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Journal Articles

Immune Profiling Reveals Distinct Features of Multiple Myeloma Subtypes Defined By Multi-Omics Network Analysis

Junia Vieira, Alison S Park, Edgar Gonzalez-Kozlova, David Melnekoff, Sherry Bhalla, Chaitanya Acharya, Mark Hamilton, George Mulligan, Immune Atlas Network, Hearn Jay Cho, Li Ding, Sacha Gnjatic, Ioannis S Vlachos, Manoj Bhasin, Sundar Jagannath, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2024) 144 (Supplement 1): 4658.
https://doi.org/10.1182/blood-2024-208677
Published: 2024
Journal Articles

Integrated Coding and Non-Coding Transcriptional Single-Cell Atlas of Multiple Myeloma: Unraveling the Effects of Myeloma Genotype on the Bone Marrow Microenvironment

Marina E Michaud, Sarthak Satpathy, William Pilcher, Edgar Gonzalez-Kozlova, Dimitra Karagkouni, Lijun Yao, Yered Pita-Juarez, Chaitanya Acharya, Mark Hamilton, Shivani Nanda, Yizhe Song, Julia T Wang, Mojtaba Bakhtiari, David Avigan, Taxiarchis Kourelis, Madhav V. Dhodapkar, Sagar Lonial, Swati Bhasin, Immune Network, Li Ding, Sacha Gnjatic, Ioannis S Vlachos, George Mulligan, Manoj Bhasin
Journal: Blood
Blood (2024) 144 (Supplement 1): 3258.
https://doi.org/10.1182/blood-2024-211579
Published: 2024
Journal Articles

Immunomodulatory Effects of MEK Inhibition in Multiple Myeloma

Chaitanya Acharya, Reyka G. Jayasinghe, Mark Hamilton, Sacha Gnjatic, Seunghee Kim-Schulze, Hearn Jay Cho, Shaji Kumar, George Mulligan
Journal: Blood
Blood (2024) 144 (Supplement 1): 6863.
https://doi.org/10.1182/blood-2024-210989
Published: 2024
Journal Articles

Immune Landscape Associated with Response to Brentuximab Vedotin with Ipilimumab and/or Nivolumab in Relapsed/Refractory Hodgkin Lymphoma (E4412 Phase 1)

Catherine S Diefenbach, Edgar Gonzalez-Kozlova, Diane Marie Del Valle, Hsin-Hui Huang, Opeyemi Jegede, Vanessa Barcessat, Kevin Tuballes, Geoffrey Kelly, Manishkumar Patel, Hui Xie, Jocelyn Harris, Kimberly Argueta, Kai Nie, Radim Moravec, Jennifer Altreuter, Dzifa Yawa Duose, Brad S. Kahl, Stephen M Ansell, Joyce Yu, Ethan Cerami, James Lindsay, Ignacio Wistuba, Seunghee Kim-Schulze, Sacha Gnjatic
Journal: Blood
Blood (2023) 142 (Supplement 1): 4382.
https://doi.org/10.1182/blood-2023-174903
Published: 2023
Journal Articles

Dysregulation of Cellular Immunity in High-Risk Multiple Myeloma

Selma Bekri, Simone Katz, Geoffrey Kelly, Travis Dawson, Darwin D'Souza, Michael Mason, Alexandre Alloy, Shameek Biswas, Seunghee Kim-Schulze, Sacha Gnjatic, Samir Parekh, Sundar Jagannath, Alessandro Lagana, Hearn Jay Cho
Journal: Blood
Blood (2023) 142 (Supplement 1): 1942.
https://doi.org/10.1182/blood-2023-189882
Published: 2023
Journal Articles

In-Depth Characterization of the High Risk-Associated Tumor Immune Landscape in Multiple Myeloma

Yered Pita-Juarez, Dimitra Karagkouni, Edgar Gonzalez-Kozlova, Yuling Ma, Lijun Yao, William Pilcher, Beena Thomas, Alessandro Lagana, Sarthak Satpathy, Swati Bhasin, Yizhe Song, Ravi Vij, Darwin D'Souza, Travis Dawson, Geoffrey Kelly, Jessica Wendy Schulman, Shaji Kunnathu Kumar, David Avigan, Seunghee Kim-Schulze, Li Ding, Hearn Jay Cho, Taxiarchis Kourelis, Eva Lepisto, Manoj Bhasin, April Cook, Mark Hamilton, George Mulligan, Immune Network, Ioannis Vlachos, Sacha Gnjatic
Journal: Blood
Blood (2023) 142 (Supplement 1): 648.
https://doi.org/10.1182/blood-2023-189940
Published: 2023
Journal Articles

Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease

Clinical Trials & Observations
Livius Penter, Yang Liu, Jacquelyn O. Wolff, Lin Yang, Len Taing, Aashna Jhaveri, Jackson Southard, Manishkumar Patel, Nicole M. Cullen, Kathleen L. Pfaff, Nicoletta Cieri, Giacomo Oliveira, Seunghee Kim-Schulze, Srinika Ranasinghe, Rebecca Leonard, Taylor Robertson, Elizabeth A. Morgan, Helen X. Chen, Minkyung H. Song, Magdalena Thurin, Shuqiang Li, Scott J. Rodig, Carrie Cibulskis, Stacey Gabriel, Pavan Bachireddy, Jerome Ritz, Howard Streicher, Donna S. Neuberg, F. Stephen Hodi, Matthew S. Davids, Sacha Gnjatic, Kenneth J. Livak, Jennifer Altreuter, Franziska Michor, Robert J. Soiffer, Jacqueline S. Garcia, Catherine J. Wu
Journal: Blood
Blood (2023) 141 (15): 1817–1830.
https://doi.org/10.1182/blood.2022018246
Published: 2023
Includes: Supplemental data
Journal Articles

Mechanisms of Response and Resistance to Combination Decitabine and Ipilimumab for Transplant Naïve and Post-Transplant AML/MDS

Livius Penter, Yang Liu, Lin Yang, Len Taing, Aashna Jhaveri, Jackson Southard, Manishkumar Patel, Jacquelyn Wolff, Nicole Cullen, Kathleen Pfaff, Nicoletta Cieri, Giacomo Oliveira, Seunghee Kim-Schulze, Srinika Ranasinghe, Rebecca Leonard, Taylor Robertson, Helen Chen, Magdalena Thurin, Shuqiang Li, Scott J. Rodig, Carrie Cibulskis, Stacey Gabriel, Jerome Ritz, Howard Streicher, Donna S. Neuberg, Stephen Hodi, Sacha Gnjatic, Kenneth J Livak, Jennifer Altreuter, Franziska Michor, Robert J Soiffer, Jacqueline S. Garcia, Catherine J. Wu
Journal: Blood
Blood (2022) 140 (Supplement 1): 10198–10199.
https://doi.org/10.1182/blood-2022-157339
Published: 2022
Journal Articles

Myeloma Developing Regimens Using Genomics (MyDRUG): Longitudinal Single-Cell Transcriptional Landscape of the Myeloma and Immune Microenvironment in Relapsed/Refractory Multiple Myeloma Patients Treated with MEK-Inhibitor, Cobimetinib

Reyka G. Jayasinghe, George Mulligan, April Cook, Mark Hamilton, Sacha Gnjatic, Seunghee Kim-Schulze, Hearn J. Cho, Shaji K Kumar
Journal: Blood
Blood (2022) 140 (Supplement 1): 7090–7091.
https://doi.org/10.1182/blood-2022-167462
Published: 2022
Journal Articles

Single-Cell RNA-Seq Analysis of CD138-Depleted Bone Marrow Samples Reveals Genetic Alterations and Disease Progression Correlate with Tumor and Bone Marrow Immune Microenvironment in the Mmrf Commpass Study

Lijun Yao, Tianjiao Wang, Sato Kazuhiro, Reyka G Jayasinghe, William Pilcher, Edgar Gonzalez-Kozlova, Yered Pita-Juarez, Taxiarchis Kourelis, Deon Doxie, Beena E Thomas, Brian Lee, Swati S Bhasin, Bhaskar Upadhyaya, Mark A Fiala, Julie Fortier, Travis Dawson, John Leech, Shaji Kumar, Hearn Jay Cho, Seunghee Kim-Schulze, Bee Raj, Stephen T. Oh, John F. DiPersio, Ravi Vij, Adeeb H Rahman, Ioannis Vlachos, Shaadi Mehr, Mark Hamilton, Daniel Auclair, Surendra Dasari, David Avigan, Madhav V Dhodapkar, Sacha Gnjatic, Manoj Bhasin, Li Ding
Journal: Blood
Blood (2021) 138 (Supplement 1): 2691.
https://doi.org/10.1182/blood-2021-154081
Published: 2021
Journal Articles

Suboptimal Humoral and Cellular Immune Response to SARS-CoV-2 RNA Vaccination in Myeloma Patients Is Associated with Anti-CD38 and BCMA-Targeted Treatment

Oliver Van Oekelen, Sarita Agte, Adolfo Aleman, Bhaskar Upadhyaya, Charles R. Gleason, Komal Srivastava, Katherine F. Beach, Kevin Tuballes, Katerina Kappes, Tarek H. Mouhieddine, Bo Wang, Seunghee Kim-Schulze, Ajai Chari, Sacha Gnjatic, Nina Bhardwaj, Brian D. Brown, Miriam Merad, Carlos Cordon-Cardo, Florian Krammer, Sundar Jagannath, Viviana Simon, Ania Wajnberg, Samir Parekh
Journal: Blood
Blood (2021) 138 (Supplement 1): 822.
https://doi.org/10.1182/blood-2021-152365
Published: 2021
Journal Articles

Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma

David G. Coffey, Francesco Maura, Edgar Gonzalez-Kozlova, Javier Diaz-Mejia3, Ping Luo, Yong Zhang, Yuexin Xu, Edus H. Warren, Eric L Smith, Hearn Jay Cho, Alexander Lesokhin, Benjamin Diamond, Dickran Kazandjian, Trevor J. Pugh, Damian J. Green, Sacha Gnjatic, Ola Landgren
Journal: Blood
Blood (2021) 138 (Supplement 1): 329.
https://doi.org/10.1182/blood-2021-154506
Published: 2021
Journal Articles

Characterization of T-Cell Exhaustion in Rapid Progressing Multiple Myeloma Using Cross Center Scrna-Seq Study

William Pilcher, Beena E Thomas, Swati S Bhasin, Reyka G Jayasinghe, Adeeb H Rahman, Seunghee Kim-Schulze, Edgar Gonzalez-Kozlova, Taxiarchis Kourelis, Madhav V Dhodapkar, Ravi Vij, Shaji Kumar, Shaadi Mehr, Mark Hamilton, Hearn Jay Cho, Daniel Auclair, David Avigan, Sacha Gnjatic, Li Ding, Manoj Bhasin
Journal: Blood
Blood (2021) 138 (Supplement 1): 401.
https://doi.org/10.1182/blood-2021-153863
Published: 2021
Journal Articles

Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation

Clinical Trials & Observations Brief Report
Livius Penter, Yi Zhang, Alexandra Savell, Teddy Huang, Nicoletta Cieri, Emily M. Thrash, Seunghee Kim-Schulze, Aashna Jhaveri, Jingxin Fu, Srinika Ranasinghe, Shuqiang Li, Wandi Zhang, Emma S. Hathaway, Matthew Nazzaro, Haesook T. Kim, Helen Chen, Magdalena Thurin, Scott J. Rodig, Mariano Severgnini, Carrie Cibulskis, Stacey Gabriel, Kenneth J. Livak, Corey Cutler, Joseph H. Antin, Sarah Nikiforow, John Koreth, Vincent T. Ho, Philippe Armand, Jerome Ritz, Howard Streicher, Donna Neuberg, F. Stephen Hodi, Sacha Gnjatic, Robert J. Soiffer, X. Shirley Liu, Matthew S. Davids, Pavan Bachireddy, Catherine J. Wu
Journal: Blood
Blood (2021) 137 (23): 3212–3217.
https://doi.org/10.1182/blood.2021010867
Published: 2021
Includes: Supplemental data
Journal Articles

Identification and Validation of CD138- Multiple Myeloma Immune and Tumor Subpopulations Using Cross Center Scrna-Seq Data

Reyka G Jayasinghe, PhD, Lijun Yao, MS, Beena Thomas, Swati S Bhasin, PhD, Nicolas Fernandez, PhD, David E. Avigan, MD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Ravi Vij, MD MBA, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, Li Ding, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15.
https://doi.org/10.1182/blood-2020-143256
Published: 2020
Journal Articles

Architecture of Sample Preparation and Data Governance of Immuno-Genomic Data Collected from Bone Marrow and Peripheral Blood Samples Obtained from Multiple Myeloma Patients

Shaadi Mehr, PhD, Daniel Auclair, Mark Hamilton, PhD, Leon Rozenblit, Hearn Jay Cho, MD PhD, Lijun Yao, MS, Reyka G Jayasinghe, PhD, Manoj Bhasin, PhD, Steven E. Labkoff, MD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Deon Doxie, Sacha Gnjatic, Cassandra Dewitt, Sergey Miron
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142882
Published: 2020
Journal Articles

Characterization of Plasma and Immune Cells Molecular Landscape That Play a Role in Rapid Progression of Multiple Myeloma Using Cross Center Scrna-Seq Study

Manoj Bhasin, PhD, Beena E Thomas, Reyka G Jayasinghe, PhD, Nicolas Fernandez, PhD, Swati S Bhasin, PhD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Ravi Vij, Shaji K. Kumar, MD, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, Li Ding, PhD, David E. Avigan, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–8.
https://doi.org/10.1182/blood-2020-143350
Published: 2020
Journal Articles

Integrated Cytof, Scrna-Seq and Cite-Seq Analysis of Bone Marrow Immune Microenvironment in the Mmrf Commpass Study

Lijun Yao, MS, Reyka G Jayasinghe, PhD, Beena E Thomas, Swati S Bhasin, PhD, Nicolas Fernandez, PhD, Taxiarchis Kourelis, MD, Deon Doxie, David E. Avigan, MD, Madhav V. Dhodapkar, MD, Shaji K. Kumar, MD, Ravi Vij, MBBS, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, PhD, Manoj Bhasin, PhD, Li Ding, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-142534
Published: 2020
Journal Articles

Genomic and Immunologic Analysis of Cmaf and Hypermutated Multiple Myeloma: Implications for Immunologic Therapy

Hearn Jay Cho, MD PhD, Deepak Perumal, PhD, Adeeb H Rahman, PhD, Donald Jackson, PhD, Michael Robbins, PhD, Seunghee Kim-Schultze, PhD, Sacha Gnjatic, PhD, Samir Parekh, MD, Jonathan J Keats, PhD, Daniel Auclair
Journal: Blood
Blood (2019) 134 (Supplement_1): 3093.
https://doi.org/10.1182/blood-2019-131274
Published: 2019
Journal Articles

Reduced Antigen Presentation May Contribute to Immunomodulatory Drug Resistance in Multiple Myeloma

David G. Coffey, MD, Ola Landgren, MD PhD, Yuexin Xu, PhD, Dickran Kazandjian, MD, Trevor J. Pugh, PhD, Sacha Gnjatic, PhD, Edus H. Warren, MD PhD, Damian J. Green, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4367.
https://doi.org/10.1182/blood-2019-126222
Published: 2019