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Kenneth H. Shain
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Journal Articles

Tumor burden quantified by Soluble B-Cell Maturation Antigen and Metabolic Tumor Volume determine myeloma CAR-T outcomes

Ciara L Freeman, Jerald Noble, Meghan Menges, Ricardo Villanueva, Justyn Y Nakashima, Nicholas B Figura, R. Petter Tonseth, Dietrich Werner Idiaquez, Lawrence Skelson, Eric C Smith, Julieta Abraham-Miranda, Salvatore Corallo, Gabriel De Avila, Omar Castaneda Puglianini, Hien D Liu, Melissa Alsina, Taiga Nishihori, Kenneth H Shain, Rachid C Baz, Brandon J Blue, Ariel Grajales-Cruz, John M. Koomen, Reginald M Atkins, Doris K Hansen, Ariosto Siqueira Silva, Jongphil Kim, Yoganand Balagurunathan, Frederick L Locke
Journal: Blood
Blood blood.2024024965.
https://doi.org/10.1182/blood.2024024965
Published: 2024
Includes: Supplemental data
Journal Articles

The Real-World Safety and Tolerability of Pirtobrutinib Among Patients with B Cell Lymphomas; A Single Center Experience

Mohammad Ammad Ud Din, Katherine Tobon, Julio C. Chavez, Lisa Nodzon, Hayder Saeed, Sameh Gaballa, Ning Dong, Leidy Lismeris Isenalumhe, Celeste M. Bello, Ariel Grajales-Cruz, Kenneth H. Shain, Lubomir Sokol, Bijal D Shah, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 6778.
https://doi.org/10.1182/blood-2024-208769
Published: 2024
Journal Articles

Activity and Safety of Venetoclax (VEN)-Based Treatment in t(11;14)-Positive Relapsed/Refractory Multiple Myeloma (R/R MM)

Filip Ionescu, Shrinjaya B Thapa, Parth C Patel, Dimitrios Drekolias, Ariosto Siqueira Silva, Praneeth R Sudalagunta, Phaedra Agius, Brandon Blue, Doris K. Hansen, Omar Castaneda, Hien Liu, Jose L. Ochoa-Bayona, Ciara Louise Freeman, Frederick Locke, Taiga Nishihori, Melissa Alsina, Kenneth H. Shain, Rachid Baz, Ariel Grajales-Cruz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4740.
https://doi.org/10.1182/blood-2024-210069
Published: 2024
Journal Articles

Genomic Determinants of Resistance to Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) Therapies in Patients with Relapsed/Refractory Multiple Myeloma

Francesco Maura, Ciara Louise Freeman, Holly Lee, Kylee H Maclachlan, Michael Durante, Bachisio Ziccheddu, Meghan Menges, Benjamin Diamond, Marios Papadimitriou, Ariosto Siqueira Silva, Praneeth Reddy Sudalagunta, Noemie Leblay, Sungwoo Ahn, Ethan Fuller, Edward Briercheck, Phaedra Agius, Doris K. Hansen, Xiaofei Song, Xiaohong Zhao, Mark B. Meads, Jamie Teer, Ross S Firestone, Juan-Jose Garces, Tomas Jelinek, Rachid Baz, Melissa Alsina, Anusuyam Ramasubramanian, Eric Smith, Sergio Giralt, Sham Mailankody, Paola Neri, Saad Z. Usmani, Frederick Locke, Nizar J. Bahlis, Ola Landgren, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 247.
https://doi.org/10.1182/blood-2024-201288
Published: 2024
Journal Articles

Daratumumab Based Response Adapted Therapy for Older Adults with Newly Diagnosed Multiple Myeloma: Final Results of a Phase II Study

Rachid Baz, Mark B. Meads, Jongphil Kim, Ariel F. Grajales-Cruz, Brandon Blue, Sonila Toska, Xiaohong Zhao, Xiaofei Song, Praneeth Reddy Sudalagunta, Alexandra Achille, David R. Noyes, Samer Sansil, Sean J. Yoder, Ariosto Siqueira Silva, Omar Castaneda, Jose L. Ochoa-Bayona, Chaomei H. Zhang, Ciara Louise Freeman, Hien Liu, Doris K. Hansen, Taiga Nishihori, Melissa Alsina, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 1995.
https://doi.org/10.1182/blood-2024-206353
Published: 2024
Journal Articles

Clinical Characteristics and Outcomes of Patients with MYD88 Positive Waldenström Macroglobulinemia: A Single Center Retrospective Analysis

Shrinjaya B Thapa, David Kaldas, Jose Laborde, Shrikar Modukuri, Filip Ionescu, Brandon Blue, Julio C. Chavez, Melissa Alsina, Celeste M. Bello, Javier Pinilla-Ibarz, Kenneth H. Shain, Rachid C. Baz, Ariel Grajales-Cruz
Journal: Blood
Blood (2024) 144 (Supplement 1): 3021.
https://doi.org/10.1182/blood-2024-208701
Published: 2024
Journal Articles

Effect of Talquetamab on Responses in Patients with Relapsed and Refractory Multiple Myeloma with Prior Exposure to T-Cell Redirecting Therapies

Omar Castaneda, Doris K. Hansen, Mariola A Vazquez-Martinez, Shrikar Modukuri, Brandon Blue, Julia Fadul, Ariel Denson, Parker Melnick, Filip Ionescu, Kristy Harvey, Blanca Lopez, Katherine Tobon, Hien Liu, Jose L. Ochoa-Bayona, Ciara Louise Freeman, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Melissa Alsina, Ariel Grajales-Cruz, Allison Graeter, Frederick Locke
Journal: Blood
Blood (2024) 144 (Supplement 1): 5168.
https://doi.org/10.1182/blood-2024-211739
Published: 2024
Journal Articles

Meaningful Change in Patient-Reported Outcomes after CAR T-Cell Therapy for Relapsed/Refractory Multiple Myeloma in Standard of Care: Differences By Race and Ethnicity

Carina E. Ferraris, Xiaoyin Li, Gabriel De Avila, Lisa M. Gudenkauf, Aasha I. Hoogland, Oanh Nguyen, Yvelise Rodriguez, Sylvia L. Crowder, Nathan Parker, Tiffany L. Carson, Rachid C. Baz, Kenneth H. Shain, Brandon Blue, Ariel Grajales-Cruz, Melissa Alsina, Ciara Louise Freeman, Omar Castaneda, Taiga Nishihori, Hien Liu, Frederick L. Locke, Heather S.L. Jim, Doris K. Hansen, Lauren C. Peres, Laura B. Oswald
Journal: Blood
Blood (2024) 144 (Supplement 1): 5165.
https://doi.org/10.1182/blood-2024-208529
Published: 2024
Journal Articles

De Novo Resistance and Relapse from Daratumumab Monotherapy in NDMM Is Associated with Immune Evasion and Immunosuppression

Mark B. Meads, Xiaohong Zhao, David R. Noyes, Alexandra Achille, Praneeth Reddy Sudalagunta, Chaomei H. Zhang, Sonila Toska, Jongphil Kim, Samer Sansil, Sean J. Yoder, Ariel Grajales-Cruz, Brandon Blue, Ciara Louise Freeman, Melissa Alsina, Ariosto Siqueira Silva, Xiaofei Song, Rachid Baz, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 1906.
https://doi.org/10.1182/blood-2024-210232
Published: 2024
Journal Articles

Predictive Markers for Outcomes after Disease Progression Post BCMA-Directed CAR T-Cell Therapy in Patients with Relapsed or Refractory Multiple Myeloma

Fnu Amisha, Ziad Abuhelwa, Wenyi Fan, Doris K. Hansen, Omar Castaneda, Ciara Louise Freeman, Hien Liu, Frederick Locke, Taiga Nishihori, Ariel Grajales-Cruz, Brandon Blue, Kenneth H. Shain, Melissa Alsina, Rachid Baz
Journal: Blood
Blood (2024) 144 (Supplement 1): 2004.
https://doi.org/10.1182/blood-2024-211822
Published: 2024
Journal Articles

Patterns of Progression and Outcomes in Multiple Myeloma after Anti-BCMA CAR T-Cell Therapy

Ziad Abuhelwa, Fnu Amisha, Wenyi Fan, Gabriel De Avila, Doris K. Hansen, Ariel F. Grajales-Cruz, Brandon Blue, Omar Castaneda, Hien Liu, Ciara Louise Freeman, Taiga Nishihori, Frederick Locke, Kenneth H. Shain, Rachid Baz, Melissa Alsina
Journal: Blood
Blood (2024) 144 (Supplement 1): 4692.
https://doi.org/10.1182/blood-2024-204270
Published: 2024
Journal Articles

Single Center Real World Experience of Talquetamab in Patients with Relapsed and Refractory Multiple Myeloma

Ariel F. Grajales-Cruz, Allison Graeter, Doris K. Hansen, Omar Castaneda, Mariola A Vazquez-Martinez, Shrikar Modukuri, Gabriel De Avila, Ariel Denson, Julia Fadul, Katherine Tobon, Brandon Blue, Blanca Lopez, Kristy Harvey, Parker Melnick, Shrinjaya B Thapa, Filip Ionescu, Hien Liu, Jose L. Ochoa-Bayona, Ciara Louise Freeman, Frederick Locke, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Melissa Alsina
Journal: Blood
Blood (2024) 144 (Supplement 1): 3784.
https://doi.org/10.1182/blood-2024-204232
Published: 2024
Journal Articles

Replication Stress Induces Hyper-Apobec Mutagenesis in Multiple Myeloma

Marios Papadimitriou, Marilena Tauro, Afsaneh Panahi, Bachisio Ziccheddu, Alexandra Maria Poos, Abdessamad Youssfi Alaoui, Dario Magaletti, Mark B. Meads, Kylee H Maclachlan, Marc S. Raab, Gareth Morgan, Saad Z. Usmani, Niels Weinhold, Ola Landgren, Kenneth H. Shain, Florian Kuchenbauer, Francesco Maura
Journal: Blood
Blood (2024) 144 (Supplement 1): 3276.
https://doi.org/10.1182/blood-2024-211173
Published: 2024
Journal Articles

Synchronous Dual Hematologic Neoplasms of Myeloid and Lymphoid Lineage Are of Common Clonal Origin

Somedeb Ball, Surendra Neupane, Hannah Newman, Joshua A Traina, Najla H. Al Ali, Abhishek Dhawan, Praneeth R Sudalagunta, Ariosto Siqueira Silva, Danny DeAvila, Mohammad Omar Hussaini, Jinming Song, Zhuoer Xie, Onyee Chan, Alison R. Walker, Christopher Ryder, Andrew T. Kuykendall, Jeffrey E Lancet, Lubomir Sokol, P. Brent Ferrell, Ling Zhang, Michael R. Savona, David Sallman, Javier Pinilla-Ibarz, Rami S. Komrokji, Kenneth H. Shain, Eric Padron
Journal: Blood
Blood (2024) 144 (Supplement 1): 4578.
https://doi.org/10.1182/blood-2024-210599
Published: 2024
Journal Articles

The Differential Effects of Bridging Therapy on Immune Microenvironment and Outcomes with Idecabtagene-Vicleucel in Multiple Myeloma

Praneeth Reddy Sudalagunta, David R. Noyes, Gabriel De Avila, Alexandra Achille, Rafael Renatino-Canevarolo, Xiaohong Zhao, Maria Silva, Angel Perez, Mark B. Meads, Lauren C. Peres, Doris K. Hansen, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2024) 144 (Supplement 1): 4645.
https://doi.org/10.1182/blood-2024-205631
Published: 2024
Journal Articles

Single-Cell Analysis of CAR-T Cell Products Idecabtagene Vicleucel and Ciltacabtagene Autoleucel Reveals Factors That Influence Clinical Outcomes

Jerald Noble, Xiaofei Song, Meghan Menges, Julieta Abraham-Miranda, Salvatore Corallo, Gabriel De Avila, Omar Puglianini, Hien Liu, Melissa Alsina, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Brandon Blue, Ariel Grajales-Cruz, Doris K. Hansen, Reginald Atkins, Frederick L. Locke, Ciara Louise Freeman
Journal: Blood
Blood (2024) 144 (Supplement 1): 7173.
https://doi.org/10.1182/blood-2024-208709
Published: 2024
Journal Articles

Outcomes of Teclistamab (Tec) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) with Prior Exposure to BCMA-Directed Therapy (BCMA-DT): A Multicenter Study from the U.S. Multiple Myeloma Immunotherapy Consortium

Danai Dima, Mariola A Vazquez-Martinez, James A Davis, Utkarsh Goel, Aimaz Afrough, Aishwarya Sannareddy, Oren Pasvolsky, Beatrice Razzo, Rahul Banerjee, Jack Khouri, Ariel Grajales-Cruz, Alex Lieberman-Cribbin, Masooma Shifa Rana, Kelley Julian, Shaun DeJarnette, Andrew J Portuguese, Mahmoud R. Gaballa, Gabriel De Avila, Sandra Susanibar-Adaniya, Shahzad Raza, Megan M Herr, Evguenia Ouchveridze, Tiffany Richards, Hitomi Hosoya, Lekha Mikkilineni, Gurbakhash Kaur, Daniel Schrum, Omar Castaneda, Adriana Rossi, Chenyu Lin, Peter A. Forsberg, Yi Lin, Shebli Atrash, Douglas W Sborov, Kenneth H. Shain, Peter M. Voorhees, Shambavi Richard, Alfred L. Garfall, Doris K. Hansen, Surbhi Sidana, Krina K. Patel, Andrew J. Cowan, Larry D Anderson, Jr., Hans C. Lee, Faiz Anwer, Christopher Ferreri, Leyla O. Shune
Journal: Blood
Blood (2024) 144 (Supplement 1): 897.
https://doi.org/10.1182/blood-2024-203409
Published: 2024
Journal Articles

Comprehensive Analysis of Pre-Treatment Biomarkers Associated with Toxicity and Durable Responses in Idecabtagene Vicleucel Therapy for Relapsed/Refractory Multiple Myeloma

Doris K. Hansen, Ciara Louise Freeman, Meghan Menges, Brett Reid, Julieta Abraham-Miranda, Kayla Reid, Luis Cuadrado Delgado, Gabriel De Avila, Laura B. Oswald, Ariel F. Grajales-Cruz, Brandon Blue, Rebecca Gonzalez, Salvatore Corallo, David R. Noyes, Mark B. Meads, Hien Liu, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Melissa Alsina, Omar Castaneda, Frederick L. Locke, Lauren C. Peres
Journal: Blood
Blood (2024) 144 (Supplement 1): 896.
https://doi.org/10.1182/blood-2024-197929
Published: 2024
Journal Articles

Safety and Efficacy of Standard of Care (SOC) Elranatamab in Patients with Relapsed/Refractory Multiple Myeloma (RRMM), a Single Center Experience

Ariel F. Grajales-Cruz, Doris K. Hansen, Omar Castaneda, Allison Graeter, Mariola A Vazquez-Martinez, Shrikar Modukuri, Gabriel De Avila, Ariel Denson, Julia Fadul, Brandon Blue, Blanca Lopez, Kristy Harvey, Shrinjaya B Thapa, Katherine Tobon, Parker Melnick, Filip Ionescu, Hien Liu, Jose L. Ochoa-Bayona, Ciara Louise Freeman, Frederick Locke, Taiga Nishihori, Kenneth H. Shain, Melissa Alsina, Rachid Baz
Journal: Blood
Blood (2024) 144 (Supplement 1): 7832.
https://doi.org/10.1182/blood-2024-204276
Published: 2024
Journal Articles

Trajectories of Patient-Reported Outcomes after Idecabtagene Vicleucel Vs. Ciltacabtagene Autoleucel CAR T-Cell Therapy Among Patients with Relapsed/Refractory Multiple Myeloma in Standard of Care

Xiaoyin Li, Carina E. Ferraris, Gabriel De Avila, Lisa M. Gudenkauf, Aasha I. Hoogland, Oanh Nguyen, Yvelise Rodriguez, Sylvia L. Crowder, Nathan Parker, Tiffany L. Carson, Rachid C. Baz, Kenneth H. Shain, Brandon Blue, Ariel Grajales-Cruz, Melissa Alsina, Ciara Louise Freeman, Omar Castaneda, Taiga Nishihori, Hien Liu, Frederick L. Locke, Heather S.L. Jim, Doris K. Hansen, Lauren C. Peres, Laura B. Oswald
Journal: Blood
Blood (2024) 144 (Supplement 1): 7842.
https://doi.org/10.1182/blood-2024-208668
Published: 2024