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Simona Soverini
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Journal Articles

T/NK Cell-Associated Transcriptomic Profile Informs Response to FLT3 Inhibitors in Acute Myeloid Leukemia

Jacopo Nanni, Jayakumar Vadakekolathu, Lorenza Bandini, Marilena Ciciarello, Karyna Volkava, Samantha Bruno, Valentina Robustelli, Letizia Zannoni, Chiara Sartor, Gianluca Cristiano, Federico Zingarelli, Andrea Davide Romagnoli, Caterina Azzimondi, Federica Ardizzoia, Raffaele Ciruolo, Giovanni Marconi, Claudia Venturi, Ajsi Kanapari, Gaia Mazzocchetti, Giorgia Simonetti, Martina Ghetti, Nicoletta Testoni, Sarah Parisi, Stefania Paolini, Simona Soverini, Emanuela Ottaviani, Cristina Papayannidis, Michele Cavo, Sergio Rutella, Antonio Curti
Journal: Blood
Blood (2024) 144 (Supplement 1): 2916.
https://doi.org/10.1182/blood-2024-205994
Published: 2024
Journal Articles

Molecular Outcome of Chronic Myeloid Leukemia Affected Patients Not in Deep Molecular Response: The “Others” from the Gimema Labnet Network

Fabio Stagno, Rosalba Cucci, Giovanni Marsili, Fausto Castagnetti, Sara Galimberti, Barbara Izzo, Federica Sorà, Simona Soverini, Monica Messina, Alfonso Piciocchi, Massimiliano Bonifacio, Daniela Cilloni, Alessandra Iurlo, Giovanni Martinelli, Gianantonio Rosti, Paola Fazi, Marco Vignetti, Massimo Breccia, Alessandro Allegra, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 992.
https://doi.org/10.1182/blood-2024-210201
Published: 2024
Journal Articles

ASXL1 Mutations at Diagnosis Did Not Impact on the Depth of Molecular Response (MR) and on Treatment-Free Remission (TFR) Eligibility in Chronic Phase (CP) Chronic Myeloid Leukemia (CML) Patients (pts) Receiving either Nilotinib (NIL) First-Line or Imatinib (IM) with Early Switch to NIL in Case of No Optimal Response in the SUSTRENIM Clinical Trial

Simona Soverini, Sara De Santis, Cecilia Monaldi, Manuela Mancini, Valentina Giai, Marco Cerrano, Isabella Capodanno, Massimiliano Bonifacio, Elisabetta Abruzzese, Alessandra Iurlo, Fausto Castagnetti, Rosaria Sancetta, Luciano Levato, Carmen Fava, Mario Tiribelli, Francesco Cavazzini, Maria Cristina Miggiano, Niccolò Bolli, Agostino Tafuri, Alessandro Lucchesi, Daniele Vallisa, Monia Lunghi, Caterina Musolino, Samantha Bruno, Cristina Mosca, Mauro Ciriello, Giovanni Marsili, Alfonso Piciocchi, Paola Fazi, Michele Cavo, Jeroen J.W.M. Janssen, Peter E. Westerweel, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 3158.
https://doi.org/10.1182/blood-2024-205465
Published: 2024
Journal Articles

Optimizing Molecular Diagnosis of Systemic Mastocytosis in the Era of KIT Tyrosine Kinase Inhibitors: Results of a Survey and of a Nationwide Proficiency Control Round of KIT D816V Mutation Testing Promoted By the RIMA (Rete Italiana MAstocitosi) Association

Simona Soverini, Cecilia Monaldi, Sara De Santis, Manuela Mancini, Francesco Albano, Luisa Anelli, Loredana Bruno, Ignazio Brusca, Grazia Fazio, Lilia Maria Corral Abascal, Francesca Guerrini, Clara Bono, Giovanni Iaquinta, Paola Grammatico, Elisabetta Novella, Omar Perbellini, Orietta Spinelli, Silvia Salmoiraghi, Stefano Baldoni, Alessia Persico, Giuseppa De Luca, Calogero Lauricella, Giovanna Piras, Angelo D. Palmas, Samantha Bruno, Cristina Mosca, Chiara Sartor, Cristina Papayannidis, Paola Guglielmelli, Alessandro M. Vannucchi, Patrizia Bonadonna, Francesco Mannelli, Nicholas C. P. Cross, Michele Cavo, Roberta Zanotti, Chiara Elena
Journal: Blood
Blood (2024) 144 (Supplement 1): 7640.
https://doi.org/10.1182/blood-2024-202485
Published: 2024
Journal Articles

Loss of Function of SETD2 Tumor Suppressor in Chronic Myeloid Leukemia (CML) Progenitors Fosters Genomic Instability and Enhances Clonogenic Potential

Sara De Santis, Manuela Mancini, Cecilia Monaldi, Gabriele Gugliotta, Samantha Bruno, Fausto Castagnetti, Miriam Iezza, Marco Cerrano, Alessandra Iurlo, Sara Galimberti, Serena Balducci, Fabio Stagno, Michele Cavo, Simona Soverini
Journal: Blood
Blood (2023) 142 (Supplement 1): 1785.
https://doi.org/10.1182/blood-2023-185677
Published: 2023
Journal Articles

T Cell/Natural Killer (NK) Cell Transcriptional Profiles Are Associated with Response to Gilteritinib in FLT3 -Mutated Acute Myeloid Leukemia

Jacopo Nanni, Jayakumar Vadakekolathu, Lorenza Bandini, Samantha Bruno, Letizia Zannoni, Chiara Sartor, Gianluca Cristiano, Sarah Parisi, Federico Zingarelli, Raffaele Ciruolo, Giovanni Marconi, Claudia Venturi, Marilena Ciciarello, Aisi Kanapari, Gaia Mazzocchetti, Giorgia Simonetti, Martina Ghetti, Nicoletta Testoni, Stefania Paolini, Simona Soverini, Emanuela Ottaviani, Cristina Papayannidis, Michele Cavo, Sergio Rutella, Antonio Curti
Journal: Blood
Blood (2023) 142 (Supplement 1): 2947.
https://doi.org/10.1182/blood-2023-184741
Published: 2023
Journal Articles

Single-Cell Metabolic Profiling Integrated with Extracellular Vesicle Analysis Reveals Novel Metabolic Vulnerabilities and Prognostic Biomarkers in Acute Myeloid Leukemia

Dorian Forte, Filippo Maltoni, Samantha Bruno, Paulina Garcia-Gonzalez, Gianluca Cristiano, Chiara Sartor, Simona Soverini, Lucia Catani, Rafael José Argüello, Michele Cavo, Antonio Curti
Journal: Blood
Blood (2023) 142 (Supplement 1): 1598.
https://doi.org/10.1182/blood-2023-185909
Published: 2023
Journal Articles

Performance and Interlaboratory Reproducibility of Droplet Digital Polymerase Chain Reaction (ddPCR) and Real Time PCR for KIT D816V Mutation Detection: A Nationwide Pilot Study By the RIMA (Rete Italiana Mastocitosi) Association

Cecilia Monaldi, Sara De Santis, Manuela Mancini, Daniela Pietra, Giovanna De Matteis, Sonia Fabris, Niccolò Bolli, Santa Errichiello, Barbara Izzo, Francesca Gesullo, Paola Guglielmelli, Gessica Minnella, Patrizia Chiusolo, Cristina Papayannidis, Chiara Sartor, Chiara Elena, Ilaria Tanasi, Massimiliano Bonifacio, Federica Grifoni, Mariarita Sciumè, Massimo Triggiani, Francesco Mannelli, Livio Pagano, Alessandro Maria Vannucchi, Nicholas C. P. Cross, Michele Cavo, Roberta Zanotti, Simona Soverini
Journal: Blood
Blood (2023) 142 (Supplement 1): 6393.
https://doi.org/10.1182/blood-2023-181521
Published: 2023
Journal Articles

Prospective assessment of NGS-detectable mutations in CML patients with nonoptimal response: the NEXT-in-CML study

Simona Soverini, Luana Bavaro, Caterina De Benedittis, Margherita Martelli, Alessandra Iurlo, Nicola Orofino, Simona Sica, Federica Sorà, Francesca Lunghi, Fabio Ciceri, Sara Galimberti, Claudia Baratè, Massimiliano Bonifacio, Luigi Scaffidi, Fausto Castagnetti, Gabriele Gugliotta, Francesco Albano, Antonella Vita Russo Rossi, Fabio Stagno, Francesco di Raimondo, Mariella D’Adda, Eros di Bona, Elisabetta Abruzzese, Gianni Binotto, Rosaria Sancetta, Marzia Salvucci, Isabella Capodanno, Mariella Girasoli, Sabrina Coluzzi, Immacolata Attolico, Caterina Musolino, Elisabetta Calistri, Mario Annunziata, Monica Bocchia, Stefania Stella, Anna Serra, Santa Errichiello, Giuseppe Saglio, Fabrizio Pane, Paolo Vigneri, Flavio Mignone, Maria Antonella Laginestra, Stefano Aldo Pileri, Antonio Percesepe, Elena Tenti, Gianantonio Rosti, Michele Baccarani, Michele Cavo, Giovanni Martinelli
Journal: Blood
Blood (2020) 135 (8): 534–541.
https://doi.org/10.1182/blood.2019002969
Published: 2020
Includes: Supplemental data
Journal Articles

Detection of Actionable BCR-ABL1 Kinase Domain (KD) Mutations in Chronic Myeloid Leukemia (CML) Patients with Failure and Warning Response to Tyrosine Kinase Inhibitors (TKIs): Potential Impact of Next-Generation Sequencing (NGS) and Droplet Digital PCR (ddPCR) on Clinical Decision Making

Simona Soverini, PhD, Margherita Martelli, Dr, Luana Bavaro, Dr, Caterina De Benedittis, Alessandra Iurlo, MD PhD, Sara Galimberti, MD PhD, Patrizia Pregno, Massimiliano Bonifacio, MD, Francesca Lunghi, MD, Fausto Castagnetti, MD PhD, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, MD, Mario Tiribelli, Vanessa Velotta, Fabio Stagno, MD, Antonella Russo Rossi, Mariella D'Adda, MD, Claudia Baratè, Monica Crugnola, MD, Luigiana Luciano, Maria Antonella Laginestra, PhD, Adam S Corner, PhD, Dianna Maar, PhD, Antonio Percesepe, MD PhD, Stefano Pileri, MD, Fabrizio Pane, MD, Giuseppe Saglio, MD, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo
Journal: Blood
Blood (2019) 134 (Supplement_1): 661.
https://doi.org/10.1182/blood-2019-126767
Published: 2019
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

Manuela Mancini, PhD, Sara De Santis, Dr, Cecilia Monaldi, Dr, Luana Bavaro, Dr, Margherita Martelli, Dr, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Gianantonio Rosti, MD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Elisa Dan, PhD, Barbara Sinigaglia, Dr, Alessandra Iurlo, MD PhD, Nicola Orofino, MD, Elisabetta Abruzzese, MD, Marzia Salvucci, MD, Patrizia Pregno, Antonella Gozzini, MD, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, MD, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, MD PhD, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4142.
https://doi.org/10.1182/blood-2019-126500
Published: 2019
Journal Articles

Ten-Year Follow-up of Patients with Chronic Myeloid Leukemia Treated with Nilotinib in First-Line: Final Results of the Gimema CML 0307 Trial

Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Massimo Breccia, MD, Luciano Levato, MD, Tamara Intermesoli, MD, Mariella D'adda, Marzia Salvucci, MD, Fabio Stagno, MD, Giovanna Rege Cambrin, MD PhD, Mario Tiribelli, Bruno Martino, MD, Monica Bocchia, Elena Trabacchi, MD, Francesco Cavazzini, MD, Ferdinando Porretto, Federica Sorà, MD, Giovanni Caocci, MD, Francesco Albano, MD, Giovanni Martinelli, MD, Simona Soverini, PhD, Robin Foà, MD, Fabrizio Pane, MD, Michele Cavo, Giuseppe Saglio, MD, Michele Baccarani, MD, Gianantonio Rosti, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4145.
https://doi.org/10.1182/blood-2019-126163
Published: 2019
Journal Articles

In Systemic Masocytosis, Midostaurin Targets Both Kit and Aurora Kinase a Reverting H3K36Me3 Deficiency and Synergizes with Second-Generation Tyrosine Kinase Inhibitors

Manuela Mancini, PhD, Cecilia Monaldi, Dr, Sara De Santis, Dr, Cristina Papayannidis, Michela Rondoni, MD, Luana Bavaro, Dr, Margherita Martelli, Dr, Antonio Curti, MD PhD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Roberta Zanotti, MD, Massimiliano Bonifacio, MD, Luigi Scaffidi, MD, Livio Pagano, MD, Marianna Criscuolo, MD, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, MD, Patrizia Tosi, Massimo Delledonne, Carla Avanzato, Luciano Xumerle, Peter Valent, MD, Giovanni Martinelli, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4204.
https://doi.org/10.1182/blood-2019-126538
Published: 2019
Journal Articles

Droplet Digital PCR Phasing (DROP-PHASE): A Novel Method for Straightforward Detection of BCR-ABL1 Compound Mutations in Tyrosine Kinase Inhibitors Resistant Chronic Myeloid Leukemia (CML) and Acute Lymphoblastic Leukemia (ALL)

Pascal Vannuffel, PhD, Luana Bavaro, Dr, Friedel Nollet, PhD, Asena Aynaci, Margherita Martelli, Dr, Helena Devos, Céline De Rop, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4660.
https://doi.org/10.1182/blood-2019-123409
Published: 2019
Journal Articles

Biology of Acute Myeloid Leukemia (AML) with Monosomy of Chromosome 7 or Loss of 7q. a Study on 487 Patients Analyzed By Gene Expression Profile (GEP), Single Nucleotide Polymorphism (SNP) Arrays and Metabolomics

Maria Chiara Fontana, MSc, Matteo Olivi, Giovanni Marconi, Mariachiara Abbenante, MD, Eugenio Fonzi, PhD, Stefania Paolini, MD PhD, Chiara Sartor, Sarah Parisi, Samantha Bruno, Martina Pazzaglia, Stefano De Polo, Jacopo Nanni, MD, Luca Bertamini, MD, Simone Ragaini, Annalisa Talami, Maria Teresa Bochicchio, Emanuela Ottaviani, Anna Ferrari, PhD, Carmen Baldazzi, Nicoletta Testoni, BSc, Torsten Haferlach, MD, Robert Kralovics, PhD, Jelena D. Milosevic Feenstra, PhD, Simona Soverini, PhD, Giovanni Martinelli, Antonio Curti, Michele Cavo, MD, Cristina Papayannidis, Giorgia Simonetti, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2748.
https://doi.org/10.1182/blood-2018-99-118183
Published: 2018
Journal Articles

Next Generation Sequencing-Based BCR-ABL1 Kinase Domain Mutation Screening in De Novo and Tyrosine Kinase Inhibitor-Resistant Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of a Prospective Study

Simona Soverini, PhD, Luana Bavaro, Margherita Martelli, Caterina De Benedittis, PhD, Cristina Papayannidis, Antonio Percesepe, MD PhD, Maria Antonella Laginestra, PhD, Simona Sica, MD, Federica Sorà, MD, Francesco Albano, MD, Livio Pagano, Marianna Criscuolo, Sara Galimberti, Marzia Salvucci, MD, Mario Annunziata, Giovanni Marconi, Antonio Curti, Sabina Russo, Annalisa Imovilli, Daniele Mannina, MD, Dario Ferrero, MD, Manuela Stulle, Claudia Basilico, MD, Elisabetta Abruzzese, Flavio Mignone, Stefano A. Pileri, MD PhD, Giovanni Martinelli, Michele Cavo, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4078.
https://doi.org/10.1182/blood-2018-99-117028
Published: 2018
Journal Articles

Compound BCR-ABL1 Kinase Domain Mutants: Prevalence, Spectrum and Correlation with Tyrosine Kinase Inhibitor Resistance in a Prospective Series of Philadelphia Chromosome-Positive Leukemia Patients Analyzed By Next Generation Sequencing

Simona Soverini, PhD, Luana Bavaro, Margherita Martelli, Caterina De Benedittis, PhD, Alessandra Iurlo, Nicola Orofino, MD, Livio Pagano, Marianna Criscuolo, Massimiliano Bonifacio, Luigi Scaffidi, MD, Simona Sica, MD, Federica Sorà, MD, Elena Maino, Michela Rondoni, MD, Maria Antonella Laginestra, PhD, Francesca Lunghi, Anna Ermacora, Mariella D'adda, MD, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, Gianantonio Rosti, Cristina Papayannidis, Giovanni Marconi, Antonio Curti, Maria Cristina Miggiano, Sara Galimberti, Antonio Percesepe, MD PhD, Fabio Stagno, Rosaria Sancetta, MD, Mario Annunziata, Franca Falzetti, MD, Isabella Capodanno, Patrizia Pregno, Margherita Maffioli, MD, Tamara Intermesoli, MD, Eros Di Bona, MD, Giovanni Caocci, MD, Imma Attolico, MD, Gianni Binotto, Monica Bocchia, MD PhD, Emanuele Angelucci, MD, Nicola Sgherza, MD, Luigiana Luciano, Flavio Mignone, Stefano A. Pileri, MD PhD, Giovanni Martinelli, Michele Cavo, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 789.
https://doi.org/10.1182/blood-2018-99-117166
Published: 2018
Journal Articles

The Use of EUTOS Long-Term Survival Score Instead of Sokal Score Is Strongly Advised in Elderly Chronic Myeloid Leukemia Patients

Fausto Castagnetti, MD PhD, Gabriele Gugliotta, MD PhD, Massimo Breccia, MD, Fabio Stagno, Giorgina Specchia, MD, Luciano Levato, Bruno Martino, MD, Mariella D'Adda, Elisabetta Abruzzese, Patrizia Pregno, Mario Tiribelli, Alessandra Iurlo, Tamara Intermesoli, MD, Anna Rita Scortechini, MD, Francesco Cavazzini, MD, Carmen Fava, Massimiliano Bonifacio, Marzia Salvucci, MD, Monica Bocchia, MD PhD, Giovanni Caocci, MD, Antonella Gozzini, MD, Micaela Bergamaschi, MD, Simona Soverini, PhD, Robin Foà, MD, Giovanni Martinelli, Michele Cavo, MD, Giuseppe Saglio, Fabrizio Pane, Michele Baccarani, MD, Gianantonio Rosti
Journal: Blood
Blood (2018) 132 (Supplement 1): 44.
https://doi.org/10.1182/blood-2018-99-117409
Published: 2018
Journal Articles

Outcome of 472 Chronic Myeloid Leukemia Patients Treated with Frontline Nilotinib: A Gimema CML WP Analysis

Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Massimo Breccia, MD, Alessandra Iurlo, Mariella D'Adda, Fabio Stagno, Luciano Levato, Bruno Martino, MD, Francesca Lunghi, Mario Tiribelli, Giovanna Rege Cambrin, MD, Elisabetta Abruzzese, MD, Serena Rupoli, MD, Antonella Gozzini, Patrizia Pregno, Marzia Salvucci, MD, Elena Trabacchi, MD, Giovanni Caocci, MD, Anna Rita Scortechini, MD, Luigia Luciano, MD, Giuseppe Tagariello, Massimiliano Bonifacio, Simona Soverini, PhD, Robin Foà, MD, Giovanni Martinelli, MD, Michele Cavo, MD, Fabrizio Pane, Giuseppe Saglio, Michele Baccarani, MD, Gianantonio Rosti
Journal: Blood
Blood (2018) 132 (Supplement 1): 458.
https://doi.org/10.1182/blood-2018-99-119182
Published: 2018
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Induces Genetic Instability and Can be Therapeutically Targeted

Manuela Mancini, PhD, Sara De Santis, Cecilia Monaldi, Luana Bavaro, Margherita Martelli, Fausto Castagnetti, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, Maria Chiara Fontana, MSc, Elisa Dan, Barbara Sinigaglia, Alessandra Iurlo, Nicola Orofino, Elisabetta Abruzzese, Marzia Salvucci, Patrizia Pregno, Antonella Gozzini, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, Michele Cavo, MD, Simona Soverini, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1726.
https://doi.org/10.1182/blood-2018-99-112908
Published: 2018