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Journal Articles

Results of the Molecular Response Evaluation and TKI Dose Adjustment in Chronic Myeloid Leukemia Patients in Prospective Study of Reduction and Discontinuation Treatment of TKI (READIT)

Oleg Shukhov, Margarita Gurianova, Ekaterina Chelysheva, Anna Petrova, Anastasiya Bykova, Irina Nemchenko, Andrey Sudarikov, Elena Kuzmina, Lyubov Gavrilova, Alina Kokhno, Anna Turkina
Journal: Blood
Blood (2024) 144 (Supplement 1): 4539.
https://doi.org/10.1182/blood-2024-199962
Published: 2024
Journal Articles

Olverembatinib (HQP1351) Overcomes Resistance/Intolerance to Asciminib and Ponatinib in Patients (pts) with Heavily Pretreated Chronic-Phase Chronic Myeloid Leukemia (CP-CML): A 1.5-Year Follow-up Update with Comprehensive Exposure-Response (E-R) Analyses

Elias Jabbour, Omer Jamy, Paul B. Koller, Vivian G. Oehler, Maria R. Baer, Elza Lomaia, Anthony M. Hunter, Olga Uspenskaya, Svetlana Samarina, Jorge E. Cortes, Sudipto Mukherjee, Dennis Dong Hwan Kim, Vera Zherebtsova, Vasily Shuvaev, Anna Turkina, Igor Davydkin, Huanshan Guo, Zi Chen, Hengbang Wang, Tommy Fu, Lixin Jiang, Zhihong Yang, Cunlin Wang, Dajun Yang, Yifan Zhai, Hagop Kantarjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 3151.
https://doi.org/10.1182/blood-2024-207139
Published: 2024
Journal Articles

Asciminib (ASC) Add-on to Imatinib (IMA) Demonstrates Sustained High Rates of Ongoing Therapy and Deep Molecular Responses (DMRs) with Prolonged Follow-up in the ASC4MORE Study

Timothy P Hughes, Giuseppe Saglio, Jan Geissler, Dong-Wook Kim, Elza Lomaia, Jiri Mayer, Anna Turkina, Shruti Kapoor, Ana Paula Torres Cardoso, Jomy Jose, Monali Sura, Jorge Cortes
Journal: Blood
Blood (2023) 142 (Supplement 1): 866.
https://doi.org/10.1182/blood-2023-182100
Published: 2023
Journal Articles

Long-Term Results from the Optic Trial: A Dose-Optimization Study of 3 Starting Doses of Ponatinib

Jorge Cortes, Michael Deininger, Elza Lomaia, Beatriz Moiraghi, Soledad Undurraga, Carolina Pavlovsky, Charles Chuah, Tomasz Sacha, Jeffrey H. Lipton, James McCloskey, Andreas Hochhaus, Philippe Rousselot, Gianantonio Rosti, Hugues de Lavallade, Anna Turkina, Lori Maness, Moshe Talpaz, Michael Mauro, Vickie Lu, Alexander Vorog, Jane F Apperley
Journal: Blood
Blood (2023) 142 (Supplement 1): 3164.
https://doi.org/10.1182/blood-2023-178790
Published: 2023
Journal Articles

The Updated Results of Asciminib Managed-Access Program (MAP) in Patients with Chronic Myeloid Leukemia in Russia

Elena Kuzmina, Ekaterina Chelysheva, Elza Lomaia, Elena V Morozova, Oleg Shukhov, Anna Petrova, Tamara Chitanava, Julia Vlasova, Evgenia Sbitiakova, Natalia Lazorko, Irina Nemchenko, Anastasiya Vitalievna Bykova, Margarita Gurianova, Alina Kokhno, Anna Turkina
Journal: Blood
Blood (2023) 142 (Supplement 1): 1803.
https://doi.org/10.1182/blood-2023-181789
Published: 2023
Journal Articles

Sustained Efficacy and Safety with Asciminib (ASC) after Almost 4 Years of Median Follow-up from Ascembl, a Phase 3 Study of ASC Vs Bosutinib (BOS) in Patients (Pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) after ≥2 Prior Tyrosine Kinase Inhibitors (TKIs): An End of Study Treatment (EOS Tx) Update, Including Results from Switch Population

Michael Mauro, Yosuke Minami, Andreas Hochhaus, Elza Lomaia, Sergei Voloshin, Anna Turkina, Dong-Wook Kim, Jane F Apperley, Jorge Cortes, Andre N.R. Abdo, Laura Maria Fogliatto, Dennis Dong Hwan Kim, Philipp le Coutre, Susanne Saussele, Mario Annunziata, Timothy P Hughes, Naeem A. Chaudhri, Lynette C.Y. Chee, Valentín García Gutiérrez, Koji Sasaki, Carla Maria Boquimpani De Moura Freitas, Shruti Kapoor, Noemi Espurz, Vishal Dhamal, Delphine Rea
Journal: Blood
Blood (2023) 142 (Supplement 1): 4536.
https://doi.org/10.1182/blood-2023-186854
Published: 2023
Journal Articles

Update of Olverembatinib (HQP1351) Overcoming Ponatinib and/or Asciminib Resistance in Patients (Pts) with Heavily Pretreated/Refractory Chronic Myeloid Leukemia (CML) and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph + ALL)

Elias Jabbour, Hagop M. Kantarjian, Paul B. Koller, Omer Jamy, Vivian G. Oehler, Elza Lomaia, Anthony M. Hunter, Olga Uspenskaya, Svetlana Samarina, Sudipto Mukherjee, Maria R. Baer, Vera Zherebtsova, Vasily Shuvaev, Anna Turkina, Igor Davydkin, Jorge Cortes, Huanshan Guo, Zi Chen, Lei Fu, Hengbang Wang, Lixin Jiang, Cunlin Wang, Dajun Yang, Yifan Zhai
Journal: Blood
Blood (2023) 142 (Supplement 1): 1798.
https://doi.org/10.1182/blood-2023-187744
Published: 2023
Journal Articles

Two-Year Updated Results of Asciminib Managed-Access Program (MAP) in Russia

Anna Turkina, Elena A. Kuzmina, Elza Lomaia, Elena Morozova, Oleg A. Shukhov, Anna N. Petrova, Tamara Chitanava, Julia J. Vlasova, Ekaterina Yu. Chelysheva, Evgeniya Sbityakova, Irina S. Nemchenko, Anastasiya V. Bykova, Margarita A. Gurianova, Alina V. Kokhno, Elena N. Parovichnikova
Journal: Blood
Blood (2022) 140 (Supplement 1): 9654–9655.
https://doi.org/10.1182/blood-2022-162268
Published: 2022
Journal Articles

Molecular Response of ≤10% BCR::ABL1 IS Is Predictive of Positive Outcomes in Treatment-Resistant Patients with Chronic Phase Chronic Myeloid Leukemia (CP-CML) Treated with Ponatinib from the Phase 2 Optic Trial

Jane F. Apperley, Jorge E. Cortes, Elias Jabbour, Andreas Hochhaus, Timothy Hughes, Charles Chuah, Hugues de Lavallade, Michael W. Deininger, Jeffrey H. Lipton, Elza Lomaia, Lori Maness, Michael Mauro, James McCloskey, Beatriz Moiraghi, Carolina Pavlovsky, Christine Rojas, Philippe Rousselot, Tomasz Sacha, Moshe Talpaz, Anna Turkina, Maria Undurraga Sutton, Xiaowei Ren, Alexander Vorog, Gianantonio Rosti
Journal: Blood
Blood (2022) 140 (Supplement 1): 6760–6762.
https://doi.org/10.1182/blood-2022-157956
Published: 2022
Journal Articles

Chronic Myeloid Leukemia Diagnosed during Pregnancy: How to Manage? Description of 86 Cases from ELN International Registry

Ekaterina Yu. Chelysheva, Anna Turkina, Jane F. Apperley, Mohamed A Yassin, Delphine Rea, Franck E. Nicolini, Daniela Barraco, Konstantin Kotlyarchuk, Khamida Kazakbaeva, Sukhrob Saliev, Adi Shacham, Dong-Wook Kim, Salam Al-Kindi, Penka Ganeva, Roman Shmakov, Jennifer Byrne, Harry Robertson, Cerrano Marco, Evgenia Polushkina, Malgorzata Monika Trawinska, Elisabetta Abruzzese
Journal: Blood
Blood (2022) 140 (Supplement 1): 1498–1500.
https://doi.org/10.1182/blood-2022-159993
Published: 2022
Journal Articles

Three-Year Update from the Optic Trial: A Dose-Optimization Study of 3 Starting Doses of Ponatinib

Jorge E. Cortes, Michael W. Deininger, Elza Lomaia, Beatriz Moiraghi, Maria Undurraga Sutton, Carolina Pavlovsky, Charles Chuah, Tomasz Sacha, Jeffrey H. Lipton, James McCloskey, Andreas Hochhaus, Philippe Rousselot, Gianantonio Rosti, Hugues de Lavallade, Christine Rojas, Anna Turkina, Lori Maness, Moshe Talpaz, Michael Mauro, Vickie Lu, Alexander Vorog, Jane F. Apperley
Journal: Blood
Blood (2022) 140 (Supplement 1): 1495–1497.
https://doi.org/10.1182/blood-2022-157822
Published: 2022
Journal Articles

ASC4OPT: A Phase 3b Open-Label Optimization Study of Oral Asciminib in Chronic Myelogenous Leukemia in Chronic Phase Previously Treated with 2 or More Tyrosine Kinase Inhibitors

Massimo Breccia, Anna Turkina, Carla Boquimpani, Charles Chuah, Giora Sharf, Luigi Di Caprio, Matthias Hoch, Justin Yssel, Yifan Zhang, Andreas Hochhaus
Journal: Blood
Blood (2022) 140 (Supplement 1): 9635–9636.
https://doi.org/10.1182/blood-2022-157991
Published: 2022
Journal Articles

A phase 3, open-label, randomized study of asciminib, a STAMP inhibitor, vs bosutinib in CML after 2 or more prior TKIs

Clinical Trials & Observations
Delphine Réa, Michael J. Mauro, Carla Boquimpani, Yosuke Minami, Elza Lomaia, Sergey Voloshin, Anna Turkina, Dong-Wook Kim, Jane F. Apperley, Andre Abdo, Laura Maria Fogliatto, Dennis Dong Hwan Kim, Philipp le Coutre, Susanne Saussele, Mario Annunziata, Timothy P. Hughes, Naeem Chaudhri, Koji Sasaki, Lynette Chee, Valentin García-Gutiérrez, Jorge E. Cortes, Paola Aimone, Alex Allepuz, Sara Quenet, Véronique Bédoucha, Andreas Hochhaus
Journal: Blood
Blood (2021) 138 (21): 2031–2041.
https://doi.org/10.1182/blood.2020009984
Published: 2021
Includes: Supplemental data
Journal Articles

Ponatinib dose-ranging study in chronic-phase chronic myeloid leukemia: a randomized, open-label phase 2 clinical trial

Clinical Trials & Observations
Jorge Cortes, Jane Apperley, Elza Lomaia, Beatriz Moiraghi, Maria Undurraga Sutton, Carolina Pavlovsky, Charles Chuah, Tomasz Sacha, Jeffrey H. Lipton, Charles A. Schiffer, James McCloskey, Andreas Hochhaus, Philippe Rousselot, Gianantonio Rosti, Hugues de Lavallade, Anna Turkina, Christine Rojas, Christopher Kevin Arthur, Lori Maness, Moshe Talpaz, Michael Mauro, Tracey Hall, Vickie Lu, Shouryadeep Srivastava, Michael Deininger
Journal: Blood
Blood (2021) 138 (21): 2042–2050.
https://doi.org/10.1182/blood.2021012082
Published: 2021
Includes: Supplemental data
Journal Articles

Treatment and Outcome Analysis of 2,904 Pateints from the EUTOS Population Based Registry

Verena Sophia Hoffmann, Dr., Michele Baccarani, Joerg Hasford, MD, Doris Lindoerfer, Sonja Burgstaller, MD, Dubravka Sertic, MD, Paul Costeas, Jiri Mayer, Karel Indrak, MD, Hele Everaus, MD PhD, Perttu Koskenvesa, Joelle Guilhot, PhD, Gabriele Schubert-Fritschle, Fausto Castagnetti, MDPhD, Francesco Di Raimondo, MDPhD, Sandra Lejniece, PhD MD, Laimonas Griskevicius, Noortje Thielen, MDPhD, Thomas Sacha, Andrzej Hellmann, MD PhD, Anna Turkina, Prof., MD, Andrey Zaritskey, MD, Andrija Bogdanovic, MD PhD MSc,, Zuzana Sninska, Irena Zupan, Felipe Casado, Bengt Simonsson, MD, Richard E. Clark, MD, Susanne Saussele, Andreas Hochhaus, MD, Ruediger Hehlmann, MD
Journal: Blood
Blood (2015) 126 (23): 2780.
https://doi.org/10.1182/blood.V126.23.2780.2780
Published: 2015
Journal Articles

The EUTOS Survival Score Is Preferable over the Sokal Score for Prognosis of Long-Term Survival of Patients with Chronic Myeloid Leukemia

Markus Pfirrmann, Joerg Hasford, MD, Susanne Saussele, Anna Turkina, Prof., MD, Witold Prejzner, MD, Juan Luis Steegmann, MD, Bengt Simonsson, MD, Andrey Zaritskey, MD, Adriana Colita, MD, Daniela Zackova, MD, Jeroen Janssen, MD, Francisco Cervantes, Karel Indrak, MD, Joelle Guilhot, PhD, Ruediger Hehlmann, MD, Michele Baccarani, MD
Journal: Blood
Blood (2015) 126 (23): 595.
https://doi.org/10.1182/blood.V126.23.595.595
Published: 2015
Journal Articles

Pharmacoeconomical Analysis of Chronic Myelogenous Leukemia Treatment Free Remission

Vasily Shuvaev, MD, Kudrat Abdulkadyrov, MD PhD, Anna Turkina, Prof., MD, Irina Martynkevich, MD PhD, Ekaterina Chelysheva, MD PhD, Mikhail Fominykh, MD, Valentin Martchenko
Journal: Blood
Blood (2015) 126 (23): 3293.
https://doi.org/10.1182/blood.V126.23.3293.3293
Published: 2015
Journal Articles

The Rate of Individual BCR-ABL Decline As an Optimized Predictor of Tyrosine Kinase Inhibitors Treatment Outcome in Chronic Phase CML Patients, Comparison with CML Prognostic Scores and Early Molecular Response Achievement

Mikhail Fominykh, MD, Vasily Shuvaev, MD, Irina Martynkevich, MD PhD, Grigory Tsaur, MDPhD, Natalya Bederak, Ekaterina Chelysheva, Oleg Shukhov, MD, Adhamjon Abdullaev, MD PhD, Vera Udaleva, MD, Regina Golovchenko, MD, Irina Zotova, Dzhariyat Shikhbabaeva, Lyubov Polushkina, Ekaterina Petrova, Marina Ivanova, Lyudmila Martynenko, Elizaveta Kleina, Natalya Cybakova, Anna Turkina, Prof., MD, Kudrat Abdulkadyrov, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5150.
https://doi.org/10.1182/blood.V126.23.5150.5150
Published: 2015
Journal Articles

Russian Registry of Chronic Myeloid Leukemia Management in Routine Clinical Practice-Local Therapy and Monitoring

Anna Turkina, Prof., MD, Anatoly Golenkov, MD, Lyudmila Napso, Irina Krylova, Tatiana Klitochenko, Olga Senderova
Journal: Blood
Blood (2015) 126 (23): 5156.
https://doi.org/10.1182/blood.V126.23.5156.5156
Published: 2015
Journal Articles

Introduction of a Treatment Approach for Chronic Myeloid Leukemia and Pregnancy Considering Leukemic Burden and Pregnancy Terms

Ekaterina Chelysheva, Anna Turkina, Prof., MD, Evgenia Polushkina, Roman G. Shmakov, MD
Journal: Blood
Blood (2015) 126 (23): 5144.
https://doi.org/10.1182/blood.V126.23.5144.5144
Published: 2015