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Bhaskar Upadhyaya
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Journal Articles

Combined PD-1 and Tim-3 Blockade Improves the in Vitro Anti-Myeloma Activity of T Cells of Patients on Talquetamab

Tarek H. Mouhieddine, Junia Vieira, Adolfo Aleman, Leah Grossman, David Melnekoff, Bhaskar Upadhyaya, Samantha St. Clair, Monica Garcia-Barros, Meghana Ram, Santiago Thibaud, Adriana Rossi, Shambavi Richard, Cesar Rodriguez, Joshua Richter, Hearn Jay Cho, Larysa Sanchez, Sundar Jagannath, Ajai Chari, Rachel Brody, Christian Salib, Alessandro Lagana, Samir Parekh
Journal: Blood
Blood (2024) 144 (Supplement 1): 357.
https://doi.org/10.1182/blood-2024-204929
Published: 2024
Journal Articles

Immune Dynamics Associated with Patient Outcomes Identified By Multimodal Single-Cell Analysis in Multiple Myeloma Patients Receiving Talquetamab Monotherapy

Tarek H. Mouhieddine, Junia Vieira dos Santos, Yogita Ghodke-Puranik, Adolfo Aleman, David Melnekoff, Bhaskar Upadhyaya, Adeeb Rahman, Shaked Afik, Hadas Lewinsky, Santiago Thibaud, Adriana C Rossi, Shambavi Richard, Cesar Rodriguez, Joshua Richter, Hearn Jay Cho, Larysa Sanchez, Sundar Jagannath, Ajai Chari, Alessandro Lagana, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 1927.
https://doi.org/10.1182/blood-2023-185308
Published: 2023
Journal Articles

Mezigdomide Treatment in Relapsed-Refractory Myeloma Patients Shifts Bone Marrow NK and T Cell Populations from Exhaustion to Activation

Lucia Y Chen, Oliver Van Oekelen, Michael Amatangelo, Tracy T. Chow, Bhaskar Upadhyaya, Alessandro Lagana, Geoffrey Kelly, Seunghee Kim-Schulze, Adolfo Aleman, Antonina Kurtova, Sarah Gooding, Sundar Jagannath, Erin Flynt, Anita K. Gandhi, Udo Oppermann, Anjan Thakurta, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 4686.
https://doi.org/10.1182/blood-2023-187748
Published: 2023
Journal Articles

Multimodal Single-Cell Transcriptomic and Proteomic Correlatives of Patients Outcomes Following Anti-BCMA Cellular Therapy with Ciltacabtagene Autoleucel (Cilta-cel) in Relapsed Multiple Myeloma

Junia Vieira dos Santos, David Melnekoff, Adolfo Aleman, Sherry Bhalla, Tarek H. Mouhieddine, Oliver Van Oekelen, Sridevi Rajeeve, Bhaskar Upadhyaya, Yogita Ghodke-Puranik, Violetta Leshchenko, Adeeb Rahman, Shaked Afik, Hadas Lewinsky, Santiago Thibaud, Hearn Jay Cho, Joshua Richter, Cesar Rodriguez, Larysa Sanchez, Adriana C Rossi, Shambavi Richard, Ajai Chari, Sundar Jagannath, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2023) 142 (Supplement 1): 93.
https://doi.org/10.1182/blood-2023-186395
Published: 2023
Journal Articles

Timing of Vaccination Impacts Serological Response to COVID-19 Myeloma Patients after BCMA-Targeted CAR T

Oliver Van Oekelen, Morgan Van Kesteren, Adolfo Aleman, Ariel Kogan Zajdman, Lucia Y Chen, Tarek H. Mouhieddine, Bhaskar Upadhyaya, Kseniya Serebryakova, Katerina Kappes, Sarita Agte, Annika Oostenink, Hayley Jackson, Charles Gleason, Komal Srivastava, Santiago Thibaud, Larysa Sanchez, Cesar Rodriguez, Joshua Richter, Hearn Jay Cho, Adriana C Rossi, Shambavi Richard, Carlos Cordon-Cardo, Ania Wajnberg, Florian Krammer, Sundar Jagannath, Viviana Simon, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 3350.
https://doi.org/10.1182/blood-2023-184409
Published: 2023
Journal Articles

Cellular Mechanisms Associated with Suboptimal Immune Responses to Sars-Cov-2 Bivalent Booster Vaccination in Patients with Multiple Myeloma

Adolfo Aleman, Morgan Van Kesteren, Ariel Kogan Zajdman, Komal Srivastava, Lucia Y Chen, Bhaskar Upadhyaya, Jessica Nardulli, Kseniya Serebryakova, Katerina Kappes, Hayley Jackson, Charles Gleason, Oliver Van Oekelen, Carlos Cordon-Cardo, Ania Wajnberg, Florian Krammer, Miriam Merad, Sundar Jagannath, Viviana Simon, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 1984.
https://doi.org/10.1182/blood-2023-187260
Published: 2023
Journal Articles

Cellular Immune Composition in Multiple Myeloma Patients Associated with Variable Humoral Responses to Sars-Cov-2 Vaccination

Ariel Kogan Zajdman, Adolfo Aleman, Bhaskar Upadhyaya, Katherine F. Beach, Kseniya Serebryakova, Sarita Agte, Katerina Kappes, Charles R. Gleason, Komal Srivastava, Oliver Van Oekelen, Carlos Cordon-Cardo, Florian Krammer, Miriam Merad, Sundar Jagannath, Ania Wajnberg, Viviana Simon, Samir Parekh
Journal: Blood
Blood (2022) 140 (Supplement 1): 4364–4365.
https://doi.org/10.1182/blood-2022-169572
Published: 2022
Journal Articles

Salvage with Sequential T Cell Redirection for Myeloma Patients Who Have Previously Progressed on T Cell Directed Therapy Is Associated with Significant Cellular Activation of the Immune Microenvironment

Adolfo Aleman, Ariel Kogan Zajdman, Yogita Ghodke-Puranik, Bhaskar Upadhyaya, Tarek H. Mouhieddine, Oliver Van Oekelen, Larysa Sanchez, Shambavi Richard, Adriana Rossi, Joshua Richter, Hearn J. Cho, Cesar Rodriguez, Ajai Chari, Sundar Jagannath, Samir Parekh
Journal: Blood
Blood (2022) 140 (Supplement 1): 4193–4195.
https://doi.org/10.1182/blood-2022-169538
Published: 2022
Journal Articles

Comprehensive Characterization of Prolonged Unexplained Cytopenias in Relapsed/Refractory Multiple Myeloma Patients Following BCMA-Directed CAR-T Cell Therapy

Santiago Thibaud, Md. Babu Mia, Oliver Van Oekelen, Tarek H. Mouhieddine, Christoph Schaniel, Yogita Ghodke-Puranik, Adolfo Aleman, Bhaskar Upadhyaya, Guido Lancman, Alessandro Lagana, Shambavi Richard, Adriana Rossi, Ajai Chari, Larysa Sanchez, Cesar Rodriguez, Hearn J. Cho, Joshua Richter, Ronald Hoffman, Sundar Jagannath, Samir Parekh
Journal: Blood
Blood (2022) 140 (Supplement 1): 614–616.
https://doi.org/10.1182/blood-2022-165646
Published: 2022
Journal Articles

Single-Cell RNA-Seq Analysis of CD138-Depleted Bone Marrow Samples Reveals Genetic Alterations and Disease Progression Correlate with Tumor and Bone Marrow Immune Microenvironment in the Mmrf Commpass Study

Lijun Yao, Tianjiao Wang, Sato Kazuhiro, Reyka G Jayasinghe, William Pilcher, Edgar Gonzalez-Kozlova, Yered Pita-Juarez, Taxiarchis Kourelis, Deon Doxie, Beena E Thomas, Brian Lee, Swati S Bhasin, Bhaskar Upadhyaya, Mark A Fiala, Julie Fortier, Travis Dawson, John Leech, Shaji Kumar, Hearn Jay Cho, Seunghee Kim-Schulze, Bee Raj, Stephen T. Oh, John F. DiPersio, Ravi Vij, Adeeb H Rahman, Ioannis Vlachos, Shaadi Mehr, Mark Hamilton, Daniel Auclair, Surendra Dasari, David Avigan, Madhav V Dhodapkar, Sacha Gnjatic, Manoj Bhasin, Li Ding
Journal: Blood
Blood (2021) 138 (Supplement 1): 2691.
https://doi.org/10.1182/blood-2021-154081
Published: 2021
Journal Articles

Large-Scale Mass Cytometry Reveals Significant Activation of Innate and Adaptive Immunity in Bone Marrow Tumor Microenvironment of Iberdomide-Treated Myeloma Patients

Oliver Van Oekelen, Michael Amatangelo, Manman Guo, Bhaskar Upadhyaya, Geoffrey Kelly, Manishkumar Patel, Seunghee Kim-Schulze, Alessandro Lagana, Sarah Gooding, Sundar Jagannath, William E. Pierceall, Udo Oppermann, Samir Parekh, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 730.
https://doi.org/10.1182/blood-2021-151542
Published: 2021
Journal Articles

Suboptimal Humoral and Cellular Immune Response to SARS-CoV-2 RNA Vaccination in Myeloma Patients Is Associated with Anti-CD38 and BCMA-Targeted Treatment

Oliver Van Oekelen, Sarita Agte, Adolfo Aleman, Bhaskar Upadhyaya, Charles R. Gleason, Komal Srivastava, Katherine F. Beach, Kevin Tuballes, Katerina Kappes, Tarek H. Mouhieddine, Bo Wang, Seunghee Kim-Schulze, Ajai Chari, Sacha Gnjatic, Nina Bhardwaj, Brian D. Brown, Miriam Merad, Carlos Cordon-Cardo, Florian Krammer, Sundar Jagannath, Viviana Simon, Ania Wajnberg, Samir Parekh
Journal: Blood
Blood (2021) 138 (Supplement 1): 822.
https://doi.org/10.1182/blood-2021-152365
Published: 2021
Journal Articles

Single-Cell Profiling Reveals Contribution of Tumor Extrinsic and Intrinsic Factors to BCMA-Targeted CAR-T Cell Efficacy in Multiple Myeloma

David T. Melnekoff, Yogita Ghodke-Puranik, Oliver Van Oekelen, Adolfo Aleman, Bhaskar Upadhyaya, Robert Sebra, Sundar Jagannath, Alessandro Lagana, Samir Parekh
Journal: Blood
Blood (2021) 138 (Supplement 1): 326.
https://doi.org/10.1182/blood-2021-150923
Published: 2021