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Journal Articles

TP53-mutated Acute Myeloid Leukemia through a single-cell lens

Free
Sun Loo, Benoit Goutorbe, Michelle Jahja, Natasha Anstee, Michel Aurrand-Lions, Christophe Lachaud, Marie-Laure Mollichella, Nadine Carbuccia, Nathalie Cervera, Frédéric Courtier, Anne-Sophie Alary, Chyn Chua, Rachel Agoglia, Andrew Wei, Sylvain Garciaz
Journal: Blood
Blood (2025) 146 (Supplement 1): 5266.
https://doi.org/10.1182/blood-2025-5266
Published: 2025
Journal Articles

Detection of KMT2A fusion transcripts after induction chemotherapy is strongly predictive of outcome in KMT2A rearranged AML: Results of an international collaborative study

Free
Jad Othman, Hsin-An Hou, Nicola Potter, Hannah Al-Yousuf, Pablo Prieto-Martinez, John Chadwick, Marzia Rahman, Sun Loo, Wen-Chien Chou, Yu-Sung Chang, Ing Tiong, Rea Grace Maamari, Hans Ommen, Robert Baker, Adam Ivey, Jelena Jovanovic, Manohursingh Runglall, Raminta Batiuskaite, Tautvile Smalinskaite, Joanna Canham, Ian Thomas, Sean Johnson, Amanda Gilkes, Alan Burnett, Andrius Zucenka, Pramila Krishnamurthy, Andrew Wei, Mike Dennis, Jenny O'Nions, Nigel Russell, Richard Dillon
Journal: Blood
Blood (2025) 146 (Supplement 1): 346.
https://doi.org/10.1182/blood-2025-346
Published: 2025
Journal Articles

Time to complete remission is an independent determinant of survival after intensive chemotherapy in AML

Available to Purchase
Rithin Nedumannil, Michael Ashby, James Rowland, Jacques A. J. Malherbe, Jared Fairbank, Kelli Gray, Sun Loo, Matthew Wright, John Reynolds, Devendra Hiwase, Paula Marlton, Shaun Fleming, Ashish Bajel, Andrew H. Wei
Journal: Blood
Blood (2025) 146 (13): 1625–1629.
https://doi.org/10.1182/blood.2025028594
Published: 2025
Includes: Supplemental data
Journal Articles

How I treat patients with AML using azacitidine and venetoclax

Available to Purchase
Andrew H. Wei, Sun Loo, Naval Daver
Journal: Blood
Blood (2025) 145 (12): 1237–1250.
https://doi.org/10.1182/blood.2024024009
Published: 2025
Includes: Supplemental data
Journal Articles

Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A- rearranged acute myeloid leukemia

Free
Sun Loo, Nicola Potter, Adam Ivey, Jenny O’Nions, Roderick Moon, Jelena Jovanovic, Chun Y. Fong, Natasha S. Anstee, Ing Soo Tiong, Jad Othman, Chong Chyn Chua, Hanna Renshaw, Robert Baker, Shaun Fleming, Nigel H. Russell, David Ritchie, Ashish Bajel, Hsin-An Hou, Richard Dillon, Andrew H. Wei
Journal: Blood
Blood (2024) 144 (24): 2554–2557.
https://doi.org/10.1182/blood.2024026605
Published: 2024
Includes: Supplemental data
Journal Articles

CD74 Antibody Conjugated to an MCL1 Inhibitor (S227928) Combines Synergistically with Venetoclax to Enhance Killing of Acute Myeloid Leukemia

Free
Donia M. Moujalled, Giovanna Pomilio, Thomas Morley, Veronique Litalien, Natasha S. Anstee, Sun Loo, Zhi-Han Yeoh, Clovis Boibessot, Laura Bresson, Ana-Leticia Maragno, Caroline Liot, Andrew H Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 4136.
https://doi.org/10.1182/blood-2024-202691
Published: 2024
Journal Articles

Revumenib As Pre-Emptive Therapy for Measurable Residual Disease in NPM1 mutated or KMT2A- rearranged Acute Myeloid Leukemia: A Domain of the Multi-Arm ALLG AMLM26 Intercept Platform Trial

Free
Sun Loo, Harry Iland, Ing Soo Tiong, David Westerman, Jad Othman, Paula Marlton, Chong Chyn Chua, Duncan Purtill, Hannah Rose, Shaun Fleming, Deepak Singhal, Anoop K Enjeti, William S. Stevenson, Teng Fong Ng, McCulloch Derek, Lachlin Vaughan, Robin Gasiorowski, Adam Ivey, Amanda Souza, Revati Pattani, Natasha S. Anstee, Rachel Koldej, David S. Ritchie, Sanam Loghavi, Naval Daver, Courtney D. DiNardo, Andrew W. Roberts, Carolyn S. Grove, John Reynolds, Andrew H Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 223.
https://doi.org/10.1182/blood-2024-202895
Published: 2024
Journal Articles

Molecular MRD is strongly prognostic in patients with NPM1 -mutated AML receiving venetoclax-based nonintensive therapy

Free
Clinical Trials & Observations Brief Report
Jad Othman, Ing S. Tiong, Jenny O'Nions, Mike Dennis, Katya Mokretar, Adam Ivey, Michael Austin, Anne-Louise Latif, Mariam Amer, Wei Yee Chan, Charles Crawley, Francesca Crolla, Joe Cross, Ray Dang, Johnathon Elliot, Chun Y. Fong, Sofia Galli, Paolo Gallipoli, Francesca Hogan, Pallavi Kalkur, Anjum Khan, Pramila Krishnamurthy, John Laurie, Sun Loo, Scott Marshall, Priyanka Mehta, Vidhya Murthy, Sateesh Nagumantry, Srinivas Pillai, Nicola Potter, Rob Sellar, Tom Taylor, Rui Zhao, Nigel H. Russell, Andrew H. Wei, Richard Dillon
Journal: Blood
Blood (2024) 143 (4): 336–341.
https://doi.org/10.1182/blood.2023021579
Published: 2024
Includes: Supplemental data
Journal Articles

Sorafenib plus intensive chemotherapy in newly diagnosed FLT3 -ITD AML: a randomized, placebo-controlled study by the ALLG

Free
Clinical Trials & Observations
Sun Loo, Andrew W. Roberts, Natasha S. Anstee, Glen A. Kennedy, Simon He, Anthony P. Schwarer, Anoop K. Enjeti, James D’Rozario, Paula Marlton, Ian A. Bilmon, John Taper, Gavin Cull, Campbell Tiley, Emma Verner, Uwe Hahn, Devendra K. Hiwase, Harry J. Iland, Nick Murphy, Sundra Ramanathan, John Reynolds, Doen Ming Ong, Ing Soo Tiong, Meaghan Wall, Michael Murray, Tristan Rawling, Joanna Leadbetter, Leesa Rowley, Maya Latimer, Sam Yuen, Stephen B. Ting, Chun Yew Fong, Kirk Morris, Ashish Bajel, John F. Seymour, Mark J. Levis, Andrew H. Wei
Journal: Blood
Blood (2023) 142 (23): 1960–1971.
https://doi.org/10.1182/blood.2023020301
Published: 2023
Includes: Supplemental data
Journal Articles

Pre-Transplant Measurable Residual Disease (MRD) Detection of KMT2A- rearranged Acute Myeloid Leukemia Is Strongly Associated with Inferior Post-Transplant Outcome

Free
Sun Loo, Nicola Potter, Adam Ivey, Jenny O'Nions, Roderick Moon, Chun Yew Fong, Natasha Anstee, Ing Soo Tiong, Chong Chyn Chua, Jad Othman, Hannah Renshaw, Robert Baker, Nigel H. Russell, Ashish Bajel, Hsin-An Hou, Richard Dillon, Andrew H. Wei
Journal: Blood
Blood (2023) 142 (Supplement 1): 1577.
https://doi.org/10.1182/blood-2023-185541
Published: 2023
Journal Articles

Venetoclax Has Potent Efficacy in NPM1 mutated AML with Acquired Resistance Associated with Either Perturbed Pro-Survival Signalling or NPM1 wild-Type Populations

Free
Chong Chyn Chua, Natasha Anstee, Christoffer Flensburg, Charis Teh, Adam Ivey, Noorul Amin, Rachel Thijssen, Stefan K. Bohlander, Purvi M. Kakadia, Zhen Xu, Chun Yew Fong, Stephen Ting, Sun Loo, Ing Soo Tiong, Daniel Gray, Shaun Fleming, Nadia Davidson, Andrew W. Roberts, Ian Majewski, Andrew H. Wei, Fiona C. Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 423.
https://doi.org/10.1182/blood-2023-185321
Published: 2023
Journal Articles

Pretransplant FLT3 -ITD MRD assessed by high-sensitivity PCR-NGS determines posttransplant clinical outcome

Free
Sun Loo, Richard Dillon, Adam Ivey, Natasha S. Anstee, Jad Othman, Ing Soo Tiong, Nicola Potter, Jelena Jovanovic, Manohursingh Runglall, Chyn Chua Chong, Ashish Bajel, David Ritchie, Kelli Gray, Zhi Han Yeoh, Michelle McBean, Amanda Gilkes, Ian Thomas, Sean Johnson, Nigel H. Russell, Andrew H. Wei
Journal: Blood
Blood (2022) 140 (22): 2407–2411.
https://doi.org/10.1182/blood.2022016567
Published: 2022
Includes: Supplemental data
Journal Articles

High Response and Prolonged Treatment-Free Remission after a Short-Course of Modified Intensive Chemotherapy and Venetoclax in Elderly AML: An Updated Analysis of the Caveat Trial

Free
Chong Chyn Chua, Sun Loo, John Reynolds, Ing S Tiong, Chun Yew Fong, Stephen B Ting, Shaun Fleming, Andrew W Roberts, Andrew H Wei
Journal: Blood
Blood (2022) 140 (Supplement 1): 1708–1710.
https://doi.org/10.1182/blood-2022-165021
Published: 2022
Journal Articles

A Prospective Phase 2 Study of Venetoclax and Low Dose Ara-C (VALDAC) to Target Rising Molecular Measurable Residual Disease and Early Relapse in Acute Myeloid Leukemia

Free
Ing S Tiong, Devendra Hiwase, Emad Uddin Abro, Ashish Bajel, Emma Palfreyman, Sun Loo, Shaun Fleming, Chun Yew Fong, Tse-Chieh Teh, Adam Ivey, Andrew H Wei
Journal: Blood
Blood (2022) 140 (Supplement 1): 1453–1455.
https://doi.org/10.1182/blood-2022-163041
Published: 2022
Journal Articles

Allogeneic Hematopoietic Cell Transplantation (HCT) and Impact on Clonal Haematopoiesis and Post-HCT Therapy-Related Myeloid Neoplasm in Heavily Treated and Poor Risk Patients with Plasma Cell Myeloma

Free
Michael D Ashby, Natasha S Anstee, Tongted Das, Ing S Tiong, Sun Loo, Andrew Spencer, Andrew H. Wei
Journal: Blood
Blood (2022) 140 (Supplement 1): 2876–2878.
https://doi.org/10.1182/blood-2022-165544
Published: 2022
Journal Articles

ALLG AMLM26 Phase 1B/2 Study Investigating Novel Therapies to Target Early Relapse and Clonal Evolution As Pre-Emptive Therapy in AML (INTERCEPT): A Multi-Arm, Precision-Based, Recursive, Platform Trial

Free
Andrew H Wei, Harry J Iland, John Reynolds, Sun Loo, Chong Chyn Chua, David Westerman, Ing S Tiong, Adam Ivey, Piers Blombery, Natasha S Anstee, Rachel M Koldej, David J. Curtis, David Kipp, David Ritchie, David M Ross, Amanda Souza, Jenny Collins, Ashish Bajel, Carolyn Grove, Paula Marlton, Andrew W Roberts, Naveen Pemmaraju, Keyur P. Patel, Sanam Loghavi, Marina Konopleva, Naval Daver, Courtney D. DiNardo
Journal: Blood
Blood (2022) 140 (Supplement 1): 3341–3343.
https://doi.org/10.1182/blood-2022-167837
Published: 2022
Journal Articles

A Phase-Ib/II Clinical Evaluation of Ponatinib in Combination with Azacitidine in FLT3 -ITD and CBL -Mutant Acute Myeloid Leukemia (PON-AZA study)

Free
David Kipp, Sun Loo, Andrew Charles Perkins, Steven W Lane, Emily Blyth, Anoop Kumar Enjeti, Ashish Bajel, John Reynolds, Andrew H. Wei
Journal: Blood
Blood (2021) 138 (Supplement 1): 2350.
https://doi.org/10.1182/blood-2021-154247
Published: 2021
Journal Articles

High Sensitivity Detection of FLT3 -ITD Measurable Residual Disease By Deep Sequencing Prior to Hematopoietic Cell Transplant Is Highly Prognostic for Outcome in Acute Myeloid Leukemia

Free
Sun Loo, Richard Dillon, Natasha S Anstee, Ing S Tiong, Adam Ivey, Nicola Potter, Jad Othman, Manohursingh Runglall, Jelena Jovanovic, Amanda Gilkes, Ian Thomas, Sean Johnson, Nigel H. Russell, Andrew H. Wei
Journal: Blood
Blood (2021) 138 (Supplement 1): 2364.
https://doi.org/10.1182/blood-2021-149301
Published: 2021
Journal Articles

Efficacy and Safety of Sabatolimab (MBG453) in Combination with Hypomethylating Agents (HMAs) in Patients (Pts) with Very High/High-Risk Myelodysplastic Syndrome (vHR/HR-MDS) and Acute Myeloid Leukemia (AML): Final Analysis from a Phase Ib Study

Free
Andrew M. Brunner, Jordi Esteve, Kimmo Porkka, Steve Knapper, Elie Traer, Sebastian Scholl, Guillermo Garcia-Manero, Norbert Vey, Martin Wermke, Jeroen Janssen, Rupa Narayan, Sun Loo, Mika Kontro, Oliver Ottmann, Purushotham Naidu, Marc Pelletier, May Han, Andrew Lewandowski, Na Zhang, Anisa Mohammed, Mikael L. Rinne, Uma Borate, Andrew H. Wei, Natalia Tovar
Journal: Blood
Blood (2021) 138 (Supplement 1): 244.
https://doi.org/10.1182/blood-2021-146039
Published: 2021
Journal Articles

A Prospective Phase 2 Study of Venetoclax and Low Dose Ara-C (VALDAC) to Target Rising Molecular Measurable Residual Disease and Early Relapse in Acute Myeloid Leukemia

Free
Ing S Tiong, Sun Loo, Emad Uddin Abro, Devendra Hiwase, Shaun Fleming, Ashish Bajel, Emma Palfreyman, Chun Yew Fong, Tse-Chieh Teh, Adam Ivey, Andrew H. Wei
Journal: Blood
Blood (2021) 138 (Supplement 1): 1261.
https://doi.org/10.1182/blood-2021-152583
Published: 2021