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Ciara L. Freeman
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Journal Articles

Tumor burden quantified by Soluble B-Cell Maturation Antigen and Metabolic Tumor Volume determine myeloma CAR-T outcomes

Ciara L Freeman, Jerald Noble, Meghan Menges, Ricardo Villanueva, Justyn Y Nakashima, Nicholas B Figura, R. Petter Tonseth, Dietrich Werner Idiaquez, Lawrence Skelson, Eric C Smith, Julieta Abraham-Miranda, Salvatore Corallo, Gabriel De Avila, Omar Castaneda Puglianini, Hien D Liu, Melissa Alsina, Taiga Nishihori, Kenneth H Shain, Rachid C Baz, Brandon J Blue, Ariel Grajales-Cruz, John M. Koomen, Reginald M Atkins, Doris K Hansen, Ariosto Siqueira Silva, Jongphil Kim, Yoganand Balagurunathan, Frederick L Locke
Journal: Blood
Blood blood.2024024965.
https://doi.org/10.1182/blood.2024024965
Published: 2024
Includes: Supplemental data
Journal Articles

CNS Relapse in High-Grade B-cell Lymphoma with MYC and BCL2 Rearrangements and Dark-Zone Signature-Expressing DLBCL

Clinical Trials & Observations
Waleed Alduaij, Aixiang Jiang, Diego Villa, Brett J Collinge, Susana Ben-Neriah, Merrill Boyle, Barbara Meissner, Laura K Hilton, Pedro Farinha, Graham W. Slack, Jeffrey W Craig, Alina S. Gerrie, Ciara L Freeman, Andrew J Mungall, Christian Steidl, Laurie H. Sehn, David W. Scott, Kerry J. Savage
Journal: Blood
Blood blood.2024025725.
https://doi.org/10.1182/blood.2024025725
Published: 2024
Includes: Supplemental data
Journal Articles

Safety and Efficacy of Standard of Care Ciltacabtagene Autoleucel for Relapsed/Refractory Multiple Myeloma

Clinical Trials & Observations
Surbhi Sidana, Krina K. Patel, Lauren C Peres, Radhika Bansal, Mehmet Hakan Kocoglu, Leyla Shune, Shebli Atrash, Kinaya Smith, Shonali Midha, Christopher J Ferreri, Binod Dhakal, Danai Dima, Patrick Costello, Charlotte Wagner, Ran Reshef, Hitomi Hosoya, Lekha Mikkilineni, Djordje Atanackovic, Saurabh Chhabra, Ricardo D Parrondo, Omar Nadeem, Hashim Mann, Nilesh Kalariya, Vanna Hovanky, Gabriel DeAvila, Ciara L Freeman, Frederick L Locke, Melissa Alsina, Sandy Wong, Megan M Herr, Myo Htut, Joseph P. McGuirk, Douglas W Sborov, Jack Khouri, Thomas Martin, Murali Janakiram, Yi Lin, Doris K Hansen
Journal: Blood
Blood blood.2024025945.
https://doi.org/10.1182/blood.2024025945
Published: 2024
Includes: Supplemental data
Journal Articles

CARs put age in the rearview mirror

Ciara L. Freeman, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (12): 1029–1031.
https://doi.org/10.1182/blood.2023021094
Published: 2023
Journal Articles

Molecular determinants of clinical outcomes in a real-world diffuse large B-cell lymphoma population

Clinical Trials & Observations
Waleed Alduaij, Brett Collinge, Susana Ben-Neriah, Aixiang Jiang, Laura K. Hilton, Merrill Boyle, Barbara Meissner, Lauren Chong, Tomoko Miyata-Takata, Graham W. Slack, Pedro Farinha, Jeffrey W. Craig, Andrew Lytle, Kerry J. Savage, Diego Villa, Alina S. Gerrie, Ciara L. Freeman, Randy D. Gascoyne, Joseph M. Connors, Ryan D. Morin, Laurie H. Sehn, Andrew J. Mungall, Christian Steidl, David W. Scott
Journal: Blood
Blood (2023) 141 (20): 2493–2507.
https://doi.org/10.1182/blood.2022018248
Published: 2023
Includes: Supplemental data
Journal Articles

FLIPI24: An Improved International Prognostic Model Developed on Early Events in Follicular Lymphoma

Matthew J. Maurer, Vit K Prochazka, Christopher R. Flowers, Lasse Hjort Jakobsen, Diego Villa, Caroline E. Weibull, Elliot J. Cahn, Alexandra Smith, Herve Ghesquieres, Robert Kridel, Maher Gandhi, Chan Y. Cheah, Eliza Hawkes, John F. Seymour, Ciara L. Freeman, Michael Roost Clausen, Björn E Wahlin, Jonathan W. Friedberg, Carla Casulo, Thomas M. Habermann, Yucai Wang, Loretta J. Nastoupil, Peter De Nully Brown, David Belada, Andrea Janíková, Heidi Mocikova, Tomáš Fürst, Richard Burack, Peter Martin, Jonathon B. Cohen, Izidore S. Lossos, Brad S. Kahl, Brian K. Link, Karin E. Smedby, Laurie H. Sehn, Marek Trneny, Tarec Christoffer Christoffer El-Galaly, James R. Cerhan
Journal: Blood
Blood (2022) 140 (Supplement 1): 2292–2295.
https://doi.org/10.1182/blood-2022-157194
Published: 2022
Journal Articles

Comparing Outcomes of Outpatient Vs. Inpatient High-Dose Melphalan Based Conditioning Regimens Followed By Autologous Hematopoietic Cell Transplantation in Myeloma

Taiga Nishihori, Doris K. Hansen, Hien D. Liu, Omar Alexis Castaneda Puglianini, Ciara L. Freeman, Brandon J. Blue, Jason Brayer, Jongphil Kim, Ariel F Grajales-Cruz, Jose Ochoa, Rachid C. Baz, Kenneth H. Shain, Frederick L. Locke, Melissa Alsina
Journal: Blood
Blood (2022) 140 (Supplement 1): 5174–5176.
https://doi.org/10.1182/blood-2022-171117
Published: 2022
Journal Articles

Risk of Central Nervous System Involvement in High-Grade B-Cell Lymphoma with MYC and BCL2 Rearrangements: Analysis of a Population-Based Cohort with Routine Fluorescence in Situ Hybridization Testing in British Columbia

Waleed Alduaij, Aixiang Jiang, Diego Villa, Brett Collinge, Susana Ben-Neriah, Merrill Boyle, Barbara Meissner, Laura K Hilton, Pedro Farinha, Graham W Slack, Jeffrey W. Craig, Alina S. Gerrie, Ciara L. Freeman, Andrew J. Mungall, Christian Steidl, Laurie H. Sehn, David W. Scott, Kerry J. Savage
Journal: Blood
Blood (2022) 140 (Supplement 1): 1332–1333.
https://doi.org/10.1182/blood-2022-159356
Published: 2022
Journal Articles

Similar Benefits of High-Dose Melphalan Based Conditioning Regimens Followed By Autologous Hematopoietic Cell Transplantation in Elderly Myeloma Population Compared to the Younger Group: Single Center Experience

Taiga Nishihori, Ciara L. Freeman, Doris K. Hansen, Brandon J. Blue, Omar Alexis Castaneda Puglianini, Jongphil Kim, Ariel F. Grajales-Cruz, Jason Brayer, Jose Ochoa, Hien D. Liu, Kenneth H. Shain, Rachid C. Baz, Frederick L. Locke, Melissa Alsina
Journal: Blood
Blood (2022) 140 (Supplement 1): 4856–4858.
https://doi.org/10.1182/blood-2022-168888
Published: 2022
Journal Articles

Baseline Systemic Inflammatory Markers Interleukin 6 and Ferritin Are Associated with Toxicities and Progression-Free Survival in Multiple Myeloma Patients Treated with Idecabtagene Vicleucel

Doris K. Hansen, Lauren C. Peres, Ciara L. Freeman, Omar Alexis Castaneda Puglianini, Rawan Faramand, Laura B. Oswald, Kayla M. Reid, Gabriel De Avila, Brandon J. Blue, Ariel F. Grajales-Cruz, Jose Ochoa, Alexandria Shrewsbury, Cole T. Powell, Christina Copponex, Krista H. Kottra, Rebecca Gonzalez, Jennifer M. Logue, Farhad Khimani, Hany Elmariah, Michael D. Jain, Taiga Nishihori, Hien D. Liu, Jason Brayer, Ken H. Shain, Rachid Baz, Frederick L. Locke, Melissa Alsina, Marco L. Davila
Journal: Blood
Blood (2022) 140 (Supplement 1): 12778–12780.
https://doi.org/10.1182/blood-2022-158080
Published: 2022
Journal Articles

Relapse Timing Is Associated with Distinct Evolutionary Dynamics and Response to Salvage Therapy in DLBCL

Laura K Hilton, Henry S. Ngu, Brett Collinge, Kostiantyn Dreval, Susana Ben-Neriah, Christopher K Rushton, Jasper Wong, Manuela Cruz, Andrew Roth, Merrill Boyle, Barbara Meissner, Graham W. Slack, Pedro Farinha, Jeffrey W. Craig, Alina S. Gerrie, Ciara L. Freeman, Diego Villa, Kerry J. Savage, Laurie H. Sehn, Marco A. Marra, Aly Karsan, Christian Steidl, Ryan D. Morin, David W. Scott
Journal: Blood
Blood (2022) 140 (Supplement 1): 1310–1312.
https://doi.org/10.1182/blood-2022-160187
Published: 2022
Journal Articles

Outpatient Treatment with Anti-Sars-Cov-2 Monoclonal Antibodies and Remdesivir for COVID19 Infections Demonstrates Encouraging Outcomes in Hematopoietic Stem Cell Transplant Recipients: A Single-Center Experience

Filip Ionescu, Eloho Ajayi, Aamia Leach, Melissa Alsina, Nelli Bejanyan, Omar Castaneda-Puglianini, Hany Elmariah, Ciara L. Freeman, Doris K. Hansen, Michael D. Jain, Farhad Khimani, Aleksandr Lazaryan, Hien D. Liu, Frederick L. Locke, Bryan McIver, Asmita Mishra, Michael Nieder, Jose Ochoa, Lia Perez, Joseph Pidala, Aliyah Baluch, Olga Klinkova, Rod Quilitz, Taiga Nishihori, Rawan Faramand
Journal: Blood
Blood (2022) 140 (Supplement 1): 10488–10490.
https://doi.org/10.1182/blood-2022-170337
Published: 2022
Journal Articles

High Metabolic Tumor Volume Is Associated with Higher Toxicity and Decreased Efficacy of BCMA CAR-T Cell Therapy in Multiple Myeloma

Ricardo Villanueva, Doris K. Hansen, Rolf Petter Tonseth, Kenneth L Gage, Zhouping Wei, Gabriel De Avila, Rachid C. Baz, Ariel F Grajales-Cruz, Omar Castaneda-Puglianini, Brandon J. Blue, Jason Brayer, Kenneth H. Shain, Melissa Alsina, Hien D. Liu, Taiga Nishihori, Meghan A Menges, Frederick L. Locke, Yoganand Balagurunathan, Ciara L. Freeman
Journal: Blood
Blood (2022) 140 (Supplement 1): 10402–10404.
https://doi.org/10.1182/blood-2022-167804
Published: 2022
Journal Articles

Factors Associated with Refractoriness or Early Progression after Idecabtagene Vicleucel (Ide-cel) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM): U.S. Myeloma CAR T Consortium Real World Experience

Hamza Hashmi, Doris K. Hansen, Lauren C. Peres, Omar Alexis Castaneda Puglianini, Ciara L. Freeman, Gabriel De Avila, Surbhi Sidana, Leyla O. Shune, Douglas W. Sborov, James Davis, Charlotte B. Wagner, M. Hakan Kocoglu, Shebli Atrash, Peter M. Voorhees, Gary Simmons, Christopher J. Ferreri, Nilesh Kalariya, Aishwarya Sannareddy, Danai Dima, Jack Khouri, Joseph P. McGuirk, Frederick L. Locke, Rachid C. Baz, Krina Patel, Melissa Alsina
Journal: Blood
Blood (2022) 140 (Supplement 1): 4642–4645.
https://doi.org/10.1182/blood-2022-164828
Published: 2022
Journal Articles

The CAR-Hematotox Score As a Prognostic Model of Toxicity and Response in Patients Receiving BCMA-Directed CAR-T for Relapsed/Refractory Multiple Myeloma

Kai Rejeski, Doris K. Hansen, Radhika Bansal, Pierre Sesques, Sikander Ailawadhi, Jennifer M. Logue, Ciara L. Freeman, Melissa Alsina, Sebastian Theurich, Frederick L. Locke, Emmanuel Bachy, Michael D. Jain, Yi Lin, Marion Subklewe
Journal: Blood
Blood (2022) 140 (Supplement 1): 7506–7508.
https://doi.org/10.1182/blood-2022-165266
Published: 2022
Journal Articles

Sarcopenia Prevalence and Influence on the Development of Toxicity and Length of Stay in Patients with Relapsed and Refractory Myeloma Treated with Commercial Anti-BCMA CART Cells

Nathan Parker, Karnav Modi, Ricardo Villanueva, Lawrence Skelson, Ashley Scotto, Margaret Booth-Jones, Gabriel De Avila, Michael D. Jain, Asmita Mishra, Rawan Faramand, Othman Salim Akhtar, Jason Brayer, Omar Castaneda-Puglianini, Ariel F. Grajales-Cruz, Rachid C. Baz, Brandon J. Blue, Kenneth H. Shain, Melissa Alsina, Hien D. Liu, Taiga Nishihori, Frederick L. Locke, Doris K. Hansen, Ciara L. Freeman
Journal: Blood
Blood (2022) 140 (Supplement 1): 4688–4690.
https://doi.org/10.1182/blood-2022-168071
Published: 2022
Journal Articles

Patterns of Relapse and Clinical Outcomes in Multiple Myeloma Patients after Anti-BCMA CAR T-Cell Therapy: Implications for Patient's Monitoring after CAR T-Cell Therapy

Omar Alexis Castaneda Puglianini, Lauren C. Peres, Doris K. Hansen, Taiga Nishihori, Ariel F Grajales-Cruz, Brandon J. Blue, Jason Brayer, Ciara L. Freeman, Kenneth H. Shain, Hien D. Liu, Jose Ochoa, Frederick L. Locke, Rachid C. Baz, Melissa Alsina
Journal: Blood
Blood (2022) 140 (Supplement 1): 7538–7539.
https://doi.org/10.1182/blood-2022-170135
Published: 2022
Journal Articles

Racial and Ethnic Differences in Clinical Outcomes Among Multiple Myeloma Patients Treated with CAR T Therapy

Lauren C. Peres, Laura B. Oswald, Christen Dillard, Gabriel De Avila, Taiga Nishihori, Brandon J. Blue, Ciara L. Freeman, Frederick L. Locke, Melissa Alsina, Omar Alexis Castaneda Puglianini, Leyla O. Shune, Douglas W. Sborov, Charlotte B Wagner, Danai Dima, Hamza Hashmi, James Davis, M. Hakan Kocoglu, Shebli Atrash, Gary Simmons, Nilesh Kalariya, Christopher J. Ferreri, Aishwarya Sannareddy, Aimaz Afrough, Peter M. Voorhees, Jack Khouri, Joseph P. McGuirk, Surbhi Sidana, Doris K. Hansen, Krina Patel
Journal: Blood
Blood (2022) 140 (Supplement 1): 623–625.
https://doi.org/10.1182/blood-2022-158478
Published: 2022
Journal Articles

Event-Free and Overall Survival in over 6,000 Patients Treated with Frontline Immunochemotherapy for Follicular Lymphoma between 2002-2018: First Report from the International FLIPI24 Consortium

Matthew J. Maurer, Vit K Prochazka, Christopher R. Flowers, Lasse H. Jakobsen, Diego Villa, Caroline Weibull, Elliot J. Cahn, Herve Ghesquieres, Robert Kridel, Maher Gandhi, Chan Yoon Cheah, Eliza Hawkes, John F. Seymour, Ciara L. Freeman, Michael Roost Clausen, Björn Wahlin, Brian K. Link, Karin Ekstroem Smedby, Laurie H. Sehn, Marek Trněný, Tarec Christoffer El-Galaly, James R. Cerhan
Journal: Blood
Blood (2021) 138 (Supplement 1): 3527.
https://doi.org/10.1182/blood-2021-145883
Published: 2021
Journal Articles

Frontline Therapy with Bendamustine-Rituximab (BR) in Patients with Treatment-Naïve Waldenstrom's Macroglobulinemia Confers Similar Long-Term Outcomes to R-CVP in a Real-World Setting: A Population-Based Analysis

Jowon Laura Kim, Alina S. Gerrie, Kerry J. Savage, Diego Villa, David W. Scott, Jeffrey W Craig, Pedro Farinha, Brian Skinnider, Graham W. Slack, Joseph M. Connors, Laurie H. Sehn, Ciara L. Freeman
Journal: Blood
Blood (2021) 138 (Supplement 1): 1353.
https://doi.org/10.1182/blood-2021-146738
Published: 2021