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Alexandra Maria Poos
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Journal Articles

Genomic Complexity Correlates with the Degree of Marrow Independence of Malignant Plasma Cells in the Context of Extramedullary Disease

Kylee H Maclachlan, Juan-Jose Garces, Tala Shekarkhand, Sridevi Rajeeve, Hamza Hashmi, Hani Hassoun, Malin Hultcrantz, Neha Korde, Carlyn Rose Tan, Sham Mailankody, Anish Simhal, David J. Chung, Gunjan L. Shah, Michael Scordo, Sergio Giralt, Alexandra Maria Poos, Lukas John, Yanming Zhang, Robert Cimera, Maria E. Arcila, Juan E Arango Ossa, Umesh Bhanot, Mala Jain, Tala Merghoub, Heather J. Landau, Alexander M. Lesokhin, Saad Z. Usmani, Niels Weinhold, Francesco Maura, Urvi A. Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 248.
https://doi.org/10.1182/blood-2024-204341
Published: 2024
Journal Articles

Whole Genome Sequencing Reveals Lower Apobec-Mutational Activity in Multiple Myeloma Patients with African Ancestry Compared with Those Having European Ancestry

Kylee H Maclachlan, Marios Papadimitriou, Patrick Blaney, Tala Shekarkhand, Timothy R. Chu, Alexandra Maria Poos, Elizabeth Brown, Antje Hoering, Benjamin Diamond, Bachisio Ziccheddu, Marc S. Raab, Niels Weinhold, Ola Landgren, Faith E Davies, Alexander M. Lesokhin, Saad Z. Usmani, Francesco Maura, Gareth Morgan
Journal: Blood
Blood (2024) 144 (Supplement 1): 766.
https://doi.org/10.1182/blood-2024-203675
Published: 2024
Journal Articles

Replication Stress Induces Hyper-Apobec Mutagenesis in Multiple Myeloma

Marios Papadimitriou, Marilena Tauro, Afsaneh Panahi, Bachisio Ziccheddu, Alexandra Maria Poos, Abdessamad Youssfi Alaoui, Dario Magaletti, Mark B. Meads, Kylee H Maclachlan, Marc S. Raab, Gareth Morgan, Saad Z. Usmani, Niels Weinhold, Ola Landgren, Kenneth H. Shain, Florian Kuchenbauer, Francesco Maura
Journal: Blood
Blood (2024) 144 (Supplement 1): 3276.
https://doi.org/10.1182/blood-2024-211173
Published: 2024
Journal Articles

Mutationally Enriched Regions of the Non-Coding Genome Harbor Functionally Impactful Mutations That Dysregulate Key Genes Involved in Multiple Myeloma Pathogenesis

Patrick Blaney, Kylee H Maclachlan, Marios Papadimitriou, Aneta Mikulasova, Dylan C Gagler, Marc J Braunstein, Oscar B Lahoud, David Kaminetzky, Yubao Wang, Sanxiong Liu, Di Zhang, Anthony Cirrincione, Alexandra Maria Poos, Bachisio Ziccheddu, Marcella Kaddoura, Monika Chojnacka, Benjamin Diamond, Neha Korde, Alexander M. Lesokhin, Saad Z. Usmani, Leo Rasche, Elias K. Mai, Marc S. Raab, Niels Weinhold, Elizabeth E. Brown, Nicolas Robine, Leif Bergsagel, Brian A. Walker, Ola Landgren, Francesco Maura, Faith E Davies, Gareth Morgan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4655.
https://doi.org/10.1182/blood-2024-211012
Published: 2024
Journal Articles

Convergent Evolution Towards CD38 Biallelic Loss Is a Recurrent Mechanism of Resistance to Anti-CD38 Antibodies in Multiple Myeloma

Benjamin Diamond, Linda B. Baughn, Mansour Poorebrahim, Alexandra Maria Poos, Holly Lee, Marcella Kaddoura, J Erin Wiedmeier-Nutor, Michael Durante, Gregory Otteson, Dragan Jevremovic, Hongwei Tang, Stefan Frohling, Marios Papadimitriou, Bachisio Ziccheddu, Tomas Jelinek, Ola Landgren, Paola Neri, P. Leif Bergsagel, Esteban Braggio, Shaji Kumar, Marc S. Raab, Rafael Fonseca, Nizar J. Bahlis, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2024) 144 (Supplement 1): 592.
https://doi.org/10.1182/blood-2024-201056
Published: 2024
Journal Articles

Clonal Evolution of Lymphoid Malignancies Following the Mutagenic Impact of Radiotherapy

Benjamin Diamond, Dhanvantri Chahar, Michael D. Jain, Alexandra Maria Poos, Michael Durante, Bachisio Ziccheddu, Marcella Kaddoura, Marios Papadimitriou, Kylee H Maclachlan, Tomas Jelinek, Faith E Davies, Nicholas B Figura, Gareth Morgan, Elias K. Mai, Hartmut Goldschmidt, Katja C. Weisel, Roland Fenk, Saad Z. Usmani, Ola Landgren, Frederick Locke, Marc S. Raab, Jonathan H. Schatz, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2024) 144 (Supplement 1): 1607.
https://doi.org/10.1182/blood-2024-200927
Published: 2024
Journal Articles

Somatic Hypermutation in Enhancer Regions Shapes Non-Coding Myeloma Genome, Generating DNA Breaks and Driving Etiology through Mutation and Structural Variation

Patrick Blaney, Brian A. Walker, Aneta Mikulasova, Dylan Gagler, Bachisio Ziccheddu, Benjamin Diamond, Yubao Wang, Liming Hou, Sanxiong Liu, Alexandra Maria Poos, Anthony Cirrincione, Kylee H Maclachlan, Elias K. Mai, Hartmut Goldschmidt, Saad Z Usmani, Marc S. Raab, Niels Weinhold, Ola Landgren, Faith E. Davies, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1401.
https://doi.org/10.1182/blood-2023-190473
Published: 2023
Journal Articles

Spatial Dissection of the Bone Marrow Microenvironment in Multiple Myeloma By High Dimensional Multiplex Tissue Imaging

Marc-Andrea Baertsch, Alexander Brobeil, John Hickey, Maximilian Haist, Alexandra Maria Poos, Guolan Lu, Wilson Kuswanto, Christian Schuerch, Harald Voehringer, Wolfgang Huber, Gunhild Mechtersheimer, Carsten Mueller-Tidow, Peter Schirmacher, Katja Weisel, Roland Fenk, Hartmut Goldschmidt, Yury Goltsev, Marc S. Raab, Niels Weinhold, Garry P. Nolan
Journal: Blood
Blood (2023) 142 (Supplement 1): 85.
https://doi.org/10.1182/blood-2023-189255
Published: 2023
Journal Articles

The Temporal Evolution of Chromosome 1q Gain and Hyperdiploidy and Its Impact on Clinical Outcomes in Multiple Myeloma

Francesco Maura, Marcella Kaddoura, Alexandra Maria Poos, Anthony Cirrincione, Benjamin Diamond, Kylee H Maclachlan, Bachisio Ziccheddu, Elias K. Mai, Hartmut Goldschmidt, Katja Weisel, Roland Fenk, Gareth J. Morgan, Saad Z Usmani, Ola Landgren, Marc S. Raab, Niels Weinhold
Journal: Blood
Blood (2023) 142 (Supplement 1): 638.
https://doi.org/10.1182/blood-2023-182267
Published: 2023
Journal Articles

Genomic and Transcriptomic Landscape of Hyper-Apobec Multiple Myeloma

Marios Papadimitriou, Marilena Tauro, Bachisio Ziccheddu, Alexandra Maria Poos, Abdessamad Youssfi Alaoui, Mark B Meads, Kylee H Maclachlan, Saad Z Usmani, Marc S. Raab, Gareth J. Morgan, Niels Weinhold, Kenneth H. Shain, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2023) 142 (Supplement 1): 639.
https://doi.org/10.1182/blood-2023-184784
Published: 2023
Journal Articles

Revealing Novel Mechanisms Underlying Inactivation of Tumor Suppressor Genes on Duplicated Chromosomes in Multiple Myeloma

Anthony Cirrincione, Marcella Kaddoura, Alexandra Maria Poos, Bachisio Ziccheddu, Kylee H Maclachlan, Monika Chojnacka, Benjamin Diamond, Patrick Blaney, Dylan Gagler, Yanming Zhang, Ahmet Dogan, Alexander Lesokhin, Faith E. Davies, Hartmut Goldschmidt, Katja Weisel, Roland Fenk, Elias K. Mai, Neha Korde, Gareth J. Morgan, Marc S. Raab, Saad Z Usmani, Ola Landgren, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2023) 142 (Supplement 1): 874.
https://doi.org/10.1182/blood-2023-186802
Published: 2023
Journal Articles

Whole-Genome Sequencing Reveals Distinct Mutational Signatures in Multiple Myeloma Patients with African Ancestry Compared with Those of Non-African Ancestry

Kylee H Maclachlan, Patrick Blaney, Anthony Cirrincione, Timothy R. Chu, Alexandra Maria Poos, Elizabeth E. Brown, Elisabet E. Manasanch, Antje Hoering, Liming Hou, Dylan Gagler, Yubao Wang, Sanxiong Liu, Benjamin Diamond, Bachisio Ziccheddu, Marc S. Raab, Niels Weinhold, Ola Landgren, Nicolas Robine, Faith E. Davies, Alexander Lesokhin, Saad Z Usmani, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3764.
https://doi.org/10.1182/blood-2023-190882
Published: 2023