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Journal Articles

Asciminib monotherapy as frontline treatment of chronic-phase chronic myeloid leukemia: results from the ASCEND study

Clinical Trials & Observations
David T. Yeung, Naranie Shanmuganathan, John Reynolds, Susan Branford, Mannu Walia, Agnes S. M. Yong, Jake Shortt, Lynette Chee, Nicholas Viiala, Ilona Cunningham, David M. Ross, Alwyn D’Souza, Matthew Wright, Rosemary Harrup, Cecily Forsyth, Robin Filshie, Steven Lane, Peter Browett, Carolyn Grove, Andrew P. Grigg, Timothy P. Hughes
Journal: Blood
Blood (2024) 144 (19): 1993–2001.
https://doi.org/10.1182/blood.2024024657
Published: 2024
Includes: Supplemental data
Journal Articles

Durable Responses Observed in Chronic Myelomonocytic Leukemia Treated with Lenzilumab and Azacitidine

Devendra Hiwase, David M Ross, David T Yeung, Agnes S. M. Yong, Steven W Lane, Anna Brown, Chun Yew Fong, Timothy P Hughes, John Reynolds, Daniel Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 1006.
https://doi.org/10.1182/blood-2024-202867
Published: 2024
Journal Articles

Update of the Ascend-CML Study of Frontline Asciminib: High Rate of Optimal Response and Resistance Due to Mutations Is Rare

David T Yeung, Naranie Shanmuganathan, Agnes S. M. Yong, Jake Shortt, Lynette C.Y. Chee, Nicholas Vialla, Ilona Cunningham, David M Ross, Alwyn D'Souza, Matthew P.F. Wright, Rosemary Harrup, Cecily Forsyth, Robin Filshie, Steven W Lane, Peter J. Browett, Carolyn S. Grove, Mannu Walia, Susan Branford, John Reynolds, Andrew P Grigg, Timothy P Hughes
Journal: Blood
Blood (2024) 144 (Supplement 1): 476.
https://doi.org/10.1182/blood-2024-201218
Published: 2024
Journal Articles

Revumenib As Pre-Emptive Therapy for Measurable Residual Disease in NPM1 mutated or KMT2A- rearranged Acute Myeloid Leukemia: A Domain of the Multi-Arm ALLG AMLM26 Intercept Platform Trial

Sun Loo, Harry Iland, Ing Soo Tiong, David Westerman, Jad Othman, Paula Marlton, Chong Chyn Chua, Duncan Purtill, Hannah Rose, Shaun Fleming, Deepak Singhal, Anoop K Enjeti, William S. Stevenson, Teng Fong Ng, McCulloch Derek, Lachlin Vaughan, Robin Gasiorowski, Adam Ivey, Amanda Souza, Revati Pattani, Natasha S. Anstee, Rachel Koldej, David S. Ritchie, Sanam Loghavi, Naval Daver, Courtney D. DiNardo, Andrew W. Roberts, Carolyn S. Grove, John Reynolds, Andrew H Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 223.
https://doi.org/10.1182/blood-2024-202895
Published: 2024
Journal Articles

A Phase II Randomized Trial Comparing Low-Dose Cytarabine and Venetoclax +/- Midostaurin in Non-Adverse Cytogenetic Risk Acute Myeloid Leukemia: The ALLG AMLM25 Intervene Trial

Chong Chyn Chua, Blake Hsu, Anoop K Enjeti, Ashish Bajel, Paula Marlton, Shaun Fleming, Devendra Hiwase, Chun Kei Kris Ma, Peter J. Browett, Travis Perera, Carolyn S. Grove, Shuhying Tan, Jad Othman, Julian Cooney, Hannah Rose, Edward S Morris, Rachel Koldej, David S. Ritchie, Kate Mason, Natasha S. Anstee, John Reynolds, Andrew H Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 217.
https://doi.org/10.1182/blood-2024-199882
Published: 2024
Journal Articles

Initial Results from the Frailty-Stratified, Randomised Controlled Bayesian Adaptive Trial of Bortezomib Versus Lenalidomide in Transplant Ineligible Myeloma (TI-NDMM) - the FRAIL-M Study (AMaRC 19-01; ALLG MM22)

Sueh-Li Lim, John Reynolds, Lucy Pemberton, Tricia Wright, Sophie Hyesuk Lee, Peter Mollee, Anita C Shetty, Helen Weston, Nina Byard, Khoa Le, Zoe K McQuilten, Hang Quach, Andrew Spencer
Journal: Blood
Blood (2024) 144 (Supplement 1): 4755.
https://doi.org/10.1182/blood-2024-209640
Published: 2024
Journal Articles

Sorafenib plus intensive chemotherapy in newly diagnosed FLT3 -ITD AML: a randomized, placebo-controlled study by the ALLG

Clinical Trials & Observations
Sun Loo, Andrew W. Roberts, Natasha S. Anstee, Glen A. Kennedy, Simon He, Anthony P. Schwarer, Anoop K. Enjeti, James D’Rozario, Paula Marlton, Ian A. Bilmon, John Taper, Gavin Cull, Campbell Tiley, Emma Verner, Uwe Hahn, Devendra K. Hiwase, Harry J. Iland, Nick Murphy, Sundra Ramanathan, John Reynolds, Doen Ming Ong, Ing Soo Tiong, Meaghan Wall, Michael Murray, Tristan Rawling, Joanna Leadbetter, Leesa Rowley, Maya Latimer, Sam Yuen, Stephen B. Ting, Chun Yew Fong, Kirk Morris, Ashish Bajel, John F. Seymour, Mark J. Levis, Andrew H. Wei
Journal: Blood
Blood (2023) 142 (23): 1960–1971.
https://doi.org/10.1182/blood.2023020301
Published: 2023
Includes: Supplemental data
Journal Articles

A Phase I/II Single Arm Study of Belantamab Mafodotin, Carfilzomib and Dexamethasone in Patients with Relapsed Multiple Myeloma: Planned Interim Analysis of Safety and Efficacy. Amarc 19-02 Belacard Study

Masa Lasica, Andrew Spencer, Noemi Horvath, Wojt Janowski, Douglas Coghlan, Craig Wallington-Gates, Philip Campbell, Hock Choong Lai, Georgia McCaughan, Nicholas Weber, Anish Puliyayil, Philip Wong, Deng Yachao, Khoa Le, John Reynolds, Hang Quach
Journal: Blood
Blood (2023) 142 (Supplement 1): 2012.
https://doi.org/10.1182/blood-2023-189005
Published: 2023
Journal Articles

Optimizing Immunoglobulin Replacement Therapy for Patients with B-Cell Malignancies and Hypogammaglobulinemia: The Investigator-Initiated, International, Randomized Phase II/III Rational Platform Trial, and the Rationalise (STOP IgRT) Domain

Erica M. Wood, Khai Li Chai, John Reynolds, Jennifer Griffiths, Brendan Beaton, Jeannie Callum, Kyle R Crassini, Philip J Crispin, Laura Fanning, Michael Gilbertson, Andrew P Grigg, Eliza A Hawkes, C. Orla Morrissey, Stephen P Mulligan, Stephen S. Opat, David L Paterson, Dennis Petrie, Jason A Roberts, Elizabeth G Ryan, Andrew Spencer, Simon J Stanworth, Le Thi Phuong Thao, Judith Trotman, Neil A Waters, Robert Weinkove, Zoe K McQuilten
Journal: Blood
Blood (2023) 142 (Supplement 1): 1295.
https://doi.org/10.1182/blood-2023-181541
Published: 2023
Journal Articles

Excellent Early and Major Molecular Responses Observed with Asciminib Treatment for CP-CML: Results from the ALLG CML13 Ascend-CML Study

David T Yeung, Naranie Shanmuganathan, John Reynolds, Susan Branford, Mannu Walia, Agnes S. M. Yong, Jake Shortt, Kate Burbury, Lynette C.Y. Chee, Nick Viiala, Ilona Cunningham, David M. Ross, Alwyn Bernard D'Souza, Matthew P.F. Wright, Rosemary Anne Harrup, Cecily Forsyth, Robin Filshie, Peter J. Browett, Steven W. Lane, Carolyn Grove, Andrew P Grigg, Timothy P Hughes, on Behalf Of The ALLG
Journal: Blood
Blood (2023) 142 (Supplement 1): 865.
https://doi.org/10.1182/blood-2023-172583
Published: 2023
Journal Articles

Isatuximab Rescue for Inadequate Response to Lenalidomide and Dexamethasone in Transplant Ineligible Patients with Newly Diagnosed Multiple Myeloma: Primary Analysis of the Phase II Iril Study of the Australian Myeloma Research Consortium (AMaRC 18-02)

Slavisa Ninkovic, Costas K. Yannakou, Nicholas Murphy, Rosemary Anne Harrup, Craig Wallington-Gates, Magdalena Sobieraj-Teague, M Hasib Sidiqi, Anish Puliyayil, Wojt Janowski, John Reynolds, Andrew Spencer, Hang Quach
Journal: Blood
Blood (2023) 142 (Supplement 1): 2019.
https://doi.org/10.1182/blood-2023-185944
Published: 2023
Journal Articles

Evaluation of Easym, a Clonotypic Mass Spectrometry Assay, and Euroflow Minimal Residual Disease Assessment in Multiple Myeloma

Jessie Zhao, Tiffany T. Khong, Malgorzata Gorniak, Abir Khaled, Zac McDonald, John Reynolds, Daniel Wong, Nicholas Bingham, Anna M. Johnston, Olga Motorna, Nicholas E. Murphy, Hang Quach, Liqiang Yang, Andrew Spencer
Journal: Blood
Blood (2023) 142 (Supplement 1): 3328.
https://doi.org/10.1182/blood-2023-179742
Published: 2023
Journal Articles

Early and Deep Molecular Responses Achieved with Frontline Asciminib in Chronic Phase CML - Interim Results from ALLG CML13 Ascend-CML

David T Yeung, Naranie Shanmuganathan, John Reynolds, Susan Branford, Mannu Walia, Agnes S.M. Yong, Jake Shortt, Kate Burbury, Nicholas Viiala, Ilona Cunningham, David M. Ross, Rosemary Harrup, Matthew Wright, Cecily Forsyth, Alwyn Bernard D'Souza, Robin J Filshie, Peter J. Browett, Steven W Lane, Carolyn Grove, Andrew Grigg, Timothy Hughes
Journal: Blood
Blood (2022) 140 (Supplement 1): 192–194.
https://doi.org/10.1182/blood-2022-157244
Published: 2022
Journal Articles

High Deliverability of a Midostaurin Triplet Regimen Incorporating Venetoclax and Low Dose Cytarabine in Non-Adverse Cytogenetic Risk Acute Myeloid Leukaemia: A Sub-Analysis of the Australasian Leukaemia Lymphoma Group (ALLG) Intervene Study

Chong Chyn Chua, Natasha S Anstee, Anoop Kumar Enjeti, Devendra Hiwase, Paula Marlton, Ashish Bajel, Shuh Ying Tan, Edward S. Morris, Chun-Kei-Kris Ma, Carolyn Grove, Julian Cooney, Ashanka Beligaswatte, Rachel M Koldej, Stephen B Ting, Travis Perera, Amanda Johnston, John Reynolds, David Ritchie, Andrew H Wei
Journal: Blood
Blood (2022) 140 (Supplement 1): 3362–3364.
https://doi.org/10.1182/blood-2022-163084
Published: 2022
Journal Articles

ALLG AMLM26 Phase 1B/2 Study Investigating Novel Therapies to Target Early Relapse and Clonal Evolution As Pre-Emptive Therapy in AML (INTERCEPT): A Multi-Arm, Precision-Based, Recursive, Platform Trial

Andrew H Wei, Harry J Iland, John Reynolds, Sun Loo, Chong Chyn Chua, David Westerman, Ing S Tiong, Adam Ivey, Piers Blombery, Natasha S Anstee, Rachel M Koldej, David J. Curtis, David Kipp, David Ritchie, David M Ross, Amanda Souza, Jenny Collins, Ashish Bajel, Carolyn Grove, Paula Marlton, Andrew W Roberts, Naveen Pemmaraju, Keyur P. Patel, Sanam Loghavi, Marina Konopleva, Naval Daver, Courtney D. DiNardo
Journal: Blood
Blood (2022) 140 (Supplement 1): 3341–3343.
https://doi.org/10.1182/blood-2022-167837
Published: 2022
Journal Articles

Secondary Analysis of the MM21 Trial: Response Adaptive Salvage Treatment with Daratumumab-Lenalidomide-Dexamethasone (DRd) for Newly Diagnosed Transplant Eligible Multiple Myeloma Patients Failing Front-Line Bortezomib-Based Induction Therapy

Sueh-li Lim, John Reynolds, Hang Quach, Anna Hutchinson, Ian H Kerridge, Jane Estell, Craig wallington-Gates, Anna Kalff, Flora Yuen, Andrew Spencer
Journal: Blood
Blood (2022) 140 (Supplement 1): 10174–10176.
https://doi.org/10.1182/blood-2022-170697
Published: 2022
Journal Articles

Circulating RAS/RAF and DNA-Repair Gene Mutations Associates with High-Risk/Treatment Resistance in Primary Refractory Multiple Myeloma

Sridurga Mithraprabhu, John Reynolds, Rose Turner, Hang Quach, Noemi Horvath, Ian H Kerridge, Flora Yuen, Tiffany Khong, Brian G.M. Durie, Andrew Spencer
Journal: Blood
Blood (2022) 140 (Supplement 1): 9933–9934.
https://doi.org/10.1182/blood-2022-171053
Published: 2022
Journal Articles

High Response and Prolonged Treatment-Free Remission after a Short-Course of Modified Intensive Chemotherapy and Venetoclax in Elderly AML: An Updated Analysis of the Caveat Trial

Chong Chyn Chua, Sun Loo, John Reynolds, Ing S Tiong, Chun Yew Fong, Stephen B Ting, Shaun Fleming, Andrew W Roberts, Andrew H Wei
Journal: Blood
Blood (2022) 140 (Supplement 1): 1708–1710.
https://doi.org/10.1182/blood-2022-165021
Published: 2022
Journal Articles

Machine Learning of Genomic Factors in 1,961 Patients with Acute Myeloid Leukemia Identifies Patients with Very Good or Very Poor Prognosis Who Do Not Benefit from Allogeneic Hematopoietic Cell Transplant in First Remission

Shaun Fleming, Cheng-Hong Tsai, Hartmut Döhner, Konstanze Döhner, Elli Papaemmanuil, Hwei-Fang Tien, John Reynolds, Andrew H. Wei, Hsin-An Hou
Journal: Blood
Blood (2021) 138 (Supplement 1): 225.
https://doi.org/10.1182/blood-2021-151972
Published: 2021
Journal Articles

An Australasian Leukemia Lymphoma Group (ALLG) Phase 2 Study to Investigate Novel Triplets to Extend Remission with Venetoclax in Elderly (INTERVENE) Acute Myeloid Leukemia

Chong Chyn Chua, John Reynolds, Anoop Kumar Enjeti, Devendra Hiwase, Paula Marlton, Ashish Bajel, Shuh Ying Tan, Edward S. Morris, Chun-Kei-Kris Ma, Carolyn Grove, Julian Cooney, Ashanka Beligaswatte, Natasha Anstee, Stephen B Ting, Travis Perera, Amanda Johnston, David Ritchie, Andrew H. Wei
Journal: Blood
Blood (2021) 138 (Supplement 1): 368.
https://doi.org/10.1182/blood-2021-149488
Published: 2021