, Brian Arciola, Ariel Perez Perez, Anthony Wood, Filip Ionescu, Jennifer M Logue, Omar Albanyan, Hassaan Yasin, Christina A Bachmeier, Kayla Reid, Meghan Menges, Salvatore Corallo, Bijal D. Shah, Julio C Chavez, Farhad Khimani, Taiga Nishihori, Rawan Faramand, Hien Liu, Aleksandr Lazaryan, Kai Rejeski, Marion Subklewe, Fabiana Perna, Marco Davila, Rahul Mhaskar, Frederick L. Locke, Michael D. Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 3512.
https://doi.org/10.1182/blood-2023-185097
Published: 2023
Journal Articles

CAR-T Phenotype and Efficacy Is Impaired By Lymphoma-Associated CD39 + T Cells

Michael D. Jain, Xiaoqing Yu, Reginald Atkins, Joel G. Turner, Jerald Noble, Meghan Menges, Kayla Reid, Salvatore Corallo, Ling Cen, Sean J. Yoder, Julieta Abraham Miranda, Samira Naderinezhad, Hien Liu, Bijal D. Shah, Julio C Chavez, Erin Dean, Johannes Fahrmann, Neeraj Y. Saini, Samir Hanash, Rebecca S. Hesterberg, Paulo C. Rodriguez, John L. Cleveland, Marco Davila, Xuefeng Wang, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 3500.
https://doi.org/10.1182/blood-2023-178113
Published: 2023
Journal Articles

Clinical Impact of Neoantigen Burden and HLA Loss in Aggressive B-Cell Lymphomas Treated with CD19 CAR T-Cell

Bachisio Ziccheddu, Michael D. Jain, Monika Chojnacka, Michael Durante, Julieta Abraham Miranda, Meghan Menges, Ola Landgren, Marco Davila, Jonathan H. Schatz, Francesco Maura, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 4362.
https://doi.org/10.1182/blood-2023-182821
Published: 2023
Journal Articles

Paired Analysis from Patients with Myeloma Elucidates Favorable CAR-T Manufacture and Phenotype, Starting from Mobilized Pre-Transplant Apheresis Vs. Non-Mobilized Apheresis after Four Prior Lines

Ciara Louise L. Freeman, Julieta Abraham Miranda, Meghan Menges, Jerald Noble, Hien Liu, Salvatore Corallo, Albert J Ribickas, Constanza Savid-Frontera, Gabriel De Avila, Omar Castaneda, Jose L. Ochoa-Bayona, Rachid Baz, Doris K. Hansen, Melissa Alsina, Kenneth H. Shain, Taiga Nishihori, Reginald Atkins, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 1931.
https://doi.org/10.1182/blood-2023-187539
Published: 2023
Journal Articles

CD19 Intron Retention Is Mechanism of CAR-T Treatment Resistance in Non-Hodgkin Lymphoma

Jerald Noble, Frederick L. Locke, Constanza Savid-Frontera, Michael D. Jain, Joel G. Turner, Julieta Abraham Miranda, Thushara W Madanayake, Samira Naderinezhad, Salvatore Corallo, Meghan Menges, Kayla Reid, Timothy J Robinson
Journal: Blood
Blood (2023) 142 (Supplement 1): 3506.
https://doi.org/10.1182/blood-2023-185074
Published: 2023
Journal Articles

Expression of Cell Surface Immunotherapy Targets across the Multiple Myeloma Disease Spectrum: Implications for Sequencing and Multi-Target Strategies

Ciara Louise L. Freeman, Meghan Menges, Jerald Noble, Raghunandan Reddy Alugubelli, Rafael Renatino-Canevarolo, Oliver Hampton, Praneeth Reddy Sudalagunta, Salvatore Corallo, Ariosto Siqueira Silva, Mark B Meads, Rachid Baz, Melissa Alsina, Doris K. Hansen, Taiga Nishihori, Omar Castaneda, Brandon Blue, Ariel F. Grajales-Cruz, Yunfei Wang, Patrick Hwu, John Koomen, Kenneth H. Shain, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 4678.
https://doi.org/10.1182/blood-2023-185930
Published: 2023
Journal Articles

Whole-genome sequencing reveals complex genomic features underlying anti-CD19 CAR T-cell treatment failures in lymphoma

Michael D. Jain, Bachisio Ziccheddu, Caroline A. Coughlin, Rawan Faramand, Anthony J. Griswold, Kayla M. Reid, Meghan Menges, Yonghong Zhang, Ling Cen, Xuefeng Wang, Mohammad Hussaini, Ola Landgren, Marco L. Davila, Jonathan H. Schatz, Frederick L. Locke, Francesco Maura
Journal: Blood
Blood (2022) 140 (5): 491–503.
https://doi.org/10.1182/blood.2021015008
Published: 2022
Includes: Supplemental data
Journal Articles

Tumor interferon signaling and suppressive myeloid cells are associated with CAR T-cell failure in large B-cell lymphoma

Michael D. Jain, Hua Zhao, Xuefeng Wang, Reginald Atkins, Meghan Menges, Kayla Reid, Kristen Spitler, Rawan Faramand, Christina Bachmeier, Erin A. Dean, Biwei Cao, Julio C. Chavez, Bijal Shah, Aleksandr Lazaryan, Taiga Nishihori, Mohammed Hussaini, Ricardo J. Gonzalez, John E. Mullinax, Paulo C. Rodriguez, Jose R. Conejo-Garcia, Claudio Anasetti, Marco L. Davila, Frederick L. Locke
Journal: Blood
Blood (2021) 137 (19): 2621–2633.
https://doi.org/10.1182/blood.2020007445
Published: 2021
Includes: Supplemental data