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David Avigan
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Journal Articles

Integrated Coding and Non-Coding Transcriptional Single-Cell Atlas of Multiple Myeloma: Unraveling the Effects of Myeloma Genotype on the Bone Marrow Microenvironment

Marina E Michaud, Sarthak Satpathy, William Pilcher, Edgar Gonzalez-Kozlova, Dimitra Karagkouni, Lijun Yao, Yered Pita-Juarez, Chaitanya Acharya, Mark Hamilton, Shivani Nanda, Yizhe Song, Julia T Wang, Mojtaba Bakhtiari, David Avigan, Taxiarchis Kourelis, Madhav V. Dhodapkar, Sagar Lonial, Swati Bhasin, Immune Network, Li Ding, Sacha Gnjatic, Ioannis S Vlachos, George Mulligan, Manoj Bhasin
Journal: Blood
Blood (2024) 144 (Supplement 1): 3258.
https://doi.org/10.1182/blood-2024-211579
Published: 2024
Journal Articles

Advances in CD137-Enriched Adoptive T Cell Therapy for Acute Myeloid Leukemia Via Ex Vivo Immune Cell Priming with DC/AML Fusion Vaccine

Kathrine S Rallis, Jessica Liegel, Giulia Cheloni, Poorva Bindal, Isabella Saldarriaga, Junyan Zhang, Georges Chedid, Joseph Abirached, Jonah Lee, John G. Clohessy, Samprity Ankita, Rajeev Relangi, Lina Bisharat, Hazal Toros, Sophia Adamia, Jasper B Lee, Donald Kufe, Kai W Wucherpfennig, Jacalyn Rosenblatt, David Avigan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4817.
https://doi.org/10.1182/blood-2024-208563
Published: 2024
Journal Articles

Long Term Outcomes of a Randomized Trial of Anti-T Lymphocyte Globulin to Improve Moderate-Severe Chronic Gvhd Free Survival after Unrelated Donor Hematopoietic Cell Transplantation: A CIBMTR Analysis

Robert J. Soiffer, Mitchell Horwitz, Joseph P. McGuirk, Sudhindra Rao, Peter Westervelt, John F. DiPersio, Laura Johnston, Jonathan Serody, Witold B Rybka, Paul Shaughnessy, Joseph A. Pidala, Vincent Ho, Andrew Artz, Madhuri Vusirikala, David L. Porter, Paul J. Martin, David Avigan, Michael R Bishop, Ran Reshef, Andrew Peterson, Kwang Wooahn, Adetola A. Kassim, Ryotaro Nakamura, Yi-Bin Chen, Linda Burns
Journal: Blood
Blood (2024) 144 (Supplement 1): 4911.
https://doi.org/10.1182/blood-2024-205572
Published: 2024
Journal Articles

Uncovering the Tumor Antigen Landscape in Patients Undergoing Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance Treatment

Dimitra Karagkouni, Giulia Cheloni, Shivani Nanda, Yuling Ma, Shuoshuo Wang, Leda Xanthi Katopodi, Isabella Saldarriaga, Yered Pita-Juarez, David J. Chung, Nina Shah, Natalie Callander, Binod Dhakal, Thinle Chodon, Nikhil C. Munshi, Kenneth C. Anderson, Yvonne A. Efebera, Peiman Hematti, Hillard M. Lazarus, Ehsan Malek, Philip L. McCarthy, Ajay K. Nooka, Krina K. Patel, Aaron P. Rapoport, Robert J. Soiffer, Edmund K. Waller, Marcelo C. Pasquini, Jacalyn Rosenblatt, David Avigan, Ioannis S Vlachos
Journal: Blood
Blood (2024) 144 (Supplement 1): 3289.
https://doi.org/10.1182/blood-2024-211352
Published: 2024
Journal Articles

Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM): Efficacy and Safety with 34-Month Median Follow-up

Michael R Bishop, Jacalyn Rosenblatt, Binod Dhakal, Noopur Raje, Daniella Cook, Mahmoud R. Gaballa, Estelle Emmanuel-Alejandro, Danielle Nissen, Kamalika Banerjee, Rebecca J Chan, Ana Kostic, Christopher R. Heery, Tim Welliver, David Avigan, Andrzej J Jakubowiak, Matthew Frigault
Journal: Blood
Blood (2024) 144 (Supplement 1): 4825.
https://doi.org/10.1182/blood-2024-201080
Published: 2024
Journal Articles

Randomized Phase II Trial of Dendritic Cell/AML Fusion Cell Vaccination Compared to Standard of Care Therapy in AML CR1

Prateek Pophali, Giulia Cheloni, Richard M. Stone, Kai W Wucherpfennig, Aric C. Hall, Amir T. Fathi, Lina Bisharat, Emma K Logan, Yiwen Liu, Donna S. Neuberg, Malgorzata McMasters, Jessica Liegel, Jacqueline S. Garcia, Daniel J. DeAngelo, Michele Narcis, Dina Stroopinsky, Pavania Elavalakanar, Ioannis S Vlachos, Ilene A. Galinsky, Jason Pyrdol, Georges Chedid, Dimitra Karagkouni, Shivani Nanda, Kathrine S Rallis, Isabella Saldarriaga, Hazal Toros, Haitham Abdelhakim, Amelia Langston, Joseph P. McGuirk, Donald Kufe, David Avigan, Jacalyn Rosenblatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 4256.
https://doi.org/10.1182/blood-2024-200876
Published: 2024
Journal Articles

Phase 1 Trial of Dendritic Cell/AML Fusion Cell Vaccine after Allogeneic Stem Cell Transplant in Acute Myeloid Leukemia

Jessica Liegel, Giulia Cheloni, Georges Chedid, Genevieve Gerhard, Dimitra Karagkouni, Richard Stone, Robert J. Soiffer, Lina Bisharat, Samprity Ankita, Isabella Saldarriaga, Emma K Logan, Michele Narcis, Jennifer Tichon, Yiwen Liu, Malgorzata McMasters, Juan Carlos Varela, Hassan El Banna, Vincent T. Ho, Rizwan Romee, Donna S. Neuberg, Kathrine S Rallis, Sophia Adamia, Benjamin L. Ebert, Donald Kufe, Ioannis Vlachos, David Avigan, Jacalyn Rosenblatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 772.
https://doi.org/10.1182/blood-2023-190832
Published: 2023
Journal Articles

4-1bb Enrichment Enhances Adoptive T Cell Therapy for Hematological Malignancies Using a Novel Approach for Ex Vivo Immune Cell Priming with DC/Tumor Fusion Vaccine

Kathrine S Rallis, Jessica Liegel, Giulia Cheloni, Poorva Bindal, Isabella Saldarriaga, Junyan Zhang, Georges Chedid, Joseph Abirached, John G. Clohessy, Sophia Adamia, Kai W Wucherpfennig, Donald Kufe, Jacalyn Rosenblatt, David Avigan
Journal: Blood
Blood (2023) 142 (Supplement 1): 2066.
https://doi.org/10.1182/blood-2023-182381
Published: 2023
Journal Articles

First-in-Human Study of the CD123 NK Cell Engager SAR443579 in Relapsed or Refractory Acute Myeloid Leukemia, B-Cell Acute Lymphoblastic Leukemia or High Risk-Myelodysplasia: Updated Safety, Efficacy, Pharmacokinetics and Pharmacodynamics

Ashish Bajel, Sylvain Garciaz, Pinkal Desai, Gerwin A Huls, Abhishek Maiti, Mojca Jongen-Lavrencic, Nicolas Boissel, Stephane De Botton, David C. de Leeuw, Shaun Fleming, C. Michel Zwaan, Martha Arellano, David Avigan, Jennifer N. Saultz, Ioannis Mantzaris, Kyle Jensen, Timothy Wagenaar, Gu Mi, Samira Ziti-Ljajic, Dobrin Draganov, Giovanni Abbadessa, Anthony Selwyn Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 3474.
https://doi.org/10.1182/blood-2023-173162
Published: 2023
Journal Articles

A Phase 2 Study of Lenalidomide in Combination with Mitoxantrone, Etoposide, and Cytarabine (Len plus MEC) in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Manik Razdan Kuchroo, Robert A. Redd, Jacqueline S. Garcia, Michael Keng, Gabriela S. Hobbs, Jacalyn Rosenblatt, Marlise R. Luskin, Rupa Narayan, Philip C. Amrein, Malgorzata McMasters, Martha Wadleigh, Hanno Hock, Richard Stone, Donna S. Neuberg, David Avigan, Karen K. Ballen, Amir T. Fathi, Daniel J. DeAngelo, Andrew M. Brunner
Journal: Blood
Blood (2023) 142 (Supplement 1): 2894.
https://doi.org/10.1182/blood-2023-188182
Published: 2023
Journal Articles

Phase 1 Study of CART-Ddbcma for the Treatment of Patients with Relapsed and/or Refractory Multiple Myeloma: Results from at Least 1-Year Follow-up in All Patients

Matthew J. Frigault, Jacalyn Rosenblatt, Binod Dhakal, Noopur S. Raje, Daniella Cook, Mahmoud Gaballa, Estelle Emmanuel-Alejandro, Danielle Nissen, Kamalika C Banerjee, Anand Rotte, Christopher R Heery, David Avigan, Andrzej J Jakubowiak, Michael R. Bishop
Journal: Blood
Blood (2023) 142 (Supplement 1): 1023.
https://doi.org/10.1182/blood-2023-189761
Published: 2023
Journal Articles

Final Analysis of a Phase 2 Trial of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Newly Diagnosed Multiple Myeloma (NDMM) without Autologous Stem Cell Transplantation (ASCT)

Benjamin A Derman, Jennifer H Cooperrider, Jacalyn Rosenblatt, David Avigan, Murtuza M. Rampurwala, Ajay Major, Theodore Karrison, Ken Jiang, Tadeusz Kubicki, Andrzej J Jakubowiak
Journal: Blood
Blood (2023) 142 (Supplement 1): 4747.
https://doi.org/10.1182/blood-2023-185309
Published: 2023
Journal Articles

Personal and Shared Tumor-Antigen Prioritization in Diffuse Large B Cell Lymphoma Patients Undergoing CD19 CAR T Cell Treatment

Dimitra Karagkouni, Xanthi Lida Katopodi, Giulia Cheloni, Yuling Ma, Brodie Miles, Gayatri Tiwari, Jenny J. Kim, Mike Mattie, Jacalyn Rosenblatt, David Avigan, Ioannis Vlachos
Journal: Blood
Blood (2023) 142 (Supplement 1): 1638.
https://doi.org/10.1182/blood-2023-190377
Published: 2023
Journal Articles

In-Depth Characterization of the High Risk-Associated Tumor Immune Landscape in Multiple Myeloma

Yered Pita-Juarez, Dimitra Karagkouni, Edgar Gonzalez-Kozlova, Yuling Ma, Lijun Yao, William Pilcher, Beena Thomas, Alessandro Lagana, Sarthak Satpathy, Swati Bhasin, Yizhe Song, Ravi Vij, Darwin D'Souza, Travis Dawson, Geoffrey Kelly, Jessica Wendy Schulman, Shaji Kunnathu Kumar, David Avigan, Seunghee Kim-Schulze, Li Ding, Hearn Jay Cho, Taxiarchis Kourelis, Eva Lepisto, Manoj Bhasin, April Cook, Mark Hamilton, George Mulligan, Immune Network, Ioannis Vlachos, Sacha Gnjatic
Journal: Blood
Blood (2023) 142 (Supplement 1): 648.
https://doi.org/10.1182/blood-2023-189940
Published: 2023
Journal Articles

Heterogeneity in Access and Toxicity Management of Commercially Available BCMA-Directed CAR-T and Bispecific T-Cell Engager Therapy Among the International Myeloma Community

Hamza Hassan, Mehmet K. Samur, Adam D. Cohen, Philippe Moreau, Paula Rodríguez Otero, Shaji Kunnathu Kumar, María Victoria Mateos, David Avigan, Adam S. Sperling, Omar Nadeem, Michael Hudecek, Carlos Fernández de Larrea, Joaquin Martínez-López, Maria Themeli, Kwee Yong, Jesus G. Berdeja, Ajai Chari, Pieter Sonneveld, Francesca Gay, Amrita Krishnan, Saad Z Usmani, Kenneth C. Anderson, Sundar Jagannath, Hermann Einsele, Nikhil C Munshi, Shonali Midha
Journal: Blood
Blood (2023) 142 (Supplement 1): 7248.
https://doi.org/10.1182/blood-2023-184710
Published: 2023
Journal Articles

G-CSF Administration Is Associated with Worse Treatment Response and Survival after CAR T-Cell Therapy

Poorva Bindal, Pavania Elavalakanar, Caitlin A. Trottier, Laura E. Dodge, Emma K. Logan, David J. Sermer, Michael Leukam, Matthew J Weinstock, Robin M. Joyce, Jessica Liegel, Jacalyn Rosenblatt, David Avigan, Carolyn D. Alonso, Jon E. Arnason
Journal: Blood
Blood (2022) 140 (Supplement 1): 5238–5240.
https://doi.org/10.1182/blood-2022-167976
Published: 2022
Journal Articles

Multivariable Analyses of Prognostic Factors for Progression-Free Survival (PFS) and Complete Response (CR) with Lenalidomide, Bortezomib, and Dexamethasone (RVd) Alone Versus Rvd Plus Autologous Stem Cell Transplantation (ASCT) in Patients (Pts) with Newly Diagnosed Multiple Myeloma (NDMM) in the Determination Phase 3 Trial

Hani Hassoun, Susanna J. Jacobus, Paul G. Richardson, Jeffrey A. Zonder, Peter M. Voorhees, Jonathan L. Kaufman, Andrew J. Yee, Emma C. Scott, Pallawi Torka, Edward Libby, Brandi Reeves, Michael L. Wang, Larry D. Anderson, Jr., Carter Milner, Cristina J. Gasparetto, Mounzer Agha, Abdullah Khan, David Duane Hurd, David Avigan, Caitlin Costello, Andrzej Jakubowiak, Sagar Lonial, Noopur Raje, Eva Medvedova, Philip L. McCarthy, Robert Z. Orlowski, Omar Nadeem, Jacob P. Laubach, Marcelo C. Pasquini, Sergio A. Giralt, Kelly Masone, Mehmet K. Samur, Aurore Perrot, Philippe Moreau, Herve Avet-Loiseau, Edie A. Weller, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 4834–4838.
https://doi.org/10.1182/blood-2022-162741
Published: 2022
Journal Articles

Durable Response to CD19 CAR T Cell Therapy Is Associated with Cytotoxicity and Clonotypic Expansion of the Native T Cell Repertoire

Giulia Cheloni, Dimitra Karagkouni, Yered Pita-Juarez, Daniela Torres, Eleni Kanata, Zachary M. Avigan, Jessica Liegel, Dina Stroopinsky, Brodie Miles, Gayatri Tiwari, Jenny Kim, Mike Mattie, Jacalyn Rosenblatt, David Avigan, Ioannis Vlachos
Journal: Blood
Blood (2022) 140 (Supplement 1): 644–645.
https://doi.org/10.1182/blood-2022-169230
Published: 2022
Journal Articles

An Open-Label, First-in-Human, Dose-Escalation Study of SAR443579 Administered As Single Agent By Intravenous Infusion in Patients with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-Cell Acute Lymphoblastic Leukemia (B-ALL) or High-Risk Myelodysplasia (HR-MDS)

Anthony S. Stein, Ashish Bajel, Shaun Fleming, Mojca Jongen-Lavrencic, Sylvain Garciaz, Abhishek Maiti, Nicolas Boissel, Stephane De Botton, Gerwin A. Huls, David C. de Leeuw, David Avigan, Kyle Jensen, Brigitte Demers, Timothy Wagenaar, Gu Mi, Samira Ziti-Ljajic, Dobrin Draganov, Giovanni Abbadessa, Andrew H Wei
Journal: Blood
Blood (2022) 140 (Supplement 1): 7476–7477.
https://doi.org/10.1182/blood-2022-166000
Published: 2022
Journal Articles

Phase 1 Study of CART-Ddbcma for the Treatment of Subjects with Relapsed and /or Refractory Multiple Myeloma

Matthew Frigault, Jacalyn Rosenblatt, Binod Dhakal, Noopur Raje, Daniella Cook, Mahmoud R. Gaballa, Estelle Emmanuel-Alejandro, Danielle Nissen, Christine Cornwell, Kamalika Banerjee, Anand Rotte, Christopher R. Heery, David Avigan, Andrzej Jakubowiak, Michael R. Bishop
Journal: Blood
Blood (2022) 140 (Supplement 1): 7439–7440.
https://doi.org/10.1182/blood-2022-163827
Published: 2022