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Matthias Hoch
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Journal Articles

Asciminib pediatric formulation shows a tolerable safety profile in pediatric patients with chronic myeloid leukemia in chronic phase (CML-CP): Second interim analysis from the ASC4KIDS study

Free
Jessica Pollard, Hiroyuki Shimada, Shruti Kapoor, Matthias Hoch, Vishal Dhamal, Nithya Agrawal, Christine Rosko, Ana Paula Cardoso, Masakatsu Yanagimachi, Ho Joon Im, Markus Metzler, Nobuko Hijiya
Journal: Blood
Blood (2025) 146 (Supplement 1): 7312.
https://doi.org/10.1182/blood-2025-7312
Published: 2025
Journal Articles

High rates of deep molecular response (DMR) in patients (pts) with chronic myeloid leukemia in chronic Phase (CML-CP) who have not achieved dmr after ≥1 year of prior imatinib (IMA) in the asciminib (ASC) monotherapy arm of the Phase 2 ASC4MORE study

Free
Jorge Cortes, Giuseppe Saglio, Jan Geissler, Jiri Mayer, Gabriel Etienne, Michael Fillitz, Elvira Mora Casterá, Shruti Kapoor, Ana Paula Cardoso, Ugo Okoroji, Amila Sarac, Matthias Hoch, Sara Quenet, Timothy Hughes
Journal: Blood
Blood (2025) 146 (Supplement 1): 5552.
https://doi.org/10.1182/blood-2025-5552
Published: 2025
Journal Articles

Asciminib (ASC) in Combination with Imatinib (IMA), Nilotinib (NIL), or Dasatinib (DAS) May be a Potential Treatment (Tx) Option in Patients (Pts) with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase or Accelerated Phase (Ph+ CML-CP/AP): Final Results from the Asciminib Phase 1 Study

Free
Jorge Cortes, Fabian Lang, Delphine Rea, Andreas Hochhaus, Massimo Breccia, Yeow Tee Goh, Michael C. Heinrich, Timothy P Hughes, Jeroen J.W.M. Janssen, Philipp le Coutre, Hironobu Minami, Koji Sasaki, Daniel J. DeAngelo, Gessami Sanchez-Olle, Nathalie Pognan, Jomy Jose, Matthias Hoch, Michael Mauro
Journal: Blood
Blood (2023) 142 (Supplement 1): 868.
https://doi.org/10.1182/blood-2023-189270
Published: 2023
Journal Articles

ASC4KIDS: A Multicenter, Open-Label, Phase Ib/II Study to Determine the Dose and Safety of Asciminib in Pediatric Patients with Chronic Myeloid Leukemia in the Chronic Phase

Free
Nobuko Hijiya, Shruti Kapoor, Matthias Hoch, Laurence Descamps, Vishal Dhamal, Ana Paula Torres Cardoso
Journal: Blood
Blood (2023) 142 (Supplement 1): 6387.
https://doi.org/10.1182/blood-2023-185535
Published: 2023
Journal Articles

ASC4KIDS: A Multicenter, Open-Label, Phase Ib/II Study to Determine the Dose and Safety of Asciminib in Pediatric Patients with Chronic Myeloid Leukemia in Chronic Phase

Free
Nobuko Hijiya, Shruti Kapoor, Matthias Hoch, Laurence Descamps, Kohinoor Dasgupta, Nicholas Ramscar
Journal: Blood
Blood (2022) 140 (Supplement 1): 12204–12205.
https://doi.org/10.1182/blood-2022-162451
Published: 2022
Journal Articles

ASC4OPT: A Phase 3b Open-Label Optimization Study of Oral Asciminib in Chronic Myelogenous Leukemia in Chronic Phase Previously Treated with 2 or More Tyrosine Kinase Inhibitors

Free
Massimo Breccia, Anna Turkina, Carla Boquimpani, Charles Chuah, Giora Sharf, Luigi Di Caprio, Matthias Hoch, Justin Yssel, Yifan Zhang, Andreas Hochhaus
Journal: Blood
Blood (2022) 140 (Supplement 1): 9635–9636.
https://doi.org/10.1182/blood-2022-157991
Published: 2022
Journal Articles

Population Pharmacokinetics in Hepatic and Renal Impairment and PBPK Drug-Drug Interaction Simulations of Asciminib, a Novel Tyrosine Kinase Inhibitor in Chronic Myeloid Leukemia in Chronic Phase

Free
Matthias Hoch, Felix Huth, Ioannis Loisios Konstantinidis, Huijuan Xu, Yu-Yun Ho, Francois Pierre Combes, Florence Hourcade-Potelleret, Heidi J Einolf
Journal: Blood
Blood (2022) 140 (Supplement 1): 6771–6773.
https://doi.org/10.1182/blood-2022-163167
Published: 2022
Journal Articles

Justification for Asciminib Dosing in Patients with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia (Ph+ CML-CP) with and without the T315I Mutation

Free
Francois Pierre Combes, Ying Fei Li, Sherwin K.B. Sy, Sebastien Lorenzo, Kohinoor Dasgupta, Shruti Kapoor, Matthias Hoch, Yu-Yun Ho
Journal: Blood
Blood (2022) 140 (Supplement 1): 6791–6792.
https://doi.org/10.1182/blood-2022-163078
Published: 2022