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Journal Articles

Efficacy and safety of pivekimab sunirine in combination with venetoclax plus azacitidine in unfit patients with newly diagnosed Acute Myeloid Leukemia

Free
Naval Daver, Anjali Advani, Adolfo De La Fuente Burguera, Pau Montesinos, Sylvain Garciaz, Maria Benedetta Giannini, Eunice Wang, Gail Roboz, Antonio Curti, Monia Lunghi, Jessica Altman, Roland Walter, Patrick Burke, Kebede Begna, Daniel Deangelo, Uwe Platzbecker, Paresh Vyas, Christoph Schliemann, Kendra Sweet, Caroline Wagstaff, Naveen Pemmaraju, Hagop Kantarjian, Yining Du, Jalaja Potluri, David Sallman
Journal: Blood
Blood (2025) 146 (Supplement 1): 651.
https://doi.org/10.1182/blood-2025-651
Published: 2025
Journal Articles

Interim analysis after 3 months of AML patients treated with venetoclax + azacitidine – first effectiveness and safety data from the prospective real world vero study

Free
Elisabetta Todisco, Caterina Alati, Ernesta Audisio, Monia Lunghi, Patrizia Zappasodi, Antonio Curti, Vincenzo Federico, Antonino Mule', MARINA PARISI, PRASSEDE SALUTARI, Massimo Breccia, Valeria Cardinali, Federico Lussana, matteo piccini, Marta Riva, Nicola Stefano Fracchiolla, Luca Maurillo, DEBORA CAPELLI, Anna Candoni, Eleonora De Bellis, SELENIA VITIELLO, PAOLA FINSINGER, LUIGI DI CAPRIO, Benedetta Neri, MELANIA RONFANI, ALESSANDRA FASANO, SIMONA MALGIERI, Matteo Della Porta
Journal: Blood
Blood (2025) 146 (Supplement 1): 3384.
https://doi.org/10.1182/blood-2025-3384
Published: 2025
Journal Articles

Treatment initiation pattern, ramp-up measures and management of AML patients treated in real life in Italy with venetoclax+azacitidine - first interim analysis of the prospective vero study

Free
Marta Ubezio, Caterina Alati, lorenzo celona, Monia Lunghi, gianluca martini, Antonio Curti, Vincenzo Federico, Antonino Mule', MARINA PARISI, PRASSEDE SALUTARI, Massimo Breccia, Valeria Cardinali, Marco Frigeni, matteo piccini, Mariarita Sciumè, DEBORA CAPELLI, Rossella Stella, AMBRA DI VEROLI, CARMINE SELLERI, PAOLA FINSINGER, LUIGI DI CAPRIO, Benedetta Neri, DARIA NUCCIARELLI, VIRGINIA SALA, SILVIA SCHIFANO, Elisabetta Todisco
Journal: Blood
Blood (2025) 146 (Supplement 1): 3383.
https://doi.org/10.1182/blood-2025-3383
Published: 2025
Journal Articles

Crenolanib plus salvage chemotherapy improves outcomes in FLT3-mutant and NPM1 co-mutated relapsed/ refractory (R/R) Acute Myeloid Leukemia (AML): Results from a randomized, placebo-controlled, double-blind trial

Free
Thomas Cluzeau, Pierre Yves Dumas, Pau Montesinos, Gaia Ciolli, Céline Berthon, Felicetto Ferrara, Adriano Venditti, José Antonio Pérez-Simón, Maria Calbacho, Richard Noppeney, Monia Lunghi, Chiara Cattaneo, Fabrizio Pane, Francesco Lanza, Juan Miguel Bergua Burgues, Alessandro Isidori, Yngvar Floisand, Vinay Jain, Eunice Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 767.
https://doi.org/10.1182/blood-2025-767
Published: 2025
Journal Articles

Risk factors for varicella zoster virus reactivation in newly diagnosed multiple myeloma patients undergoing autologous stem cell transplantation

Free
Paola Boggione, Riccardo Dondolin, Gloria Margiotta Casaluci, Lorenzo De Paoli, Monia Lunghi, Mariangela Greco, Matilde Picco, Clara Deambrogi, Abdurraouf Mahmoud, Wael Alessa, Golsa Farazmand, Gianluca Gaidano, Riccardo Moia
Journal: Blood
Blood (2025) 146 (Supplement 1): 7482.
https://doi.org/10.1182/blood-2025-7482
Published: 2025
Journal Articles

CPX-351 is a feasible bridge to allogeneic hematopoietic stem cell transplantation in TP53 mutated acute myeloid leukemia with  myelodisplastic related changes or therapy related without del(17p): Sub-analysis from a large italian real world retrospective study

Free
Elisabetta Todisco, Ivana Lotesoriere, Federico Lussana, Valentina Mancini, Federica Gigli, Cristina Papayannidis, Michela Rondoni, Felicetto Ferrara, Sara Mastaglio, Annalina Piccioni, Michelina Dargenio, Andrea Corbingi, Francesco Mannelli, Alessandro Cignetti, Patrizia Zappasodi, Maria Paola Martelli, Monia Lunghi, Luana Fianchi, Patrizia Chiusolo, Francesco Grimaldi, Federica Pilo, Carla Fili, Debora Capelli, Massimo Breccia, Monica Bocchia, Monica Fumagalli, Sara Galimberti, Luca Maurillo, Calogero Vetro, Alessandra Sperotto, Caterina Patti, Erika Borlenghi, Federica Lessi, Alessandro Isidori, Raffaele Palmieri, Caterina Alati, Samuele Gatani, Chiara Pessina, Paola Minetto, Carola Riva, Marco Frigeni, Nicola Stefano Fracchiolla, Carla Mazzone, Marco Cerrano, Massimo Bernardi, Michele Gottardi, Roberto Cairoli, Adriano Venditti, Livio Pagano, Roberto Lemoli, Fabio Guolo
Journal: Blood
Blood (2025) 146 (Supplement 1): 4608.
https://doi.org/10.1182/blood-2025-4608
Published: 2025
Journal Articles

First interim analysis of venetoclax real-world observational study on newly-diagnosed AML patients in Italy (VERO): Focus on patient and diseases characteristics and quality of life at baseline

Free
Ivana Lotesoriere, Caterina Alati, lorenzo celona, Monia Lunghi, gianluca martini, jacopo nanni, Vincenzo Federico, Antonino Mule', MARINA PARISI, PRASSEDE SALUTARI, Ida Carmosino, Valeria Cardinali, ANDREA PASQUINI, Marco Frigeni, Roberto Cairoli, FEDERICO MORETTI, Anna Candoni, SELENIA VITIELLO, Irene Zacheo, Benedetta Neri, PAOLA FINSINGER, LUIGI DI CAPRIO, GIULIANA GUALBERTI, LUDOVICA MAGI, CARMEN STEFANINI, Marta Ubezio
Journal: Blood
Blood (2025) 146 (Supplement 1): 5159.
https://doi.org/10.1182/blood-2025-5159
Published: 2025
Journal Articles

International, prospective study comparing nilotinib versus imatinib with early switch to nilotinib to obtain sustained treatment-free remission (TFR) in patients with chronic myeloid leukemia: The tfr rate at the end of follow-up

Free
Massimo Breccia, Fausto Castagnetti, Elisabetta Abruzzese, Renato Bassan, Gianni Binotto, Massimiliano Bonifacio, Giovanni Caocci, Isabella Capodanno, Francesco Cavazzini, Giuseppe Cimino, Paola Fazi, Antonella Gozzini, Alessandra Iurlo, Jeroen Janssen, Monia Lunghi, Roberto Marasca, Bruno Martino, Monica Messina, Francesco Muriano, Francesca Paoloni, Alfonso Piciocchi, Gianantonio Rosti, Antonella Russo Rossi, Giuseppe Saglio, Simona Sica, Simona Soverini, Agostino Tafuri, Daniele Vallisa, Peter Westerweel, Fabrizio Pane
Journal: Blood
Blood (2025) 146 (Supplement 1): 905.
https://doi.org/10.1182/blood-2025-905
Published: 2025
Journal Articles

First results of the Phase III GIMEMA ALL2820 trial comparing ponatinib plus blinatumomab to imatinib and chemotherapy for newly diagnosed adult ph+ acute lymphoblastic leukemia patients

Free
Sabina Chiaretti, Mariangela Di Trani, Cristina Skert, Loredana Elia, Giada Almici, Irene Della Starza, Deborah Cardinali, Vittorio Bellomarino, Stefano Soddu, Monica Messina, Martina Rachele Marino, Maria Stefania De Propris, Erika Borlenghi, Francesco Di Raimondo, Michela Ansuinelli, Caterina Alati, Daniele G. Mattei, Valentina Mancini, Patrizia Chiusolo, Barbara Scappini, Maria Paola Martelli, Prassede Salutari, Marco Cerrano, Bianca Serio, Antonella Cucca, Mario Luppi, Daniele Vallisa, Crescenza Pasciolla, Claudio Romani, Martina Chiarucci, Federico Mosna, Massimiliano Bonifacio, Nicola Stefano Fracchiolla, Monica Bocchia, Silvia Imbergamo, Catello Califano, Giuseppe Rodolfo Nunziata, Mario Annunziata, Antonino Mule', Patrizia Zappasodi, Fabio Giglio, Daniela Pietrasanta, Matteo Della Porta, Maurizio Musso, Monia Lunghi, Francesco Zaja, Elisabetta Todisco, Claudia Maria Basilico, Alfonso Piciocchi, Paola Fazi, Alessandro Rambaldi, Robin Foà
Journal: Blood
Blood (2025) 146 (Supplement 1): 439.
https://doi.org/10.1182/blood-2025-439
Published: 2025
Journal Articles

Up-front blinatumomab improves MRD clearance and outcome in adult Ph – B-lineage ALL: the GIMEMA LAL2317 phase 2 study

Available to Purchase
Clinical Trials & Observations
Renato Bassan, Sabina Chiaretti, Irene Della Starza, Alessandra Santoro, Orietta Spinelli, Manuela Tosi, Loredana Elia, Deborah Cardinali, Maria Stefania De Propris, Matteo Piccini, Federico Lussana, Mario Annunziata, Patrizia Chiusolo, Patrizia Zappasodi, Erika Borlenghi, Matteo Leoncin, Catello Califano, Monica Bocchia, Francesco Di Raimondo, Francesco Grimaldi, Mario Tiribelli, Anna Candoni, Albana Lico, Ernesta Audisio, Monia Lunghi, Anna Maria Mianulli, Mariangela Di Trani, Valentina Arena, Monica Messina, Alfonso Piciocchi, Paola Fazi, Alessandro Rambaldi, Robin Foà
Journal: Blood
Blood (2025) 145 (21): 2447–2459.
https://doi.org/10.1182/blood.2024027500
Published: 2025
Includes: Supplemental data
Journal Articles

Evaluating the Impact of Cross-over from Imatinib to Nilotinib on the Overall Survival in Chronic Myeloid Leukemia Using Inverse Probability of Censoring Weighting: Results from the Gimema Sustrenim Study

Free
Alfonso Piciocchi, Giovanni Marsili, Ylenia Belperio, Monica Messina, Francesca Paola Paoloni, Stefano Soddu, Isabella Capodanno, Rosaria Sancetta, Elisabetta Abruzzese, Alessandro Pulsoni, Monia Lunghi, Giovanni Caocci, Fausto Castagnetti, Paola Fazi, Marco Vignetti, Massimo Breccia, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 4530.
https://doi.org/10.1182/blood-2024-198366
Published: 2024
Journal Articles

Final Analysis of the Italian Campus ALL Observational Study on 476 Older Patients with Philadelphia-Negative Acute Lymphoblastic Leukemia

Free
Marco Cerrano, Lazzarotto Davide, Eleonora Boscaro, Erika Borlenghi, Ilaria Tanasi, Patrizia Chiusolo, Paola Minetto, Francesco Grimaldi, Michelina Dargenio, Matteo Leoncin, Silvia Trappolini, Cristina Papayannidis, Fabio Forghieri, Carmela Gurrieri, Patrizia Zappasodi, Roberta La Starza, Nicola Fracchiolla, Federica Di Biase, Maria Ilaria Del Principe, Marzia Defina, Crescenza Pasciolla, Benedetta Cambò, Federico Mosna, Daniela Pietrasanta, Sabrina Mariani, Valentina Mancini, Fabio Guolo, Federico Lussana, Elisabetta Todisco, Mario Annunziata, Valeria Calafiore, Maria Ciccone, Matteo Piccini, Matteo Emidio Dragani, Beatrice Sani, Endri Mauro, Claudia Basilico, Beatrice De Marco, Marco Antonacci, Laura Forlani, Monica Fumagalli, Fabio Trastulli, Monia Lunghi, Prassede Salutari, Sara Mastaglio, Sabina Chiaretti, Anna Candoni, Felicetto Ferrara, Giovanni Pizzolo, Robin Foà, Massimiliano Bonifacio
Journal: Blood
Blood (2024) 144 (Supplement 1): 113.
https://doi.org/10.1182/blood-2024-206854
Published: 2024
Journal Articles

Measurable Residual Disease Monitoring for Philadelphia Positive Acute Lymphoblastic Leukemia (Ph+ALL) in the Setting of the Gimema ALL2820 Trial

Free
Marco Beldinanzi, Vittorio Bellomarino, Deborah Cardinali, Irene Della Starza, Mabel Matarazzo, Mariangela Di Trani, Matteo Leoncin, Clara Minotti, Lara Pochintesta, Erika Borlenghi, Caterina Alati, Simona Sica, Valentina Mancini, Barbara Scappini, Bianca Serio, Marina Parisi, Lucia Ammirati, Antonella Cucca, Federico Lussana, Ernesta Audisio, Federico Mosna, Patrizia Zappasodi, Monica Bocchia, Silvia Imbergamo, Mario Luppi, Valeria Cardinali, Crescenza Pasciolla, Claudio Romani, Albana Lico, Benedetta Cambò, Massimiliano Bonifacio, Monica Messina, Daniele G. Mattei, Sara Mastaglio, Lara Aprile, Monia Lunghi, Anna Guarini, Robin Foà, Sabina Chiaretti
Journal: Blood
Blood (2024) 144 (Supplement 1): 2836.
https://doi.org/10.1182/blood-2024-210731
Published: 2024
Journal Articles

Italian Real-World Experience of Gilteritinib Monotherapy in Patients with Relapsed/Refractory FLT3-Mutated Acute Myeloid Leukemia: Preliminary Results

Free
Rosa Greco, Silvia Imbergamo, Elisabetta Pierdomenico, Barbara Di Camillo, Cristina Papayannidis, Elisabetta Todisco, Erika Borlenghi, Nicola Fracchiolla, Claudia Basilico, Monica Fumagalli, Patrizia Zappasodi, Mauro Turrini, Anna Candoni, Monia Lunghi, Maurizio Musso, Calogero Vetro, Fabio Guolo, Donato Mannina, Albana Lico, Anna Maria Scattolin, Gianpaolo Nadali, Monica Crugnola, Sara Galimberti, Francesco Marchesi, Elisabetta Metafuni, Tommaso Caravita di Toritto, Clara Minotti, Pellegrino Musto, Valentina Mancini, Marta Riva, Lorenzo Rizzo, Giovanni Grillo, Roberto Cairoli
Journal: Blood
Blood (2024) 144 (Supplement 1): 5188.
https://doi.org/10.1182/blood-2024-205427
Published: 2024
Journal Articles

ASXL1 Mutations at Diagnosis Did Not Impact on the Depth of Molecular Response (MR) and on Treatment-Free Remission (TFR) Eligibility in Chronic Phase (CP) Chronic Myeloid Leukemia (CML) Patients (pts) Receiving either Nilotinib (NIL) First-Line or Imatinib (IM) with Early Switch to NIL in Case of No Optimal Response in the SUSTRENIM Clinical Trial

Free
Simona Soverini, Sara De Santis, Cecilia Monaldi, Manuela Mancini, Valentina Giai, Marco Cerrano, Isabella Capodanno, Massimiliano Bonifacio, Elisabetta Abruzzese, Alessandra Iurlo, Fausto Castagnetti, Rosaria Sancetta, Luciano Levato, Carmen Fava, Mario Tiribelli, Francesco Cavazzini, Maria Cristina Miggiano, Niccolò Bolli, Agostino Tafuri, Alessandro Lucchesi, Daniele Vallisa, Monia Lunghi, Caterina Musolino, Samantha Bruno, Cristina Mosca, Mauro Ciriello, Giovanni Marsili, Alfonso Piciocchi, Paola Fazi, Michele Cavo, Jeroen J.W.M. Janssen, Peter E. Westerweel, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 3158.
https://doi.org/10.1182/blood-2024-205465
Published: 2024
Journal Articles

Efficacy and Toxicity of Frontline Ponatinib Plus Blinatumomab for Adult Ph+ ALL Patients of All Ages. Intermediate Analysis of the Gimema ALL2820

Free
Sabina Chiaretti, Matteo Leoncin, Loredana Elia, Stefano Soddu, Alfonso Piciocchi, Mabel Matarazzo, Mariangela Di Trani, Maurizio Martelli, Erika Borlenghi, Marina Parisi, Valentina Mancini, Caterina Alati, Daniele G. Mattei, Maria Paola Martelli, Prassede Salutari, Patrizia Chiusolo, Ernesta Audisio, Mario Luppi, Lara Pochintesta, Crescenza Pasciolla, Bianca Serio, Barbara Scappini, Antonella Cucca, Martina Chiarucci, Massimiliano Bonifacio, Nicola Fracchiolla, Silvia Imbergamo, Lucia Ammirati, Federico Mosna, Patrizia Zappasodi, Sara Mastaglio, Daniela Pietrasanta, Monica Bocchia, Monia Lunghi, Elisabetta Todisco, Paola Fazi, Alessandro Rambaldi, Robin Foà
Journal: Blood
Blood (2024) 144 (Supplement 1): 835.
https://doi.org/10.1182/blood-2024-207892
Published: 2024
Journal Articles

CPX-351 Induces High Rate of Complete Remission in the New ICC/ELN 2022 Adverse-Risk Entity ‘AML with MDS-Related Gene Mutations’: Evidence from a Large Real-World Italian Study

Free
Gaetano Cimino, Matteo Caridi, Valeria Cardinali, Sofia Sciabolacci, Luana Fianchi, Federico Lussana, Sara Mastaglio, Monica Fumagalli, Sara Galimberti, Luca Maurillo, Federica Gigli, Caterina Patti, Erika Borlenghi, Monia Lunghi, Samuele Gatani, Jr., Ivana Lotesoriere, Marco Frigeni, Nicola Stefano Fracchiolla, Patrizia Chiusolo, Roberta La Starza, Caterina Matteucci, Massimo Bernardi, Antonio Pierini, Alessandra Carotti, Roberto Cairoli, Livio Pagano, Roberto Massimo Lemoli, Maria Teresa Voso, Adriano Venditti, Fabio Guolo, Elisabetta Todisco, Maria Paola Martelli
Journal: Blood
Blood (2024) 144 (Supplement 1): 2849.
https://doi.org/10.1182/blood-2024-210042
Published: 2024
Journal Articles

LONG-TERM Results of the Frontline Dasatinib/Blinatumomabprotocol (D-ALBA, GIMEMA LAL2116) for Adult Ph+ Acutelymphoblastic Leukemia

Free
Robin Foà, Renato Bassan, Loredana Elia, Alfonso Piciocchi, Stefano Soddu, Monica Messina, Felicetto Ferrara, Monia Lunghi, Antonino Mulè, Massimiliano Bonifacio, Nicola Fracchiolla, Prassede Salutari, Paola Fazi, Anna Guarini, Alessandro Rambaldi, Sabina Chiaretti
Journal: Blood
Blood (2023) 142 (Supplement 1): 4250.
https://doi.org/10.1182/blood-2023-187773
Published: 2023
Journal Articles

Pivekimab Sunirine (PVEK, IMGN632), a CD123-Targeting Antibody-Drug Conjugate, in Combination with Azacitidine and Venetoclax in Patients with Newly Diagnosed Acute Myeloid Leukemia

Free
Naval Daver, Pau Montesinos, Jessica K. Altman, Eunice S. Wang, Giovanni Martinelli, Gail J. Roboz, Kebede Begna, Paresh Vyas, Monia Lunghi, Uwe Platzbecker, Patrick W. Burke, Roland B. Walter, Anjali S. Advani, Sylvain Garciaz, Lauris Gastaud, David A Sallman, Naveen Pemmaraju, Laura Torres, Yasmin Abaza, Onyee Chan, Hagop M. Kantarjian, Benjamin Oshrine, Yining Du, Kara Malcolm, Kendra Sweet
Journal: Blood
Blood (2023) 142 (Supplement 1): 2906.
https://doi.org/10.1182/blood-2023-173413
Published: 2023
Journal Articles

International, Prospective Study Comparing Nilotinib Versus Imatinib with Early Switch to Nilotinib to Obtain Sustained Treatment-Free Remission in Patients with Chronic Myeloid Leukemia (SUSTRENIM trial): Analysis of the Eligibility to Treatment Discontinuation

Free
Fabrizio Pane, Fausto Castagnetti, Alfonso Piciocchi, Elisabetta Abruzzese, Renato Bassan, Gianni Binotto, Massimiliano Bonifacio, Giovanni Caocci, Francesco Cavazzini, Giuseppe Cimino, Antonella Gozzini, Monia Lunghi, Roberto Marasca, Bruno Martino, Francesco Muriano, Gianantonio Rosti, Antonella Russo Rossi, Simona Sica, Agostino Tafuri, Daniele Vallisa, Monica Messina, Francesca Paola Paoloni, Paola Fazi, Peter E Westerweel, Jeroen J.W.M. Janssen, Giuseppe Saglio, Massimo Breccia
Journal: Blood
Blood (2023) 142 (Supplement 1): 3169.
https://doi.org/10.1182/blood-2023-182220
Published: 2023