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Noemie Leblay
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Journal Articles

Impact of soluble BCMA and non–T-cell factors on refractoriness to BCMA-targeting T-cell engagers in multiple myeloma

CME
Holly Lee, Michael Durante, Sheri Skerget, Deeksha Vishwamitra, Sacha Benaoudia, Sungwoo Ahn, Mansour Poorebrahim, Elie Barakat, David Jung, Noémie Leblay, Bachisio Ziccheddu, Benjamin Diamond, Marios Papadimitriou, Adam D. Cohen, Ola Landgren, Paola Neri, Francesco Maura, Nizar J. Bahlis
Journal: Blood
Blood (2024) 144 (25): 2637–2651.
https://doi.org/10.1182/blood.2024026212
Published: 2024
Includes: Supplemental data
Journal Articles

NF-Kb Pathway Activation Driven By TRAF3 Loss Mediates Resistance to Anti-BCMA T-Cell Based Therapies in Multiple Myeloma

David Jung, Holly Lee, Sejal Chikhale, Mansour Poorebrahim, Sungwoo Ahn, Sacha Benaoudia, Noemie Leblay, Francesco Maura, Nizar J. Bahlis, Paola Neri
Journal: Blood
Blood (2024) 144 (Supplement 1): 591.
https://doi.org/10.1182/blood-2024-206347
Published: 2024
Journal Articles

Genomic Determinants of Resistance to Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) Therapies in Patients with Relapsed/Refractory Multiple Myeloma

Francesco Maura, Ciara Louise Freeman, Holly Lee, Kylee H Maclachlan, Michael Durante, Bachisio Ziccheddu, Meghan Menges, Benjamin Diamond, Marios Papadimitriou, Ariosto Siqueira Silva, Praneeth Reddy Sudalagunta, Noemie Leblay, Sungwoo Ahn, Ethan Fuller, Edward Briercheck, Phaedra Agius, Doris K. Hansen, Xiaofei Song, Xiaohong Zhao, Mark B. Meads, Jamie Teer, Ross S Firestone, Juan-Jose Garces, Tomas Jelinek, Rachid Baz, Melissa Alsina, Anusuyam Ramasubramanian, Eric Smith, Sergio Giralt, Sham Mailankody, Paola Neri, Saad Z. Usmani, Frederick Locke, Nizar J. Bahlis, Ola Landgren, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 247.
https://doi.org/10.1182/blood-2024-201288
Published: 2024
Journal Articles

Tumor Intrinsic and Antigen-Independent Resistance Mechanisms to Bispecific T Cell Engagers in Multiple Myeloma

Holly Lee, Sungwoo Ahn, Mansour Poorebrahim, David Jung, Sacha Benaoudia, Noémie Leblay, Francesco Maura, Lawrence H. Boise, Paola Neri, Nizar J. Bahlis
Journal: Blood
Blood (2024) 144 (Supplement 1): 1892.
https://doi.org/10.1182/blood-2024-211979
Published: 2024
Journal Articles

BCMA Extracellular Domain Functional Hotspots and Resistance to Variable Anti-BCMA T Cell Engagers in Multiple Myeloma

Holly Lee, David Jung, Mansour Poorebrahim, Sacha Benaoudia, Sungwoo Ahn, Noémie Leblay, Eric Letouzé, Philippe Moreau, Herve Avet-Loiseau, Leo Rasche, Jonathan J Keats, Francesco Maura, Paola Neri, Nizar J. Bahlis
Journal: Blood
Blood (2024) 144 (Supplement 1): 4651.
https://doi.org/10.1182/blood-2024-211833
Published: 2024
Journal Articles

Immune and Tumor Mediators of Resistance to Daratumumab-IMiDs Based Therapies in Relapsed Multiple Myeloma

Noémie Leblay, Sungwoo Ahn, Holly Lee, Matteo Claudio Da Vià, Mansour Poorebrahim, Sacha Benaoudia, David Jung, Elham Hasheminasabgorji, Niccolò Bolli, Nizar J. Bahlis, Paola Neri
Journal: Blood
Blood (2024) 144 (Supplement 1): 4642.
https://doi.org/10.1182/blood-2024-208842
Published: 2024
Journal Articles

Integrated epigenetic and transcriptional single-cell analysis of t(11;14) multiple myeloma and its BCL2 dependency

Noémie Leblay, Sungwoo Ahn, Rémi Tilmont, Mansour Poorebrahim, Ranjan Maity, Holly Lee, Elie Barakat, Jean-Baptiste Alberge, Sarthak Sinha, Arzina Jaffer, Benjamin G. Barwick, Lawrence H. Boise, Nizar Bahlis, Paola Neri
Journal: Blood
Blood (2024) 143 (1): 42–56.
https://doi.org/10.1182/blood.2023020276
Published: 2024
Includes: Supplemental data
Journal Articles

Bclxl Prevents Progressive Exhaustion in BCMA CAR T Cells with Maintenance of High TCF1 Expressing T Cells

Mansour Poorebrahim, Holly Lee, Sacha Benaoudia, Ranjan Maity, Sungwoo Ahn, Noémie Leblay, Elie Barakat, Remi Tilmont, Douglas Mahoney, Lawrence H. Boise, Paola Neri, Nizar J Bahlis
Journal: Blood
Blood (2023) 142 (Supplement 1): 454.
https://doi.org/10.1182/blood-2023-189747
Published: 2023
Journal Articles

The Impact of Soluble BCMA and BCMA Gain on Anti-BCMA Immunotherapies in Multiple Myeloma

Holly Lee, Michael Durante, Sungwoo Ahn, Noemie Leblay, Mansour Poorebrahim, Ranjan Maity, Rémi Tilmont, Elie Barakat, David Jung, Bachisio Ziccheddu, Alexis Brake, Ola Landgren, Benjamin Diamond, Francesco Maura, Paola Neri, Nizar J Bahlis
Journal: Blood
Blood (2023) 142 (Supplement 1): 4688.
https://doi.org/10.1182/blood-2023-188080
Published: 2023
Journal Articles

Immune and Genome Profiling of Myeloma Patients Treated with Sequential Immunotherapies Reveal Differential Non-Overlapping Mechanisms of Resistance

Holly Lee, Sungwoo Ahn, Ranjan Maity, Noémie Leblay, Michael Durante, Bachisio Ziccheddu, Alexis Brake, Remi Tilmont, Elie Barakat, Mansour Poorebrahim, Ola Landgren, Benjamin Diamond, Francesco Maura, Paola Neri, Nizar J Bahlis
Journal: Blood
Blood (2023) 142 (Supplement 1): 1945.
https://doi.org/10.1182/blood-2023-190517
Published: 2023
Journal Articles

A High-Risk Subgroup Multiple Myeloma Classification Based on the Detection of PR Minor Subclones

Noemie Leblay, Sungwoo Ahn, Sheri Skerget, Rémi Tilmont, Holly Lee, Mansour Poorebrahim, Daniel Penaherrera, Elie Barakat, David Jung, Nizar J Bahlis, Jonathan Keats, Paola Neri
Journal: Blood
Blood (2023) 142 (Supplement 1): 1941.
https://doi.org/10.1182/blood-2023-189567
Published: 2023
Journal Articles

CRBN Structural Changes, Copy Number Changes and COP9 Signalosome Subunits Gene Expression Mediate Sensitivity to New Celmod Compound CC-92480 in Multiple Myeloma Patients

Remi Tilmont, Ranjan Maity, Noemie Leblay, Holly Lee, Elie Barakat, Paola Neri, Nizar J. Bahlis
Journal: Blood
Blood (2022) 140 (Supplement 1): 9964–9965.
https://doi.org/10.1182/blood-2022-169550
Published: 2022
Journal Articles

Role of TNFRSF17 and GPRC5D Structural and Point Mutations in Resistance to Targeted Immunotherapies in Multiple Myeloma (MM)

Holly Lee, Paola Neri, Sungwoo Ahn, Ranjan Maity, Noemie Leblay, Bachisio Ziccheddu, Monika Chojnacka, Rémi Tilmont, Elie Barakat, Ola Landgren, Francesco Maura, Nizar Jacques Bahlis
Journal: Blood
Blood (2022) 140 (Supplement 1): 252–253.
https://doi.org/10.1182/blood-2022-167602
Published: 2022
Journal Articles

Dysfunctional Hyper-Expanded Clonotypes and Lack of TCR Clonal Replacement Predict Resistance to T Cell Engagers in Multiple Myeloma

Paola Neri, Sungwoo Ahn, Holly Lee, Noemie Leblay, Mirco Friedrich, Ranjan Maity, Rémi Tilmont, Elie Barakat, Marc S Raab, Nizar Jacques Bahlis
Journal: Blood
Blood (2022) 140 (Supplement 1): 2093–2094.
https://doi.org/10.1182/blood-2022-164717
Published: 2022
Journal Articles

Mapping the Multiple Myeloma T Cell Landscape By Immunotherapeutic Perturbation Reveals Mechanism and Determinants of Response to Bispecific T Cell Engagers

Mirco Friedrich, Paola Neri, Noemie Leblay, Niklas Kehl, Julius Michel, Holly Lee, Elie Barakat, Sungwoo Ahn, Hartmut Goldschmidt, Michael Platten, Niels Weinhold, Marc-Steffen Raab, Nizar J. Bahlis
Journal: Blood
Blood (2021) 138 (Supplement 1): 731.
https://doi.org/10.1182/blood-2021-152149
Published: 2021
Journal Articles

Integrated Epigenetic and Transcriptional Single Cell Analysis of t(11;14) Myeloma and Its BCL2 Dependency

Noemie Leblay, Sungwoo Ahn, Ranjan Maity, Holly Lee, Elie Barakat, Nizar J. Bahlis, Paola Neri
Journal: Blood
Blood (2021) 138 (Supplement 1): 725.
https://doi.org/10.1182/blood-2021-152993
Published: 2021
Journal Articles

A BCL2L1 Armoured BCMA Targeting CAR T Cell to Overcome Exhaustion and Enhance Persistence in Multiple Myeloma

Ranjan Maity, Sacha Benaoudia, Franz Zemp, Holly Lee, Elie Barakat, Noemie Leblay, Sungwoo Ahn, Douglas Mahoney, Paola Neri, Nizar J. Bahlis
Journal: Blood
Blood (2021) 138 (Supplement 1): 327.
https://doi.org/10.1182/blood-2021-153871
Published: 2021
Journal Articles

Cite-Seq Profiling of T Cells in Multiple Myeloma Patients Undergoing BCMA Targeting CAR-T or Bites Immunotherapy

Noemie Leblay, PhD, Ranjan Maity, PhD, Elie Barakat, Sylvia McCulloch, MD MSc, Peter Duggan, MD FRCPC, Victor Jimenez-Zepeda, MD, Nizar J. Bahlis, MD, Paola Neri, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-137650
Published: 2020