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Journal Articles

Immunomodulatory Effects of MEK Inhibition in Multiple Myeloma

Chaitanya Acharya, Reyka G. Jayasinghe, Mark Hamilton, Sacha Gnjatic, Seunghee Kim-Schulze, Hearn Jay Cho, Shaji Kumar, George Mulligan
Journal: Blood
Blood (2024) 144 (Supplement 1): 6863.
https://doi.org/10.1182/blood-2024-210989
Published: 2024
Journal Articles

DNA Methylation Analysis of Commpass Reveals Distinct Epigenetic Programs of High-Risk Disease

Benjamin G. Barwick, Robert M Chavez, Doris R. Powell, Yu Zhang, Mark Hamilton, Daniel Auclair, George Mulligan, Karen N Conneely, Jonathan J Keats, Paula M Vertino, Lawrence H. Boise, Sagar Lonial
Journal: Blood
Blood (2024) 144 (Supplement 1): 251.
https://doi.org/10.1182/blood-2024-201447
Published: 2024
Journal Articles

Integrated Coding and Non-Coding Transcriptional Single-Cell Atlas of Multiple Myeloma: Unraveling the Effects of Myeloma Genotype on the Bone Marrow Microenvironment

Marina E Michaud, Sarthak Satpathy, William Pilcher, Edgar Gonzalez-Kozlova, Dimitra Karagkouni, Lijun Yao, Yered Pita-Juarez, Chaitanya Acharya, Mark Hamilton, Shivani Nanda, Yizhe Song, Julia T Wang, Mojtaba Bakhtiari, David Avigan, Taxiarchis Kourelis, Madhav V. Dhodapkar, Sagar Lonial, Swati Bhasin, Immune Network, Li Ding, Sacha Gnjatic, Ioannis S Vlachos, George Mulligan, Manoj Bhasin
Journal: Blood
Blood (2024) 144 (Supplement 1): 3258.
https://doi.org/10.1182/blood-2024-211579
Published: 2024
Journal Articles

Single-Cell Analysis Reveals Depletion of Antigen-Presenting Cell (APC) and IFN-Stimulated CD4 T Cell Populations in High-Risk Newly Diagnosed Multiple Myeloma Patients

Junia Vieira, Alison S Park, David Melnekoff, Tarek H. Mouhieddine, Alessia D'anna, Adolfo Aleman, Meghana Ram, Katerina Kappes, Mark Hamilton, George Mulligan, Arun P Wiita, Ajai Chari, Thomas Martin, Michael Slade, Li Ding, Ravi Vij, Brian Brown, Benjamin Tycko, Rena Feinman, David S. Siegel, Sundar Jagannath, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2024) 144 (Supplement 1): 4654.
https://doi.org/10.1182/blood-2024-208308
Published: 2024
Journal Articles

Ectopic NSD2 Remodels H3K36me2 and DNA Methylation to Promote Oncogenic Gene Expression in Multiple Myeloma

Robert M Chavez, Doris R. Powell, Kiran Lakhani, John Attelah, Erin Flynt, Terry Connolly, Mark Hamilton, George Mulligan, Daniel Auclair, Jonathan Keats, Paula M Vertino, Lawrence H. Boise, Sagar Lonial, Karen N Conneely, Benjamin G. Barwick
Journal: Blood
Blood (2024) 144 (Supplement 1): 1359.
https://doi.org/10.1182/blood-2024-210929
Published: 2024
Journal Articles

Immune Profiling Reveals Distinct Features of Multiple Myeloma Subtypes Defined By Multi-Omics Network Analysis

Junia Vieira, Alison S Park, Edgar Gonzalez-Kozlova, David Melnekoff, Sherry Bhalla, Chaitanya Acharya, Mark Hamilton, George Mulligan, Immune Atlas Network, Hearn Jay Cho, Li Ding, Sacha Gnjatic, Ioannis S Vlachos, Manoj Bhasin, Sundar Jagannath, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2024) 144 (Supplement 1): 4658.
https://doi.org/10.1182/blood-2024-208677
Published: 2024
Journal Articles

In-Depth Characterization of the High Risk-Associated Tumor Immune Landscape in Multiple Myeloma

Yered Pita-Juarez, Dimitra Karagkouni, Edgar Gonzalez-Kozlova, Yuling Ma, Lijun Yao, William Pilcher, Beena Thomas, Alessandro Lagana, Sarthak Satpathy, Swati Bhasin, Yizhe Song, Ravi Vij, Darwin D'Souza, Travis Dawson, Geoffrey Kelly, Jessica Wendy Schulman, Shaji Kunnathu Kumar, David Avigan, Seunghee Kim-Schulze, Li Ding, Hearn Jay Cho, Taxiarchis Kourelis, Eva Lepisto, Manoj Bhasin, April Cook, Mark Hamilton, George Mulligan, Immune Network, Ioannis Vlachos, Sacha Gnjatic
Journal: Blood
Blood (2023) 142 (Supplement 1): 648.
https://doi.org/10.1182/blood-2023-189940
Published: 2023
Journal Articles

The Mydrug Platform Trial: Efficacy and Safety of Daratumumab, Ixazomib, Pomalidomide, and Dexamethasone in Patients with Functionally High-Risk Multiple Myeloma

Shaji K Kumar, Craig C Hofmeister, Noa Biran, Gurbakhash Kaur, Jing Christine Ye, Jeffrey A. Zonder, Umar Syed, Jennifer Yesil, Karen Woolley, George Mulligan, Hearn J. Cho
Journal: Blood
Blood (2022) 140 (Supplement 1): 4434–4435.
https://doi.org/10.1182/blood-2022-163737
Published: 2022
Journal Articles

Myeloma Developing Regimens Using Genomics (MyDRUG): Longitudinal Single-Cell Transcriptional Landscape of the Myeloma and Immune Microenvironment in Relapsed/Refractory Multiple Myeloma Patients Treated with MEK-Inhibitor, Cobimetinib

Reyka G. Jayasinghe, George Mulligan, April Cook, Mark Hamilton, Sacha Gnjatic, Seunghee Kim-Schulze, Hearn J. Cho, Shaji K Kumar
Journal: Blood
Blood (2022) 140 (Supplement 1): 7090–7091.
https://doi.org/10.1182/blood-2022-167462
Published: 2022
Journal Articles

Randomized Phase 2 Open-Label Study of R-CHOP ± Bortezomib in Patients (Pts) with Untreated Non-Germinal Center B-Cell-like (Non-GCB) Subtype Diffuse Large Cell Lymphoma (DLBCL): Results from the Pyramid Trial (NCT00931918)

John P. Leonard, MD, Kathryn Kolibaba, MD, James A. Reeves, MD, Anil Tulpule, MD, Ian W. Flinn, MD PhD, Tatjana Kolevska, MD, Robert Robles, MD, Christopher Flowers, MD, Robert Collins, MD, Nicholas J. DiBella, MD, Steven W. Papish, MD, Parameswaran Venugopal, MD, Andrew Horodner, MD, Amir Tabatabai, MD, Julio Hajdenberg, MD, George Mulligan, PhD, Rachel Neuwirth, PhD, Kaveri Suryanarayan, Dixie-Lee Esseltine, MD, Sven de Vos, MD PhD
Journal: Blood
Blood (2015) 126 (23): 811.
https://doi.org/10.1182/blood.V126.23.811.811
Published: 2015
Journal Articles

RPL5 Is a Candidate Tumor Suppressor on 1p22.1 in Multiple Myeloma of Which the Expression Is Linked to Bortezomib Response

Isabel JF Hofman, Mark van Duin, PhD, George Mulligan, PhD, Ellen Geerdens, Emanuela Garelli, Cecilia Mancini, Heidi Lemmens, Michel Delforge, Peter Vandenberghe, MDPhD, Iwona Wlodarska, Anna Aspesi, Lucienne Michaux, Pieter Sonneveld, MD PhD, Kim De Keersmaecker
Journal: Blood
Blood (2015) 126 (23): 2969.
https://doi.org/10.1182/blood.V126.23.2969.2969
Published: 2015
Journal Articles

In-Depth Molecular Profiling of Multiple Myeloma in African Americans

Zarko Manojlovic, PhD, Austin Christofferson, Christophe Legendre, PhD, Gill Spreyer, PhD, Seungchan Kim, PhD, Winnie Liang, PhD, George Mulligan, PhD, Pamela G. Kidd, MD, Scott Jewell, PhD, Mary Derome, MS, Jen Troups, Daniel Auclair, PhD, Sagar Lonial, MD, David Craig, PhD, Jonathan J Keats, PhD, John David Carpten, PhD
Journal: Blood
Blood (2015) 126 (23): 2973.
https://doi.org/10.1182/blood.V126.23.2973.2973
Published: 2015
Journal Articles

Prediction of high- and low-risk multiple myeloma based on gene expression and the International Staging System

Clinical Trials & Observations
Rowan Kuiper, Mark van Duin, Martin H. van Vliet, Annemiek Broijl, Bronno van der Holt, Laila el Jarari, Erik H. van Beers, George Mulligan, Hervé Avet-Loiseau, Walter M. Gregory, Gareth Morgan, Hartmut Goldschmidt, Henk M. Lokhorst, Pieter Sonneveld
Journal: Blood
Blood (2015) 126 (17): 1996–2004.
https://doi.org/10.1182/blood-2015-05-644039
Published: 2015
Includes: Supplemental data
Journal Articles

Prediction of High and Low-Risk Multiple Myeloma Based on the EMC92 Gene Expression Signature and the International Staging System

Rowan Kuiper, BSc, Martin H. Van Vliet, PhD, Erik H. van Beers, PhD, Annemiek Broijl, MDPhD, George Mulligan, PhD, Hervé Avet-Loiseau, Walter Gregory, PhD, Gareth J. Morgan, MD PhD, Hartmut Goldschmidt, MD, Henk Lokhorst, MDPhD, Mark van Duin, PhD, Pieter Sonneveld, MDPhD
Journal: Blood
Blood (2014) 124 (21): 3358.
https://doi.org/10.1182/blood.V124.21.3358.3358
Published: 2014
Journal Articles

Studies of the Proteasome Inhibitor Sensitivity Modulator Tight Junction Protein 1 Highlight a Role for Signaling through the Epidermal Growth Factor Receptor in Determining Proteasome Capacity

Xing-Ding Zhang, PhD, Veerabhadran Baladandayuthapani, PhD, Heather Yan Lin, PhD, George Mulligan, PhD, Bin Li, PhD, Dixie-Lee Esseltine, MD, Lin Qi, PhD, Jian-Liang Xu, PhD, Walter Hunziker, PhD, Bart Barlogie, MD, PhD, Saad Z. Usmani, MD, Qing Zhang, PhD, John Crowley, PhD, Antje Hoering, PhD, Bing-Zong Li, MD, PhD, Huihan Wang, MD, PhD, Jiexin Zhang, M.S., Isere Kuiatse, PhD, Jin-Le Tang, PhD, Jin He, Jing Yang, PhD, Richard Eric Davis, MD, Wencai Ma, PhD, Zhiqiang Wang, PhD, Lin Yang, MD, PhD, Robert Z. Orlowski, PhD MD
Journal: Blood
Blood (2014) 124 (21): 3414.
https://doi.org/10.1182/blood.V124.21.3414.3414
Published: 2014
Journal Articles

Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy

Clinical Trials & Observations
George Mulligan, David I. Lichter, Alessandra Di Bacco, Stephen J. Blakemore, Allison Berger, Erik Koenig, Hugues Bernard, William Trepicchio, Bin Li, Rachel Neuwirth, Nibedita Chattopadhyay, Joseph B. Bolen, Andrew J. Dorner, Helgi van de Velde, Deborah Ricci, Sundar Jagannath, James R. Berenson, Paul G. Richardson, Edward A. Stadtmauer, Robert Z. Orlowski, Sagar Lonial, Kenneth C. Anderson, Pieter Sonneveld, Jesús F. San Miguel, Dixie-Lee Esseltine, Matthew Schu
Journal: Blood
Blood (2014) 123 (5): 632–639.
https://doi.org/10.1182/blood-2013-05-504340
Published: 2014
Includes: Supplemental data
Journal Articles

Comparison Of Conventional, FISH and GEP Prognostic Factors In Multiple Myeloma: Introducing a Novel Risk Stratification

Rowan Kuiper, Martin van Vliet, Annemiek Broyl, Yvonne de Knegt, Bronno van der Holt, Laila el Jarari, George Mulligan, Walter Gregory, PhD, Gareth J Morgan, MD PhD, Hartmut Goldschmidt, MD, Uta Bertsch, MD, Henk Lokhorst, Mark van Duin, Erik van Beers, Pieter Sonneveld, MD, Ph.D
Journal: Blood
Blood (2013) 122 (21): 3092.
https://doi.org/10.1182/blood.V122.21.3092.3092
Published: 2013
Journal Articles

Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone

Brief Report
David I. Lichter, Hadi Danaee, Michael D. Pickard, Olga Tayber, Michael Sintchak, Hongliang Shi, Paul G. Richardson, Jamie Cavenagh, Joan Bladé, Thierry Façon, Ruben Niesvizky, Melissa Alsina, William Dalton, Pieter Sonneveld, Sagar Lonial, Helgi van de Velde, Deborah Ricci, Dixie-Lee Esseltine, William L. Trepicchio, George Mulligan, Kenneth C. Anderson
Journal: Blood
Blood (2012) 120 (23): 4513–4516.
https://doi.org/10.1182/blood-2012-05-426924
Published: 2012
Includes: Supplemental data
Journal Articles

Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma

Clinical Trials & Observations
Shaji Kumar, Ian Flinn, Paul G. Richardson, Parameswaran Hari, Natalie Callander, Stephen J. Noga, A. Keith Stewart, Francesco Turturro, Robert Rifkin, Jeffrey Wolf, Jose Estevam, George Mulligan, Hongliang Shi, Iain J. Webb, S. Vincent Rajkumar
Journal: Blood
Blood (2012) 119 (19): 4375–4382.
https://doi.org/10.1182/blood-2011-11-395749
Published: 2012
Journal Articles

Identification of Patient Subgroups Demonstrating Longer Progression-Free Survival (PFS) Benefit with Bortezomib-Rituximab Versus Rituximab in Patients with Relapsed or Refractory Follicular Lymphoma (FL): Biomarker Analyses of the Phase 3 LYM3001 Study

Bertrand Coiffier, MD, Weimin Li, Erin D Henitz, BS, J. D. Karkera, PhD, Reyna Favis, PhD, Dana Gaffney, MS, Alice Shapiro, MS, Panteli Theocharous, BSc (hons), MSc, PhD, Yusri A Elsayed, MD, PhD, Helgi van de Velde, MD, PhD, Evgenii A Osmanov, MD, PhD, Xiaonan Hong, MD, Adriana Scheliga, MD, Fritz C. Offner, MD, PhD, Simon Rule, Adriana C Teixeira, MD, Jan Walewski, MD, PhD, Sven de Vos, MD, PhD, Michael Crump, MD, FRCPC, Ofer Shpilberg, MD, MPH, Pier Luigi Zinzani, MD, PhD, Andrew Z Cakana, MD, FRCPath, Dixie-Lee Esseltine, MD, FRCPC, George Mulligan, PhD, Deborah S Ricci, PhD
Journal: Blood
Blood (2011) 118 (21): 265.
https://doi.org/10.1182/blood.V118.21.265.265
Published: 2011