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Journal Articles

CML Patients Who Fail to Achieve ≤ 1% BCR::ABL1 at 12 Months or ≤ 0.1% BCR::ABL1 at 24 Months (major molecular response, MMR) Show Significantly Inferior Survival, but Not Due to CML-Related Deaths: Data from an Italian Real-Life Observational Study

Valentina Giai, Tiziana Rosso, Fausto Castagnetti, Patrizia Pregno, Massimiliano Bonifacio, Isabella Capodanno, Mario Tiribelli, Fabio Stagno, Giovanni Caocci, Antonella Gozzini, Luigiana Luciano, Sara Galimberti, Monica Bocchia, Andrea Patriarca, Giuseppe Lanzarone, Bruno Martino, Anna Guella, Anna Rita Scortechini, Carmen Fava, Claudio Fozza, Simona Sica, Nicola Di Renzo, Pellegrino Musto, Domenico Pastore, Alessandro Maggi, Michele Pizzuti, Lorella Maria Antonia Melillo, Angelo Michele Carella, Giuseppe Tarantini, Anna Mele, Elisabetta Calistri, Maria Rosaria Coppi, Fabio Saccona, Emilia Scalzulli, Beatrice Battaglio, Miriam Iezza, Cinzia Bitetti, Roberto Freilone, Gianantonio Rosti, Francesco Albano, Fabrizio Pane, Giorgina Specchia, Massimo Breccia, Giovannino Ciccone, Giuseppe Saglio
Journal: Blood
Blood (2024) 144 (Supplement 1): 3155.
https://doi.org/10.1182/blood-2024-207877
Published: 2024
Journal Articles

Tyrosine Kinase Inhibitors Discontinuation in Chronic Myeloid Leukemia: Observational Study of 673 Patients in Italy

Valentina Bonuomo, Emanuele Koumantakis, Selene Grano, Paola Berchialla, Fausto Castagnetti, Bruno Martino, Chiara Elena, Monica Bocchia, Isabella Capodanno, Tamara Intermesoli, Maria Cristina Miggiano, Carlo Gambacorti-Passerini, Alessandra Iurlo, Francesca Lunghi, Luigiana Luciano, Elisabetta Abruzzese, Angelo Michele Carella, Massimo Breccia, Felicetto Ferrara, Sabrina Leonetti Crescenzi, Barbara Scappini, Marco De Gobbi, Federica Sorà, Davide Rapezzi, Debora Luzi, Sara Galimberti, Monica Crugnola, Anna Rita Scortechini, Alessandro Maggi, Massimiliano Bonifacio, Mario Annunziata, Giovanni Caocci, Germana Beltrami, Francesco Cavazzini, Giuseppe Pietrantuono, Leonardo Campiotti, Fabio Stagno, Caterina Musolino, Daniela Cilloni, Giuseppe Saglio, Carmen Fava
Journal: Blood
Blood (2024) 144 (Supplement 1): 3162.
https://doi.org/10.1182/blood-2024-201493
Published: 2024
Journal Articles

Retrospective Study to Compare Treatment Outcomes of Asciminib Vs. Ponatinib in 99 Patients with T315I Mutated Chronic Myeloid Leukemia

Maria Agustina Perusini, Camille Kockerols, Daniela Žáčková, Franck E. Nicolini, Fausto Castagnetti, Carolina Pavlovsky, Massimo Breccia, Delphine Rea, Carmen Fava, Lynn Savoie, Christophe Bouvier, Petra Čičátková, Julien Bollard, Swe Linn, Gopila Gupta, Emilia Scalzulli, Tomoiku Takaku, Hiroshi Ureshino, Shinya Kimura, Sung-Eun Lee, Dragana Milojkovic, Andrew J Innes, Simone Claudiani, Valentín García Gutiérrez, Sr., Jiri Mayer, Peter E. Westerweel, Dennis Dong Hwan Kim
Journal: Blood
Blood (2024) 144 (Supplement 1): 3149.
https://doi.org/10.1182/blood-2024-205681
Published: 2024
Journal Articles

ASXL1 Mutations at Diagnosis Did Not Impact on the Depth of Molecular Response (MR) and on Treatment-Free Remission (TFR) Eligibility in Chronic Phase (CP) Chronic Myeloid Leukemia (CML) Patients (pts) Receiving either Nilotinib (NIL) First-Line or Imatinib (IM) with Early Switch to NIL in Case of No Optimal Response in the SUSTRENIM Clinical Trial

Simona Soverini, Sara De Santis, Cecilia Monaldi, Manuela Mancini, Valentina Giai, Marco Cerrano, Isabella Capodanno, Massimiliano Bonifacio, Elisabetta Abruzzese, Alessandra Iurlo, Fausto Castagnetti, Rosaria Sancetta, Luciano Levato, Carmen Fava, Mario Tiribelli, Francesco Cavazzini, Maria Cristina Miggiano, Niccolò Bolli, Agostino Tafuri, Alessandro Lucchesi, Daniele Vallisa, Monia Lunghi, Caterina Musolino, Samantha Bruno, Cristina Mosca, Mauro Ciriello, Giovanni Marsili, Alfonso Piciocchi, Paola Fazi, Michele Cavo, Jeroen J.W.M. Janssen, Peter E. Westerweel, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 3158.
https://doi.org/10.1182/blood-2024-205465
Published: 2024
Journal Articles

Treatment-Free Remission in CML Patients Discontinuing Post-First Line Therapy

Selene Grano, Valentina Bonuomo, Emanuele Koumantakis, Paola Berchialla, Fausto Castagnetti, Massimo Martino, Chiara Elena, Monica Bocchia, Isabella Capodanno, Tamara Intermesoli, Maria Cristina Miggiano, Carlo Gambacorti-Passerini, Alessandra Iurlo, Francesca Lunghi, Luigiana Luciano, Elisabetta Abruzzese, Angelo Michele Carella, Massimo Breccia, Felicetto Ferrara, Sabrina Leonetti Crescenzi, Barbara Scappini, Marco De Gobbi, Federica Sorà, Davide Rapezzi, Debora Luzi, Sara Galimberti, Monica Crugnola, Anna Rita Scortechini, Alessandro Maggi, Massimiliano Bonifacio, Mario Annunziata, Giovanni Caocci, Germana Beltrami, Francesco Cavazzini, Giuseppe Pietrantuono, Leonardo Campiotti, Fabio Stagno, Caterina Musolino, Carmen Fava
Journal: Blood
Blood (2024) 144 (Supplement 1): 1778.
https://doi.org/10.1182/blood-2024-200208
Published: 2024
Journal Articles

Molecular Outcome of Chronic Myeloid Leukemia Affected Patients Not in Deep Molecular Response: The “Others” from the Gimema Labnet Network

Fabio Stagno, Rosalba Cucci, Giovanni Marsili, Fausto Castagnetti, Sara Galimberti, Barbara Izzo, Federica Sorà, Simona Soverini, Monica Messina, Alfonso Piciocchi, Massimiliano Bonifacio, Daniela Cilloni, Alessandra Iurlo, Giovanni Martinelli, Gianantonio Rosti, Paola Fazi, Marco Vignetti, Massimo Breccia, Alessandro Allegra, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 992.
https://doi.org/10.1182/blood-2024-210201
Published: 2024
Journal Articles

Evaluating the Impact of Cross-over from Imatinib to Nilotinib on the Overall Survival in Chronic Myeloid Leukemia Using Inverse Probability of Censoring Weighting: Results from the Gimema Sustrenim Study

Alfonso Piciocchi, Giovanni Marsili, Ylenia Belperio, Monica Messina, Francesca Paola Paoloni, Stefano Soddu, Isabella Capodanno, Rosaria Sancetta, Elisabetta Abruzzese, Alessandro Pulsoni, Monia Lunghi, Giovanni Caocci, Fausto Castagnetti, Paola Fazi, Marco Vignetti, Massimo Breccia, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 4530.
https://doi.org/10.1182/blood-2024-198366
Published: 2024
Journal Articles

Probability of Switch of TKIs Treatment According to Baseline Features in a Large Chronic Myeloid Leukemia (CML) Population: Italian CML Network

Massimo Breccia, Valentina Giai, Tiziana Rosso, Patrizia Pregno, Fausto Castagnetti, Massimiliano Bonifacio, Isabella Capodanno, Mario Tiribelli, Fabio Stagno, Olga Mulas, Antonella Gozzini, Luigiana Luciano, Sara Galimberti, Andrea Patriarca, Giuseppe Lanzarone, Bruno Martino, Anna Guella, Anna Rita Scortechini, Carmen Fava, Claudio Fozza, Federica Sorà, Alessandro Maggi, Michele Pizzuti, Sara Freducci, Giuseppina Loglisci, Antonella Russo Rossi, Maria Laura Di Noi, Giuseppina Spinosa, Maria Teresa Santeramo, Grazia Sanpaolo, Giuseppe Pietrantuono, Clara Mannarella, Elisabetta Calistri, Eleonora Prete, Gianantonio Rosti, Fabrizio Pane, Giuseppe Saglio, Giovannino Ciccone, Giorgina Specchia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4535.
https://doi.org/10.1182/blood-2024-202477
Published: 2024
Journal Articles

Real-World Effectiveness of Asciminib in Patients with Chronic Myeloid Leukemia (CML) Harboring the T315I Mutation: A Global Chart Review Study of Patients Treated in the Asciminib Managed Access Program (MAP)

Dragana Milojkovic, Nicole Blijlevens, Yok-Lam Kwong, Uzma Zaidi, Fausto Castagnetti, Paolo Gallipoli, Maria Cristina Miggiano, Peter E Westerweel, Melissa Chen, M. Carmen Garcia Hernandez, William J. Kell, Pankit Vachhani, Neha Agarwal, Alessandra Colasante, Sridhar Meka, Aoife Smyth, Germano Ferreira, Jeroen J.W.M. Janssen
Journal: Blood
Blood (2023) 142 (Supplement 1): 4541.
https://doi.org/10.1182/blood-2023-181937
Published: 2023
Journal Articles

Propensity Score Matching Comparing Asciminib Versus Ponatinib in Chronic Myeloid Leukemia Patients Who Failed Prior Tyrosine Kinase Inhibitor Therapy

Maria Agustina Perusini, Camille Kockerols, Daniela Žáčková, Franck E. Nicolini, Fausto Castagnetti, Carolina Pavlovsky, Massimo Breccia, Delphine Rea, Carmen Fava, Mary Lynn Savoie, Christophe Bouvier, Petra Čičátková, Julien Bollard, Swe Mar Linn, Gopila Gupta, Emilia Scalzulli, Jiří Mayer, Peter E Westerweel, Dennis Dong Hwan Kim
Journal: Blood
Blood (2023) 142 (Supplement 1): 6360.
https://doi.org/10.1182/blood-2023-190293
Published: 2023
Journal Articles

On the Children Side. Overview of 194 Outcomes from Gimema Registry of Conception/Pregnancy in Chronic Myeloid Leukemia (CML)

Elisabetta Abruzzese, Elena Chiara, Fausto Castagnetti, Mario Annunziata, Carlo Gambacorti-Passerini, Luigiana Luciano, Antonella Russo Rossi, Alessandra Iurlo, Isabella Capodanno, Valentina Giai, Mariella D'Adda, Fabio Stagno, Antonella Gozzini, Mario Tiribelli, Federica Sorà, Sara Galimberti, Monica Bocchia, Germana Beltrami, Carmen Fava, Maria Cristina Miggiano, Massimo Breccia, Marco Cerrano, Anna Rita Scortechini, Olga Mulas, Clementina Caracciolo, Stefana Impera, Claudio Fozza, Alessandra Malato, Lucia Mastrullo, Marzia Salvucci, Monia Lunghi, Filippo Gherlinzoni, Paolo De Fabritiis, Paola Fazi, Sonia Maria Orlando, Alfonso Piciocchi, Fabrizio Pane
Journal: Blood
Blood (2023) 142 (Supplement 1): 3178.
https://doi.org/10.1182/blood-2023-188305
Published: 2023
Journal Articles

3-YEARS and Beyond Study Completion Results of the Otpkima Randomized Clinical Trial in Elderly CML Patients

Michele Malagola, Alessandra Iurlo, Cristina Bucelli, Elisabetta Abruzzese, Massimiliano Bonifacio, Fabio Stagno, Gianni Binotto, Mariella D'Adda, Monia Lunghi, Monica Crugnola, Maria Luisa Ferrari, Francesca Lunghi, Fausto Castagnetti, Gianantonio Rosti, Roberto Massimo Lemoli, Rosaria Sancetta, Maria Rosaria Coppi, Maria Teresa Corsetti, Matteo Dalmazzo, Atelda Romano, Mario Tiribelli, Antonella Russo Rossi, Sabina Russo, Anna Sicuranza, Aldo Roccaro, Giulia Butturini, Mirko Farina, Simona Bernardi, Simone Pellizzeri, Nicola Polverelli, Domenico Russo
Journal: Blood
Blood (2023) 142 (Supplement 1): 3165.
https://doi.org/10.1182/blood-2023-177619
Published: 2023
Journal Articles

Loss of Function of SETD2 Tumor Suppressor in Chronic Myeloid Leukemia (CML) Progenitors Fosters Genomic Instability and Enhances Clonogenic Potential

Sara De Santis, Manuela Mancini, Cecilia Monaldi, Gabriele Gugliotta, Samantha Bruno, Fausto Castagnetti, Miriam Iezza, Marco Cerrano, Alessandra Iurlo, Sara Galimberti, Serena Balducci, Fabio Stagno, Michele Cavo, Simona Soverini
Journal: Blood
Blood (2023) 142 (Supplement 1): 1785.
https://doi.org/10.1182/blood-2023-185677
Published: 2023
Journal Articles

International, Prospective Study Comparing Nilotinib Versus Imatinib with Early Switch to Nilotinib to Obtain Sustained Treatment-Free Remission in Patients with Chronic Myeloid Leukemia (SUSTRENIM trial): Analysis of the Eligibility to Treatment Discontinuation

Fabrizio Pane, Fausto Castagnetti, Alfonso Piciocchi, Elisabetta Abruzzese, Renato Bassan, Gianni Binotto, Massimiliano Bonifacio, Giovanni Caocci, Francesco Cavazzini, Giuseppe Cimino, Antonella Gozzini, Monia Lunghi, Roberto Marasca, Bruno Martino, Francesco Muriano, Gianantonio Rosti, Antonella Russo Rossi, Simona Sica, Agostino Tafuri, Daniele Vallisa, Monica Messina, Francesca Paola Paoloni, Paola Fazi, Peter E Westerweel, Jeroen J.W.M. Janssen, Giuseppe Saglio, Massimo Breccia
Journal: Blood
Blood (2023) 142 (Supplement 1): 3169.
https://doi.org/10.1182/blood-2023-182220
Published: 2023
Journal Articles

The Use of 2 nd Generation TKIs As First Line Therapy Does Not Prevent CML Related Deaths: Results of an Italian CML Campus Prospective Study in 1277 Patients Treated First Line with Imatinib or 2 nd Generation TKIs

Valentina Giai, Fabio Stagno, Tiziana Rosso, Fausto Castagnetti, Isabella Capodanno, Massimiliano Bonifacio, Mario Tiribelli, Sara Galimberti, Monica Bocchia, Antonella Gozzini, Giovanni Caocci, Andrea Patriarca, Giuseppe Lanzarone, Anna Guella, Federica Sorà, Luigiana Luciano, Anna Rita Scortechini, Nicola Di Renzo, Pellegrino Musto, Domenico Pastore, Alessandro Maggi, Carmen Fava, Vincenzo Pavone, Claudio Fozza, Giuseppina Spinosa, Angelo Michele Carella, Giuseppe Tarantini, Bruno Martino, Michele Pizzuti, Clara Mannarella, Fabio Saccona, Gianantonio Rosti, Patrizia Pregno, Massimo Breccia, Fabrizio Pane, Giovannino Ciccone, Giorgina Specchia, Giuseppe Saglio
Journal: Blood
Blood (2023) 142 (Supplement 1): 3168.
https://doi.org/10.1182/blood-2023-182981
Published: 2023
Journal Articles

Outcome of Patients with Chronic Myeloid Leukemia in Chronic Phase Showing Clinical Resistance to Frontline Treatment with Second Generation Tyrosine Kinase Inhibitors. an Italian Prospective Study from the CML Campus

Fabio Stagno, Valentina Giai, Patrizia Pregno, Gabriele Gugliotta, Tiziana Rosso, Fausto Castagnetti, Isabella Capodanno, Massimiliano Bonifacio, Mario Tiribelli, Sara Galimberti, Monica Bocchia, Antonella Gozzini, Giovanni Caocci, Andrea Patriarca, Giuseppe Lanzarone, Anna Guella, Simona Sica, Luigiana Luciano, Anna Rita Scortechini, Maria Pia Loglisci, Antonella Russo Rossi, Maria Rosaria Coppi, Alessandro Maggi, Maria Teresa Santeramo, Carmen Fava, Giuseppina Greco, Claudio Fozza, Giuseppina Spinosa, Grazia Sanpaolo, Bruno Martino, Michele Pizzuti, Giuseppe Pietrantuono, Fabio Saccona, Gianantonio Rosti, Massimo Breccia, Fabrizio Pane, Giovannino Ciccone, Giorgina Specchia, Giuseppe Saglio
Journal: Blood
Blood (2023) 142 (Supplement 1): 6363.
https://doi.org/10.1182/blood-2023-188523
Published: 2023
Journal Articles

Treatment-Free Remission after Ponatinib Cessation in Chronic Phase (CP) Chronic Myeloid Leukemia (CML) Patients. the Ponastop Observational Study

Franck E. Nicolini, Elisabetta Abruzzese, Gabrielle Roth-Guepin, Rami Abi-Tayeh, Vincent Alcazer, Sandrine Hayette, Stéphane Morisset, Françoise Huguet, Miriam Iezza, Fausto Castagnetti, Delphine Rea
Journal: Blood
Blood (2023) 142 (Supplement 1): 1799.
https://doi.org/10.1182/blood-2023-178326
Published: 2023
Journal Articles

Treatment and Disease Characteristics of Chronic Myeloid Leukemia in Blast Crisis: The European Leukemianet Blast Crisis Registry

Annamaria Brioli, Elza Lomaia, Christian Fabisch, Tomasz Sacha, Hana Klamová, Elena Morozova, Aleksandra Golos, Philipp Ernst, Ulla Olsson-Strömberg, Jiri Mayer, Franck E. Nicolini, Han Bao, Fausto Castagnetti, Elzbieta Patkowska, Klaus Hirschbühl, Edyta Paczkowska, Anne Parry, Astghik Voskanyan, Susanne Saussele, Georg-Nikolaus Franke, Alexander Kiani, Edgar Faber, Krzysztof Lewandowski, Stefan W. Krause, Elke Dammann, Peter Anhut, Justyna Gil, Thomas Südhoff, Sonja Heibl, Markus Pfirrmann, Andreas Hochhaus, Michael Lauseker
Journal: Blood
Blood (2022) 140 (Supplement 1): 818–820.
https://doi.org/10.1182/blood-2022-162252
Published: 2022
Journal Articles

Multicenter, Prospective and Retrospective Observational Cohort Study of Ponatinib in Patients with CML in Italy: Primary Analysis of the Oiti Trial

Massimo Breccia, Luigia Luciano, Mario Annunziata, Imma Attolico, Alessandra Malato, Elisabetta Abruzzese, Massimiliano Bonifacio, Anna Rita Scortechini, Nicola Cascavilla, Nicola Di Renzo, Stefana Impera, Monia Lunghi, Marco Santoro, Fausto Castagnetti, Alessandro Maggi, Valeria Sargentini, Alfonso Piciocchi, Claudia Galimberti, Alessandra Iurlo
Journal: Blood
Blood (2021) 138 (Supplement 1): 3603.
https://doi.org/10.1182/blood-2021-146139
Published: 2021
Journal Articles

Sequential Treatments in Chronic Phase Chronic Myeloid Leukemia (CML) Patients without Optimal Response after Frontline Nilotinib or Dasatinib: An Italian CML Campus Study

Gabriele Gugliotta, MD PhD, Mario Annunziata, MD, Isabella Capodanno, MD, Davide Rapezzi, MD, Immacolata Attolico, MD, Iolanda Donatella Vincelli, Mario Tiribelli, MD, Alessandra Malato, MD PhD, Michele Pizzuti, MD, Vincenzo Accurso, MD, Massimiliano Bonifacio, MD, Sara Galimberti, MD PhD, Giuseppina Loglisci, MD, Elisabetta Abruzzese, MD, Monica Bocchia, Antonella Gozzini, MD, Micaela Bergamaschi, MD, Maria Cristina Miggiano, MD, Agostino Tafuri, MD, Grazia Sanpaolo, MD, Gianni Binotto, MD, Fausto Castagnetti, MDPhD, Giorgina Specchia, MD, Francesco Di Raimondo, MD, Michele Cavo, Gianantonio Rosti, MD, Robin Foà, MD, Giuseppe Saglio, MD PhD, Massimo Breccia, MD, Fabio Stagno, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
https://doi.org/10.1182/blood-2020-141077
Published: 2020