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George Mulligan
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Journal Articles

Combinations of high risk cytogenetic events in multiple myeloma drive distinct immune remodeling patterns and worse outcomes

Free
William Pilcher, Marina Michaud, Sarthak Satpathy, Denis Ohlstrom, Katherine Ferguson, Edgar Gonzalez-Kozlova, Chaitanya Acharya, Dimitra Karagkouni, Yizhe Song, MMRF Immune Atlas Network, Alessandro Lagana, Shaji Kumar, Madhav Dhodapkar, Samir Parekh, Ravi Vij, Hearn Cho, David Avigan, Taxiarchis Kourelis, Ioannis Vlachos, Sacha Gnjatic, Li Ding, George Mulligan, Sagar Lonial, Ajay Nooka, Manoj Bhasin
Journal: Blood
Blood (2025) 146 (Supplement 1): 2179.
https://doi.org/10.1182/blood-2025-2179
Published: 2025
Journal Articles

Spatial biomarkers of CAR-T treatment response in relapsed refractory multiple myeloma

Free
Julia Wang, Chenchen Peng, Reyka Jayasinghe, Michael Slade, Xiangwei Fang, Julie Fortier, Mark Fiala, Yuxuan Pan, Preet Lal, Yuting Zhao, Kiran Vij, Chaitanya Acharya, George Mulligan, John DiPersio, Feng Chen, Ravi Vij, Li Ding
Journal: Blood
Blood (2025) 146 (Supplement 1): 5804.
https://doi.org/10.1182/blood-2025-5804
Published: 2025
Journal Articles

An immune proteomic atlas of 300 million bone marrow cells reveals prognostic cell states in multiple myeloma

Free
Dimitra Karagkouni, Shivani Nanda, Patrick Foley, Chaitanya Acharya, William Pilcher, Edgar Gonzalez-Kozlova, Giulia Cheloni, MMRF Immune Atlas Network, Shaji Kumar, Samir Parekh, Ravi Vij, Sagar Lonial, Hearn Cho, David Avigan, Taxiarchis Kourelis, Sacha Gnjatic, Li Ding, Manoj Bhasin, George Mulligan, Ioannis Vlachos
Journal: Blood
Blood (2025) 146 (Supplement 1): 5801.
https://doi.org/10.1182/blood-2025-5801
Published: 2025
Journal Articles

Commpass explorer: An interactive platform to explore clinico-genomic data from newly diagnosed multiple myeloma patients from the commpass observational trial

Free
Wanxing Zhang, Chaitanya Acharya, Steven Foltz, MMRF Immune Atlas Network, David Avigan, Samir Parekh, Ravi Vij, Shaji Kumar, Taxiarchis Kourelis, Sagar Lonial, Hearn Cho, Ioannis Vlachos, Sacha Gnjatic, Li Ding, Manoj Bhasin, George Mulligan
Journal: Blood
Blood (2025) 146 (Supplement 1): 7470.
https://doi.org/10.1182/blood-2025-7470
Published: 2025
Journal Articles

Daratumumab-based quadruplet therapy in functional high-risk relapse/refractory multiple myeloma patients induces changes associated with CD8 T cell signaling, activation and expansion

Free
Chaitanya Acharya, Reyka Jayasinghe, Darwin D'Souza, Mark Hamilton, Steven Foltz, Zhihong Chen, Seunghee Kim-Schulze, Hearn Cho, Shaji Kumar, George Mulligan
Journal: Blood
Blood (2025) 146 (Supplement 1): 3955.
https://doi.org/10.1182/blood-2025-3955
Published: 2025
Journal Articles

Mapping the immune checkpoint receptor-ligand landscape in newly diagnosed multiple myeloma may help prioritize patients for immune checkpoint inhibitor therapy

Free
Steven Foltz, Reyka Jayasinghe, MMRF Immune Atlas Network, David Avigan, Samir Parekh, Ravi Vij, Shaji Kumar, Taxiarchis Kourelis, Sagar Lonial, Hearn Cho, Ioannis Vlachos, Sacha Gnjatic, Li Ding, Manoj Bhasin, Chaitanya Acharya, Alexander Gout, George Mulligan
Journal: Blood
Blood (2025) 146 (Supplement 1): 4024.
https://doi.org/10.1182/blood-2025-4024
Published: 2025
Journal Articles

Immunomodulatory Effects of MEK Inhibition in Multiple Myeloma

Free
Chaitanya Acharya, Reyka G. Jayasinghe, Mark Hamilton, Sacha Gnjatic, Seunghee Kim-Schulze, Hearn Jay Cho, Shaji Kumar, George Mulligan
Journal: Blood
Blood (2024) 144 (Supplement 1): 6863.
https://doi.org/10.1182/blood-2024-210989
Published: 2024
Journal Articles

Single-Cell Analysis Reveals Depletion of Antigen-Presenting Cell (APC) and IFN-Stimulated CD4 T Cell Populations in High-Risk Newly Diagnosed Multiple Myeloma Patients

Free
Junia Vieira, Alison S Park, David Melnekoff, Tarek H. Mouhieddine, Alessia D'anna, Adolfo Aleman, Meghana Ram, Katerina Kappes, Mark Hamilton, George Mulligan, Arun P Wiita, Ajai Chari, Thomas Martin, Michael Slade, Li Ding, Ravi Vij, Brian Brown, Benjamin Tycko, Rena Feinman, David S. Siegel, Sundar Jagannath, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2024) 144 (Supplement 1): 4654.
https://doi.org/10.1182/blood-2024-208308
Published: 2024
Journal Articles

Ectopic NSD2 Remodels H3K36me2 and DNA Methylation to Promote Oncogenic Gene Expression in Multiple Myeloma

Free
Robert M Chavez, Doris R. Powell, Kiran Lakhani, John Attelah, Erin Flynt, Terry Connolly, Mark Hamilton, George Mulligan, Daniel Auclair, Jonathan Keats, Paula M Vertino, Lawrence H. Boise, Sagar Lonial, Karen N Conneely, Benjamin G. Barwick
Journal: Blood
Blood (2024) 144 (Supplement 1): 1359.
https://doi.org/10.1182/blood-2024-210929
Published: 2024
Journal Articles

Immune Profiling Reveals Distinct Features of Multiple Myeloma Subtypes Defined By Multi-Omics Network Analysis

Free
Junia Vieira, Alison S Park, Edgar Gonzalez-Kozlova, David Melnekoff, Sherry Bhalla, Chaitanya Acharya, Mark Hamilton, George Mulligan, Immune Atlas Network, Hearn Jay Cho, Li Ding, Sacha Gnjatic, Ioannis S Vlachos, Manoj Bhasin, Sundar Jagannath, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2024) 144 (Supplement 1): 4658.
https://doi.org/10.1182/blood-2024-208677
Published: 2024
Journal Articles

Integrated Coding and Non-Coding Transcriptional Single-Cell Atlas of Multiple Myeloma: Unraveling the Effects of Myeloma Genotype on the Bone Marrow Microenvironment

Free
Marina E Michaud, Sarthak Satpathy, William Pilcher, Edgar Gonzalez-Kozlova, Dimitra Karagkouni, Lijun Yao, Yered Pita-Juarez, Chaitanya Acharya, Mark Hamilton, Shivani Nanda, Yizhe Song, Julia T Wang, Mojtaba Bakhtiari, David Avigan, Taxiarchis Kourelis, Madhav V. Dhodapkar, Sagar Lonial, Swati Bhasin, Immune Network, Li Ding, Sacha Gnjatic, Ioannis S Vlachos, George Mulligan, Manoj Bhasin
Journal: Blood
Blood (2024) 144 (Supplement 1): 3258.
https://doi.org/10.1182/blood-2024-211579
Published: 2024
Journal Articles

DNA Methylation Analysis of Commpass Reveals Distinct Epigenetic Programs of High-Risk Disease

Free
Benjamin G. Barwick, Robert M Chavez, Doris R. Powell, Yu Zhang, Mark Hamilton, Daniel Auclair, George Mulligan, Karen N Conneely, Jonathan J Keats, Paula M Vertino, Lawrence H. Boise, Sagar Lonial
Journal: Blood
Blood (2024) 144 (Supplement 1): 251.
https://doi.org/10.1182/blood-2024-201447
Published: 2024
Journal Articles

In-Depth Characterization of the High Risk-Associated Tumor Immune Landscape in Multiple Myeloma

Free
Yered Pita-Juarez, Dimitra Karagkouni, Edgar Gonzalez-Kozlova, Yuling Ma, Lijun Yao, William Pilcher, Beena Thomas, Alessandro Lagana, Sarthak Satpathy, Swati Bhasin, Yizhe Song, Ravi Vij, Darwin D'Souza, Travis Dawson, Geoffrey Kelly, Jessica Wendy Schulman, Shaji Kunnathu Kumar, David Avigan, Seunghee Kim-Schulze, Li Ding, Hearn Jay Cho, Taxiarchis Kourelis, Eva Lepisto, Manoj Bhasin, April Cook, Mark Hamilton, George Mulligan, Immune Network, Ioannis Vlachos, Sacha Gnjatic
Journal: Blood
Blood (2023) 142 (Supplement 1): 648.
https://doi.org/10.1182/blood-2023-189940
Published: 2023
Journal Articles

Myeloma Developing Regimens Using Genomics (MyDRUG): Longitudinal Single-Cell Transcriptional Landscape of the Myeloma and Immune Microenvironment in Relapsed/Refractory Multiple Myeloma Patients Treated with MEK-Inhibitor, Cobimetinib

Free
Reyka G. Jayasinghe, George Mulligan, April Cook, Mark Hamilton, Sacha Gnjatic, Seunghee Kim-Schulze, Hearn J. Cho, Shaji K Kumar
Journal: Blood
Blood (2022) 140 (Supplement 1): 7090–7091.
https://doi.org/10.1182/blood-2022-167462
Published: 2022
Journal Articles

The Mydrug Platform Trial: Efficacy and Safety of Daratumumab, Ixazomib, Pomalidomide, and Dexamethasone in Patients with Functionally High-Risk Multiple Myeloma

Free
Shaji K Kumar, Craig C Hofmeister, Noa Biran, Gurbakhash Kaur, Jing Christine Ye, Jeffrey A. Zonder, Umar Syed, Jennifer Yesil, Karen Woolley, George Mulligan, Hearn J. Cho
Journal: Blood
Blood (2022) 140 (Supplement 1): 4434–4435.
https://doi.org/10.1182/blood-2022-163737
Published: 2022
Journal Articles

RPL5 Is a Candidate Tumor Suppressor on 1p22.1 in Multiple Myeloma of Which the Expression Is Linked to Bortezomib Response

Free
Isabel JF Hofman, Mark van Duin, PhD, George Mulligan, PhD, Ellen Geerdens, Emanuela Garelli, Cecilia Mancini, Heidi Lemmens, Michel Delforge, Peter Vandenberghe, MDPhD, Iwona Wlodarska, Anna Aspesi, Lucienne Michaux, Pieter Sonneveld, MD PhD, Kim De Keersmaecker
Journal: Blood
Blood (2015) 126 (23): 2969.
https://doi.org/10.1182/blood.V126.23.2969.2969
Published: 2015
Journal Articles

In-Depth Molecular Profiling of Multiple Myeloma in African Americans

Free
Zarko Manojlovic, PhD, Austin Christofferson, Christophe Legendre, PhD, Gill Spreyer, PhD, Seungchan Kim, PhD, Winnie Liang, PhD, George Mulligan, PhD, Pamela G. Kidd, MD, Scott Jewell, PhD, Mary Derome, MS, Jen Troups, Daniel Auclair, PhD, Sagar Lonial, MD, David Craig, PhD, Jonathan J Keats, PhD, John David Carpten, PhD
Journal: Blood
Blood (2015) 126 (23): 2973.
https://doi.org/10.1182/blood.V126.23.2973.2973
Published: 2015
Journal Articles

Randomized Phase 2 Open-Label Study of R-CHOP ± Bortezomib in Patients (Pts) with Untreated Non-Germinal Center B-Cell-like (Non-GCB) Subtype Diffuse Large Cell Lymphoma (DLBCL): Results from the Pyramid Trial (NCT00931918)

Free
John P. Leonard, MD, Kathryn Kolibaba, MD, James A. Reeves, MD, Anil Tulpule, MD, Ian W. Flinn, MD PhD, Tatjana Kolevska, MD, Robert Robles, MD, Christopher Flowers, MD, Robert Collins, MD, Nicholas J. DiBella, MD, Steven W. Papish, MD, Parameswaran Venugopal, MD, Andrew Horodner, MD, Amir Tabatabai, MD, Julio Hajdenberg, MD, George Mulligan, PhD, Rachel Neuwirth, PhD, Kaveri Suryanarayan, Dixie-Lee Esseltine, MD, Sven de Vos, MD PhD
Journal: Blood
Blood (2015) 126 (23): 811.
https://doi.org/10.1182/blood.V126.23.811.811
Published: 2015
Journal Articles

Prediction of high- and low-risk multiple myeloma based on gene expression and the International Staging System

Free
Clinical Trials & Observations
Rowan Kuiper, Mark van Duin, Martin H. van Vliet, Annemiek Broijl, Bronno van der Holt, Laila el Jarari, Erik H. van Beers, George Mulligan, Hervé Avet-Loiseau, Walter M. Gregory, Gareth Morgan, Hartmut Goldschmidt, Henk M. Lokhorst, Pieter Sonneveld
Journal: Blood
Blood (2015) 126 (17): 1996–2004.
https://doi.org/10.1182/blood-2015-05-644039
Published: 2015
Includes: Supplemental data
Journal Articles

Studies of the Proteasome Inhibitor Sensitivity Modulator Tight Junction Protein 1 Highlight a Role for Signaling through the Epidermal Growth Factor Receptor in Determining Proteasome Capacity

Free
Xing-Ding Zhang, PhD, Veerabhadran Baladandayuthapani, PhD, Heather Yan Lin, PhD, George Mulligan, PhD, Bin Li, PhD, Dixie-Lee Esseltine, MD, Lin Qi, PhD, Jian-Liang Xu, PhD, Walter Hunziker, PhD, Bart Barlogie, MD, PhD, Saad Z. Usmani, MD, Qing Zhang, PhD, John Crowley, PhD, Antje Hoering, PhD, Bing-Zong Li, MD, PhD, Huihan Wang, MD, PhD, Jiexin Zhang, M.S., Isere Kuiatse, PhD, Jin-Le Tang, PhD, Jin He, Jing Yang, PhD, Richard Eric Davis, MD, Wencai Ma, PhD, Zhiqiang Wang, PhD, Lin Yang, MD, PhD, Robert Z. Orlowski, PhD MD
Journal: Blood
Blood (2014) 124 (21): 3414.
https://doi.org/10.1182/blood.V124.21.3414.3414
Published: 2014