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Michael J. Mauro
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Journal Articles

Phase I Study of Ruxolitinib in Combination with Abemaciclib for Patients with Primary or Post-Polycythemia Vera/Essential Thrombocythemia Myelofibrosis

Jan Philipp Bewersdorf, Andriy Derkach, Amer M. Zeidan, Eytan M. Stein, Michael J. Mauro, Nikolai A. Podoltsev, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 6659.
https://doi.org/10.1182/blood-2024-194918
Published: 2024
Journal Articles

First Results of Asciminib As Initial Therapy with Addition of Lower Dose Tyrosine Kinase Inhibitors for Patients with Chronic Myeloid Leukemia Who Do Not Achieve a Deep Molecular Remission (ALERT CML) from the H Jean Khoury Cure CML Consortium (HJKC3)

Jorge E. Cortes, Michael J. Mauro, Alexis Visotcky, Srinivas K Tantravahi, James E Thompson, Jay Yang, Arielle Baim, Yan Gao, Sonia Maldonado-Schmidt, Claire Olig, Kathryn E. Flynn, Jerald P. Radich, Ehab L. Atallah
Journal: Blood
Blood (2024) 144 (Supplement 1): 6601.
https://doi.org/10.1182/blood-2024-207884
Published: 2024
Journal Articles

Increased Inflammatory Cytokines in Plasma Are Associated with Sustained Treatment-Free Remission in Chronic Myeloid Leukaemia

Chung Hoow Kok, Verity A Saunders, Naranie Shanmuganathan, Liu Liu, Yazad Daruis Irani, Jade Clarson, Phuong Dang, David T Yeung, Agnes S. M. Yong, Susan Branford, Javier Pinilla-Ibarz, Richard A. Larson, Jorge E. Cortes, Michael J. Mauro, James E Thompson, Neil P. Shah, Martha Wadleigh, Ehab L. Atallah, Jerald P. Radich, Timothy P Hughes, David M Ross
Journal: Blood
Blood (2024) 144 (Supplement 1): 993.
https://doi.org/10.1182/blood-2024-201881
Published: 2024
Journal Articles

Asciminib Provides Long-Term, Durable Molecular Responses in Patients with T315I-Mutated CML-CP: Final Analysis from a Phase 1 Trial

Jorge E. Cortes, Delphine Rea, Michael J. Mauro, Andreas Hochhaus, Dong-Wook Kim, Koji Sasaki, Fabian Lang, Michael C. Heinrich, Massimo Breccia, Michael W. Deininger, Yeow Tee Goh, Jeroen J.W.M. Janssen, Moshe Talpaz, Valle Gomez G De Soria, Philipp le Coutre, Francois-Xavier Mahon, Daniel Deangelo, Shruti Kapoor, Gessami Sanchez-Olle, Meng Cao, Nithya Agrawal, Timothy P Hughes
Journal: Blood
Blood (2024) 144 (Supplement 1): 1765.
https://doi.org/10.1182/blood-2024-209537
Published: 2024
Journal Articles

Efficacy and Safety of Asciminib in Chronic Myeloid Leukemia in Chronic Phase (CML-CP): Interim Results from the Phase 2 ASC2ESCALATE Trial in the Cohort of Patients (Pts) after 1 Prior Tyrosine Kinase Inhibitor (TKI)

Ehab L. Atallah, Moshe Y. Levy, Paul B. Koller, Koji Sasaki, Srinivas K Tantravahi, David Andorsky, Celesteann T Bremer, Joshua F Zeidner, Marlise R. Luskin, Reinhold Munker, Daisy Yang, Dramane Laine, John Sabo, Ennan Gu, Michael J. Mauro, Jorge E. Cortes
Journal: Blood
Blood (2024) 144 (Supplement 1): 479.
https://doi.org/10.1182/blood-2024-200717
Published: 2024
Journal Articles

Cardinal: A Phase I, Multicenter, Open-Label, Dose-Escalation and Dose-Optimization Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Tern-701 in Chronic Myeloid Leukemia

Elias Jabbour, Delphine Rea, Jorge E. Cortes, Andreas Hochhaus, Timothy P Hughes, Dong-Wook Kim, Hagop M. Kantarjian, Leanne Holes, Emil T. Kuriakose, Michael J. Mauro
Journal: Blood
Blood (2024) 144 (Supplement 1): 6594.
https://doi.org/10.1182/blood-2024-204153
Published: 2024
Journal Articles

Novel Nilotinib Tablet Formulation: Pharmacokinetic Characterization and Effects of Food

Michael J. Mauro, Jerald P. Radich, Paras Jain, David Sequeira, Dan Douer
Journal: Blood
Blood (2024) 144 (Supplement 1): 5799.
https://doi.org/10.1182/blood-2024-194406
Published: 2024
Journal Articles

5-Year Follow-up of the Phase 2 Optic Study in Patients with Chronic-Phase Chronic Myeloid Leukemia: Efficacy, Safety, and First End-of-Treatment Mutational Results

Jorge E. Cortes, Michael W. Deininger, Jane Apperley, Chrisopher Kevin Arthur, Charles Chuah, Andreas Hochhaus, Hugues de Lavallade, Jeffrey H. Lipton, Elza Lomaia, James McCloskey, Michael J. Mauro, Beatriz Moiraghi, Carolina Pavlovsky, Gianantonio Rosti, Philippe Rousselot, Maria Undurraga, Lin Yang, Alexander Vorog, Tammie Yeh, L. Evan Reddick, Niti Patel, Hagop M. Kantarjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 3148.
https://doi.org/10.1182/blood-2024-207634
Published: 2024
Journal Articles

U.S. Expert Consensus on Defining Intolerance to Tyrosine Kinase Inhibitor Treatment in Chronic Phase Chronic Myeloid Leukemia (CML)

Ehab L. Atallah, Michael S. Broder, Onyee Chan, Hannah Dalglish, Kathryn E. Flynn, Jeffrey Gilreath, Marisa Hine, Anthony M. Hunter, Michael J. Mauro, Javier Pinilla-Ibarz, Lindsay A.M. Rein, Neil P. Shah, Evan Stemper, Srinivas K Tantravahi, Jay Yang
Journal: Blood
Blood (2024) 144 (Supplement 1): 5052.
https://doi.org/10.1182/blood-2024-194617
Published: 2024
Journal Articles

A phase 3, open-label, randomized study of asciminib, a STAMP inhibitor, vs bosutinib in CML after 2 or more prior TKIs

Clinical Trials & Observations
Delphine Réa, Michael J. Mauro, Carla Boquimpani, Yosuke Minami, Elza Lomaia, Sergey Voloshin, Anna Turkina, Dong-Wook Kim, Jane F. Apperley, Andre Abdo, Laura Maria Fogliatto, Dennis Dong Hwan Kim, Philipp le Coutre, Susanne Saussele, Mario Annunziata, Timothy P. Hughes, Naeem Chaudhri, Koji Sasaki, Lynette Chee, Valentin García-Gutiérrez, Jorge E. Cortes, Paola Aimone, Alex Allepuz, Sara Quenet, Véronique Bédoucha, Andreas Hochhaus
Journal: Blood
Blood (2021) 138 (21): 2031–2041.
https://doi.org/10.1182/blood.2020009984
Published: 2021
Includes: Supplemental data
Journal Articles

Second Treatment Free Remission after Combination Therapy with Ruxolitinib Plus Tyrosine Kinase Inhibitors in Chronic Phase Chronic Myeloid Leukemia (CML)

Kendra Sweet, Ehab L. Atallah, Jerry P. Radich, Mei-Jie Zhang, Eva Sahakian, Melanie Mediavilla-Varela, Alexis Vistocky, Michael C. Heinrich, James E. Thompson, Michael J. Mauro, Kathryn E Flynn, Arielle Baim, Javier Pinilla Ibarz
Journal: Blood
Blood (2021) 138 (Supplement 1): 2555.
https://doi.org/10.1182/blood-2021-147954
Published: 2021
Journal Articles

Dose Modification Dynamics of Ponatinib in Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) from the PACE and Optic Trials

Elias J. Jabbour, Michael W. Deininger, Elisabetta Abruzzese, Jane F Apperley, Jorge E. Cortes, Charles Chuah, Daniel J. DeAngelo, John F. DiPersio, Andreas Hochhaus, Jeffrey H. Lipton, Franck E. Nicolini, Javier Pinilla Ibarz, Delphine Rea, Gianantonio Rosti, Philippe Rousselot, Michael J. Mauro, Neil P Shah, Moshe Talpaz, Alexander Vorog, Vickie Lu, Hagop Kantarjian
Journal: Blood
Blood (2021) 138 (Supplement 1): 2550.
https://doi.org/10.1182/blood-2021-146175
Published: 2021
Journal Articles

Post Hoc Analysis of Responses to Ponatinib in Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) By Baseline BCR-ABL1 Level and Baseline Mutation Status in the Optic Trial

Michael W. Deininger, Jane F Apperley, Christopher Kevin Arthur, Charles Chuah, Andreas Hochhaus, Hugues De Lavallade, Jeffrey H. Lipton, Elza Lomaia, James K McCloskey, Lori J. Maness, Michael J. Mauro, Beatriz Moiraghi, Carolina Pavlovsky, Gianantonio Rosti, Philippe Rousselot, Soledad S. Undurraga, Vickie Lu, Alexander Vorog, Jorge E. Cortes
Journal: Blood
Blood (2021) 138 (Supplement 1): 307.
https://doi.org/10.1182/blood-2021-145995
Published: 2021
Journal Articles

Trial in Progress: Asciminib in Monotherapy 4 CML (AIM4CML), a Phase IIIb Study of Asciminib Monotherapy in Patients with Chronic Myeloid Leukemia in Chronic Phase without or with T315I Mutations

David Andorsky, Sarah Tomassetti, Yehuda E. Deutsch, E Randolph Broun, Ghayas C. Issa, Moshe Y. Levy, Michael W. Deininger, Rodrigo Maegawa, Alok Shrestha, Michael J. Mauro
Journal: Blood
Blood (2021) 138 (Supplement 1): 3599.
https://doi.org/10.1182/blood-2021-147337
Published: 2021
Journal Articles

COVID-19 in Patients with Chronic Myeloid Leukemia: Poor Outcomes for Patients with Comorbidities, Older Age, Advanced Phase Disease, and Those from Low-Income Countries: An Update of the Candid Study

Katia B Pagnano, Chung Hoow Kok, Michael J. Mauro, Jorge E. Cortes, Nicola Evans, Qian Jiang, Dragana Milojkovic, Beatriz Moiraghi, Franck E. Nicolini, Matilda Ongondi, Daniela Zackova, Delphine Rea, Timothy P. Hughes
Journal: Blood
Blood (2021) 138 (Supplement 1): 634.
https://doi.org/10.1182/blood-2021-150026
Published: 2021
Journal Articles

An Update of Safety and Efficacy Results from Phase 1 Dose-Escalation and Expansion Study of Vodobatinib, a Novel Oral BCR-ABL1 Tyrosine Kinase Inhibitor (TKI), in Patients with Chronic Myeloid Leukemia (CML) and Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Failing Prior TKI Therapies

Jorge E. Cortes, Tapan Saikia, Dong-Wook Kim, Yesid Alvarado, Franck E. Nicolini, Krishnakumar Rathnam, Navin Khattry, Jane F Apperley, Michael W. Deininger, Hugues de Lavallade, Aude Charbonnier, Nikki Granacher, Carlo Gambacorti-Passerini, Alessandro Lucchesi, Michael J. Mauro, Peter Vandenberghe, Gregor Verhoef, Andrew R. Whiteley, Arijit Nag, Vivek S Radhakrishnan, Shashikant Apte, Siu-Long Yao, Sandeep Inamdar, Jayasree Sreenivasan, Ruchika Irene Dillu, Geetanjali Chimote
Journal: Blood
Blood (2021) 138 (Supplement 1): 309.
https://doi.org/10.1182/blood-2021-152548
Published: 2021
Journal Articles

Efficacy and Safety Results from Ascembl, a Multicenter, Open-Label, Phase 3 Study of Asciminib, a First-in-Class STAMP Inhibitor, Vs Bosutinib in Patients with Chronic Myeloid Leukemia in Chronic Phase after ≥2 Prior Tyrosine Kinase Inhibitors: Update after 48 Weeks

Michael J. Mauro, Yosuke Minami, Delphine Rea, Andreas Hochhaus, Elza Lomaia, Sergey Voloshin, Anna G. Turkina, Dong-Wook Kim, Jane F Apperley, Jorge E. Cortes, Andre N.R. Abdo, Laura Fogliatto, Dennis Dong Hwan Kim, Philipp D le Coutre, Susanne Saussele, Mario Annunziata, Timothy P. Hughes, Naeem A. Chaudhri, Lynette C.Y. Chee, Valentín Garcia Gutierrez, Koji Sasaki, Shruti Kapoor, Alex Allepuz, Sarah Quenet, Véronique Bédoucha, Carla Boquimpani
Journal: Blood
Blood (2021) 138 (Supplement 1): 310.
https://doi.org/10.1182/blood-2021-152561
Published: 2021
Journal Articles

Efficacy and Safety Results from ASCEMBL, a Multicenter, Open-Label, Phase 3 Study of Asciminib, a First-in-Class STAMP Inhibitor, vs Bosutinib (BOS) in Patients (Pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Previously Treated with ≥2 Tyrosine Kinase Inhibitors (TKIs

Andreas Hochhaus, MD, Carla Boquimpani, MD, Delphine Rea, MDPhD, Yosuke Minami, MDPhD, Elza Lomaia, MD PhD, Sergey Voloshin, MD PhD, Anna G. Turkina, Prof., MD, Dong-Wook Kim, MD, Jane Apperley, FRCP, FRCPath, MB, Jorge E. Cortes, MD, Andre Abdo, MD, Laura Maria Fogliatto, MD PhD, Dennis Dong Hwan Kim, MD PhD, Philipp D le Coutre, MD, Susanne Saussele, MD, Mario Annunziata, MD, Timothy P. Hughes, MDMBBS,FRACP,FRCPA, Naeem A. Chaudhri, MD, Lynette C.Y. Chee, MBBS,PhDFRACP,FRCPA, Valentín García Gutiérrez, MD PhD, Koji Sasaki, MD, Paola Aimone, MD, Alex Allepuz, MD MPH, Sarah Quenet, Véronique Bédoucha, Michael J. Mauro, MD
Journal: Blood
Blood (2020) 136 (Supplement_2): LBA-4.
https://doi.org/10.1182/blood-2020-143816
Published: 2020
Journal Articles

Cardiovascular and Metabolic Risk in Patients with Chronic Myeloid Leukemia in Chronic Phase Receiving First-Line BCR-ABL1 Tyrosine Kinase Inhibitors in the United States: Baseline and Six-Month Follow-up Results from a Prospective Real-World Observational Study

Michael J. Mauro, MD, Vivian G. Oehler, MD, James E. Thompson, MD, James K. McCloskey, MD, Michael C. Heinrich, MD, Shaker R. Dakhil, MD, Irene DeGutis, PharmD, David Tabano, PhD, Wasiulla Khan, PhD, Javid J. Moslehi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-137613
Published: 2020
Journal Articles

Impact of COVID19 Pandemic on an International MPN Patient Population: Survey Results from 1560 MPN Patients

Jeanne M. Palmer, MD, Carolyn Mead-Harvey, MS, Claire Harrison, DM, FRCP, FRCPath, Amylou C. Dueck, PhD, Ryan Eckert, MS, Heidi E. Kosiorek, MS, Pablo Muxi, MD, Naveen Pemmaraju, MD, Guillermo Ruiz Arguelles, Alessandro M. Vannucchi, MD, Vikas Gupta, MD FRCP, FRCPath, John Mascarenhas, MD, Kerry Taylor, MBBS(Hons) FRACP FRCPA, Krisstina L. Gowin, DO, Holly L. Geyer, MD, Kazuya Shimoda, MD PhD, Jean-Jacques Kiladjian, MD PhD, Norio Komatsu, MD PhD, Grace Kam Li Shan, MBBS, Virginia Abello, MD, David Gomez-Almaguer, MD, Robyn M. Scherber, MD, Qian Jiang, MD, Xuelan Zuo, Jennifer Huberty, PhD, Lesley Anderson, MD, Blake T. Langlais, MS, Ann Brazeau, Michelle Woehrle, Michael J. Mauro, MD, Ruben Mesa, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–3.
https://doi.org/10.1182/blood-2020-138953
Published: 2020