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Agnes S. M. Yong
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Journal Articles

Asciminib monotherapy as frontline treatment of chronic-phase chronic myeloid leukemia: results from the ASCEND study

Clinical Trials & Observations
David T. Yeung, Naranie Shanmuganathan, John Reynolds, Susan Branford, Mannu Walia, Agnes S. M. Yong, Jake Shortt, Lynette Chee, Nicholas Viiala, Ilona Cunningham, David M. Ross, Alwyn D’Souza, Matthew Wright, Rosemary Harrup, Cecily Forsyth, Robin Filshie, Steven Lane, Peter Browett, Carolyn Grove, Andrew P. Grigg, Timothy P. Hughes
Journal: Blood
Blood (2024) 144 (19): 1993–2001.
https://doi.org/10.1182/blood.2024024657
Published: 2024
Includes: Supplemental data
Journal Articles

Increased Inflammatory Cytokines in Plasma Are Associated with Sustained Treatment-Free Remission in Chronic Myeloid Leukaemia

Chung Hoow Kok, Verity A Saunders, Naranie Shanmuganathan, Liu Liu, Yazad Daruis Irani, Jade Clarson, Phuong Dang, David T Yeung, Agnes S. M. Yong, Susan Branford, Javier Pinilla-Ibarz, Richard A. Larson, Jorge E. Cortes, Michael J. Mauro, James E Thompson, Neil P. Shah, Martha Wadleigh, Ehab L. Atallah, Jerald P. Radich, Timothy P Hughes, David M Ross
Journal: Blood
Blood (2024) 144 (Supplement 1): 993.
https://doi.org/10.1182/blood-2024-201881
Published: 2024
Journal Articles

High Dose Ascorbate Reduces Interleukin-1 Beta Secretion in TET2 Mutant Monocytes and Demonstrates Excellent Safety and Tolerability in CMML Patients in Combination with Azacitidine

Maha M Kamel, Nirmal Robinson, Monika Kutyna, Kelly Lim, Chloe Thompson-Peach, Steven W Lane, David T Yeung, Agnes S. M. Yong, David M Ross, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 1817.
https://doi.org/10.1182/blood-2024-204177
Published: 2024
Journal Articles

CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity

Kelly Lim, Monika Kutyna, Winnie Kan, Angel F. Lopez, Anna Brown, Agnes S. M. Yong, Steven W Lane, Chun Yew Fong, Timothy P Hughes, David T Yeung, David M Ross, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 3196.
https://doi.org/10.1182/blood-2024-202682
Published: 2024
Journal Articles

Longitudinal Clonal Tracking Reveals That Early and Sensitive Detection of Blood Cancer-Related Gene Variants in Patients with Chronic Myeloid Leukemia Predicts Treatment Failure

Susan Branford, Adelina Fernandes, Carol Wadham, Muneeza Maqsood, Nur Hezrin Shahrin, David M Ross, Agnes S. M. Yong, Ming Lin, Rosalie Kenyon, Dominik Kaczorowski, Verity A Saunders, Ilaria Stefania Pagani, John Toubia, Joe McConnell, David T Yeung, Chung Hoow Kok, Timothy P Hughes, Naranie Shanmuganathan
Journal: Blood
Blood (2024) 144 (Supplement 1): 996.
https://doi.org/10.1182/blood-2024-198827
Published: 2024
Journal Articles

Update of the Ascend-CML Study of Frontline Asciminib: High Rate of Optimal Response and Resistance Due to Mutations Is Rare

David T Yeung, Naranie Shanmuganathan, Agnes S. M. Yong, Jake Shortt, Lynette C.Y. Chee, Nicholas Vialla, Ilona Cunningham, David M Ross, Alwyn D'Souza, Matthew P.F. Wright, Rosemary Harrup, Cecily Forsyth, Robin Filshie, Steven W Lane, Peter J. Browett, Carolyn S. Grove, Mannu Walia, Susan Branford, John Reynolds, Andrew P Grigg, Timothy P Hughes
Journal: Blood
Blood (2024) 144 (Supplement 1): 476.
https://doi.org/10.1182/blood-2024-201218
Published: 2024
Journal Articles

Durable Responses Observed in Chronic Myelomonocytic Leukemia Treated with Lenzilumab and Azacitidine

Devendra Hiwase, David M Ross, David T Yeung, Agnes S. M. Yong, Steven W Lane, Anna Brown, Chun Yew Fong, Timothy P Hughes, John Reynolds, Daniel Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 1006.
https://doi.org/10.1182/blood-2024-202867
Published: 2024
Journal Articles

Lineage-specific detection of residual disease predicts relapse in patients with chronic myeloid leukemia stopping therapy

Brief Report
Ilaria S. Pagani, Naranie Shanmuganathan, Phuong Dang, Verity A. Saunders, Randall Grose, Chung H. Kok, Jane James, Molly Tolland, Jodi A. Braley, Haley K. Altamura, David T. Yeung, Susan Branford, Agnes S. M. Yong, Timothy P. Hughes, David M. Ross
Journal: Blood
Blood (2023) 142 (25): 2192–2197.
https://doi.org/10.1182/blood.2023021119
Published: 2023
Includes: Supplemental data
Journal Articles

Excellent Early and Major Molecular Responses Observed with Asciminib Treatment for CP-CML: Results from the ALLG CML13 Ascend-CML Study

David T Yeung, Naranie Shanmuganathan, John Reynolds, Susan Branford, Mannu Walia, Agnes S. M. Yong, Jake Shortt, Kate Burbury, Lynette C.Y. Chee, Nick Viiala, Ilona Cunningham, David M. Ross, Alwyn Bernard D'Souza, Matthew P.F. Wright, Rosemary Anne Harrup, Cecily Forsyth, Robin Filshie, Peter J. Browett, Steven W. Lane, Carolyn Grove, Andrew P Grigg, Timothy P Hughes, on Behalf Of The ALLG
Journal: Blood
Blood (2023) 142 (Supplement 1): 865.
https://doi.org/10.1182/blood-2023-172583
Published: 2023
Journal Articles

Cytokine and Mutation Profiling Reveal Patterns of Complete Remission Rates with Lenzilumab Combination Therapy in Chronic Myelomonocytic Leukemia

Monika Kutyna, Maha M Kamel, David M. Ross, Agnes S. M. Yong, Chun Yew Fong, Chloe Thompson-Peach, Steven W. Lane, David T Yeung, Timothy P Hughes, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 1852.
https://doi.org/10.1182/blood-2023-179706
Published: 2023
Journal Articles

Lenzilumab in Addition to Azacitidine Improves Complete Response Rates in Chronic Myelomonocytic Leukemia

Devendra Hiwase, David M. Ross, Steven W. Lane, Chloe Thompson-Peach, Chun Yew Fong, Agnes S. M. Yong, David T Yeung, Timothy P Hughes, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 1847.
https://doi.org/10.1182/blood-2023-179688
Published: 2023
Journal Articles

Age-Related Clonal Hematopoiesis Mutations Detected at the Time of Stopping Tyrosine Kinase Inhibitor Therapy Predict the Achievement of Treatment-Free Remission for Patients with CML

Susan Branford, Carol Wadham, Naranie Shanmuganathan, Adelina Fernandes, Nur Hezrin Shahrin, Jinghua Feng, John Toubia, Paul Wang, Chung Hoow Kok, Muneeza Maqsood, Verity Saunders, Rob King, Ming Lin, Rosalie Kenyon, Ilaria Stefania Pagani, David T Yeung, David M. Ross, Agnes S. M. Yong, Timothy P Hughes
Journal: Blood
Blood (2023) 142 (Supplement 1): 447.
https://doi.org/10.1182/blood-2023-174425
Published: 2023
Journal Articles

Suppression of KRAS and CBL Mutations and Hematological Improvement By Lenzilumab and Azacitidine Treatment in Proliferative Chronic Myelomonocytic Leukemia

Maha M Kamel, Monika Kutyna, David M. Ross, Steven W. Lane, Chloe Thompson-Peach, Chun Yew Fong, Agnes S. M. Yong, David T Yeung, Timothy P Hughes, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2023-188340
Published: 2023
Journal Articles

Early BCR-ABL1 kinetics are predictive of subsequent achievement of treatment-free remission in chronic myeloid leukemia

Clinical Trials & Observations
Naranie Shanmuganathan, Ilaria S. Pagani, David M. Ross, Sahee Park, Agnes S. M. Yong, Jodi A. Braley, Haley K. Altamura, Devendra K. Hiwase, David T. Yeung, Dong-Wook Kim, Susan Branford, Timothy P. Hughes
Journal: Blood
Blood (2021) 137 (9): 1196–1207.
https://doi.org/10.1182/blood.2020005514
Published: 2021
Includes: Supplemental data
Journal Articles

Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells

Nadia El Khawanky, Bsc(Biomed), BHlthSc(Hons), Amy Hughes, PhD, Wenbo Yu, PhD, Sanaz Taromi, PhD, Jade Clarson, BSc, Angel F. Lopez, MD PhD, Michael P. Brown, MD PhD, Justus Duyster, MD, Timothy P. Hughes, MDMBBS,FRACP,FRCPA, Deborah L. White, PhD FFSc (RCPA), Agnes S. M. Yong, MD PhD, Robert Zeiser, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3904.
https://doi.org/10.1182/blood-2019-124684
Published: 2019
Journal Articles

Combination of Nilotinib and Pegylated Interferon Alfa-2B Results in High Rates of MR4.5 at 24 Months - Primary Analysis of the ALLG CML 11 Pinnacle Study

David T Yeung, PhDBSc,FRACP,FRCPA,MBBS, Naranie Shanmuganathan, MBBS FRACP FRCPA, Andrew Grigg, Ilona Cunningham, MBBS FRACP FRCPA, Jake Shortt, FRACP,FRCPA,PhD, Philip Rowling, MBBS FRACP FRCPA, John Reynolds, PhD, Rosemary Anne Harrup, MBBS, FRACP, FRCPA, David M Ross, MD PhD, David Kipp, MBBS,FRCPA,FRACP, Anthony K Mills, FRACP, FRCPA, MBBS, Christopher K Arthur, MBBS FRACP FRCPA, Anthony P Schwarer, MD MBBS (Hons), FRACP, FRCPA, Kathryn Jackson, MBBS FRACP FRCPA, Nicholas Viiala, MBBS FRACP FRCPA, Robert Weinkove, MD, Agnes S. M. Yong, MD PhD, Deborah L. White, PhD FFSc (RCPA), Susan Branford, PhD, Timothy P. Hughes, MDMBBS,FRACP,FRCPA, On Behalf of the ALLG
Journal: Blood
Blood (2019) 134 (Supplement_1): 2926.
https://doi.org/10.1182/blood-2019-125740
Published: 2019
Journal Articles

Modeling the safe minimum frequency of molecular monitoring for CML patients attempting treatment-free remission

Clinical Trials & Observations
Naranie Shanmuganathan, Jodi A. Braley, Agnes S. M. Yong, Devendra K. Hiwase, David T. Yeung, David M. Ross, Timothy P. Hughes, Susan Branford
Journal: Blood
Blood (2019) 134 (1): 85–89.
https://doi.org/10.1182/blood.2019000120
Published: 2019
Includes: Supplemental data
Journal Articles

Combination of Nilotinib and Pegylated Interferon Alfa-2b Results in High Molecular Response Rates in Chronic Phase CML: Interim Results of the ALLG CML 11 Pinnacle Study

David T Yeung, PhDBSc,FRACP,FRCPA,MBBS, Andrew P. Grigg, MBBS, FRACP, FRCPA, MD, Naranie Shanmuganathan, MBBS, Ilona Cunningham, MBBS FRACP FRCPA, Jake Shortt, FRACP,FRCPA,PhD, Philip Rowling, MBBS FRACP FRCPA, John Reynolds, PhD, Rachel Cushion, Rosemary Anne Harrup, MD, David M Ross, David Kipp, MBBS,FRCPA,FRACP, Anthony K Mills, FRACP, FRCPA, MBBS, Christopher K Arthur, Anthony P Schwarer, MD MBBS(Hons), FRACP, FRCPA, Kathryn Jackson, MBBS FRACP, FRCPA, Nicholas Viiala, MBBS, FRACP, FRCPA, Robert Weinkove, MA, MBBS, PhD, FRCPath, FRACP, Agnes S. M. Yong, MD, PhD, Deborah L White, PhD, Susan Branford, PhD, Timothy P. Hughes, MD, MBBS, FRACP, FRCPA, On Behalf of the ALLG
Journal: Blood
Blood (2018) 132 (Supplement 1): 459.
https://doi.org/10.1182/blood-2018-99-110569
Published: 2018
Journal Articles

Integration of Multiple Bioassays Using Machine Learning to Identify High-Risk CP-CML Patients Treated with Frontline Imatinib

Chung Hoow Kok, PhD BSc, Sakrapee Paisitkriangkrai, PhD, David T Yeung, PhD BSc, FRACP, FRCPA MBBS, Liu Liu, PhD BSc, Verity A Saunders, Phuong Dang, Agnes S. M. Yong, MD PhD, Deborah L White, PhD, Timothy P. Hughes, MD MBBS, FRACP, FRCPA
Journal: Blood
Blood (2018) 132 (Supplement 1): 1728.
https://doi.org/10.1182/blood-2018-99-117633
Published: 2018
Journal Articles

The e13a2 BCR-ABL1 Transcript Is Associated with Higher Rates of Molecular Recurrence after Treatment-Free Remission Attempts: Retrospective Analysis of the Adelaide Cohort

Naranie Shanmuganathan, MBBS, Susan Branford, PhD, Agnes S. M. Yong, MDPhD, Devendra K Hiwase, MBBS, MD FRACP, FRCPA, PhD, David T Yeung, PhDBSc,FRACP,FRCPA,MBBS, David M Ross, Timothy P. Hughes, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1731.
https://doi.org/10.1182/blood-2018-99-111083
Published: 2018