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Saad Z. Usmani
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Journal Articles

Efficacy and safety of teclistamab in patients with relapsed/refractory multiple myeloma after BCMA-targeting therapies

Clinical Trials & Observations
Cyrille Touzeau, Amrita Y. Krishnan, Philippe Moreau, Aurore Perrot, Saad Z. Usmani, Salomon Manier, Michele Cavo, Carmen Martinez Chamorro, Ajay K. Nooka, Thomas G. Martin, Lionel Karlin, Xavier Leleu, Nizar J. Bahlis, Britta Besemer, Lixia Pei, Sarah Stein, Shun Xin Wang Lin, Danielle Trancucci, Raluca I. Verona, Suzette Girgis, Xin Miao, Clarissa M. Uhlar, Katherine Chastain, Alfred L. Garfall
Journal: Blood
Blood (2024) 144 (23): 2375–2388.
https://doi.org/10.1182/blood.2023023616
Published: 2024
Includes: Supplemental data
Journal Articles

Impact of Daratumumab Refractoriness on Clinical Outcomes Following CAR T-Cell Therapy for Relapsed/Refractory Multiple Myeloma

Sridevi Rajeeve, Bruno Almeida Costa, Eric M Jurgens, Noriko Nishimura, Tasmin Farzana, Ross S Firestone, Kevin Miller, Alexander M. Lesokhin, Gunjan L. Shah, Neha Korde, Carlyn Rose Tan, David J. Chung, Heather J. Landau, Michael Scordo, Hani Hassoun, Kylee H Maclachlan, Urvi A. Shah, Malin Hultcrantz, Issam S. Hamadeh, Sergio Giralt, Sham Mailankody, Saad Z. Usmani, Hamza Hashmi
Journal: Blood
Blood (2024) 144 (Supplement 1): 7090.
https://doi.org/10.1182/blood-2024-206511
Published: 2024
Journal Articles

Belantamab Mafodotin , nirogacestat and Pomalidomide for Patients with Relapsed/Refractory Multiple Myeloma

Malin Hultcrantz, Hani Hassoun, Carlyn Rose Tan, Neha Korde, Alexander M. Lesokhin, Hamza Hashmi, Kylee H Maclachlan, Sridevi Rajeeve, Urvi A. Shah, Dhwani Patel, Andriy Derkach, Selena Hamid, Tala Shekarkhand, Linh Tran, Julia Caple, Kelly Barnett, Tara Sood, Blaslov Jenna, Amanda Konsky, Kazunori Murata, Mikhail Roshal, Sergio A. Giralt, Saad Z. Usmani, Sham Mailankody
Journal: Blood
Blood (2024) 144 (Supplement 1): 7077.
https://doi.org/10.1182/blood-2024-211857
Published: 2024
Journal Articles

Infectious Complications during Treatment with Commercial CAR T-Cell Therapy and Bispecific Antibodies for Relapsed/Refractory Multiple Myeloma

Eric M Jurgens, Tala Shekarkhand, Tasmin Farzana, Colin Rueda, David Nemirovsky, Andriy Derkach, Ross S Firestone, Noriko Nishimura, Kevin Miller, Bruno Almeida Costa, Karthik Nath, Sridevi Rajeeve, Alexander M. Lesokhin, Neha Korde, Carlyn Rose Tan, Hamza Hashmi, Hani Hassoun, Kylee H Maclachlan, Urvi A. Shah, Malin Hultcrantz, Issam S. Hamadeh, Sergio A. Giralt, David J. Chung, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Saad Z. Usmani, Sham Mailankody, Zainab Shahid
Journal: Blood
Blood (2024) 144 (Supplement 1): 6935.
https://doi.org/10.1182/blood-2024-207977
Published: 2024
Journal Articles

Real-World Safety and Early Efficacy of Talquetamab in Patients with Heavily-Pretreated Relapsed/Refractory Multiple Myeloma

Bruno Almeida Costa, Carlyn Rose Tan, Tala Shekarkhand, Ross S Firestone, Eric M Jurgens, Kevin Miller, Alexander M. Lesokhin, Gunjan L. Shah, Neha Korde, Sridevi Rajeeve, David J. Chung, Heather J. Landau, Michael Scordo, Hani Hassoun, Kylee H Maclachlan, Urvi A. Shah, Malin Hultcrantz, Issam S. Hamadeh, Sergio Giralt, Sham Mailankody, Saad Z. Usmani, Hamza Hashmi
Journal: Blood
Blood (2024) 144 (Supplement 1): 7026.
https://doi.org/10.1182/blood-2024-206413
Published: 2024
Journal Articles

Defining the Rates of Cytokine Release Syndrome Associated with Talquetamab Step-up Doses

Issam S. Hamadeh, Tala Shekarkhand, Colin Rueda, Ross S Firestone, Alice X Wang, Neha Korde, Malin Hultcrantz, Alexander M. Lesokhin, Sham Mailankody, Hani Hassoun, Urvi A. Shah, Kylee H Maclachlan, Sridevi Rajeeve, Hamza Hashmi, Gunjan L. Shah, Michael Scordo, David J. Chung, Heather J. Landau, Sergio A. Giralt, Saad Z. Usmani, Carlyn Rose Tan
Journal: Blood
Blood (2024) 144 (Supplement 1): 6990.
https://doi.org/10.1182/blood-2024-209891
Published: 2024
Journal Articles

High WEE1 Expression Correlates with Poor Survival in Multiple Myeloma, Independent of Standard Prognostic Factors

Anish Kumar Simhal, Ross S Firestone, Jung Hun Oh, Larry Norton, Malin Hultcrantz, Saad Z. Usmani, Kylee H Maclachlan, Joseph O. Deasy
Journal: Blood
Blood (2024) 144 (Supplement 1): 6827.
https://doi.org/10.1182/blood-2024-205838
Published: 2024
Journal Articles

Body Mass Index Trajectory during Triplet Induction Therapy: Clinical Implications in Newly Diagnosed Multiple Myeloma

Ram Prakash Thirugnanasambandam, Ross S Firestone, Andriy Derkach, Helena Furberg, Tala Shekarkhand, Colin Rueda, Kylee H Maclachlan, Malin Hultcrantz, Sham Mailankody, Dhwani Patel, Oscar Boutros Lahoud, Heather J. Landau, David J. Chung, Gunjan L. Shah, Michael Scordo, Hani Hassoun, Alexander M. Lesokhin, Sergio Giralt, Neha Korde, Saad Z. Usmani, Carlyn Rose Tan, Urvi A. Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 6948.
https://doi.org/10.1182/blood-2024-201845
Published: 2024
Journal Articles

Comparison of Acute Kidney Injury in Patients with Relapsed or Refractory Multiple Myeloma Following CAR T-Cell and Bispecific Antibody Therapies

Noriko Nishimura, Sham Mailankody, David Nemirovsky, Andriy Derkach, Bruno Almeida Costa, Tasmin Farzana, Aisha Shaikh, Sheron Latcha, Victoria Gutgarts, Eric M Jurgens, Ross S Firestone, Karthik Nath, David J. Chung, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Roni Shouval, Hamza Hashmi, Hani Hassoun, Kylee H Maclachlan, Malin Hultcrantz, Neha Korde, Alexander M. Lesokhin, Urvi A. Shah, Carlyn Rose Tan, Sergio A. Giralt, Saad Z. Usmani, Sridevi Rajeeve
Journal: Blood
Blood (2024) 144 (Supplement 1): 6944.
https://doi.org/10.1182/blood-2024-212006
Published: 2024
Journal Articles

Mezigdomide (MEZI) in Novel-Novel Combinations for Relapsed or Refractory Multiple Myeloma (RRMM): Preliminary Results from the CA057-003 Trial

Luciano J. Costa, Fredrik Schjesvold, Rakesh Popat, David Siegel, Saad Z. Usmani, Syed Abbas Ali, Michael P. Chu, Monique A. Hartley-Brown, Nizar J. Bahlis, Albert Oriol, Joaquín Martínez Lopez, Enrique M. Ocio, Karthik Ramasamy, Donna Reece, Emma Searle, Allison Gaudy, Antonina Kurtova, Wen Zhang, Rafael Sarmiento, August Dietrich, Jessica Katz, Michael Pourdehnad, Paul G. Richardson
Journal: Blood
Blood (2024) 144 (Supplement 1): 677.
https://doi.org/10.1182/blood-2024-198403
Published: 2024
Journal Articles

Genomic Complexity Correlates with the Degree of Marrow Independence of Malignant Plasma Cells in the Context of Extramedullary Disease

Kylee H Maclachlan, Juan-Jose Garces, Tala Shekarkhand, Sridevi Rajeeve, Hamza Hashmi, Hani Hassoun, Malin Hultcrantz, Neha Korde, Carlyn Rose Tan, Sham Mailankody, Anish Simhal, David J. Chung, Gunjan L. Shah, Michael Scordo, Sergio Giralt, Alexandra Maria Poos, Lukas John, Yanming Zhang, Robert Cimera, Maria E. Arcila, Juan E Arango Ossa, Umesh Bhanot, Mala Jain, Tala Merghoub, Heather J. Landau, Alexander M. Lesokhin, Saad Z. Usmani, Niels Weinhold, Francesco Maura, Urvi A. Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 248.
https://doi.org/10.1182/blood-2024-204341
Published: 2024
Journal Articles

Genomic Determinants of Resistance to Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) Therapies in Patients with Relapsed/Refractory Multiple Myeloma

Francesco Maura, Ciara Louise Freeman, Holly Lee, Kylee H Maclachlan, Michael Durante, Bachisio Ziccheddu, Meghan Menges, Benjamin Diamond, Marios Papadimitriou, Ariosto Siqueira Silva, Praneeth Reddy Sudalagunta, Noemie Leblay, Sungwoo Ahn, Ethan Fuller, Edward Briercheck, Phaedra Agius, Doris K. Hansen, Xiaofei Song, Xiaohong Zhao, Mark B. Meads, Jamie Teer, Ross S Firestone, Juan-Jose Garces, Tomas Jelinek, Rachid Baz, Melissa Alsina, Anusuyam Ramasubramanian, Eric Smith, Sergio Giralt, Sham Mailankody, Paola Neri, Saad Z. Usmani, Frederick Locke, Nizar J. Bahlis, Ola Landgren, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 247.
https://doi.org/10.1182/blood-2024-201288
Published: 2024
Journal Articles

Whole Genome Sequencing Reveals Lower Apobec-Mutational Activity in Multiple Myeloma Patients with African Ancestry Compared with Those Having European Ancestry

Kylee H Maclachlan, Marios Papadimitriou, Patrick Blaney, Tala Shekarkhand, Timothy R. Chu, Alexandra Maria Poos, Elizabeth Brown, Antje Hoering, Benjamin Diamond, Bachisio Ziccheddu, Marc S. Raab, Niels Weinhold, Ola Landgren, Faith E Davies, Alexander M. Lesokhin, Saad Z. Usmani, Francesco Maura, Gareth Morgan
Journal: Blood
Blood (2024) 144 (Supplement 1): 766.
https://doi.org/10.1182/blood-2024-203675
Published: 2024
Journal Articles

Immune-MRD Status Informs Tumor-MRD Outcome Prognostication in Multiple Myeloma Patients on Lenalidomide Maintenance

Ross S Firestone, Anish Kumar Simhal, Devin McAvoy, Eric M Jurgens, Juan-José Garcés, David Nemirovsky, Andriy Derkach, Kylee H Maclachlan, Malin Hultcrantz, Sham Mailankody, Urvi A. Shah, Carlyn Rose Tan, Neha Korde, Hani Hassoun, Sridevi Rajeeve, Hamza Hashmi, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Sergio Giralt, Benjamin Diamond, Francesco Maura, Kinga K. Hosszu, David J. Chung, Ola Landgren, Saad Z. Usmani, Alexander M. Lesokhin
Journal: Blood
Blood (2024) 144 (Supplement 1): 672.
https://doi.org/10.1182/blood-2024-206646
Published: 2024
Journal Articles

A High-Fiber Dietary Intervention (NUTRIVENTION) in Precursor Plasma Cell Disorders Improves Biomarkers of Disease and May Delay Progression to Myeloma

Urvi A. Shah, Laura Lucia Cogrossi, Andriy Derkach, Francesca Castro, Teng Fei, Susan DeWolf, Juan-Jose Garces, Anna Policastro, Matteo Grioni, Sofia Sisti, Blaslov Jenna, Peter Adintori, Kinga K. Hosszu, Devin McAvoy, Mirae Baichoo, Justin Cross, Aishwarya Anuraj, Charlotte Pohl, Ruben Ramos, Jenny Paredes Sanchez, Brianna Gipson, Kylee H Maclachlan, Ana Gradissimo, Leonardo Boiocchi, Richard Koche, Ronan Chaligne, Torin Block, Neha Korde, Carlyn Rose Tan, Malin Hultcrantz, Hani Hassoun, Gunjan L. Shah, Michael Scordo, Oscar B Lahoud, David J. Chung, Heather J. Landau, Jonathan U. Peled, Nicola Clementi, Marta Chesi, P. Leif Bergsagel, Sham Mailankody, Michael Pollak, Anita D'Souza, Ola Landgren, Susan Chimonas, Sergio Giralt, Saad Z. Usmani, Neil M. Iyengar, Alexander M. Lesokhin, Matteo Bellone, Marcel R.M. van den Brink
Journal: Blood
Blood (2024) 144 (Supplement 1): 671.
https://doi.org/10.1182/blood-2024-202224
Published: 2024
Journal Articles

Phase I Study of Belantamab Mafodotin in Combination with Standard of Care in Transplant-Ineligible Newly Diagnosed Multiple Myeloma: Dreamm-9 Updated Interim Analysis

Saad Z. Usmani, Michal Mielnik, Mamta Garg, Irwindeep Sandhu, Al-Ola Abdallah, Youngil Koh, Albert Oriol, Hang Quach, Katja C. Weisel, Aranzazu Alonso Alonso, Enrique M Ocio, Wojciech Janowski, Chang-Ki Min, Karthik Ramasamy, Ricarda García Sánchez, Paula Rodríguez-Otero, Chris Brawley, Jacqueline L Egger, Morrys C Kaisermann, Marek Hus
Journal: Blood
Blood (2024) 144 (Supplement 1): 497.
https://doi.org/10.1182/blood-2024-198669
Published: 2024
Journal Articles

Phase 3 Randomized Study of Daratumumab (DARA) + Bortezomib, Lenalidomide and Dexamethasone (VRd) Versus Alone in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma or for Whom Transplant Is Not Planned As Initial Therapy: Analysis of Minimal Residual Disease in the Cepheus Trial

Sonja Zweegman, Thierry Facon, Vania Hungria, Nizar J. Bahlis, Christopher P. Venner, Marc Braunstein, Luděk Pour, Josep Marti Tutusaus, Supratik Basu, Yael C. Cohen, Morio Matsumoto, Kenshi Suzuki, Cyrille Hulin, Sebastian Grosicki, Wojciech Maciej Legiec, Meral Beksac, Angelo Maiolino, Hiroyuki Takamatsu, Aurore Perrot, Mehmet Turgut, Weiping Liu, Jianping Wang, Katherine Chastain, Jessica Vermeulen, Maria Krevvata, Lorena Lopez-Masi, Jodi Carey, Melissa Rowe, Robin Carson, Saad Z. Usmani
Journal: Blood
Blood (2024) 144 (Supplement 1): 362.
https://doi.org/10.1182/blood-2024-200871
Published: 2024
Journal Articles

CAR-Tography: Longitudinal Mapping of CAR-T Toxicities across B-Cell Malignancies Reveals Biologically Distinct and Prognostically Relevant Toxicity Phenotypes

Kai Rejeski, Teng Fei, Alejandro Luna, Mohammad Alhomoud, Yannis K. Valtis, Noriko Nishimura, Marina Gomez-Llobell, Noa Golan Accav, Ofrat Beyar-Katz, Sandeep S. Raj, Magdalena Corona, Alfredo Rivas-Delgado, Hamza Hashmi, Sridevi Rajeeve, Efrat Luttwak, Michael Scordo, Gunjan L. Shah, Maria Lia Palomba, Michael von Bergwelt-Baildon, Marion Subklewe, Abraham Avigdor, Ronit Marcus, Avichai Shimoni, Arnon Nagler, Tsila Zuckerman, Jabour Halloun, Uri Greenbaum, Sham Mailankody, Saad Z. Usmani, Gilles Salles, Jae H. Park, Miguel Angel Perales, Roni Shouval
Journal: Blood
Blood (2024) 144 (Supplement 1): 912.
https://doi.org/10.1182/blood-2024-203520
Published: 2024
Journal Articles

Enhanced Prognostic Value of the SKY92 Classifier over High-Risk Cytogenetic Aberrations in Multiple Myeloma: Results from the Prommis Real-World Study

Noa Biran, Binod Dhakal, Ruben Niesvizky, Suzanne Lentzsch, John T Mckay, David H. Vesole, Ajay K. Nooka, Barry Paul, Parameswaran N. Hari, Silvia D'Ambrosi, Rowan Kuiper, Martin H van Vliet, David S. Siegel, Saad Z. Usmani, Frits van Rhee
Journal: Blood
Blood (2024) 144 (Supplement 1): 1929.
https://doi.org/10.1182/blood-2024-209903
Published: 2024
Journal Articles

A Phase III Randomized Trial for Frail Newly Diagnosed Multiple Myeloma Patients Comparing Bortezomib- Lenalidomide-Dexamethasone (VRd-Lite followed by Len maintenance) with Daratumumab-Lenalidomide- Dexamethasone (DRd followed by Len+/- Dara Maintenance): SWOG S2209

Sikander Ailawadhi, Antje Hoering, J Christine Ye, Brea Lipe, Thomas R. Chauncey, Krisstina Gowin, David Calverley, Sarah A. Holstein, Erica L. Campagnaro, Adam Rosenthal, Jack Aiello, Saad Z. Usmani, Vincent Rajkumar, Robert Z. Orlowski
Journal: Blood
Blood (2024) 144 (Supplement 1): 3381.3.
https://doi.org/10.1182/blood-2024-209626
Published: 2024