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Carolina Pavlovsky
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Journal Articles

5-Year Follow-up of the Phase 2 Optic Study in Patients with Chronic-Phase Chronic Myeloid Leukemia: Efficacy, Safety, and First End-of-Treatment Mutational Results

Jorge E. Cortes, Michael W. Deininger, Jane Apperley, Chrisopher Kevin Arthur, Charles Chuah, Andreas Hochhaus, Hugues de Lavallade, Jeffrey H. Lipton, Elza Lomaia, James McCloskey, Michael J. Mauro, Beatriz Moiraghi, Carolina Pavlovsky, Gianantonio Rosti, Philippe Rousselot, Maria Undurraga, Lin Yang, Alexander Vorog, Tammie Yeh, L. Evan Reddick, Niti Patel, Hagop M. Kantarjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 3148.
https://doi.org/10.1182/blood-2024-207634
Published: 2024
Journal Articles

Asciminib Shows High Efficacy and Favorable Tolerability at 80 Mg Once Daily and 40 Mg Twice Daily in Patients with Chronic Phase Chronic Myelogenous Leukemia Previously Treated with 2 or More Tyrosine Kinase Inhibitors: Primary Analysis from the ASC4OPT Study

Andreas Hochhaus, Philipp le Coutre, Dragana Milojkovic, Dennis Dong Hwan Kim, Soo Min Lim, Carolina Pavlovsky, Thanh HA Nguyen, Franck E. Nicolini, Beatriz Moiraghi, Sebastian Grosicki, Chi Dung Phu, Gabriel Etienne, Fernando Marco De Lucas, Rosa Ayala, Massimo Breccia, Charles Chuah, Giora Sharf, Roberto Abi Rached, Himanshu Pokhriyal, Santoshkumar Tota, Asmae Mirkou, Peter Schuld, Carla Boquimpani
Journal: Blood
Blood (2024) 144 (Supplement 1): 4526.
https://doi.org/10.1182/blood-2024-200017
Published: 2024
Journal Articles

Assessing Molecular Relapse-Free Survival in Latin American Chronic Myeloid Leukemia Patients Undergoing TKI Dose Reduction

Melina Gisel Luft, Ricardo Khalil Tannuri, María Jose Mela Osorio, Maria Elisa Riva, Beatriz Moiraghi, Ana Ines Varela, Ana Inés Prado, Veronica Ventriglia, Maria Josefina Freitas, Olivia Maria Gelo, Federico Sackmann Massa, Maria Fernanda Tosin, Mariel Ana Perez, Mariana Stevenazzi, Victoria Matosas, Carolina Barreto, Miguel Arturo Pavlovsky, Isolda Isabel Fernandez, Carolina Pavlovsky
Journal: Blood
Blood (2024) 144 (Supplement 1): 6620.
https://doi.org/10.1182/blood-2024-209195
Published: 2024
Journal Articles

Retrospective Study to Compare Treatment Outcomes of Asciminib Vs. Ponatinib in 99 Patients with T315I Mutated Chronic Myeloid Leukemia

Maria Agustina Perusini, Camille Kockerols, Daniela Žáčková, Franck E. Nicolini, Fausto Castagnetti, Carolina Pavlovsky, Massimo Breccia, Delphine Rea, Carmen Fava, Lynn Savoie, Christophe Bouvier, Petra Čičátková, Julien Bollard, Swe Linn, Gopila Gupta, Emilia Scalzulli, Tomoiku Takaku, Hiroshi Ureshino, Shinya Kimura, Sung-Eun Lee, Dragana Milojkovic, Andrew J Innes, Simone Claudiani, Valentín García Gutiérrez, Sr., Jiri Mayer, Peter E. Westerweel, Dennis Dong Hwan Kim
Journal: Blood
Blood (2024) 144 (Supplement 1): 3149.
https://doi.org/10.1182/blood-2024-205681
Published: 2024
Journal Articles

Functional Ex-Vivo Testing Combined with Machine Learning Predicts Clinical Response to Azacitidine+Venetoclax in AML

Diego Andino, Maria Laura Bernaschini, Agustina Conrrero, María Rita Drocchi, Sofia Carbajosa, Alejandra Garcia, Isolda Isabel Fernandez, María Jose Mela Osorio, Miguel Arturo Pavlovsky, Carolina Pavlovsky, Silvina Palmer, Nicolás Cazap, Jorge Solimano, Adriana Rinflerch, Erika Barbara Brulc, Paula González Hermida, Andrea Arruda, Mark D. Minden, Gimena Ferreira, Marisa Piaggio, Tarek Ali Zaki, Gerardo Gatti, Candelaria Llorens, Gastón Soria
Journal: Blood
Blood (2023) 142 (Supplement 1): 2274.
https://doi.org/10.1182/blood-2023-187284
Published: 2023
Journal Articles

Long-Term Results from the Optic Trial: A Dose-Optimization Study of 3 Starting Doses of Ponatinib

Jorge Cortes, Michael Deininger, Elza Lomaia, Beatriz Moiraghi, Soledad Undurraga, Carolina Pavlovsky, Charles Chuah, Tomasz Sacha, Jeffrey H. Lipton, James McCloskey, Andreas Hochhaus, Philippe Rousselot, Gianantonio Rosti, Hugues de Lavallade, Anna Turkina, Lori Maness, Moshe Talpaz, Michael Mauro, Vickie Lu, Alexander Vorog, Jane F Apperley
Journal: Blood
Blood (2023) 142 (Supplement 1): 3164.
https://doi.org/10.1182/blood-2023-178790
Published: 2023
Journal Articles

Long-Term Follow-up of the AST Trial of Treatment-Free Remission in Chronic Myeloid Leukemia Patients

Ricardo K Tannuri, Beatriz Moiraghi, Ana Varela, Michele Bianchini, Miguel Arturo Pavlovsky, Georgina Bendek Del Prete, Maria Rosario Custidiano, Maria Josefina Freitas, Veronica Ventriglia, Eduardo Bullorsky, Pedro Negri Aranguren, Isolda Isabel Fernandez, Federico Sackmann Massa, Ana Garcia Labanca, Romina Mariano, Maria Fernanda Tosin, Juan Carlos Dupont, Francisca Rojas, Carina Gumpel, Etelvina Macchiavelo, Mariano Paoletti, Isabel Giere, Mariana Juni, Bianca Vasconcelos, Maria Belen Sanchez, Julio Cesar Sanchez Avalos, María Jose Mela Osorio, Carolina Pavlovsky
Journal: Blood
Blood (2023) 142 (Supplement 1): 6365.
https://doi.org/10.1182/blood-2023-189393
Published: 2023
Journal Articles

Final Report: Somatic Mutations and HMGCLL1 Haplotype Are Not Associated with Molecular Relapse-Free Survival in Patients with Chronic Myeloid Leukemia Who Attempt Treatment-Free Remission

Maria Agustina Perusini, Katia Pagnano, Carolina Pavlovsky, Beatriz Moiraghi, Ana Varela, Michele Bianchini, Carmen Fava, Jiří Mayer, Daniela Žáčková, Anežka Kvetková, Tomáš Jurček, Ivana Ježíšková, Ana Beatriz Pascoal Lopes, Gislaine Borba Oliveira, Carmino De Souza, Amirthagowri Ambalavanan, Anthea Travas, Jaeyoon John Kim, Danielle Pyne, Jessie Medeiros, Sagi Abelson, Dennis Dong Hwan Kim
Journal: Blood
Blood (2023) 142 (Supplement 1): 4543.
https://doi.org/10.1182/blood-2023-189797
Published: 2023
Journal Articles

Propensity Score Matching Comparing Asciminib Versus Ponatinib in Chronic Myeloid Leukemia Patients Who Failed Prior Tyrosine Kinase Inhibitor Therapy

Maria Agustina Perusini, Camille Kockerols, Daniela Žáčková, Franck E. Nicolini, Fausto Castagnetti, Carolina Pavlovsky, Massimo Breccia, Delphine Rea, Carmen Fava, Mary Lynn Savoie, Christophe Bouvier, Petra Čičátková, Julien Bollard, Swe Mar Linn, Gopila Gupta, Emilia Scalzulli, Jiří Mayer, Peter E Westerweel, Dennis Dong Hwan Kim
Journal: Blood
Blood (2023) 142 (Supplement 1): 6360.
https://doi.org/10.1182/blood-2023-190293
Published: 2023
Journal Articles

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

Alejandra Garcia, Laura Bertoldi, Paula Scaglia, Sofia Carbajosa, Natalia Cavallo, Agustina Garcia-Melani, Laura Guantay, Marisa Piaggio, Gimena Ferreira, Maria Sol Jarchum, Gustavo Jarchum, Miguel Arturo Pavlovsky, Isolda Isabel Fernandez, María Jose Mela Osorio, Carolina Pavlovsky, Blanca Rossi, Martín Alonso, Juan José García, Nicolás Cazap, Jorge Solimano, Silvina Palmer, Adriana Rinflerch, Erika Barbara Brulc, Paula González Hermida, Alberto Gimenez Conca, Emilio Sarkotic, Andrea Arruda, Mark D. Minden, Virginia García, Federico Molineris, Maximiliano Zeballos, Maria Laura Bernaschini, Diego Andino, Agustina Conrrero, María Rita Drocchi, Tarek Ali Zaki, Gerardo Gatti, Candelaria Llorens, Gaston Soria
Journal: Blood
Blood (2023) 142 (Supplement 1): 7132.
https://doi.org/10.1182/blood-2023-181119
Published: 2023
Journal Articles

Economic Impact Analysis of Treatment-Free Remission in Chronic Myeloid Leukemia Patients with Sustained Deep Molecular Response in the AST-2018 Trial

Ricardo Khalil Khalil Tannuri, Beatriz Moiraghi, Miguel Arturo Pavlovsky, Ana Ines Varela, Michele Bianchini, Isabel Giere, Isolda I. Fernandez, Georgina Bendek, Romina Mariano, Josefina Freitas, Veronica Ventriglia, Maria Del Rosario Custidiano, Ana Garcia de Labanca, Julio Cesar Sanchez Avalos, Maria J. Mela Osorio, Bianca Vasconcelos Cordoba, Maria Belen Sanchez, Mariana Juni, Marcos Bianco, Carolina Pavlovsky
Journal: Blood
Blood (2022) 140 (Supplement 1): 5088–5089.
https://doi.org/10.1182/blood-2022-162407
Published: 2022
Journal Articles

Impact of Ibrutinib in Quality of Life (QoL) in Patients with Chronic Lymphocytic Leukemia(CLL): Real World Experience in Argentina

María Jose Mela Osorio, Astrid Pavlovsky, Carolina Pavlovsky, Isolda I Fernandez, Manuela Clavijo, Augusto Miroli, Federico Sackmann, Guillermina Remaggi, Luciana C Ferrari, Mariana Juni, Carolina Sighel, Maximiliano Riddick, Miguel Arturo Pavlovsky
Journal: Blood
Blood (2022) 140 (Supplement 1): 12403–12404.
https://doi.org/10.1182/blood-2022-165626
Published: 2022
Journal Articles

Ex-Vivo Testing Using Patient Micro Avatars (PMAs) Predicts Clinical Response in Acute Leukemias

Alejandra Garcia, Lía Buffa, Magalí Ridano, Paula Scaglia, Maribel Nicola, Sofía Carbajosa, Cintia Garro, Daniela Arroyo, Agustina Conrrero, Juan Pablo Fiorenza, Valentina Alfonso, María Laura Bernaschini, Diego Andino, Natalia Cavallo, Gimena Ferreira, Virginia García, Federico Molineris, Maximiliano Zeballos, Silvina Palmer, Isolda I Fernandez, Maria J Mela Osorio, Carolina Pavlovsky, Juan José García, Martín Alonso, Blanca de los Milagros Rossi, Gustavo Jarchum, Daiana Rodriguez, Andrea Arruda, Mark D. Minden, Nicolás Cazap, Jorge Solimano, Tarek Ali Zaki, Gerardo Gatti, Candelaria Llorens, Gastón Soria
Journal: Blood
Blood (2022) 140 (Supplement 1): 13027–13028.
https://doi.org/10.1182/blood-2022-164847
Published: 2022
Journal Articles

The Prognostic Impact of HMGCLL1 Gene Variant on Treatment Outcomes in Chronic Myeloid Leukemia (CML) Patients: Adverse Impact on the Response, Failure, and Progression with Imatinib Which Can be Abrogated By the Use of 2 nd Generation Tyrosine Kinase Inhibitor (TKI) Upfront Therapy

Maria Agustina Perusini, Taehyung Simon Kim, Daniela Žácková, Katia B Pagnano, Jiří Mayer, Carolina Pavlovsky, Ivana Ježíšková, Anežka Kvetková, Tomáš Jurček, Beatriz Moiraghi, Ana Ines Varela, Michele Bianchini, Ana Beatriz Pascoal Lopes, Gislaine B O Duarte, Young Seok Yoo, Carmino Antonio Souza, Jessie Medeiros, Hye Won Lee, Kyoung Ha Kim, Seong Yoon Yi, Myung Hee Chang, Sagi Abelson, Dennis Dong Hwan Kim
Journal: Blood
Blood (2022) 140 (Supplement 1): 6774–6775.
https://doi.org/10.1182/blood-2022-168228
Published: 2022
Journal Articles

Molecular Response of ≤10% BCR::ABL1 IS Is Predictive of Positive Outcomes in Treatment-Resistant Patients with Chronic Phase Chronic Myeloid Leukemia (CP-CML) Treated with Ponatinib from the Phase 2 Optic Trial

Jane F. Apperley, Jorge E. Cortes, Elias Jabbour, Andreas Hochhaus, Timothy Hughes, Charles Chuah, Hugues de Lavallade, Michael W. Deininger, Jeffrey H. Lipton, Elza Lomaia, Lori Maness, Michael Mauro, James McCloskey, Beatriz Moiraghi, Carolina Pavlovsky, Christine Rojas, Philippe Rousselot, Tomasz Sacha, Moshe Talpaz, Anna Turkina, Maria Undurraga Sutton, Xiaowei Ren, Alexander Vorog, Gianantonio Rosti
Journal: Blood
Blood (2022) 140 (Supplement 1): 6760–6762.
https://doi.org/10.1182/blood-2022-157956
Published: 2022
Journal Articles

Three-Year Update from the Optic Trial: A Dose-Optimization Study of 3 Starting Doses of Ponatinib

Jorge E. Cortes, Michael W. Deininger, Elza Lomaia, Beatriz Moiraghi, Maria Undurraga Sutton, Carolina Pavlovsky, Charles Chuah, Tomasz Sacha, Jeffrey H. Lipton, James McCloskey, Andreas Hochhaus, Philippe Rousselot, Gianantonio Rosti, Hugues de Lavallade, Christine Rojas, Anna Turkina, Lori Maness, Moshe Talpaz, Michael Mauro, Vickie Lu, Alexander Vorog, Jane F. Apperley
Journal: Blood
Blood (2022) 140 (Supplement 1): 1495–1497.
https://doi.org/10.1182/blood-2022-157822
Published: 2022
Journal Articles

Somatic Mutations Are Frequently Detected in CML Patients before Treatment-Free Remission (TFR) Attempt with Tyrosine Kinase Inhibitor (TKI) Discontinuation but with Uncertain Predictive Value for Tfr Failure

Maria Agustina Perusini, Katia B Pagnano, Carolina Pavlovsky, Beatriz Moiraghi, Ana Ines Varela, Michele Bianchini, Jiří Mayer, Daniela Žácková, Anežka Kvetková, Tomáš Jurček, Ivana Ježíšková, Ana Beatriz Pascoal Lopes, Gislaine B O Duarte, Carmino Antonio Souza, Jessie J.F. Medeiros, Taehyung Simon Kim, Young Seok Yoo, Kyoung Ha Kim, Hye Won Lee, Myung Hee Chang, Seong Yoon Yi, Sagi Abelson, Dennis Kim
Journal: Blood
Blood (2022) 140 (Supplement 1): 6782–6783.
https://doi.org/10.1182/blood-2022-167927
Published: 2022
Journal Articles

Ponatinib dose-ranging study in chronic-phase chronic myeloid leukemia: a randomized, open-label phase 2 clinical trial

Clinical Trials & Observations
Jorge Cortes, Jane Apperley, Elza Lomaia, Beatriz Moiraghi, Maria Undurraga Sutton, Carolina Pavlovsky, Charles Chuah, Tomasz Sacha, Jeffrey H. Lipton, Charles A. Schiffer, James McCloskey, Andreas Hochhaus, Philippe Rousselot, Gianantonio Rosti, Hugues de Lavallade, Anna Turkina, Christine Rojas, Christopher Kevin Arthur, Lori Maness, Moshe Talpaz, Michael Mauro, Tracey Hall, Vickie Lu, Shouryadeep Srivastava, Michael Deininger
Journal: Blood
Blood (2021) 138 (21): 2042–2050.
https://doi.org/10.1182/blood.2021012082
Published: 2021
Includes: Supplemental data
Journal Articles

Post Hoc Analysis of Responses to Ponatinib in Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) By Baseline BCR-ABL1 Level and Baseline Mutation Status in the Optic Trial

Michael W. Deininger, Jane F Apperley, Christopher Kevin Arthur, Charles Chuah, Andreas Hochhaus, Hugues De Lavallade, Jeffrey H. Lipton, Elza Lomaia, James K McCloskey, Lori J. Maness, Michael J. Mauro, Beatriz Moiraghi, Carolina Pavlovsky, Gianantonio Rosti, Philippe Rousselot, Soledad S. Undurraga, Vickie Lu, Alexander Vorog, Jorge E. Cortes
Journal: Blood
Blood (2021) 138 (Supplement 1): 307.
https://doi.org/10.1182/blood-2021-145995
Published: 2021
Journal Articles

High Level of Successful TKI Discontinuation in Chronic Myeloid Leukemia (CML) Patients: Preliminary Results of AST-Argentina Stop Trial

Carolina Pavlovsky, Ana Ines Varela, MD, Isolda I. Fernandez, MD, Maria Belen Sanchez, Maria Del Rosario Custidiano, MD, Josefina Freitas, MD, Veronica Ventriglia, MD, Ana Garcia de Labanca, MD, Georgina Bendek, MD, Romina Mariano, MD, Estrella Levy, PhD, Masiel Vera, Isabel Giere, PhD, Bianca Vasconcelos Cordoba, María Jose Mela Osorio, MD, Miguel A. Pavlovsky, MD, Julio Cesar Sanchez Avalos, MD, Cecilia Foncouberta, MD, Mariana Juni, Ms, Maximiliano Riddick, Michele Bianchini, PhD, Beatriz Moiraghi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–5.
https://doi.org/10.1182/blood-2020-142416
Published: 2020