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Journal Articles

Efficacy and Safety of Daratumumab in Intermediate/High-risk Smoldering Multiple Myeloma: Final Analysis of CENTAURUS

Carl Ola Landgren, Ajai Chari, Yael C. Cohen, Andrew Spencer, Peter M Voorhees, Irwindeep Sandhu, Matthew W Jenner, Dean Smith, Michele Cavo, Niels W.C.J. van de Donk, Meral Beksac, Phillippe Moreau, Hartmut Goldschmidt, Diego Vieyra, Linlin Sha, Liang Li, Els Rousseau, Robyn M. Dennis, Robin Carson, Craig C. Hofmeister
Journal: Blood
Blood blood.2024025897.
https://doi.org/10.1182/blood.2024025897
Published: 2024
Includes: Supplemental data
Journal Articles

Minimal Residual Disease Measured after Treatment with Bispecifics in Relapsed Multiple Myeloma: Experience from an Academic Medical Center

Alberto Blanco, Ajai Chari, Thomas G Martin, Shagun Arora, Alfred Chung, Anupama Deepa Kumar, Nina Shah, Sandy W. Wong, Hiroyuki Takamatsu, Joaquin Martínez-López, Jeffrey Lee Wolf
Journal: Blood
Blood (2024) 144 (Supplement 1): 7020.
https://doi.org/10.1182/blood-2024-203768
Published: 2024
Journal Articles

A Phase 2 Study of Daratumumab in Combination with Dose-Attenuated Bortezomib, Lenalidomide, and Dexamethasone in Transplant Ineligible Older Adults with Newly Diagnosed Multiple Myeloma

Larysa J Sanchez, Erin Moshier, Alex Lieberman-Cribbin, Joshua Richter, Shambavi Richard, Adriana Rossi, Cesar Rodriguez, Santiago Thibaud, Hearn Jay Cho, Samir Parekh, Sundar Jagannath, Ajai Chari
Journal: Blood
Blood (2024) 144 (Supplement 1): 7043.
https://doi.org/10.1182/blood-2024-211704
Published: 2024
Journal Articles

Teclistamab, Daratumumab, and Pomalidomide in Patients with Relapsed/Refractory Multiple Myeloma: Results from the Majestec-2 Cohort a and Trimm-2 Studies

Anita D'Souza, Luciano J. Costa, Jesús F. San-Miguel, Jesus G Berdeja, Daniel Morillo Giles, Cyrille Touzeau, John T McKay, Bhagirathbhai Dholaria, Thomas G Martin, Aurore Perrot, Albert Oriol, Anna Sureda Balari, Thomas Prior, Debopriya Ghosh, Lijuan Kang, Julie S Larsen, Hein Ludlage, Lien Vandenberk, Lingling Chen, Bas D Koster, Weili Sun, Rachel Kobos, Emma Searle, Jeffrey V Matous, Ajai Chari, Tobias Kampfenkel
Journal: Blood
Blood (2024) 144 (Supplement 1): 495.
https://doi.org/10.1182/blood-2024-200181
Published: 2024
Journal Articles

Combined PD-1 and Tim-3 Blockade Improves the in Vitro Anti-Myeloma Activity of T Cells of Patients on Talquetamab

Tarek H. Mouhieddine, Junia Vieira, Adolfo Aleman, Leah Grossman, David Melnekoff, Bhaskar Upadhyaya, Samantha St. Clair, Monica Garcia-Barros, Meghana Ram, Santiago Thibaud, Adriana Rossi, Shambavi Richard, Cesar Rodriguez, Joshua Richter, Hearn Jay Cho, Larysa Sanchez, Sundar Jagannath, Ajai Chari, Rachel Brody, Christian Salib, Alessandro Lagana, Samir Parekh
Journal: Blood
Blood (2024) 144 (Supplement 1): 357.
https://doi.org/10.1182/blood-2024-204929
Published: 2024
Journal Articles

Single-Cell Analysis Reveals Depletion of Antigen-Presenting Cell (APC) and IFN-Stimulated CD4 T Cell Populations in High-Risk Newly Diagnosed Multiple Myeloma Patients

Junia Vieira, Alison S Park, David Melnekoff, Tarek H. Mouhieddine, Alessia D'anna, Adolfo Aleman, Meghana Ram, Katerina Kappes, Mark Hamilton, George Mulligan, Arun P Wiita, Ajai Chari, Thomas Martin, Michael Slade, Li Ding, Ravi Vij, Brian Brown, Benjamin Tycko, Rena Feinman, David S. Siegel, Sundar Jagannath, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2024) 144 (Supplement 1): 4654.
https://doi.org/10.1182/blood-2024-208308
Published: 2024
Journal Articles

Delayed Neurotoxicity after CAR-T in Multiple Myeloma: Results from a Global IMWG Registry

Anupama Deepa Kumar, Suheil Albert Atallah-Yunes, Sridevi Rajeeve, Ahmed Abdelhak, Hamza Hashmi, Andre Corraes, Myo Htut, Paula Rodriguez-Otero, Ricardo D. Parrondo, Saurabh Chhabra, K. Martin Kortüm, Lukas Scheller, Sofie-Katrin Kadel, Hermann Einsele, Niels W.C.J. van de Donk, Jana Mihalyova, Roman Hajek, Joaquin Martinez Lopez, Noa Biran, Carlos Fernández de Larrea, Ingerid Weum Abrahamsen, Szu-Ying Chen, Melissa Ng, Bonell Patino Escobar, Simon J Harrison, Caitlin Costello, Isadora Matos, Edvan Crusoe, Luciano J. Costa, Arun P Wiita, Sasha Gupta, Thomas Martin, Yi Lin, Ajai Chari
Journal: Blood
Blood (2024) 144 (Supplement 1): 4758.
https://doi.org/10.1182/blood-2024-201783
Published: 2024
Journal Articles

Late Polyclonal P-BCMA-101 CAR-T Cell Re-Expansion and Rapid Complete Response in a Patient with Relapsed Multiple Myeloma Treated with One Cycle of Talquetamab, More Than 3 Years after CAR-T Infusion

Anupama Deepa Kumar, Ajai Chari, Srishti Gupta, Joseph Rohr, Rajesh Belani, Blair Madison, Zhibo Ma, Chris E Martin, Katherine McArthur, Hilary Ostwald, Syed Rizvi, Thomas G Martin
Journal: Blood
Blood (2024) 144 (Supplement 1): 2083.
https://doi.org/10.1182/blood-2024-211578
Published: 2024
Journal Articles

Pharmacodynamic Signatures and Correlatives of Response in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) Treated with Talquetamab or Teclistamab Plus Daratumumab and Pomalidomide

Deeksha Vishwamitra, Sheri Skerget, Diana Cortes, Kalpana Bakshi, Lien Vandenberk, Weili Sun, Jaszianne Tolbert, Colleen Kane, Hein Ludlage, Bas D Koster, Julie S Larsen, Tobias Kampfenkel, Ching Li, Farheen Zishan, Thomas Prior, Luciano J. Costa, Jesus G Berdeja, Cyrille Touzeau, Aurore Perrot, Emma Searle, Jeffrey V Matous, Ajai Chari, Donna Reece, Manisha Bhutani, Bhagirathbhai Dholaria, Anita D'Souza, Thomas G Martin, John T. McKay, Alfred L Garfall, Amrita Y Krishnan, Niels W.C.J. van de Donk, Nizar J. Bahlis, Ricardo M. Attar
Journal: Blood
Blood (2024) 144 (Supplement 1): 594.
https://doi.org/10.1182/blood-2024-200300
Published: 2024
Journal Articles

Feasibility and Implementation of the ASH Research Collaborative's COVID-19 Outcomes in Myeloma and the Impact of Vaccines (COSMIC): A Decentralized, Real-World Evidence Study for Patients with Multiple Myeloma to Monitor Outcomes Related to COVID-19 Vaccines and Infections

William A. Wood, Emily A. Semmel, Shandra James, Donna S. Neuberg, Kathleen Hewitt, Kenneth C. Anderson, Shaji Kumar, Mark A. Schroeder, David J. Chung, Aaron S. Rosenberg, Jeffrey A. Zonder, Samuel M. Rubinstein, Anita D'Souza, Thomas Martin, Ajai Chari, Ravi Vij, Ajay K. Nooka, Brendan M. Weiss, Levi D. Pederson, Andriy Derkach, Susan M. Geyer, Saad Z. Usmani
Journal: Blood
Blood (2024) 144 (Supplement 1): 2393.
https://doi.org/10.1182/blood-2024-203892
Published: 2024
Journal Articles

Development of the ASH Research Collaborative Multiple Myeloma Program: A Multicenter, Real-World Evidence Generation Network

Shaji Kumar, William A. Wood, Kenneth C. Anderson, Emily A. Semmel, Shandra James, Donna S. Neuberg, Kathleen Hewitt, Mark A. Schroeder, David J. Chung, Aaron S. Rosenberg, Jeffrey A. Zonder, Samuel M. Rubinstein, Anita D'Souza, Thomas Martin, Ajai Chari, Ravi Vij, Ajay K. Nooka, Manisha Bhutani, Peter M. Voorhees, Adam S. Sperling, Susan M. Geyer, Michael W. Craige, Sam Walters, Andriy Derkach, Saad Z. Usmani
Journal: Blood
Blood (2024) 144 (Supplement 1): 3792.5.
https://doi.org/10.1182/blood-2024-210957
Published: 2024
Journal Articles

Initial Results from the ASH Research Collaborative's COVID-19 Outcomes in Myeloma and the Impact of Vaccines (COSMIC): A Decentralized, Real-World Evidence Study for Patients with Multiple Myeloma to Monitor Outcomes Related to COVID-19 Vaccines and Infections

Saad Z. Usmani, Emily A. Semmel, Shandra James, William A. Wood, Mark A. Schroeder, David J. Chung, Aaron S. Rosenberg, Jeffrey A. Zonder, Samuel M. Rubinstein, Anita D'Souza, Thomas Martin, Ajai Chari, Ravi Vij, Ajay K. Nooka, Kenneth C. Anderson, Donna S. Neuberg, Kathleen Hewitt, Brendan M. Weiss, Levi D. Pederson, Andriy Derkach, Susan M. Geyer, Shaji Kumar
Journal: Blood
Blood (2024) 144 (Supplement 1): 1972.
https://doi.org/10.1182/blood-2024-210377
Published: 2024
Journal Articles

Analysis of Repeat Step-up Dosing and Cytokine Release Syndrome Events Following Prolonged Dosing Intervals of Teclistamab in the Phase 1/2 Majestec-1 Study

Niels W.C.J. van de Donk, Ajai Chari, Lionel Karlin, Amrita Y Krishnan, Katarina Uttervall, Thomas Chalopin, Laura Rosinol Dachs, Albert Oriol, Jeffrey V Matous, Manisha Bhutani, Cesar Rodriguez, Natalia A Quijano Cardé, Yue Guo, Caroline Hodin, Clarissa Uhlar, Tara Stephenson, Athena Zuppa, Margaret Doyle, Katherine Chastain, Alfred L Garfall
Journal: Blood
Blood (2024) 144 (Supplement 1): 4734.
https://doi.org/10.1182/blood-2024-200344
Published: 2024
Journal Articles

Immune Dynamics Associated with Patient Outcomes Identified By Multimodal Single-Cell Analysis in Multiple Myeloma Patients Receiving Talquetamab Monotherapy

Tarek H. Mouhieddine, Junia Vieira dos Santos, Yogita Ghodke-Puranik, Adolfo Aleman, David Melnekoff, Bhaskar Upadhyaya, Adeeb Rahman, Shaked Afik, Hadas Lewinsky, Santiago Thibaud, Adriana C Rossi, Shambavi Richard, Cesar Rodriguez, Joshua Richter, Hearn Jay Cho, Larysa Sanchez, Sundar Jagannath, Ajai Chari, Alessandro Lagana, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 1927.
https://doi.org/10.1182/blood-2023-185308
Published: 2023
Journal Articles

Efficacy and Safety of Daratumumab (DARA) Monotherapy in Patients with Intermediate-Risk or High-Risk Smoldering Multiple Myeloma (SMM): Final Analysis of the Phase 2 Centaurus Study

Ola Landgren, Ajai Chari, Yael C. Cohen, Andrew Spencer, Peter M. Voorhees, Irwindeep Sandhu, Matthew W. Jenner, Dean Smith, Michele Cavo, Niels WCJ van de Donk, Meral Beksac, Philippe Moreau, Hartmut Goldschmidt, Linlin Sha, Liang Li, Els Rousseau, Robyn Dennis, Robin Carson, Craig C. Hofmeister
Journal: Blood
Blood (2023) 142 (Supplement 1): 210.
https://doi.org/10.1182/blood-2023-181765
Published: 2023
Journal Articles

Efficacy and Safety of Less Frequent/Lower Intensity Dosing of Talquetamab in Patients with Relapsed/Refractory Multiple Myeloma: Results from the Phase 1/2 MonumenTAL-1 Study

Ajai Chari, Albert Oriol, Amrita Krishnan, Maria Del Carmen Martinez Chamorro, Luciano Costa, Maria Victoria Mateos, Monique C Minnema, Michela Campagna, Tara J Masterson, Brandi W Hilder, Jaszianne Tolbert, Thomas Renaud, M. Damiette Smit, Swarna Ramanjulu, Paula Rodríguez Otero
Journal: Blood
Blood (2023) 142 (Supplement 1): 1010.
https://doi.org/10.1182/blood-2023-181228
Published: 2023
Journal Articles

Clinical Outcomes of Subsequent Therapies in Patients with Relapsed/Refractory Multiple Myeloma Following Talquetamab Treatment: Analyses from the Phase 1/2 MonumenTAL-1 Study

Larysa Sanchez, Carolina Schinke, Amrita Krishnan, Jésus G Berdeja, Niels WCJ van de Donk, María Victoria Mateos, Ajai Chari, Samir Parekh, Tarek H. Mouhieddine, Sundar Jagannath, Nizar J Bahlis, Cyrille Touzeau, Albert Oriol, Jesus San-Miguel, Paula Rodriguez Otero, Monique C Minnema, Michela Campagna, Tara J Masterson, Brandi W Hilder, Jaszianne Tolbert, Thomas Renaud, Kathleen Gray, Damiette Smit, Christoph Heuck, Leo Rasche
Journal: Blood
Blood (2023) 142 (Supplement 1): 2007.
https://doi.org/10.1182/blood-2023-182330
Published: 2023
Journal Articles

Early and Consistent CRS Detection Using Wearable Device for Remote Patient Monitoring Following CAR-T Therapy in Relapsed/Refractory Multiple Myeloma (RRMM): Early Results of an Investigator-Initiated Trial

Sridevi Rajeeve, Nicole Zahradka, Matt Wilkes, Darren Pan, Nicholas J Calafat, Kseniya Serebryakova, Katerina Kappes, Hayley Jackson, Nicole Buchenholz, Sarita Agte, Santiago Thibaud, Larysa Sanchez, Shambavi Richard, Joshua Richter, Cesar Rodriguez, Hearn Jay Cho, Ajai Chari, Sundar Jagannath, Adriana C Rossi, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 1007.
https://doi.org/10.1182/blood-2023-181936
Published: 2023
Journal Articles

Inflammatory Marker Levels, Age, Race and Prior Treatment Burden Independently Predict Delayed Hematologic Recovery after BCMA-Directed CART Therapy in Multiple Myeloma

Santiago Thibaud, Jerrel Catlett, Saoirse Bodnar, MD Babu Mia, Ajai Chari, Joshua Richter, Hearn Jay Cho, Larysa J Sanchez, Cesar Rodriguez, Adriana C Rossi, Sundar Jagannath, Shambavi Richard, Samir Parekh
Journal: Blood
Blood (2023) 142 (Supplement 1): 2002.
https://doi.org/10.1182/blood-2023-190772
Published: 2023
Journal Articles

Updated Results of Talquetamab, a GPRC5D×CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma with Prior Exposure to T-Cell Redirecting Therapies: Results of the Phase 1/2 MonumenTAL-1 Study

Andrzej J Jakubowiak, Sebastien Anguille, Lionel Karlin, Ajai Chari, Carolina Schinke, Leo Rasche, Jesus San-Miguel, Michela Campagna, Brandi W Hilder, Tara J Masterson, Xiang Qin, Thomas Renaud, Jaszianne Tolbert, Deeksha Vishwamitra, Sheri Skerget, Philippe Moreau
Journal: Blood
Blood (2023) 142 (Supplement 1): 3377.
https://doi.org/10.1182/blood-2023-187242
Published: 2023