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Jonathan J Keats
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Journal Articles

DNA Methylation Analysis of Commpass Reveals Distinct Epigenetic Programs of High-Risk Disease

Benjamin G. Barwick, Robert M Chavez, Doris R. Powell, Yu Zhang, Mark Hamilton, Daniel Auclair, George Mulligan, Karen N Conneely, Jonathan J Keats, Paula M Vertino, Lawrence H. Boise, Sagar Lonial
Journal: Blood
Blood (2024) 144 (Supplement 1): 251.
https://doi.org/10.1182/blood-2024-201447
Published: 2024
Journal Articles

BCMA Extracellular Domain Functional Hotspots and Resistance to Variable Anti-BCMA T Cell Engagers in Multiple Myeloma

Holly Lee, David Jung, Mansour Poorebrahim, Sacha Benaoudia, Sungwoo Ahn, Noémie Leblay, Eric Letouzé, Philippe Moreau, Herve Avet-Loiseau, Leo Rasche, Jonathan J Keats, Francesco Maura, Paola Neri, Nizar J. Bahlis
Journal: Blood
Blood (2024) 144 (Supplement 1): 4651.
https://doi.org/10.1182/blood-2024-211833
Published: 2024
Journal Articles

Comprehensive Assessment of Immunoglobulin Translocation Detection in Multiple Myeloma By Whole Genome Sequencing

Christophe Legendre, Shari Kyman, Felix Madrid, Yaden Santana, Bryce Turner, Daniel Enriquez, Jonathan J Keats
Journal: Blood
Blood (2024) 144 (Supplement 1): 3274.
https://doi.org/10.1182/blood-2024-211604
Published: 2024
Journal Articles

Geometric Network Analysis Defines Poor-Prognosis Subtypes in Multiple Myeloma

Anish K Simhal, Kylee H Maclachlan, Rena Elkin, Jiening Zhu, Saad Usmani, Jonathan J Keats, Larry Norton, Joseph O. Deasy, Jung Hun Oh, Allen Tannenbaum
Journal: Blood
Blood (2022) 140 (Supplement 1): 9991–9992.
https://doi.org/10.1182/blood-2022-167248
Published: 2022
Journal Articles

The Frequency of Alternative Splicing in Multiple Myeloma Is Determined By the Non-Homologous End Joining Pathway

Enze Liu, Nathan Becker, Parvathi Sudha, Chuanpeng Dong, Yunlong Liu, Jonathan J Keats, Gareth J. Morgan, Brian A. Walker
Journal: Blood
Blood (2022) 140 (Supplement 1): 4259–4260.
https://doi.org/10.1182/blood-2022-167322
Published: 2022
Journal Articles

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma

Georgina S.F. Anderson, Jose Ballester-Beltran, George Giotopoulos, Jose A. Guerrero, Sylvanie Surget, James C. Williamson, Tsz So, David Bloxham, Anna Aubareda, Ryan Asby, Ieuan Walker, Lesley Jenkinson, Elizabeth J. Soilleux, James P. Roy, Ana Teodósio, Catherine Ficken, Leah Officer-Jones, Sara Nasser, Sheri Skerget, Jonathan J. Keats, Peter Greaves, Yu-Tzu Tai, Kenneth C. Anderson, Marion MacFarlane, James E. Thaventhiran, Brian J.P. Huntly, Paul J. Lehner, Michael A. Chapman
Journal: Blood
Blood (2022) 139 (16): 2471–2482.
https://doi.org/10.1182/blood.2021015161
Published: 2022
Includes: Supplemental data
Journal Articles

High-Risk Gene Expression Subtype Provides Molecular Basis for Different Clinical Presentation of Primary and Secondary Plasma Cell Leukemia

Sheri Skerget, Daniel Penaherrera, Joseph Mikhael, Jonathan J Keats
Journal: Blood
Blood (2021) 138 (Supplement 1): 726.
https://doi.org/10.1182/blood-2021-148138
Published: 2021
Journal Articles

Clonal Hematopoiesis Prevalence Increases throughout Treatment of Newly Diagnosed Multiple Myeloma Patients

Tarek H. Mouhieddine, Chidimma Nzerem, Robert A. Redd, Andrew Dunford, Matthew Joseph Leventhal, Romanos Sklavenitis-Pistofidis, Sabrin Tahri, Habib El-Khoury, David P. Steensma, Benjamin L. Ebert, Robert J. Soiffer, Jonathan J Keats, Shaadi Mehr, Daniel Auclair, Adam S. Sperling, Chip Stewart, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2021) 138 (Supplement 1): 1091.
https://doi.org/10.1182/blood-2021-152025
Published: 2021
Journal Articles

Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression

Vikas A. Gupta, Benjamin G. Barwick, Shannon M. Matulis, Ryosuke Shirasaki, David L. Jaye, Jonathan J. Keats, Benjamin Oberlton, Nisha S. Joseph, Craig C. Hofmeister, Leonard T. Heffner, Madhav V. Dhodapkar, Ajay K. Nooka, Sagar Lonial, Constantine S. Mitsiades, Jonathan L. Kaufman, Lawrence H. Boise
Journal: Blood
Blood (2021) 137 (26): 3604–3615.
https://doi.org/10.1182/blood.2020007899
Published: 2021
Includes: Supplemental data
Journal Articles

Chromatin Accessibility Identifies Regulatory Elements Predictive of Oncogene Expression in Multiple Myeloma

Benjamin G Barwick, PhD, Vikas A. Gupta, MD PhD, Shannon M Matulis, PhD, Jonathan C Patton, B.S., Doris R Powell, MA, Yanyan Gu, MD PhD, David L. Jaye, MD, Karen N Conneely, PhD, Yin C Lin, PhD, Craig C Hofmeister, MDMPH, Ajay Nooka, MDMPH, Jonathan J Keats, PhD, Sagar Lonial, MD FACP, Paula M Vertino, PhD, Larry H. Boise, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-140717
Published: 2020
Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey M Matthews, PhD, Dennis Buckley, Joseline Raja, Quinlan L Sievers, PhD, Olga Dashevsky, PhD, Haley Poarch, Huihui Tang, PhD, Megan Bariteau, BSc, Michal Sheffer, PhD, Sondra L. Downey-Kopyscinski, PhD, Paul Hengeveld, Brian Glassner, PhD, Eugen Dhimolea, PhD, Christopher J. Ott, PhD, Tinghu Zhang, PhD, Nicholas P Kwiatkowski, PhD, Jacob P. Laubach, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Aedin Culhane, PhD, Richard W.J. Groen, PhD, Eric Fischer, Benjamin L. Ebert, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, PhD, Daniel Auclair, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, James Bradner, MD, Nathanael Gray, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 318.
https://doi.org/10.1182/blood-2019-130549
Published: 2019
Journal Articles

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Geoffrey Matthews, PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Joshua Dempster, PhD, Robin M. Meyers, PhD, Jordan Bryan, James M. McFarland, Johanna Brueggenthies, Huihui Tang, PhD, Megan Bariteau, BSc, Minasri Borah, Quinlan L Sievers, PhD, Benjamin Ebert, MD, Brian Glassner, PhD, Christopher J. Ott, PhD, Nicholas P Kwiatkowski, PhD, John G Doench, PhD, Daniel Auclair, Joan Levy, PhD, Lawrence H. Boise, PhD, Jonathan J Keats, PhD, Jonathan D. Licht, MD, Richard Groen, Nathanael Gray, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4407.
https://doi.org/10.1182/blood-2019-130901
Published: 2019
Journal Articles

The CCND1 870G Risk Allele Is Enriched in African Individuals with Plasma Cell Dyscrasias

Linda B Baughn, PhD, Zhou Li, MS, Kathryn E. Pearce, Celine M. Vachon, PhD, Mei-Yin Polley, PhD, Jonathan J Keats, PhD, Eran Elhaik, PhD, Michael L. Baird, PhD, Terry Therneau, PhD, James R. Cerhan, MD PhD, P. Leif Bergsagel, MD, Angela Dispenzieri, MD, S.Vincent Rajkumar, MD, Yan Asmann, PhD, Shaji K. Kumar, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4362.
https://doi.org/10.1182/blood-2019-124979
Published: 2019
Journal Articles

ADAR1 Drives Disease Progression in Multiple Myeloma By Acting Both As an RNA Editor of Specific Transcripts and As a DNA Mutator of Their Cognate Genes

Rafail Nikolaos Tasakis, MSc, BSc, Alessandro Lagana, PhD, Violetta Leshchenko, PhD, David Melnekoff, BS,MS, Itai Beno, PhD, Jonathan J Keats, PhD, Daniel Auclair, Deepu Madduri, MD, Joshua Richter, MD, Ajai Chari, MD, Hearn Jay Cho, MD PhD, Sundar Jagannath, MD, Joel Dudley, PhD, F. Nina Papavasiliou, PhD, Samir Parekh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3092.
https://doi.org/10.1182/blood-2019-130669
Published: 2019
Journal Articles

Genomic and Immunologic Analysis of Cmaf and Hypermutated Multiple Myeloma: Implications for Immunologic Therapy

Hearn Jay Cho, MD PhD, Deepak Perumal, PhD, Adeeb H Rahman, PhD, Donald Jackson, PhD, Michael Robbins, PhD, Seunghee Kim-Schultze, PhD, Sacha Gnjatic, PhD, Samir Parekh, MD, Jonathan J Keats, PhD, Daniel Auclair
Journal: Blood
Blood (2019) 134 (Supplement_1): 3093.
https://doi.org/10.1182/blood-2019-131274
Published: 2019
Journal Articles

Unsupervised Clustering of DNA Copy Number Profiles Identifies a High-Risk Subtype of Hyperdiploid Multiple Myeloma: An Mmrf Commpass Analysis

Austin Christofferson, BSc, Sheri Skerget, PhD, Jessica Aldrich, Christophe Legendre, PhD, Sara Nasser, PhD, Jennifer Yesil, Daniel Auclair, The MMRF CoMMpass Network, Sagar Lonial, Jonathan J Keats, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1805.
https://doi.org/10.1182/blood-2019-132152
Published: 2019
Journal Articles

Molecular Characterization of Bone Marrow and Peripheral Blood Compartments from Patients with Plasma Cell Leukemia in the Mmrf Commpass Study

Sheri Skerget, PhD, Austin Christofferson, BSc, Sara Nasser, PhD, Christophe Legendre, PhD, The MMRF CoMMpass Network, Jennifer Yesil, Daniel Auclair, Sagar Lonial, Jonathan J Keats, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1782.
https://doi.org/10.1182/blood-2019-130697
Published: 2019
Journal Articles

Proteasome Inhibitors Impair the Innate Antiviral Immune Response and Potentiate Pelareorep-Based Viral Therapy in Multiple Myeloma

Ada Dona', PhD, Domenico Viola, Enrico Caserta, PhD, Francesca Besi, PhD, James F Sanchez, PhD, Guido Marcucci, MD, Jonathan J Keats, PhD, Amrita Y. Krishnan, MD, Matt Coffey, PhD, Douglas W. Sborov, MDMSc, Gerard Nuovo, MD, Craig C Hofmeister, MDMPH, Flavia Pichiorri, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1816.
https://doi.org/10.1182/blood-2019-128740
Published: 2019
Journal Articles

Multiple Myeloma Epigenetic Programming Prognostic of Outcome Converges with Loci Reprogrammed in Relapsed/Refractory Disease

Benjamin G Barwick, PhD, Sheri Skerget, PhD, Jonathan J Keats, PhD, Daniel Auclair, Sagar Lonial, Lawrence H. Boise, PhD, Paula M Vertino, PhD, Doris R Powell, MA
Journal: Blood
Blood (2019) 134 (Supplement_1): 858.
https://doi.org/10.1182/blood-2019-124422
Published: 2019
Journal Articles

MAGE-A3 Promotes Chemotherapy Resistance and Proliferation in Multiple Myeloma through Regulation of BIM and p21 Cip1

Hearn Jay Cho, MD, Anna Huo-Chang Mei, MS, Kaity Tung, BS, Jessie Han, Deepak Perumal, PhD, Jonathan J Keats, PhD, Daniel Auclair, PhD, Ajai Chari, MD, Sundar Jagannath, MD, Samir Parekh, MD, Alessandro Lagana, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4464.
https://doi.org/10.1182/blood-2018-99-118692
Published: 2018