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Xiaohong Zhao
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Journal Articles

Genomic Determinants of Resistance to Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) Therapies in Patients with Relapsed/Refractory Multiple Myeloma

Francesco Maura, Ciara Louise Freeman, Holly Lee, Kylee H Maclachlan, Michael Durante, Bachisio Ziccheddu, Meghan Menges, Benjamin Diamond, Marios Papadimitriou, Ariosto Siqueira Silva, Praneeth Reddy Sudalagunta, Noemie Leblay, Sungwoo Ahn, Ethan Fuller, Edward Briercheck, Phaedra Agius, Doris K. Hansen, Xiaofei Song, Xiaohong Zhao, Mark B. Meads, Jamie Teer, Ross S Firestone, Juan-Jose Garces, Tomas Jelinek, Rachid Baz, Melissa Alsina, Anusuyam Ramasubramanian, Eric Smith, Sergio Giralt, Sham Mailankody, Paola Neri, Saad Z. Usmani, Frederick Locke, Nizar J. Bahlis, Ola Landgren, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 247.
https://doi.org/10.1182/blood-2024-201288
Published: 2024
Journal Articles

The Differential Effects of Bridging Therapy on Immune Microenvironment and Outcomes with Idecabtagene-Vicleucel in Multiple Myeloma

Praneeth Reddy Sudalagunta, David R. Noyes, Gabriel De Avila, Alexandra Achille, Rafael Renatino-Canevarolo, Xiaohong Zhao, Maria Silva, Angel Perez, Mark B. Meads, Lauren C. Peres, Doris K. Hansen, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2024) 144 (Supplement 1): 4645.
https://doi.org/10.1182/blood-2024-205631
Published: 2024
Journal Articles

Daratumumab Based Response Adapted Therapy for Older Adults with Newly Diagnosed Multiple Myeloma: Final Results of a Phase II Study

Rachid Baz, Mark B. Meads, Jongphil Kim, Ariel F. Grajales-Cruz, Brandon Blue, Sonila Toska, Xiaohong Zhao, Xiaofei Song, Praneeth Reddy Sudalagunta, Alexandra Achille, David R. Noyes, Samer Sansil, Sean J. Yoder, Ariosto Siqueira Silva, Omar Castaneda, Jose L. Ochoa-Bayona, Chaomei H. Zhang, Ciara Louise Freeman, Hien Liu, Doris K. Hansen, Taiga Nishihori, Melissa Alsina, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 1995.
https://doi.org/10.1182/blood-2024-206353
Published: 2024
Journal Articles

De Novo Resistance and Relapse from Daratumumab Monotherapy in NDMM Is Associated with Immune Evasion and Immunosuppression

Mark B. Meads, Xiaohong Zhao, David R. Noyes, Alexandra Achille, Praneeth Reddy Sudalagunta, Chaomei H. Zhang, Sonila Toska, Jongphil Kim, Samer Sansil, Sean J. Yoder, Ariel Grajales-Cruz, Brandon Blue, Ciara Louise Freeman, Melissa Alsina, Ariosto Siqueira Silva, Xiaofei Song, Rachid Baz, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 1906.
https://doi.org/10.1182/blood-2024-210232
Published: 2024
Journal Articles

Single Cell RNA Sequencing of Sequential Samples before and after BCMA-Directed CAR-T Reveal Features Associated with Non-Durable Response, Exhausted T-Cells and Decreased Expression of Genes Encoding Key Surface Targets in Particular in Patients with Extramedullary Disease

Ciara Louise L. Freeman, Xiaohong Zhao, Mark B Meads, Jerald Noble, Raghunandan Reddy Alugubelli, Rafael Renatino-Canevarolo, Oliver Hampton, Praneeth Reddy Sudalagunta, Ariosto Siqueira Silva, Rachid Baz, Melissa Alsina, Doris K. Hansen, Xiaofei Song, Kenneth H. Shain
Journal: Blood
Blood (2023) 142 (Supplement 1): 3304.
https://doi.org/10.1182/blood-2023-191013
Published: 2023
Journal Articles

Ex Vivo Mathematical Myeloma Advisor (EMMA) - a Clinical, Molecular, and Phenotypic Platform to Tailor Personalized Therapeutic Strategies for Multiple Myeloma

Rafael Renatino-Canevarolo, Maria Silva, Mark B Meads, Xiaohong Zhao, Alexandra Achille, David Noyes, Praneeth Reddy Sudalagunta, Raghunandan Reddy Alugubelli, Daniel Lastorino, Leticia Tordesillas, Miguel Gomez Fontela, Oliver Hampton, Daniel Abate-Daga, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2023) 142 (Supplement 1): 2280.
https://doi.org/10.1182/blood-2023-190479
Published: 2023
Journal Articles

Selinexor Disrupts Epigenetic Programing and Modulates Immunogenicity in Multiple Myeloma

Praneeth Reddy Sudalagunta, Rafael Renatino-Canevarolo, Mark B Meads, David Noyes, Alexandra Achille, Maria Silva, Xiaohong Zhao, Raghunandan Reddy Alugubelli, Daniel Lastorino, Oliver Hampton, Ciara Louise L. Freeman, Stephen Wu, Andrea Ellero, Lauren C. Peres, Doris K. Hansen, Tomer Mark, Christopher J. Walker, Pietro Taverna, Rachid Baz, Kenneth Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2023) 142 (Supplement 1): 3301.
https://doi.org/10.1182/blood-2023-190658
Published: 2023
Journal Articles

A Multiomic Approach to Reversing Therapy Resistance in Multiple Myeloma Using Paired Ex Vivo Drug Sensitivity Measures and RNA Sequencing Data

Praneeth Reddy Sudalagunta, Mark B. Meads, Rafael Renatino-Canevarolo, Maria L. Coelho Siqueira Silva, Xiaohong Zhao, Rhett Waldron, Christopher Cubitt, Raghunandan Reddy Alugubelli, Gabriel De Avila, Oliver Hampton, Robert Gatenby, Rachid C. Baz, Kenneth H. Shain, Ariosto Siqueira Silva
Journal: Blood
Blood (2022) 140 (Supplement 1): 4245–4246.
https://doi.org/10.1182/blood-2022-162454
Published: 2022
Journal Articles

CDK9 As a New Therapeutic Vulnerability for Ibrutinib Resistance Mantle Cell Lymphoma (MCL)

Michelle Wang, BSE, Xiaohong Zhao, MD PhD, Huijuan Jiang, MD, Joy Catherine Yan, Eduardo Sotomayor, MD, Kenneth H. Shain, MD PhD, Bijal Shah, MD, Jianguo Tao, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-141386
Published: 2020
Journal Articles

Pharmaocogenomic Characterization of MCL-1 Inhibitor Response and Resistance in Aggressive B-Cell Lymphomas

Michelle Wang, BSE, Tao Li, MD, Yuan Ren, PhD, Bijal Shah, MD, Tint Lwin, MD PhD, Jing Gao, PhD, Kenneth H. Shain, MD PhD, Wei Zhang, PhD, Xiaohong Zhao, MD PhD, Jianguo Tao, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–21.
https://doi.org/10.1182/blood-2020-141407
Published: 2020
Journal Articles

Pharmacoproteomics Identifies PLK1 As Vulnerability for Aggressive B-Cell Lymphomas

Yuan Ren, PhD, Chengfeng Bi, MD PhD, Xiaohong Zhao, MD PhD, Tint Lwin, MD PhD, Wang Cheng, MD, Ji Yuan, Ariosto Siqueira Silva, PhD, Bijal D. Shah, MD, Bin Fang, PhD, Tao Li, John M. Koomen, PhD, Huijuan Jiang, MD, Julio C. Chavez, MD, Lan V. Pham, PhD, Praneeth Reddy Sudalagunta, PhD, Lixin Wan, Xuefeng Wang, PhD, William S. Dalton, PhD MD, Lynn C. Moscinski, MD, Kenneth H. Shain, MD PhD, Julie M. Vose, MD MBA, John Cleveland, PhD, Eduardo Sotomayor, MD, Kai Fu, MD PhD, Jianguo Tao, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2853.
https://doi.org/10.1182/blood-2018-99-118004
Published: 2018
Journal Articles

Targeting Kinome Reprogramming for Overcoming Ibrutinib-Resistance (IR) in Mantle Cell Lymphoma (MCL)

Xiaohong Zhao, MD PhD, Huijuan Jiang, MD, Michelle Wang, Tao Li, MD, Jing Gao, PhD, Tint Lwin, MD PhD, Yuan Ren, PhD, Eduardo Sotomayor, MD, Bijal D. Shah, MD, Jianguo Tao, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2651.
https://doi.org/10.1182/blood-2018-99-116756
Published: 2018
Journal Articles

BRD4: epigenetic origin and target of CTCL

Xiaohong Zhao, Jianguo Tao
Journal: Blood
Blood (2018) 131 (7): 712–713.
https://doi.org/10.1182/blood-2017-12-820266
Published: 2018
Journal Articles

Venetoclax As a Single Agent and in Combination with PI3K-mTOR1/2 Kinase Inhibitors Against Ibrutinib Sensitive and Resistant Mantle Cell Lymphoma

Huijuan Jiang, MD, Tint Lwin, MD PhD, Bijal D. Shah, MD, Grace T Li, Yuan Ren, Michael W Yan, Lynn C. Moscinski, MD, Xiaohong Zhao, MD PhD, Jianguo Tao, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5197.
https://doi.org/10.1182/blood.V130.Suppl_1.5197.5197
Published: 2017
Journal Articles

JQ 1, a Selective Bromodomain Inhibitor, Decreased the Expression of the Tolerogenic Molecule PDL1 in Antigen-Presenting Cells (APCs) and Restores the Responsiveness of Anergic CD4+ T Cells

Hongwei Wang, MD, Fengdong Cheng, MD, Limin Xing, MD, Xiaohong Zhao, PhD, Alejandro Villagra, PhD, Javier Pinilla-Ibarz, MD PhD, Jianguo Tao, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2749.
https://doi.org/10.1182/blood.V124.21.2749.2749
Published: 2014
Journal Articles

PU.1 Is Essential For MLL Leukemia Via Activation Of The Meis/HOX Pathway and A Monocytic Cytokine Mediated Anti-Apoptotic Inflammatory Program

Jing Zhou, Jun Wu, Bo Li, Dan Liu, Jian Yu, Xiaomei Yan, Si Zheng, Jiguang Wang, Lixia Zhang, Lin Zhang, Fuhong He, Qiang Li, Aili Chen, Yue Zhang, MD,, Xinghui Zhao, Yinghui Guan, Xiaohong Zhao, Jin Yan, Jun Ni, Marcelo Nobrega, Bob Löwenberg, MD, PhD, Ruud Delwel, Peter J. Valk, PhD, Ashish Kumar, MBBS, PhD, Xie Lu, Daniel G. Tenen, MD, Gang Huang, PhD, Qian-fei Wang, Ph.D
Journal: Blood
Blood (2013) 122 (21): 1276.
https://doi.org/10.1182/blood.V122.21.1276.1276
Published: 2013
Journal Articles

Silencing c-Myc Using Myc Inhibitor JQ1 and EZH2 Inhibitor DZNep Blocks Converging Survival Signals in Aggressive B-Cell Lymphomas

Xiaohong Zhao, PhD, Tint Lwin, MD, PhD, Xinwei Zhang, MD, Andy Huang, Jian Wang, Victor E. Marquez, PhD, Selina Chen-Kiang, PhD, James E Bradner, MD, William S. Dalton, PhD, MD, Eduardo M. Sotomayor, MD, Jianguo Tao, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 4618.
https://doi.org/10.1182/blood.V120.21.4618.4618
Published: 2012
Journal Articles

Targeting Mir-548m-HDAC6 Axis Circumvents Stroma- Mediated Drug Resistance (CAM-DR) and Clonogenicity in Non-Hodgkin B-Cell Lymphomas

Tint Lwin, MD, PhD, Xiaohong Zhao, PhD, Fengdong Cheng, MD, Xinwei Zhang, MD, Yizhuo Zhang, Andy Huang, Lynn Moscinski, MD, William S. Dalton, PhD, MD, Eduardo M. Sotomayor, MD, Jianguo Tao, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 5094.
https://doi.org/10.1182/blood.V120.21.5094.5094
Published: 2012
Journal Articles

B Cell Receptor (BCR) Signal Pathways Confer Microenvironment-Mediated Drug Resistance and Are Promising Therapeutic Targets for B Cell Lymphomas

Jiangchuan Tao, Tint Lwin, MD, PhD, Xiaohong Zhao, PhD, Ling Zhang, MD, Lynn Moscinski, MD, Eduardo M. Sotomayor, MD, William S. Dalton, PhD, MD, Jianguo Tao, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 4918.
https://doi.org/10.1182/blood.V120.21.4918.4918
Published: 2012