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Journal Articles

Efficacy and Toxicity of Frontline Ponatinib Plus Blinatumomab for Adult Ph+ ALL Patients of All Ages. Intermediate Analysis of the Gimema ALL2820

Sabina Chiaretti, Matteo Leoncin, Loredana Elia, Stefano Soddu, Alfonso Piciocchi, Mabel Matarazzo, Mariangela Di Trani, Maurizio Martelli, Erika Borlenghi, Marina Parisi, Valentina Mancini, Caterina Alati, Daniele G. Mattei, Maria Paola Martelli, Prassede Salutari, Patrizia Chiusolo, Ernesta Audisio, Mario Luppi, Lara Pochintesta, Crescenza Pasciolla, Bianca Serio, Barbara Scappini, Antonella Cucca, Martina Chiarucci, Massimiliano Bonifacio, Nicola Fracchiolla, Silvia Imbergamo, Lucia Ammirati, Federico Mosna, Patrizia Zappasodi, Sara Mastaglio, Daniela Pietrasanta, Monica Bocchia, Monia Lunghi, Elisabetta Todisco, Paola Fazi, Alessandro Rambaldi, Robin Foà
Journal: Blood
Blood (2024) 144 (Supplement 1): 835.
https://doi.org/10.1182/blood-2024-207892
Published: 2024
Journal Articles

Sequential Chemotherapy and Blinatumomab to Improve Minimal Residual Disease in Adult Ph- B-Lineage Acute Lymphoblastic Leukemia. Final Results of the Phase II Gimema LAL2317 Trial

Sabina Chiaretti, Irene Della Starza, Alessandra Santoro, Orietta Spinelli, Loredana Elia, Maria Stefania De Propris, Matteo Piccini, Patrizia Chiusolo, Felicetto Ferrara, Patrizia Zappasodi, Erika Borlenghi, Catello Califano, Monica Bocchia, Elisa Mauro, Fabrizio Pane, Anna Candoni, Albana Lico, Ernesta Audisio, Monia Lunghi, Anna Maria Mianulli, Mariangela Di Trani, Valentina Arena, Monica Messina, Alfonso Piciocchi, Paola Fazi, Alessandro Rambaldi, Robin Foà, Renato Bassan
Journal: Blood
Blood (2023) 142 (Supplement 1): 826.
https://doi.org/10.1182/blood-2023-174973
Published: 2023
Journal Articles

LONG-TERM Results of the Frontline Dasatinib/Blinatumomabprotocol (D-ALBA, GIMEMA LAL2116) for Adult Ph+ Acutelymphoblastic Leukemia

Robin Foà, Renato Bassan, Loredana Elia, Alfonso Piciocchi, Stefano Soddu, Monica Messina, Felicetto Ferrara, Monia Lunghi, Antonino Mulè, Massimiliano Bonifacio, Nicola Fracchiolla, Prassede Salutari, Paola Fazi, Anna Guarini, Alessandro Rambaldi, Sabina Chiaretti
Journal: Blood
Blood (2023) 142 (Supplement 1): 4250.
https://doi.org/10.1182/blood-2023-187773
Published: 2023
Journal Articles

Comparison between Dasatinib-Blinatumomab Vs Ponatinib-Blinatumomab Chemo-Free Strategy for Newly Diagnosed Ph+ Acute Lymphoblastic Leukemia Patients. Preliminary Results of the Gimema ALLL2820 Trial

Sabina Chiaretti, Matteo Leoncin, Loredana Elia, Alfonso Piciocchi, Mabel Matarazzo, Mariangela Di Trani, Simona Sica, Mario Luppi, Valentina Mancini, Erika Borlenghi, Silvia Imbergamo, Carmine Selleri, Giuseppe Visani, Bruno Martino, Daniele Vallisa, Calogero Vetro, Stefano Soddu, Monica Messina, Paola Fazi, Alessandro Rambaldi, Robin Foà
Journal: Blood
Blood (2023) 142 (Supplement 1): 4249.
https://doi.org/10.1182/blood-2023-189632
Published: 2023
Journal Articles

A Propensity Score Weighting Analysis Emphasizes the Progress of the Gimema Approach in Adult Ph-Positive Acute Lymphoblastic Leukemia in the TKI Era

Alfonso Piciocchi, Sabina Chiaretti, Marta Cipriani, Monica Messina, Loredana Elia, Irene Della Starza, Antonella Vitale, Paola Fazi, Marco Vignetti, Robin Foa
Journal: Blood
Blood (2023) 142 (Supplement 1): 4200.
https://doi.org/10.1182/blood-2023-179102
Published: 2023
Journal Articles

Digital Droplet PCR for Minimal Residual Disease Assessment in Philadelphia-Positive Acute Lymphoblastic Leukemia Using IG/TR Genes and BCR/ABL1 as Markers. Preliminary Results of a Comparative Analysis

Marco Beldinanzi, Irene Della Starza, Deborah Cardinali, Vittorio Bellomarino, Loredana Elia, Mabel Matarazzo, Mariangela Di Trani, Sabina Chiaretti, Robin Foà
Journal: Blood
Blood (2022) 140 (Supplement 1): 11866–11867.
https://doi.org/10.1182/blood-2022-163141
Published: 2022
Journal Articles

Role of Blinatumomab in Minimal Residual Disease and Hematologic Relapsed/Refractory Adult Acute Lymphoblastic Leukemia Patients Treated over 5 Years. a Single Center Experience

Michela Ansuinelli, MD, Antonella Vitale, MD, Giovanna Pecoraro, MD, Saveria Capria, MD, Silvia Maria Trisolini, MD, Clara Minotti, MD, Claudio Cartoni, MD, Anna Maria Testi, MD, Maria Luisa Moleti, MD, Anna Paola Iori, MD, Walter Barberi, MD PhD, Irene Della Starza, PhD, Loredana Elia, Bs, Francesca Mancini, Maria Stefania De Propris, Anna Guarini, PhD, Sabina Chiaretti, MD PhD, Robin Foà, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5121.
https://doi.org/10.1182/blood-2019-128156
Published: 2019
Journal Articles

Prognostic Impact of t(4;11)(q21;q23)/ KMT2A-AFF1 -Positivity in 926 BCR-ABL1 -Negative B-Lineage Acute Lymphoblastic Leukemia Patients Treated in Gimema Clinical Trials Since 1996

Alfonso Piciocchi, Monica Messina, Loredana Elia, Bs, Antonella Vitale, MD, Stefano Soddu, Anna Maria Testi, MD, Sabina Chiaretti, MD PhD, Marco Mancini, MD, Giorgina Specchia, MD, Antonio Spadano, MD, Mauro Krampera, Roberto Cairoli, MD, Francesco Di Raimondo, MD, Felicetto Ferrara, MD, Giuseppe Cimino, MD, Renato Bassan, MD, Paola Fazi, MD, Marco Vignetti, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1469.
https://doi.org/10.1182/blood-2019-121977
Published: 2019
Journal Articles

Dasatinib-Blinatumomab Combination for the Front-Line Treatment of Adult Ph+ ALL Patients. Updated Results of the Gimema LAL2116 D-Alba Trial

Sabina Chiaretti, MD PhD, Renato Bassan, MD, Antonella Vitale, MD, Loredana Elia, Bs, Alfonso Piciocchi, Cristina Puzzolo, PhD, Martina Canichella, MD, Felicetto Ferrara, MD, Monia Lunghi, MD PhD, Francesco Fabbiano, MD, Massimiliano Bonifacio, MD, Nicola Fracchiolla, Prassede Salutari, MD, Alessandra Mancino, Bs, Marco Vignetti, MD, Anna Guarini, PhD, Alessandro Rambaldi, MD, Robin Foà, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 740.
https://doi.org/10.1182/blood-2019-128759
Published: 2019
Journal Articles

Multicenter Total Therapy Gimema LAL 1509 Protocol for De Novo Adult Ph+ Acute Lymphoblastic Leukemia (ALL) Patients. Updated Results and Refined Genetic-Based Prognostic Stratification

Sabina Chiaretti, Antonella Vitale, Loredana Elia, Anna Lucia Fedullo, Silvana Albino, Alfonso Piciocchi, Paola Fazi, Francesco Di Raimondo, Antonella Fornaro, Francesco Fabbiano, Alfonso Maria D'Arco, Giovanni Martinelli, MD PhD, Francesca Ronco, Lidia Edwige Santoro, Nicola Cascavilla, MD, Piero Galieni, Alessandra Tedeschi, MD, Simona Sica, Nicola Di Renzo, Angela Melpignano, Angelo Michele Carella, Felicetto Ferrara, Marco Vignetti, Robin Foà
Journal: Blood
Blood (2015) 126 (23): 81.
https://doi.org/10.1182/blood.V126.23.81.81
Published: 2015
Journal Articles

First Results of the Multicenter Total Therapy Gimema LAL 1509 Protocol for De Novo Adult Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) Patients

Sabina Chiaretti, MDPhD, Antonella Vitale, MD, Loredana Elia, PhD, Silvana Albino, Bsc, Alfonso Piciocchi, PhD, Paola Fazi, MD, Francesco Di Raimondo, MD, Antonella Fornaro, MD, Francesco Fabbiano, MD, Alfonso Maria D'Arco, MD, Giovanni Martinelli, MD, Francesca Ronco, MD, Lidia Edwige Santoro, MD, Nicola Cascavilla, MD, Piero Galieni, MD, Alessandra Tedeschi, MD, Simona Sica, MD, Nicola Di Renzo, MD, Angela Melpignano, MD, Angelo Michele Carella, Felicetto Ferrara, Marco Vignetti, MD, Robin Foa, MD
Journal: Blood
Blood (2014) 124 (21): 797.
https://doi.org/10.1182/blood.V124.21.797.797
Published: 2014
Journal Articles

Adult B-Cell Precursor Acute Lymphoblastic Leukemia (BC-ALL) Negative For Recurrent Fusion Genes Are Characterized By a High Complex Genetic Heterogeneity Influencing Prognosis

Ilaria Iacobucci, Anna Ferrari, Margherita Perricone, Valentina Robustelli, Cristina Papayannidis, MD, Roberta Zuntini, Maria Chiara Abbenante, Claudia Venturi, Carmen Baldazzi, Emanuela Ottaviani, Barbara Giannini, Andrea Ghelli Luserna Di Rorà, Annalisa Lonetti, Antonella Vitale, Loredana Elia, Viviana Guadagnuolo, Nicoletta Testoni, BS, Simona Soverini, Stefania Paolini, Sarah Parisi, Chiara Sartor, Federica Cattina, Domenico Russo, Robin Foà, Sabina Chiaretti, Alexander Kohlmann, PhD, Giovanni Martinelli
Journal: Blood
Blood (2013) 122 (21): 2622.
https://doi.org/10.1182/blood.V122.21.2622.2622
Published: 2013
Journal Articles

Whole Transcriptome Sequencing In Refractory T-Cell Acute Lymphoblastic Leukemia

Valentina Gianfelici, Sabina Chiaretti, Zeynep Kalender Atak, Fulvia Brugnoletti, Messina Monica, Gert Hulselmans, Kim de Keersmaecker, Ellen Geerdens, Marco Mancini, Antonella Vitale, Loredana Elia, Mabel Matarazzo, Davide Rossi, Gianluca Gaidano, Anna Guarini, Stein Aerts, Jan Cools, Robin Foà
Journal: Blood
Blood (2013) 122 (21): 350.
https://doi.org/10.1182/blood.V122.21.350.350
Published: 2013
Journal Articles

Dasatinib as first-line treatment for adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia

Clinical Trials & Observations
Robin Foà, Antonella Vitale, Marco Vignetti, Giovanna Meloni, Anna Guarini, Maria Stefania De Propris, Loredana Elia, Francesca Paoloni, Paola Fazi, Giuseppe Cimino, Francesco Nobile, Felicetto Ferrara, Carlo Castagnola, Simona Sica, Pietro Leoni, Eliana Zuffa, Claudio Fozza, Mario Luppi, Anna Candoni, Ilaria Iacobucci, Simona Soverini, Franco Mandelli, Giovanni Martinelli, Michele Baccarani, on behalf of the GIMEMA Acute Leukemia Working Party
Journal: Blood
Blood (2011) 118 (25): 6521–6528.
https://doi.org/10.1182/blood-2011-05-351403
Published: 2011
Journal Articles

International Standardization of Minimal Residual Disease Assessment for in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL) Expressing m-BCR-ABL Transcripts: Updated Results of Quality Control Procedures by the EWALL and ESG-MRD-ALL Consortia

Heike Pfeifer, MD, Giovanni Cazzaniga, Orietta Spinelli, Jean-Michel Cayuela, Hélène Cavé, Peter Vandenberghe, MD, PhD, Carmen Chillon, Tomasz Sacha, MD, Sandrine Hayette, PhD, Silja Roettgers, PhD, Thomas Lion, MD, PhD, Professor, Letizia Foroni, MD PhD, Vincent H.J. van der Velden, PhD, Jan Zuna, Monica Hermanson, PhD, Martin Christian Mueller, MD, Thoralf Lange, Miroslaw Majewski, MD, Israel Bendit, MD, Fabrizio Pane, Ilaria Iacobucci, PhD, Veli Kairisto, MD, PhD, Christa Homburg, Smadar Avigad, Eng Juh Allen Yeoh, Beat Schäfer, Adele Fielding, Loredana Elia, Katarzyna Borg, Eric Delabesse, Susanne Schnittger, PhD, Sandra Markovic, Volker Werner, Nicola Goekbuget, MD, Dieter Hoelzer, MD, Jacques J.M. van Dongen, PhD, Oliver G. Ottmann, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2535.
https://doi.org/10.1182/blood.V118.21.2535.2535
Published: 2011
Journal Articles

Ultra-Deep Amplicon Sequencing Using Roche 454 Technology Allows High Sensitivity Bcr-Abl Kinase Domain Mutation Screening and Anticipates Emerging Mutations Leading to Resistance to Tyrosine Kinase Inhibitors in Philadelphia-Positive Leukemia Patients,

Simona Soverini, Caterina De Benedittis, Alessandra Gnani, Ilaria Iacobucci, PhD, Domenico Russo, Federica Cattina, MD, Fausto Castagnetti, Gabriele Gugliotta, Cristina Papayannidis, Antonella Vitale, Loredana Elia, Robin Foà, Francesca Palandri, Annalisa Lonetti, Maria Teresa Bochicchio, Sandra Durante, Gianantonio Rosti, MD, Michele Baccarani, MD, Giovanni Martinelli
Journal: Blood
Blood (2011) 118 (21): 3775.
https://doi.org/10.1182/blood.V118.21.3775.3775
Published: 2011
Journal Articles

Drug Resistance and Bcr-Abl Kinase Domain Mutations In Philadelphia-Positive Acute Lymphoblastic Leukemia From the Imatinib to the 2 nd -Generation Tyrosine Kinase Inhibitor Era: The Main Changes Are In the Type of Mutations, but Not In the Frequency of Mutation Involvement

Simona Soverini, Alessandra Gnani, Caterina De Benedittis, Ilaria Iacobucci, PhD, Annalisa Lonetti, Cristina Papayannidis, Leonardo Potenza, Mario Luppi, Serena Merante, Michele Malagola, Domenico Russo, Mario Tiribelli, Marzia Salvucci, Alfonso Zaccaria, Barbara Giannini, Giovanni Poletti, Antonella Vitale, Loredana Elia, Marco Vignetti, Robin Foà, Michele Baccarani, MD, Giovanni Martinelli
Journal: Blood
Blood (2011) 118 (21): 575.
https://doi.org/10.1182/blood.V118.21.575.575
Published: 2011
Journal Articles

Line Treatment of Adult Ph+ Acute Lymphoblastic Leukemia (ALL) Patients. Final Results of the GIMEMA LAL1205 Study

Robert Foà, Antonella Vitale, Anna Guarini, Maria Sefania De Propris, Loredana Elia, Giuseppe Cimino, Mario Luppi, Carlo Castagnola, Simona Sica, Rosa Nieddu, Maria-Novella Piersantelli, Felicetto Ferrara, Francesco Nobile, Renato Fanin, Francesco Fabbiano, Marco Vignetti, Paola Fazi, Simona Soverini, Franco Mandelli, Giovanni Martinelli, Giovanna Meloni, Michele Baccarani
Journal: Blood
Blood (2008) 112 (11): 305.
https://doi.org/10.1182/blood.V112.11.305.305
Published: 2008
Journal Articles

Philadelphia-Positive Acute Lymphoblastic Leukemia Patients Already Harbor Bcr-Abl Kinase Domain Mutations at Low Levels at the Time of Diagnosis - a Report by the GIMEMA ALL Working Party

Simona Soverini, Giovanni Martinelli, Antonella Vitale, Alessandra Gnani, Sabrina Colarossi, Stefania Paolini, Ilaria Iacobucci, Cristina Papayannidis, Marco Vignetti, Annalisa Lonetti, Loredana Elia, Giuseppe Leone, Mario Lazzarino, Giuseppe Torelli, Renato Fanin, Giuseppe Cimino, Giovanna Meloni, Anna Guarini, Franco Mandelli, Michele Baccarani, Robin Foà
Journal: Blood
Blood (2008) 112 (11): 722.
https://doi.org/10.1182/blood.V112.11.722.722
Published: 2008
Journal Articles

BCR-ABL Protein Detection by Flow Cytometry in Acute Lymphoblastic Leukemia Samples

Anna Guarini, Sara Raponi, Maria Sefania De Propris, Loredana Elia, Hobert Wai, Robert Foà
Journal: Blood
Blood (2008) 112 (11): 4859.
https://doi.org/10.1182/blood.V112.11.4859.4859
Published: 2008