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Journal Articles

TRK Protein Expression in TP53 Altered Acute Erythroid Leukemia

Rupa Narayan, Ronan T. Swords, Philip C. Amrein, Andrew M. Brunner, Gabriela S. Hobbs, Hanno Hock, Michelle Hyunju Lee, Timothy Aaron Graubert, Amir T. Fathi, Robert P Hasserjian, Valentina Nardi
Journal: Blood
Blood (2024) 144 (Supplement 1): 6154.
https://doi.org/10.1182/blood-2024-211201
Published: 2024
Journal Articles

Tyrosine Kinase Inhibitor (TKI) Response in Patients with Chronic Myelogenous Leukemia (CML) and BCR-ABL 35 Base Pair Intron 8 Insertion (35INS)

Roxana A Portillo, Michelle Hyunju Lee, Harrison K. Tsai, Daniel J DeAngelo, Amir T. Fathi, Rupa Narayan, Marlise R Luskin, Gabriela S. Hobbs
Journal: Blood
Blood (2024) 144 (Supplement 1): 6598.
https://doi.org/10.1182/blood-2024-206655
Published: 2024
Journal Articles

Safety and Activity of the TIM3 Inhibitor Sabatolimab in Patients with Lower-Risk Myelodysplastic Syndromes

Andrew M. Brunner, Yiwen Liu, Rupa Narayan, Michelle Hyunju Lee, Philip C. Amrein, Hanno Hock, Gabriela S. Hobbs, Donna S. Neuberg, Timothy Aaron Graubert, Amir T. Fathi
Journal: Blood
Blood (2024) 144 (Supplement 1): 6726.
https://doi.org/10.1182/blood-2024-196718
Published: 2024
Journal Articles

Clinical Activity and Safety of the Oral ATR Inhibitor Ceralasertib (AZD6738) in Patients with MDS or CMML after Prior HMA Therapy

Andrew M. Brunner, Yiwen Liu, Jacqueline S. Garcia, Lourdes Mendez, Catherine Gutierrez, Philip C. Amrein, Rupa Narayan, Rahul Vedula, Donna S. Neuberg, Marcio Andrade-Campos, Simon Smith, Richard M Stone, Amir T. Fathi, Matthew J. Walter, Timothy Aaron Graubert, Meagan Jacoby
Journal: Blood
Blood (2024) 144 (Supplement 1): 1833.
https://doi.org/10.1182/blood-2024-195793
Published: 2024
Journal Articles

Retrospective Single-Institution Review of Bosutinib Dose Optimization for Efficacy and Safety with Dose Ramp-up and Titration

Jessica Freydman, David Sirignano, Philip C. Amrein, Meghan Bergeron, Andrew M. Brunner, Elsie Foster, Amir T. Fathi, Timothy Aaron Graubert, Hanno Hock, Michelle Hyunju Lee, Jenna Moran, Rupa Narayan, Gabriela S. Hobbs
Journal: Blood
Blood (2024) 144 (Supplement 1): 6591.
https://doi.org/10.1182/blood-2024-203629
Published: 2024
Journal Articles

A Phase 2 Study of Lenalidomide in Combination with Mitoxantrone, Etoposide, and Cytarabine (Len plus MEC) in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Manik Razdan Kuchroo, Robert A. Redd, Jacqueline S. Garcia, Michael Keng, Gabriela S. Hobbs, Jacalyn Rosenblatt, Marlise R. Luskin, Rupa Narayan, Philip C. Amrein, Malgorzata McMasters, Martha Wadleigh, Hanno Hock, Richard Stone, Donna S. Neuberg, David Avigan, Karen K. Ballen, Amir T. Fathi, Daniel J. DeAngelo, Andrew M. Brunner
Journal: Blood
Blood (2023) 142 (Supplement 1): 2894.
https://doi.org/10.1182/blood-2023-188182
Published: 2023
Journal Articles

Changes in White Blood Cell Counts Early during Treatment of Acute Leukemia Using Differentiating Chemotherapies

Amyah C. Harris, Christopher S. Bell, Gabriela S. Hobbs, Hanno Hock, Philip C. Amrein, Rupa Narayan, Amir T. Fathi, Andrew M. Brunner
Journal: Blood
Blood (2023) 142 (Supplement 1): 1486.
https://doi.org/10.1182/blood-2023-187367
Published: 2023
Journal Articles

Single-Cell Multiomics Analysis Reveals Potential Drivers of Response to the Anti-TIM3 Inhibitor Sabatolimab Combined with Azacitidine in MDS and CMML

Aonkon Dey, Rupa Narayan, Neal Smith, Alice Tirard, Benjamin Arnold, John McGuire, Thomas Chan, Jennifer Lombardi Story, Timothy Casson, Tanya Toni Behnan, Amir T. Fathi, Gabriela S. Hobbs, Hanno Hock, Philip C. Amrein, Patrick Reeves, Timothy Aaron Graubert, Andrew M. Brunner, Alexandra-Chloé Villani
Journal: Blood
Blood (2023) 142 (Supplement 1): 4319.
https://doi.org/10.1182/blood-2023-189858
Published: 2023
Journal Articles

Phase 1/2 Study of Donor-Derived Anti-CD33 Chimeric Antigen Receptor Expressing T Cells (VCAR33) in Patients with Relapsed or Refractory Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation

Nirali N. Shah, Jacques Azzi, Brenda W Cooper, Abhinav Deol, John DiPersio, Divya Koura, Brian McClune, Lori S. Muffly, Muhammad Umair Mushtaq, Rupa Narayan, Hyung Chan Suh, Gregory Yanik, Sritama Nath, Jennifer Whangbo, Guenther Koehne
Journal: Blood
Blood (2023) 142 (Supplement 1): 4862.
https://doi.org/10.1182/blood-2023-180990
Published: 2023
Journal Articles

Methods of Estimating Renal Function for Use in Clinical Trial Eligibility Criteria Widely Vary in Phase II and III Clinical Trials in Acute Myeloid Leukemia

Priyanka Pullarkat, Yael Flamand, Harish Seethapathy, Meghan Sise, Andrew M. Brunner, Amir T. Fathi, Rupa Narayan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3727.
https://doi.org/10.1182/blood-2023-191110
Published: 2023
Journal Articles

A Phase 2 Randomized Study Comparing Venetoclax and Azacitidine to Conventional Induction Chemotherapy for Newly Diagnosed Fit Adults with Acute Myeloid Leukemia

Amir T. Fathi, Geoffrey G Fell, Areej El-Jawahri, Alexander E. Perl, Brian A. Jonas, Ajoy L. Dias, Alice S. Mims, Uma Borate, Brittany Knick Ragon, Michael R. Grunwald, Mary Linton B. Peters, Timothy A. Graubert, Philip C. Amrein, Hanno R. Hock, Andrew M. Brunner, Gabriela S. Hobbs, Rupa Narayan, Donna S. Neuberg, Ibrahim Aldoss
Journal: Blood
Blood (2022) 140 (Supplement 1): 3284–3286.
https://doi.org/10.1182/blood-2022-162525
Published: 2022
Journal Articles

Phase I Study of Ixazomib with Conventional Chemotherapy in the Treatment of Acute Myeloid Leukemia in Older Adults

Philip C. Amrein, Eyal C. Attar, Geoffrey G Fell, Traci M. Blonquist, Andrew M. Brunner, Gabriela S. Hobbs, Hanno R. Hock, Steven McAfee, Rupa Narayan, Jenna A. Moran, Meghan Bergeron, Julia E. Foster, Christina Bertoli, Kristin McGregor, Meghan Burke, Tanya T. Behnan, Tina T. Som, Aura Y. Ramos, Megan K. Vartanian, Jennifer Lombardi Story, Donna S. Neuberg, Amir T. Fathi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3309–3311.
https://doi.org/10.1182/blood-2022-160100
Published: 2022
Journal Articles

Allogeneic Hematopoietic Cell Transplantation Outcomes of Patients with R/R AML or Higher-Risk MDS Treated with the TIM-3 Inhibitor MBG453 (Sabatolimab) and Hypomethylating Agents

Andrew M. Brunner, Elie Traer, Norbert Vey, Sebastian Scholl, Natalia Tovar, Kimmo Porkka, Rupa Narayan, Guillermo Garcia-Manero, Steve Knapper, Martin Wermke, Jeroen J. Janssen, Jordi Esteve, Sun Loo, Mika Kontro, Zachariah Defilipp, Andrew H. Wei, Uma Borate
Journal: Blood
Blood (2021) 138 (Supplement 1): 3677.
https://doi.org/10.1182/blood-2021-151455
Published: 2021
Journal Articles

Efficacy and Safety of Sabatolimab (MBG453) in Combination with Hypomethylating Agents (HMAs) in Patients (Pts) with Very High/High-Risk Myelodysplastic Syndrome (vHR/HR-MDS) and Acute Myeloid Leukemia (AML): Final Analysis from a Phase Ib Study

Andrew M. Brunner, Jordi Esteve, Kimmo Porkka, Steve Knapper, Elie Traer, Sebastian Scholl, Guillermo Garcia-Manero, Norbert Vey, Martin Wermke, Jeroen Janssen, Rupa Narayan, Sun Loo, Mika Kontro, Oliver Ottmann, Purushotham Naidu, Marc Pelletier, May Han, Andrew Lewandowski, Na Zhang, Anisa Mohammed, Mikael L. Rinne, Uma Borate, Andrew H. Wei, Natalia Tovar
Journal: Blood
Blood (2021) 138 (Supplement 1): 244.
https://doi.org/10.1182/blood-2021-146039
Published: 2021
Journal Articles

Sabatolimab (MBG453) Dose Selection and Dose-Response Analysis in Myelodysplastic Syndrome (MDS)/Acute Myeloid Leukemia (AML): Population Pharmacokinetics (PK) Modeling and Evaluation of Clinical Efficacy/Safety By Dose

Andrew H. Wei, MBBS, PhD, Jordi Esteve, Kimmo Porkka, Steve Knapper, Norbert Vey, MD, Sebastian Scholl, Guillermo Garcia-Manero, MD, Martin Wermke, Jeroen Janssen, Elie Traer, Sun Loo, Rupa Narayan, Natalia Tovar, Mika Kontro, Oliver Ottmann, Siyan Xu, Serena Liao, Andrew Stein, Fariba Khanshan, Purushotham Naidu, Na Zhang, Anisa Mohammed, Mikael L. Rinne, Haiying Sun, Andrew M. Brunner, MD, Uma Borate
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–42.
https://doi.org/10.1182/blood-2020-137307
Published: 2020
Journal Articles

Phase I Study of Ixazomib with Conventional Chemotherapy in the Treatment of Acute Myeloid Leukemia in Older Adults

Philip C. Amrein, MD, Eyal C. Attar, MD, Geoffrey Fell, Traci M. Blonquist, MS, Andrew M. Brunner, Gabriela S. Hobbs, MD, Hanno R. Hock, MD PhD, Steven L. McAfee, MD, Rupa Narayan, MD, Jenna A. Moran, NP, Meghan Bergeron, NP, Julia E. Foster, NP, Christina Bertoli, NP, Kristin McGregor, Molly Macrae, Meghan Burke, Tanya T. Behnan, BS, Tina T. Som, RN, Aura Y. Ramos, RN, Megan K. Vartanian, RN, Jennifer Lombardi Story, Donna S. Neuberg, ScD, Amir T. Fathi
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-140584
Published: 2020
Journal Articles

A Phase 1 Trial of Regorafenib in Advanced Myeloid Malignancies

Chi-Joan How, MD, Siyang Ren, Jennifer Lombardi Story, Meghan Bergeron, NP, Julia E. Foster, NP, Philip C. Amrein, MD, Andrew M. Brunner, Amir T. Fathi, Hanno R. Hock, MD PhD, Jenna A. Moran, NP, Rupa Narayan, Donna S. Neuberg, ScD, Aura Y. Ramos, RN, Tina T. Som, RN, Megan Vartanian, RN, Yi-Bin Chen, MD, Gabriela S. Hobbs, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-140278
Published: 2020
Journal Articles

A Phase I Study of the IDH2 Inhibitor Enasidenib As Maintenance Therapy for IDH2 -Mutant Myeloid Neoplasms Following Hematopoietic Cell Transplantation

Amir T. Fathi, Shuli Li, PhD, Robert J. Soiffer, MD, Mark Levis, MD PhD, Alice S. Mims, MD, Steven M Devine, MD, Zachariah Defilipp, MD, Areej El-Jawahri, MD, Steven L. McAfee, MD, Thomas R. Spitzer, MD, Matthew J Frigault, MD MSc, Bimalangshu R. Dey, MD, Philip C. Amrein, MD, Gabriela S. Hobbs, MD, Andrew M. Brunner, MD, Hanno R. Hock, MD PhD, Rupa Narayan, Laura W. Knight, Devon Kelley, AJ S. Bottoms, Jami L. Brown, MS, Candice J. Del Rio, RN, MS, Julie E. Vanderklish, ANP, Colleen Danielson, NP, Meredith L. Saylor, NP, Chrisa L. Hunnewell, Lindsey H. Perry, Jonathan L. Wahl, Elayne Breton, Vincent T. Ho, MD, Yi-Bin Chen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-140176
Published: 2020
Journal Articles

Concurrent FLT3 Inhibitor and IDH Inhibitor Therapy in Patients with Acute Myeloid Leukemia (AML)

Amir T. Fathi, Alexander E. Perl, MD, Mark Levis, MD PhD, Catherine C. Smith, MD, Andrew M. Brunner, Koichi Takahashi, MD PhD, Philip C. Amrein, MD, Hanno R. Hock, MD PhD, Gabriela S. Hobbs, MD, Rupa Narayan, Jenna A. Moran, NP, Meghan Bergeron, NP, Julia E. Foster, NP, Naval Daver, MD, Courtney D. DiNardo, MD MSCE
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-140118
Published: 2020
Journal Articles

Efficacy and Safety of Sabatolimab (MBG453) in Combination with Hypomethylating Agents (HMAs) in Patients with Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS): Updated Results from a Phase 1b Study

Andrew M. Brunner, MD, Jordi Esteve, Kimmo Porkka, Steve Knapper, Norbert Vey, MD, Sebastian Scholl, Guillermo Garcia-Manero, MD, Martin Wermke, Jeroen Janssen, Elie Traer, Sun Loo, Rupa Narayan, Natalia Tovar, Mika Kontro, Oliver Ottmann, Purushotham Naidu, Sema Kurtulus, Jessica Makofske, Serena Liao, Anisa Mohammed, Catherine A. Sabatos-Peyton, Mikael L. Rinne, Uma Borate, Andrew H. Wei, MBBS, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-136855
Published: 2020